Akt protects the heart against ischaemia-reperfusion injury by modulating mitochondrial morphology

Thrombosis and Haemostasis

Volumn 113, Issue 3, 2015, Pages 513-521

  Ong, Sang Bing ^a   Hall, Andrew R ^a   Dongworth, Rachel K ^a   Kalkhoran, Siavash ^a   Pyakurel, Aswin ^b   Scorrano, Luca ^b   Hausenloy, Derek J ^a  

^a UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^b VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

Author keywords

Akt; Ischaemia; Mitochondrial morphology; Myocardial infarction; Reperfusion

Indexed keywords

CYCLOSPORIN A; ERYTHROPOIETIN; HYBRID PROTEIN; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PROTEIN KINASE B; TETRAMETHYLRHODAMINE METHYL ESTER; CARRIER PROTEIN; GUANOSINE TRIPHOSPHATASE; MFN1 PROTEIN, MOUSE;

ANIMAL MODEL; ARTICLE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; ELECTRON MICROSCOPY; GENETIC TRANSFECTION; HEART PROTECTION; MALE; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MORPHOLOGY MODULATION; MODULATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REPERFUSION INJURY; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CARDIAC MUSCLE; CELL LINE; DISEASE MODEL; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; GENETICS; HEART MITOCHONDRION; METABOLISM; MITOCHONDRIAL VOLUME; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY; SIGNAL TRANSDUCTION; TIME FACTOR; ULTRASTRUCTURE;

ANIMALS; CELL DEATH; CELL LINE; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; ERYTHROPOIETIN; GTP PHOSPHOHYDROLASES; MALE; MICE, INBRED C57BL; MITOCHONDRIA, HEART; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL SIZE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

EID: 84924098618     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH14-07-0592     Document Type: Article

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