Effects of Cyclosporine A in Ex Vivo Reperfused Pig Lungs

Microcirculation

Volumn 21, Issue 1, 2014, Pages 84-92

  Gennai, Stéphane ^a,b   Souilamas, Redha ^c   Maignan, Maxime ^a,b   Brouta, Angélique ^b   Pison, Christophe ^d   Fontaine, Eric ^d   Briot, Raphaël ^a,b  

^a GRENOBLE UNIVERSITY HOSPITAL   (France)

^b LABORATOIRE TIMC IMAG   (France)

^c HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^d Domaine Universitaire   (France)

Author keywords

Ischemia reperfusion injury; Lung physiology; Lung transplantation; Pulmonary function

Indexed keywords

CYCLOSPORIN A; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAPILLARY PERMEABILITY; CAPILLARY PRESSURE; COLD ISCHEMIA; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MEGADOSE; EVALUATION STUDY; EX VIVO STUDY; EXPERIMENTAL PIG; EXTRACORPOREAL CIRCULATION; GAS EXCHANGE; LUNG ALVEOLUS; LUNG HEMODYNAMICS; LUNG INJURY; LUNG VASCULAR RESISTANCE; NONHUMAN; OXYGEN TENSION; PERMEABILITY; PRIORITY JOURNAL; REPERFUSION; REPERFUSION INJURY; WARMING;

ISCHEMIA/REPERFUSION INJURY; LUNG PHYSIOLOGY; LUNG TRANSPLANTATION; PULMONARY FUNCTION;

ANIMALS; CAPILLARY PERMEABILITY; CYCLOSPORINE; CYTOKINES; IMMUNOSUPPRESSIVE AGENTS; LUNG INJURY; PERFUSION; PULMONARY ALVEOLI; PULMONARY GAS EXCHANGE; SWINE;

EID: 84891609317     PISSN: 10739688     EISSN: 15498719     Source Type: Journal    
DOI: 10.1111/micc.12082     Document Type: Article

References (50)

