Increased Circulating Anti-inflammatory Cells in Marathon-trained Runners

International Journal of Sports Medicine

Volumn 36, Issue 10, 2015, Pages 832-836

  Rehm, K ^a,c   Sunesara, I ^b   Marshall, G D ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^c UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

cytokine; immunology; intracellular cytokine staining; T cell

Indexed keywords

ADULT; CD4+ T LYMPHOCYTE; CROSS-SECTIONAL STUDY; DISEASE PREDISPOSITION; ENDURANCE; FEMALE; HELPER CELL; HUMAN; IMMUNOLOGY; MALE; METABOLISM; MIDDLE AGED; PHYSICAL EDUCATION; PHYSIOLOGY; REGULATORY T LYMPHOCYTE; RUNNING; T LYMPHOCYTE SUBPOPULATION;

ADULT; CD4-POSITIVE T-LYMPHOCYTES; CROSS-SECTIONAL STUDIES; DISEASE SUSCEPTIBILITY; FEMALE; HUMANS; MALE; MIDDLE AGED; PHYSICAL EDUCATION AND TRAINING; PHYSICAL ENDURANCE; RUNNING; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY;

EID: 84939567503     PISSN: 01724622     EISSN: 14393964     Source Type: Journal    
DOI: 10.1055/s-0035-1547218     Document Type: Article

References (37)

