Protective role of cyclosporine a and minocycline on mitochondrial disequilibrium-related podocyte injury and proteinuria occurrence induced by adriamycin

Nephrology Dialysis Transplantation

Volumn 30, Issue 6, 2015, Pages 957-969

  Guan, Na ^a   Ren, Ya Li ^a   Liu, Xiao Ya ^a   Zhang, Ying ^a   Pei, Pei ^a   Zhu, Sai Nan ^a   Fan, Qingfeng ^a,b  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

cyclosporine A; minocycline; mitochondria; mitofusin; podocyte

Indexed keywords

CASPASE 3; CYCLOSPORIN A; CYTOCHROME C; DOXORUBICIN; MINOCYCLINE; MITOFUSIN 1; MITOFUSIN 2; PODOCIN; ANTIINFECTIVE AGENT; ANTINEOPLASTIC ANTIBIOTIC; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT;

ACTIN FILAMENT; ADRIAMYCIN-INDUCED NEPHROPATHY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL DAMAGE; CELL DENSITY; CELL PROTECTION; CELL SHAPE; CELL STRUCTURE; CELL SURFACE; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPATHOLOGY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MITOCHONDRIAL DISEQUILIBRIUM RELATED PODOCYTE INJURY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEINURIA; QUANTITATIVE ANALYSIS; RENAL PROTECTION; STEREOMETRY; SURFACE AREA; TREATMENT DURATION; URINALYSIS; ANIMAL; APOPTOSIS; CHEMICALLY INDUCED; DRUG EFFECTS; FLUORESCENT ANTIBODY TECHNIQUE; KIDNEY DISEASES; METABOLISM; PATHOLOGY; PODOCYTE; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CASPASE 3; CYCLOSPORINE; DOXORUBICIN; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOSUPPRESSIVE AGENTS; KIDNEY DISEASES; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MINOCYCLINE; MITOCHONDRIA; PODOCYTES; PROTEINURIA; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84939620527     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfv015     Document Type: Article

References (41)