1. Andrade CF, Kaneda H, Der S, Tsang M, Lodyga M, Chimisso Dos Santos C, Keshavjee S, Liu M. Toll-like receptor and cytokine gene expression in the early phase of human lung transplantation. J Heart Lung Transplant 25: 1317-1323, 2006.
2. Anglade D, Corboz M, Menaouar A, Parker JC, Sanou S, Bayat S, Benchetrit G, Grimbert FA. Blood flow vs. venous pressure effects on filtration coefficient in oleic acid-injured lung. J Appl Physiol 84: 1011-1023, 1998.
3. Baconnier PF, Eberhard A, Grimbert FA. Theoretical analysis of occlusion techniques for measuring pulmonary capillary pressure. J Appl Physiol 73: 1351-1359, 1992.
4. Brimioulle S, Julien V, Gust R, Kozlowski JK, Naeije R, Schuster DP. Importance of hypoxic vasoconstriction in maintaining oxygenation during acute lung injury. Crit Care Med 30: 874-880, 2002.
5. Briot R, Bayat S, Anglade D, Martiel JL, Grimbert F. Monitoring the capillary-alveolar leakage in an A.R.D.S. model using broncho-alveolar lavage. Microcirculation 15: 237-249, 2008.
6. Briot R, Bayat S, Anglade D, Martiel JL, Grimbert F. Increased cardiac index due to terbutaline treatment aggravates capillary-alveolar macromolecular leakage in oleic acid lung injury in dogs. Crit Care 13: R166, 2009.
7. Briot R, Frank JA, Uchida T, Lee JW, Calfee CS, Matthay MA. Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs. Chest 135: 269-275, 2009.
8. Burckart GJ, Venkataramanan R, Ptachcinski RJ, Starzl TE, Gartner JC, Zitelli BJ, Malatack JJ, Shaw BW, Iwatsuki S, Van Thiel DH. Cyclosporine absorption following orthotopic liver transplantation. J Clin Pharmacol 26: 647-651, 1986.
9. Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N, Matthay MA. Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury. Thorax 63: 1083-1089, 2008.
10. Chen HT, Yang CX, Li H, Zhang CJ, Wen XJ, Zhou J, Fan YL, Huang T, Zeng YM. Cardioprotection of sevoflurane postconditioning by activating extracellular signal-regulated kinase 1/2 in isolated rat hearts. Acta Pharmacol Sin 29: 931-941, 2008.
11. Christie JD, Sager JS, Kimmel SE, Ahya VN, Gaughan C, Blumenthal NP, Kotloff RM. Impact of primary graft failure on outcomes following lung transplantation. Chest 127: 161-165, 2005.
12. Cypel M, Yeung JC, Liu M, Anraku M, Chen F, Karolak W, Sato M, Laratta J, Azad S, Madonik M, Chow CW, Chaparro C, Hutcheon M, Singer LG, Slutsky AS, Yasufuku K, de Perrot M, Pierre AF, Waddell TK, Keshavjee S. Normothermic ex vivo lung perfusion in clinical lung transplantation. N Engl J Med 364: 1431-1440, 2012.
13. De Perrot M, Liu M, Waddell TK, Keshavjee S. State of the art. Ischemia reperfusion-induced-injury. Am J Respir Crit Care Med 167: 490-511, 2003.
14. Den Hengst WA, Gielis JF, Lin JY, Van Schil PE, De Windt LJ, Moens AL. Lung ischemia-reperfusion injury: a molecular and clinical view on a complex pathophysiological process. Am J Physiol Heart Circ Physiol 299: H1283-H1299, 2010.
15. Farivar AS, Mackinnon-Patterson BC, Barnes AD, McCourtie AS, Mulligan MS. Cyclosporine modulates the response to hypoxia-reoxygenation in pulmonary artery endothelial cells. Ann Thorac Surg 79: 1010-1016, 2005.
16. First MR, Neylan JF, Rocher LL, Tejani A. Hypertension after renal transplantation. J Am Soc Nephrol 4: S30-S36, 1994.
17. Frank JA, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay MA. Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs. Am J Physiol Lung Cell Mol Physiol 293: L52-L59, 2007.
18. Gerlach J, Jorres A, Nohr R, Zeilinger K, Spatkowski G, Neuhaus P. Local liberation of cytokines during liver preservation. Transpl Int 12: 261-265, 1999.
19. Gomez L, Thibault H, Gharib A, Dumont JM, Vuagniaux G, Scalfaro P, Derumeaux G, Ovize M. Inhibition of mitochondrial permeability transition improves functional recovery and reduces mortality following acute myocardial infarction in mice. Am J Physiol Heart Circ Physiol 293: 1654-1661, 2007.
20. Griffiths EJ, Halestrap AP. Protection by Cyclosporin A of ischemia/reperfusion-induced damage in isolated rat hearts. J Mol Cell Cardiol 25: 1461-1469, 1993.
21. International Society for Heart and Lung Transplantation. Annual report. 2010.
22. Jabaudon M, Futier E, Roszyk L, Chalus E, Guerin R, Petit A, Mrozek S, Perbet S, Cayot-Constantin S, Chartier C, Sapin V, Bazin JE, Constantin JM. Soluble form of the receptor for advanced glycation end products is a marker of acute lung injury but not of severe sepsis in critically ill patients. Crit Care Med 39: 480-488, 2011.
23. Kanaya N, Kobayashi I, Nakayama M, Fujita S, Namiki A. ATP sparing effect of isoflurane during ischaemia and reperfusion of the canine heart. Br J Anaesth 74: 563-568, 1995.
24. Koulmann N, Novel-Chate V, Peinnequin A, Chapot R, Serrurier B, Simler N, Richard H, Ventura-Clapier R, Bigard X. Cyclosporin A inhibits hypoxia-induced pulmonary hypertension and right ventricle hypertrophy. Am J Respir Crit Care Med 174: 699-705, 2006.
25. Krishnadasan B, Naidu BV, Rosengart M, Farr AL, Barnes A, Verrier ED, Mulligan MS. Decreased lung ischemia-reperfusion injury in rats after preoperative administration of cyclosporine and tacrolimus. J Thorac Cardiovasc Surg 123: 756-767, 2002.
