A new fusion gene TPM3-ALK in anaplastic large cell lymphoma created by a (1;2)(q25;p23) translocation

Blood

Volumn 93, Issue 9, 1999, Pages 3088-3095

  Lamant, Laurence ^b   Dastugue, Nicole ^b   Pulford, Karen ^b   Delsol, Georges ^a   Mariamé, Bernard ^b  

^a CHU PURPAN   (France)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE;

ARTICLE; CASE REPORT; CHROMOSOME 1Q; CHROMOSOME 2Q; CHROMOSOME 5Q; CHROMOSOME TRANSLOCATION 1; CHROMOSOME TRANSLOCATION 2; FUSION GENE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARGE CELL LYMPHOMA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0033134786     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.9.3088.409k30_3088_3095     Document Type: Article

References (49)

1. Mason DY, Bastard C, Rimokh R, Dastugue N, Huret JL, Kristoffersson U, Magaud JP, Nezelof C, Tilly H, Vannier JP, Hemet J, Warnke R: CD30-positive large cell lymphomas ("Ki-1 lymphoma") are associated with a chromosomal translocation involving 5q35. Br J Haematol 74:161, 1990
2. Downing JR, Shurtleff SA, Zielenska M, Curcio-Brint AM, Behm FG, Head DR, Sandlund JT, Weisenburger DD, Kossakowska AE, Thorner P, Lorenzana A, Ladanyi M, Morris SW: Molecular detection of the (2;5) translocation of non-Hodgkin's lymphoma by reverse transcriptase-polymerase chain reaction. Blood 85:3416, 1995
3. Elmberger PG, Lozano MD, Weisenburger DD, Sanger W, Chan WC: Transcripts of the npm-alk fusion gene in anaplastic large cell lymphoma, Hodgkin's disease, and reactive lymphoid lesions. Blood 86:3517, 1995
4. Wellmann A, Otsuki T, Vogelbruch M, Clark HM, Jaffe ES, Raffeld M: Analysis of the t(2;5)(p23;q35) translocation by reverse-transcription-polymerase chain reaction in CD30+ anaplastic large-cell lymphomas, in other non-Hodgkin's lymphomas of T-cell phenotype and in Hodgkin's disease. Blood 86:2321, 1995
5. Lamant L, Meggetto F, Al Saati T, Brugieres L, Bressac de Paillerets B, Dastugue N, Bernheim A, Rubie H, Terrier Lacombe M, Robert A, Brousset P, Rigal F, Schlaifer D, Shiota M, Mori S, Delsol G: High incidence of the t(2;5) (p23;q35) translocation in anaplastic large cell lymphoma and its lack of detection in Hodgkin's disease: Comparison of cytogenetic analysis, RT-PCR and p80 immunostaining. Blood 87:284, 1996
6. Benharroch D, Meguerian-Bedoyan Z, Lamant L, Amin C, Brugieres L, Terrier-Lacombe MJ, Haralambieva E, Pulford K, Pileri S, Morris SW, Mason DY, Delsol G: ALK-positive lymphoma; a single disease with a broad spectrum of morphology. Blood 91:2076, 1998
7. Lopategui JR, Sun LH, Chan JKC, Gaffey MJ, Frierson HF, Glackin C, Weiss LM: Low frequency association of the t(2;5)(p23;q35) chromosomal translocation with CD30+ lymphomas from american and asian patients. Am J Pathol 146:3238, 1995
8. Morris SW, Kirstein MN, Valentine MB, Dittmer KG, Shapiro DN, Saltman DL, Look AT: Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science 263:1281, 1994
9. Iwahara T, Fujimoto J, Wen D, Cupples R, Bucay N, Arakawa T, Mori S, Ratzkin B, Yamamoto T: Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. Oncogene 14:439, 1997
10. Morris SW, Naeve C, Mathew P, James PL, Kirstein MN, Cui X, Witte DP: ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK). Oncogene 14:2175, 1997