1. Agarwal S. K., Marshall G. D. Jr. Glucocorticoid-induced type 1/type 2 cytokine alterations in humans: a model for stress-related immune dysfunction. J Interferon Cytokine Res: 1998; 18 1059 1068
2. Allan S. E., Broady R., Gregori S., Himmel M. E., Locke N., Roncarolo M. G., Bacchetta R., Levings M. K. CD4+ T-regulatory cells: toward therapy for human diseases. Immunol Rev: 2008; 223 391 421
3. Baum M., Muller-Steinhardt M., Liesen H., Kirchner H. Moderate and exhaustive endurance exercise influences the interferon-gamma levels in whole-blood culture supernatants. Eur J Appl Physiol: 1997; 76 165 169
4. Bretscher P. A. On the mechanism determining the TH1/TH2 phenotype of an immune response, and its pertinence to strategies for the prevention, and treatment, of certain infectious diseases. Scand J Immunol: 2014; 79 361 376
5. Czarkowska-Paczek B., Bartlomiejczyk I., Przybylski J. The serum levels of growth factors: PDGF, TGF-beta and VEGF are increased after strenuous physical exercise. J Physiol Pharmacol: 2006; 57 189 197
6. Fu H., Yu P. The effect of aerobic exercise on serum IL-4 and TNF-alpha of patients with allergic rhinitis. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi: 2013; 27 1321 1323
7. Gabrysova L., Howes A., Saraiva M., O'Garra A. The regulation of IL-10 expression. Curr Top Microbiol Immunol: 2014; 380 157 190
8. Garcia-Aymerich J., Varraso R., Danaei G., Camargo C. A. Jr, Hernan M. A. Incidence of adult-onset asthma after hypothetical interventions on body mass index and physical activity: an application of the parametric g-formula. Am J Epidemiol: 2014; 179 20 26
9. Gleeson M. Immune system adaptation in elite athletes. Curr Opin Clin Nutr Metab Care: 2006; 9 659 665
10. Gleeson M., Bishop N., Oliveira M., Tauler P. Influence of training load on upper respiratory tract infection incidence and antigen-stimulated cytokine production. Scand J Med Sci Sports: 2013; 23 451 457
11. Handzlik M. K., Shaw A. J., Dungey M., Bishop N. C., Gleeson M. The influence of exercise training status on antigen-stimulated IL-10 production in whole blood culture and numbers of circulating regulatory T cells. Eur J Appl Physiol: 2013; 113 1839 1848
12. Harriss D. J., Atkinson G. Ethical standards in sport and exercise science research: 2014 update. Int J Sports Med: 2013; 34 1025 1028
13. Hausswirth C., Louis J., Aubry A., Bonnet G., Duffield R., LE Meur Y. Evidence of disturbed sleep and increased illness in overreached endurance athletes. Med Sci Sports Exerc: 2014; 46 1036 1045
14. Lancaster G. I., Khan Q., Drysdale P. T., Wallace F., Jeukendrup A. E., Drayson M. T., Gleeson M. Effect of prolonged exercise and carbohydrate ingestion on type 1 and type 2 T lymphocyte distribution and intracellular cytokine production in humans. J Appl Physiol: 2005; 98 565 571
15. Lang P. O., Govind S., Bokum A. T., Kenny N., Matas E., Pitts D., Aspinall R. Immune senescence and vaccination in the elderly. Curr Top Med Chem: 2013; 13 2541 2550
16. Marshall G. D. Jr, Agarwal S. K., Lloyd C., Cohen L., Henninger E. M., Morris G. J. Cytokine dysregulation associated with exam stress in healthy medical students. Brain Behav Immun: 1998; 12 297 307
17. Matthews C. E., Ockene I. S., Freedson P. S., Rosal M. C., Merriam P. A., Hebert J. R. Moderate to vigorous physical activity and risk of upper-respiratory tract infection. Med Sci Sports Exerc: 2002; 34 1242 1248
18. Maue A. C., Haynes L. CD4+ T cells and immunosenescence - a mini-review. Gerontology: 2009; 55 491 495
19. Moyna N. M., Acker G. R., Fulton J. R., Weber K., Goss F. L., Robertson R. J., Tollerud D. J., Rabin B. S. Lymphocyte function and cytokine production during incremental exercise in active and sedentary males and females. Int J Sports Med: 1996; 17 585 591
20. Nieman D. C., Johanssen L. M., Lee J. W., Arabatzis K. Infectious episodes in runners before and after the Los Angeles Marathon. J Sports Med Phys Fitness: 1990; 30 316 328
21. Pedersen L., Elers J., Backer V. Asthma in elite athletes: pathogenesis, diagnosis, differential diagnoses, and treatment. Phys Sportsmed: 2011; 39 163 171
22. Perry C., Pick M., Bdolach N., Hazan-Halevi I., Kay S., Berr I., Reches A., Harishanu Y., Grisaru D. Endurance exercise diverts the balance between Th17 cells and regulatory T cells. PloS one: 2013; 8 e74722
23. Rehm K. E., Elci O. U., Hahn K., Marshall G. D. Jr. The impact of self-reported psychological stress levels on changes to peripheral blood immune biomarkers in recreational marathon runners during training and recovery. Neuroimmunomodulation: 2013; 20 164 176
24. Robson-Ansley P., Howatson G., Tallent J., Mitcheson K., Walshe I., Toms C., DU Toit G., Smith M., Ansley L. Prevalence of allergy and upper respiratory tract symptoms in runners of the London marathon. Med Sci Sports Exerc: 2012; 44 999 1004
25. Sakaguchi S., Wing K., Onishi Y., Prieto-Martin P., Yamaguchi T. Regulatory T cells: how do they suppress immune responses? Int Immunol: 2009; 21 1105 1111
26. Salicru A. N., Sams C. F., Marshall G. D. Cooperative effects of corticosteroids and catecholamines upon immune deviation of the type-1/type-2 cytokine balance in favor of type-2 expression in human peripheral blood mononuclear cells. Brain Behav Immun: 2007; 21 913 920
27. Schroder K., Hertzog P. J., Ravasi T., Hume D. A. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol: 2004; 75 163 189
28. Skoluda N., Dettenborn L., Stalder T., Kirschbaum C. Elevated hair cortisol concentrations in endurance athletes. Psychoneuroendocrinology: 2012; 37 611 617
29. Sokol C. L., Barton G. M., Farr A. G., Medzhitov R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol: 2008; 9 310 318
30. Steensberg A., Toft A. D., Bruunsgaard H., Sandmand M., Halkjaer-Kristensen J., Pedersen B. K. Strenuous exercise decreases the percentage of type 1 T cells in the circulation. J Appl Physiol: 2001; 91 1708 1712
31. Taylor A., Verhagen J., Blaser K., Akdis M., Akdis C. A. Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells. Immunology: 2006; 117 433 442
32. Walsh N. P., Gleeson M., Shephard R. J., Gleeson M., Woods J. A., Bishop N. C., Fleshner M., Green C., Pedersen B. K., Hoffman-Goetz L., Rogers C. J., Northoff H., Abbasi A., Simon P. Position statement. Part one: Immune function and exercise. Exerc Immunol Rev: 2011; 17 6 63
33. Wilson L. D., Zaldivar F. P., Schwindt C. D., Wang-Rodriguez J., Cooper D. M. Circulating T-regulatory cells, exercise and the elite adolescent swimmer. Pediatr Exerc Sci: 2009; 21 305 317
34. Xiang L., Marshall G. D. Jr. Immunomodulatory effects of in vitro stress hormones on FoxP3, Th1/Th2 cytokine and costimulatory molecule mRNA expression in human peripheral blood mononuclear cells. Neuroimmunomodulation: 2011; 18 1 10
35. Xiang L., Marshall G. D. Jr. Immunomodulatory effects of dexamethasone on gene expression of cytokine and stress hormone receptors in peripheral blood mononuclear cells. Int Immunopharmacol: 2013; 17 556 560
36. Yeh S. H., Chuang H., Lin L. W., Hsiao C. Y., Eng H. L. Regular tai chi chuan exercise enhances functional mobility and CD4CD25 regulatory T cells. Br J Sports Med: 2006; 40 239 243
37. Yu N., Li X., Song W., Li D., Yu D., Zeng X., Li M., Leng X., Li X. CD4(+)CD25 (+)CD127 (low/-) T cells: a more specific Treg population in human peripheral blood. Inflammation: 2012; 35 1773 1780