Microvesicles Derived from Human Mesenchymal Stem Cells Restore Alveolar Fluid Clearance in Human Lungs Rejected for Transplantation

American Journal of Transplantation

Volumn 15, Issue 9, 2015, Pages 2404-2412

  Gennai, S ^a   Monsel, A ^b   Hao, Q ^c   Park, J ^c   Matthay, M A ^c   Lee, J W ^c  

^a GRENOBLE UNIVERSITY HOSPITAL   (France)

^b ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

lung failure injury; stem cells; tissue injury and repair

Indexed keywords

ANGIOPOIETIN 1; SYNDECAN 1; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CARBON DIOXIDE TENSION; CLINICAL ARTICLE; CONTROLLED STUDY; EX VIVO STUDY; FEMALE; HEMODYNAMIC PARAMETERS; HOST CELL; HUMAN; HUMAN CELL; INTERNALIZATION; LUNG ALVEOLUS CELL; LUNG ALVEOLUS OXYGEN TENSION; LUNG ARTERY PRESSURE; LUNG COMPLIANCE; LUNG EDEMA; LUNG FIBROBLAST; LUNG INJURY; LUNG PERFUSION; LUNG TRANSPLANTATION; LUNG VASCULAR RESISTANCE; LUNG VENTILATION; LUNG WEIGHT; MALE; MEMBRANE MICROPARTICLE; MESENCHYMAL STEM CELL; MIDDLE AGED; PRIORITY JOURNAL; THORAX RADIOGRAPHY; TIDAL VOLUME; CELL CULTURE; COMPLICATION; DONOR SELECTION; FOLLOW UP; IMMUNOLOGY; LUNG ALVEOLUS; LUNG DISEASES; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; METABOLISM; ORGAN PRESERVATION; PATHOLOGY; PERFUSION; PROCEDURES; PROGNOSIS; PULMONARY EDEMA; TRANSPLANTATION;

ADULT; CELL-DERIVED MICROPARTICLES; CELLS, CULTURED; DONOR SELECTION; FEMALE; FOLLOW-UP STUDIES; HUMANS; LUNG DISEASES; LUNG TRANSPLANTATION; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MIDDLE AGED; ORGAN PRESERVATION; PERFUSION; PROGNOSIS; PULMONARY ALVEOLI; PULMONARY EDEMA; TISSUE AND ORGAN PROCUREMENT;

EID: 84939568760     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.13271     Document Type: Article

References (35)