11. Chan WY, Liu QR, Borjigin J, Busch H, Rennert OM, Tease LA, Chan PK: Characterization of the cDNA encoding human nucleophosmin and studies of its role in normal and abnormal growth. Biochemistry 28:1033, 1989
12. Chan PK, Chan FY, Morris SW, Xie Z: Isolation and characterization of the human nucleophosmin/B23 (NPM) gene: Identification of the YY1 binding site at the 5′ enhancer region. Nucleic Acid Res 25:1225, 1997
13. Bischof D, Pulford K, Mason DY, Morris SW: Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphomaassociated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis. Mol Cell Biol 17:2312, 1997
14. Mason DY, Pulford KAF, Bischof D, Kuefer MU, Butler LH, Lamant L, Delsol G, Morris SW: Nucleolar localization of the NPM-ALK tyrosine kinase is not required for malignant transformation. Cancer Res 58:1057, 1998
15. Morgan MS, Hecht BK, Sandberg AA, Hecht F: Chromosome 5q35 breakpoint in malignant histiocytosis. N Engl J Med 314:1322, 1986
16. Ladanyi M, Cavalchire G: Molecular variant of the NPM-ALK rearrangement of Ki-1 lymphoma involving a cryptic ALK splice site. Genes Chromosom Cancer 15:173, 1996
17. Sainati L, Montaldi A, Stella M, Putti MC, Zanesco L, Basso G: A novel variant translocation t(2;13)(p23;q34) in Ki-1 large cell anaplastic lymphoma. Br J Haematol 75:621, 1990
18. Park JP, Curran MJ, Levy NB, Davis TH, Elliot JH, Mohandas TK: Diffuse large cell, B-cell type lymphoma with a novel translocation (2;22)(p23;q11.2). Cancer Genet Cytogenet 96:118, 1997
19. Pittaluga S, Wlodarska I, Pulford K, Campo E, Morris SW, Van den Berghe H, De Wolf-Peeters C: The monoclonal antibody ALK1 identifies a distinct morphological subtype of anaplastic large cell lymphoma associated with 2p23/ALK rearrangements. Am J Pathol 151:343, 1997
20. Pulford K, Lamant L, Morris SW, Butler LH, Wood KM, Stroud D, Delsol G, Mason DY: Detection of anaplastic lymphoma kinase (ALK) and nucleolar protein nucleophosmin (NPM)-ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1. Blood 89:1394, 1997
21. Shiota M, Fujimoto J, Takenaga M, Satoh H, Ichinohasama R, Abe M, Nakano M, Yamamoto T, Mori S: Diagnosis of t(2;5)(p23;q35)-associated Ki-1 lymphoma with immunohistochemistry. Blood 84: 3648, 1994
22. Siebert PD, Chenchik A, Kellogg DE, Lukyanov KA, Lukyanov SA: An improved PCR method for walking in uncloned genomic DNA. Nucleic Acids Res 23:1087, 1995
23. Martin-Zanca D, Hughes SH, Barbacid M: A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature 319:743, 1986
24. Reinach FC, MacLeod AR: Tissue-specific expression of the human tropomyosin gene involved in the generation of the trk oncogene. Nature 322:648, 1986
25. Butti MG, Bongarzone I, Ferraresi G, Mondellini P, Borrello MG, Pierotti MA: A sequence analysis of the genomic regions involved in the rearrangements between TPM3 and NTRK1 genes producing TRK oncogenes in papillary thyroid carcinomas. Genomics 28:15, 1995
26. Stein H, Mason DY, Gerdes J, O'Connor N, Wainscoat J, Pallesen G, Gatter K, Falini B, Delsol G, Lemke H, Schwarting R, Lennert K: The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: Evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood 66:848, 1985
27. Delsol G, Chittal S, Brousset P, Caverivière P, Roda D, Mazerolles C, Barillet-Alard C, Al Saati T, Gorguet B, Voigt JJ: Immunohistochemical demonstration of leucocyte differentiation antigens on paraffin sections using a modified AMeX (ModAMeX) method. Histopathology 15:461, 1989