1. Grahammer F, Schell C, Huber TB. The podocyte slit diaphragm - from a thin grey line to a complex signalling hub. Nat Rev Nephrol 2013; 9: 587-598
2. Tharaux PL, Huber TB. How many ways can a podocyte die? Semin Nephrol 2012; 32: 394-404
3. Estaquier J, Vallette F, Vayssiere JL et al. The mitochondrial pathways of apoptosis. Adv Exp Med Biol 2012; 942: 157-183
4. Hoppins S. The regulation of mitochondrial dynamics. Curr Opin Cell Biol 2014; 29C: 46-52
5. Imasawa T, Rossignol R. Podocyte energy metabolism and glomerular diseases. Int J Biochem Cell Biol 2013; 45: 2109-2118
6. Güçer S, Talim B, Aşan E et al. Focal segmental glomerulosclerosis associated with mitochondrial cytopathy: report of two cases with special emphasis on podocytes. Pediatr Dev Pathol 2005; 8: 710-717
7. Su M, Dhoopun AR, Yuan Y et al. Mitochondrial dysfunction is an early event in aldosterone-induced podocyte injury. Am J Physiol Renal Physiol 2013; 305: F520-F531
8. Abe Y, Sakairi T, Beeson C et al. TGF-β1 stimulates mitochondrial oxidative phosphorylation and generation of reactive oxygen species in cultured mouse podocytes, mediated in part by the mTOR pathway. Am J Physiol Renal Physiol 2013; 305: F1477-F1490
9. Sack MN. Mitofusin function is dependent on the distinct tissue and organ specific roles of mitochondria. J Mol Cell Cardiol 2011; 511: 881-882
10. Brooks C, Cho SG, Wang CY et al. Fragmented mitochondria are sensitized to Bax insertion and activation during apoptosis. Am J Physiol Cell Physiol 2011; 300: C447-C455
11. Brooks C, Wei Q, Cho S et al. Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models. J Clin Invest 2009; 119: 1275-1285
12. Liesa M, Palacin M, Zorzano A. Mitochondrial dynamics in mammalian health and disease. Physiol Rev 2009; 89: 799-845
13. Cattran DC. Cyclosporine in the treatment of idiopathic focal segmental glomerulosclerosis. Semin Nephrol 2003; 23: 234-241
14. Tábara LC, Poveda J, Martin-Cleary C et al. Mitochondria-targeted therapies for acute kidney injury. Expert Rev Mol Med 2014; 16: e13
15. Karachitos A, Jordan J, Kmita H. Cytoprotective activity of minocycline includes improvement of mitochondrial coupling: the importance of minocycline concentration and the presence of VDAC. J Bioenerg Biomembr 2012; 44: 297-307
16. Fan Q, Xing Y, Ding J et al. The relationship among nephrin, podocin, CD2AP, and alpha-actinin might not be a true 'interaction' in podocyte. Kidney Int 2006; 69: 1207-1215
17. Ogawa Y, Nishioka A, Kobayashi T et al. Mitochondrial cytochrome c release in radiation-induced apoptosis of human peripheral T cells. Int J Mol Med 2002; 10: 263-268
18. Pippin JW, Brinkkoetter PT, Cormack-Aboud FC et al. Inducible rodent models of acquired podocyte diseases. Am J Physiol Renal Physiol 2009; 296: F213-F229
19. Yang ZW. Essential Tools for Morphometric Studies of Biological Tissues: Practical Stereological Methods. Beijing: Science Press, 2012, 106 pp
20. Picard M, White K, Turnbull DM. Mitochondrial morphology, topology, and membrane interactions in skeletal muscle: a quantitative three-dimensional electron microscopy study. J Appl Physiol (1985) 2013; 114: 161-171
21. Boatright KM, Salvesen GS. Mechanisms of caspase activation. Curr Opin Cell Biol 2003; 15: 725-731
22. Benard G, Karbowski M. Mitochondrial fusion and division: regulation and role in cell viability. Semin Cell Dev Biol 2009; 20: 365-374
23. Dinour D, Mini S, Polak-Charcon S et al. Progressive nephropathy associated with mitochondrial tRNA gene mutation. Clin Nephrol 2004; 62: 149-154
24. Diomedi-Camassei F, Di Giandomenico S, Santorelli FM et al. COQ2 nephropathy: a newly described inherited mitochondriopathy with primary renal involvement. J Am Soc Nephrol 2007; 18: 2773-2780
25. Picard M, Shirihai OS, Gentil BJ et al. Mitochondrial morphology transitions and functions: implications for retrograde signaling? Am J Physiol Regul Integr Comp Physiol 2013; 304: R393-R406
26. Lee VW, Harris DC. Adriamycin nephropathy: a model of focal segmental glomerulosclerosis. Nephrology 2011; 16: 30-38
27. Zhu C, Xuan X, Che R et al. Dysfunction of the PGC-1α-mitochondria axis confers adriamycin-induced podocyte injury. Am J Physiol Renal Physiol 2014; 306: F1410-F1417
28. DuBoff B, Feany M, Götz J. Why size matters - balancing mitochondrial dynamics in Alzheimer's disease. Trends Neurosci 2013; 36: 325-335
29. Trudeau K, Molina AJ, Roy S. High glucose induces mitochondrial morphology and metabolic changes in retinal pericytes. Invest Ophthalmol Vis Sci 2011; 52: 8657-8664
30. Coimbra TM, Janssen U, Gröne HJ et al. Early events leading to renal injury in obese Zucker (fatty) rats with type II diabetes. Kidney Int 2000; 57: 167-182
31. Papeta N, Zheng Z, Schon EA et al. Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice. J Clin Invest 2010; 120: 4055-4064
32. Gedik N, Heusch G, Skyschally A. Infarct size reduction by cyclosporine A at reperfusion involves inhibition of the mitochondrial permeability transition pore but does not improve mitochondrial respiration. Arch Med Sci 2013; 9: 968-975
33. Uchino H, Hatakeyama K, Morota S et al. Cyclophilin-D inhibition in neuroprotection: dawn of a new era of mitochondrial medicine. Acta Neurochir Suppl 2013; 118: 311-315
34. Pottecher J, Guillot M, Belaidi E et al. Cyclosporine A normalizes mitochondrial coupling, reactive oxygen species production, and inflammation and partially restores skeletal muscle maximal oxidative capacity in experimental aortic cross-clamping. J Vasc Surg 2013; 57: 1100-1108
35. Schwartz J, Holmuhamedov E, Zhang X et al. Minocycline and doxycycline, but not other tetracycline-derived compounds, protect liver cells from chemical hypoxia and ischemia/reperfusion injury by inhibition of the mitochondrial calcium uniporter. Toxicol Appl Pharmacol 2013; 273: 172-179
36. Orsucci D, Mancuso M, Filosto M et al. Tetracyclines and neuromuscular disorders. Curr Neuropharmacol 2012; 10: 134-138
37. Karachitos A, García Del Pozo JS, de Groot PW et al. Minocycline mediated mitochondrial cytoprotection: premises for therapy of cerebrovascular and neurodegenerative diseases. Curr Drug Targets 2013; 14: 47-55
38. Castanares M, Vera Y, Erkkilä K et al. Minocycline up-regulates BCL-2 levels in mitochondria and attenuates male germ cell apoptosis. Biochem Biophys Res Commun 2005; 337: 663-669
39. Wang W, Wang Y, Long J et al. Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells. Cell Metab 2012; 15: 186-200
40. Guo X, Chen KH, Guo Y et al. Mitofusin 2 triggers vascular smooth muscle cell apoptosis via mitochondrial death pathway. Circ Res 2007; 101: 1113-1122
41. Ong SB, Hall AR, Dongworth RK et al. Akt protects the heart against ischaemia-reperfusion injury by modulating mitochondrial morphology. Thromb Haemost 2014; 113 (Epub ahead of print)