1. ISHLT. International Society of Heart and Lung Transplantation 2014. Available from: http://www.ishlt.org/.
2. SRTR. The U. S. Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients 2014. Available from: http://www.srtr.org/.
3. Cypel M, Keshavjee S,. The clinical potential of ex vivo lung perfusion. Expert Rev Respir Med 2012; 6: 27-35.
4. Cypel M, Yeung JC, Liu M, et al., Normothermic ex vivo lung perfusion in clinical lung transplantation. N Engl J Med 2011; 364: 1431-1440.
5. Lee JW, Krasnodembskaya A, McKenna DH, Song Y, Abbott J, Matthay MA,. Therapeutic effects of human mesenchymal stem cells in ex vivo human lungs injured with live bacteria. Am J Respir Crit Care Med 2013; 187: 751-760.
6. Gennai S, Souilamas R, Maignan M, et al., Effects of cyclosporine a in ex vivo reperfused pig lungs. Microcirculation 2014; 21: 84-92.
7. McAuley DF, Curley GF, Hamid UI, et al., Clinical grade allogeneic human mesenchymal stem cells restore alveolar fluid clearance in human lungs rejected for transplantation. Am J Physiol Lung Cell Mol Physiol 2014; 306: L809-L815.
8. Ware LB, Matthay MA,. Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med 2001; 163: 1376-1383.
9. Lee JW, Fang X, Gupta N, Serikov V, Matthay MA,. Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Proc Natl Acad Sci USA 2009; 106: 16357-16362.
10. Prockop DJ,. Defining the probability that a cell therapy will produce a malignancy. Mol Ther 2010; 18: 1249-1250.
11. Nauta AJ, Westerhuis G, Kruisselbrink AB, Lurvink EG, Willemze R, Fibbe WE,. Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting. Blood 2006; 108: 2114-2120.
12. Gyorgy B, Szabo TG, Pasztoi M, et al., Membrane vesicles, current state-of-the-art: Emerging role of extracellular vesicles. Cell Mol Life Sci 2011; 68: 2667-2688.
13. Bruno S, Grange C, Deregibus MC, et al., Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J Am Soc Nephrol 2009; 20: 1053-1067.
14. Zhu YG, Feng XM, Abbott J, et al., Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin-induced acute lung injury in mice. Stem Cells 2014; 32: 116-125.
15. Dominici M, Le Blanc K, Mueller I, et al., Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006; 8: 315-317.
16. Bruno S, Grange C, Collino F, et al., Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury. PloS ONE 2012; 7: e33115.
17. Fang X, Neyrinck AP, Matthay MA, Lee JW,. Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1. J Biol Chem 2010; 285: 26211-26222.
18. Murray JF, Matthay MA, Luce JM, Flick MR,. An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis 1988; 138: 720-723.
19. Ware LB, Golden JA, Finkbeiner WE, Matthay MA,. Alveolar epithelial fluid transport capacity in reperfusion lung injury after lung transplantation. Am J Rspir Crit Care Med 1999; 159: 980-988.
20. Sugita M, Ferraro P, Dagenais A, et al., Alveolar liquid clearance and sodium channel expression are decreased in transplanted canine lungs. Am J Respir Crit Care Med 2003; 167: 1440-1450.
21. Christie JD, Bavaria JE, Palevsky HI, et al., Primary graft failure following lung transplantation. Chest 1998; 114: 51-60.
22. Christie JD, Sager JS, Kimmel SE, et al., Impact of primary graft failure on outcomes following lung transplantation. Chest 2005; 127: 161-165.
23. Thurston G, Rudge JS, Ioffe E, et al., Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med 2000; 6: 460-463.
24. Salmon AH, Neal CR, Sage LM, Glass CA, Harper SJ, Bates DO,. Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx. Cardiovasc Res 2009; 83: 24-33.
25. Arslan F, Lai RC, Smeets MB, et al., Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury. Stem Cell Res 2013; 10: 301-312.
26. Lai RC, Yeo RW, Tan KH, Lim SK,. Mesenchymal stem cell exosome ameliorates reperfusion injury through proteomic complementation. Regen Med 2013; 8: 197-209.
27. Kim HS, Choi DY, Yun SJ, et al., Proteomic analysis of microvesicles derived from human mesenchymal stem cells. J Proteome Res 2012; 11: 839-849.
28. Islam MN, Das SR, Emin MT, et al., Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury. Nat Med 2012; 18: 759-765.
29. Gao P, Yang X, Mungur L, Kampo S, Wen Q,. Adipose tissue-derived stem cells attenuate acute lung injury through eNOS and eNOS-derived NO. Int J Mol Med 2013; 31: 1313-1318.
30. Salvolini E, Lucarini G, Zizzi A, Orciani M, Di Benedetto G, Di Primio R,. Human skin-derived mesenchymal stem cells as a source of VEGF and nitric oxide. Arch Dermatol Res 2010; 302: 367-374.
31. Oh I, Ozaki K, Sato K, et al., Interferon-gamma and NF-kappaB mediate nitric oxide production by mesenchymal stromal cells. Biochem Biophys Res Commun 2007; 355: 956-962.
32. Zhu H, Mitsuhashi N, Klein A, et al., The role of the hyaluronan receptor CD44 in mesenchymal stem cell migration in the extracellular matrix. Stem Cells 2006; 24: 928-935.
33. Thabut G, Mal H, Cerrina J, et al., Graft ischemic time and outcome of lung transplantation: A multicenter analysis. Am J Respir Crit Care Med 2005; 171: 786-791.
34. Rehm M, Bruegger D, Christ F, et al., Shedding of the endothelial glycocalyx in patients undergoing major vascular surgery with global and regional ischemia. Circulation 2007; 116: 1896-1906.
35. Schmidt EP, Yang Y, Janssen WJ, et al., The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. Nat Med 2012; 18: 1217-1223.