28. Gu SY, Tann BF, Zeng Y, Zhou WP, Li K, Zhao MC: Establishment of an epithelial cell line (CNE-2) from an NPC patient with poorly differentiated squamous cell carcinoma. Chin J Cancer 2:70, 1983
29. Pileri S, Falini B, Delsol G, Stein H, Baglioni P, Poggi S, Martelli MF, Rivano MT, Mason DY, Stansfeld AG: Lymphohistiocytic T-cell lymphoma CD30/Ki-1+ with high content of reactive histiocytes. Histopathology 16:383, 1990
30. Delsol G, Blancher A, Al Saati T, Ralfkiaer E, Lauritzen A, Brugières L, Brousset P, Rigal-Huguet F, Mazerolles C, Robert A, Chittal SM: Antibody BNH9 detects red blood cell-related antigens on anaplastic large cell (CD30+) lymphomas. Br J Cancer 64:321, 1991
31. Mitelman F (ed): An International System for Human Cytogenetic Nomenclature. Basel, Switzerland, Karger, 1995
32. Sambrook J, Fritsh EF, Maniatis T: Molecular Cloning. A Laboratory Manual. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory, 1989
33. 35S-dATP concentrations. Biotechnique 21:18, 1996
34. nm, a human cytoskeletal tropomyosin. Nucleic Acids Res 14:8413, 1986
35. Lin JJC, Warren KS, Wamboldt DD, Wang T, Lin JLC: Tropomyosin isoforms in nonmuscle cells. Int Rev Cytol 170:1, 1997
36. Kolibaba KS, Druker BJ: Protein tyrosine kinases and cancer. Biochim Biophys Acta 1333:F217, 1997
37. Borer RA, Lehner CF, Eppenberger HM, Nigg EA: Major nucleolar proteins shuttle between nucleus and cytoplasm. Cell 56:379, 1989
38. Yung BYM, Chan PK: Identification and characterization of a hexameric form of nucleolar phosphoprotein B23. Biochim Biophys Acta 925:74, 1987
39. Bailey K: Tropomyosin: A new asymetric protein component of the muscle fibril. Biochem J 43:271, 1948
40. Fine RE, Blitz AL: A chemical composition of tropomyosin from muscle and non-muscle tissues. J Mol Biol 95:447, 1975
41. Matsumura F, Lin JJC, Yamashiro-Matsumura S, Thomas GP, Topp WC: Differential expression of tropomyosin forms in the microfilaments isolated from normal and transformed rat cultured cells. J Biol Chem 258:13954, 1983
42. Smillie LB: Structure and function of tropomyosins from muscle and non-muscle sources. Trends Biochem Sci 4:151, 1979
43. nm gene. Implications for the evolution of muscle and non-muscle tropomyosins. J Mol Biol 201:507, 1988
44. Radice P, Sozzi G, Miozzo M, De Benedetti V, Cariani T, Bongarzone I, Spurr NK, Pierotti MA, Della Porta G: The human tropomyosin gene involved in the generation of the TRK oncogene maps to chromosome 1q31. Oncogene 6:2145, 1991
45. Wilton SD, Eyre H, Akkari PA, Watkins HC, MacRae C, Laing NG, Callen DC: Assignment of the human α-tropomyosin gene TPM3 to 1q22-23 by fluorescence in situ hybridisation. Cytogenet Cell Genet 68:122, 1995
46. Wyatt RT, Rudders RA, Zelenetz A, Delellis RA, Krontiris TG: BCL2 oncogene translocation is mediated by a χ-like consensus. J Exp Med 175:1575, 1993
47. Boehm T, Mengle-Gaw L, Kees UR, Spurr N, Lavenir I, Forster A, Rabbitts TH: Alternating purine-pyrimidine tracts may promote chromosomal translocations seen in a variety of human lymphoid tumors. EMBO J 8:2621, 1989
48. - acute leukemias: Implication of Alu sequences in a chromosomal translocation occurring in the new cluster region within the BCR gene. Oncogene 4:195, 1989
49. Cote GP, Smillie LB: Preparation and some properties of equine platelet tropomyosin. J Biol Chem 256:11004, 1981