26. Lee YH, Park KH, Ku YS. Pharmacokinetic changes of cyclosporine after intravenous and oral administration to rats with uranyl nitrate-induced acute renal failure. Int J Pharm 194: 221-227, 2000.
27. Lemay S, Rabb H, Postler G, Singh AK. Prominent and sustained up-regulation of gp130-signaling cytokines and the chemokine MIP-2 in murine renal ischemia-reperfusion injury. Transplantation 69: 959-963, 2000.
28. Lim SW, Li C, Ahn KO. Cyclosporine-induced renal injury induces toll-like receptor and maturation of dendritic cells. Transplantation 80: 691-699, 2005.
29. Morrison RJ, Short HD, Noon GP, Frost AE. Hypertension after lung transplantation. J Heart Lung Transplant 12: 928-931, 1993.
30. Naidu BV, Krishnadasan B, Byrne K, Farr AL, Rosengart M, Verrier ED, Mulligan MS. Regulation of chemokine expression by Cyclosporine A in alveolar macrophages exposed to hypoxia and reoxygenation. Ann Thorac Surg 74: 899-905, 2002.
31. Obal D, Dettwiler S, Favoccia C, Scharbatke H, Preckel B, Schlack W. The influence of mitochondrial KATP-channels in the cardioprotection of preconditioning and postconditioning by sevoflurane in the rat in vivo. Anesth Analg 101: 1252-1260, 2005.
32. Oto T, Griffiths AP, Levvey BJ, Pilcher DV, Williams TJ, Snell GI. Definitions of primary graft dysfunction after lung transplantation: differences between bilateral and single lung transplantation. J Thorac Cardiovasc Surg 132: 140-147, 2006.
33. Piot C, Croisille P, Staat P, Thibault H, Rioufol G, Mewton N, Elbelghiti R, Cung TT, Bonnefoy E, Angoulvant D, Macia C, Raczka F, Sportouch C, Gahide G, Finet G, André-Fouët X, Revel D, Kirkorian G, Monassier JP, Derumeaux G, Ovize M. Effect of cyclosporine on reperfusion injury in acute myocardial infarction. N Engl J Med 359: 473-481, 2008.
34. Preckel B, Schlack W, Comfère T, Obal D, Barthel H, Thämer V. Effects of enflurane, isoflurane, sevoflurane and desflurane on reperfusion injury after regional myocardial ischemia in the rabbit heart in vivo. Br J Anesth 81: 905-912, 1998.
35. Redondo-Horcajo M, Romero N, Martínez-Acedo P, Martínez-Ruiz A, Quijano C, Lourenço CF, Movilla N, Enríquez JA, Rodríguez-Pascual F, Rial E, Radi R, Vázquez J, Lamas S. Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide. Cardiovasc Res 87: 356-365, 2010.
36. Sanchez PG, Bittle GJ, Burdorf L, Pierson RN, Griffith BP. State of art: clinical ex vivo lung perfusion: rationale, current status, and future directions. J Heart Lung Transplant 31: 339-348, 2012.
37. Sander M, Lyson T, Thomas GD, Victor RG. Sympathetic neural mechanisms of cyclosporine-induced hypertension. Am J Hypertens 9: S121-S138, 1996.
38. Scherrer U, Vissing SF, Morgan BJ, Rollins JA, Tindall RS, Ring S, Hanson P, Mohanty PK, Victor RG. Cyclosporine-induced sympathetic activation and hypertension after heart transplantation. N Engl J Med 323: 693-699, 1990.
39. Serrick C, Adoumie R, Giaid A, Shennib H. The early release of interleukin-2, tumor necrosis factor-alpha and interferon-gamma after ischemia reperfusion injury in the lung allograft. Transplantation 58: 1158-1162, 1994.
40. Shargall Y, Guenther G, Ahya VN, Ardehali A, Singhal A, Keshavjee S; ISHLT Working Group on Primary Lung Graft Dysfunction. Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part VI: treatment. J Heart Lung Transplant 24: 1489-1500, 2005.
41. Soccal PM, Gasche Y, Miniati DN, Hoyt G, Berry GJ, Doyle RL, Theodore J, Robbins RC. Matrix metalloproteinase inhibition decreases ischemia-reperfusion injury after lung transplantation. Am J Transplant 4: 41-50, 2004.
42. Starling EH. On the absorption of fluids from the connective tissue spaces. J Physiol 19: 312-326, 1896.
43. Steen S, Liao Q, Wierup PN, Bolys R, Pierre L, Sjöberg T. Transplantation of lungs from non-heart-beating donors after functional assessment ex vivo. Ann Thorac Surg 76: 244-252, 2003.
44. Theissen IL, Meissner A. Hypoxic pulmonary vasoconstriction. Anaesthesist 45: 643-652, 1996.
45. Travis DL, Fabia R, Netto GG, Husberg BS, Goldstein RM, Klintmalm GB, Levy MF. Protection by Cyclosporine A against normothermic liver ischemia-reperfusion in pigs. J Surg Res 75: 116-126, 1998.
46. Uchida T, Shirasawa M, Ware LB, Kojima K, Hata Y, Makita K, Mednick G, Matthay ZA, Matthay MA. Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury. Am J Respir Crit Care Med 173: 1008-1015, 2006.
47. Van Assche G, D'Haens G, Noman M, Vermeire S, Hiele M, Asnong K, Arts J, D'Hoore A, Penninckx F, Rutgeerts P. Randomized, double-blind comparison of 4 mg/kg versus 2 mg/kg intravenous cyclosporine in severe ulcerative colitis. Gastroenterology 125: 1025-1031, 2003.
48. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 342: 1334-1349, 2000.
49. Winkler M, Brinkmann C, Jost U, Oldhafer K, Ringe B, Pichlmayr R. Long-term side effects of cyclosporine-based immunosuppression in patients after liver transplantation. Transplant Proc 26: 2679-2682, 1994.
50. Yang CW, Ahn HJ, Han HJ, Kim WY, Li C, Shin MJ, Kim SK, Park JH, Kim YS, Moon IS, Bang BK. Pharmacological preconditioning with low-dose cyclosporine or FK506 reduces subsequent ischemia/reperfusion injury in rat kidney. Transplantation 72: 1753-1759, 2001.