Glucocorticoid-induced type 1/type 2 cytokine alterations in humans: A model for stress-related immune dysfunction

Journal of Interferon and Cytokine Research

Volumn 18, Issue 12, 1998, Pages 1059-1068

  Agarwal, Sandeep K ^a   Marshall Jr , Gailen D ^a,b  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; DEXAMETHASONE; GAMMA INTERFERON; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR ANTAGONIST; HYDROCORTISONE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; MIFEPRISTONE; MONOCLONAL ANTIBODY CD3; PHYTOHEMAGGLUTININ; TETANUS TOXOID;

ADULT; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPATHOLOGY; MONONUCLEAR CELL; NORMAL HUMAN; PRIORITY JOURNAL; STRESS;

EID: 0032423321     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.1998.18.1059     Document Type: Article

References (42)

1. McEWEN, B.S., and STELLAE, E. (1993). Stress and the individual. Mechanisms leading to disease. Arch. Intern Med. 153, 2093-2099.
2. SHERIDAN, J.F., DOBBS, C., BROWN, D., and ZWILLING, B. (1994). Psychoneuroimmunology stress effects on pathogenesis and immunity during infection. Clin. Microbiol. Rev. 7, 200-209.
3. BIONDI, M., and ZANNINO, L.G. (1997). Psychological stress, neuroimmunomodulation, and susceptibility to infectious diseases in animals and man. a review. Psychother. Psychosom. 66, 3-10.
4. COHEN, S., TYRRELL, D.A.J., and SMITH, A.P. (1991). Psychological stress and susceptibility to the common cold. N. Engl. J. Med. 325, 606-612.
5. MICHEL, F.B. (1994). Psychology of the allergic patient. Allergy 49, 28-30.
6. PARKER, C.W. (1991). Environmental stress and immunity: possible implications for IgE-mediated allergy. Perspect. Biol. Med. 34, 197-212.
7. KOH, K.B., and HONG, C.S. (1993). The relationship of stress with serum IgE level in patients with bronchial asthma. Yonsei Med. J. 34, 166-174.
8. BUSSE, W.W., KIECOLT-GLASER, J.K., COE, C., MARTIN, R.J., WEISS, S.T., and PARKER, S.R. (1995). Stress and asthma. Am. J. Respir. Crit. Care Med. 151, 249-252.
9. GLASER, R., RICE, J., SHERIDAN, J., FERTEL, R., STOUT, J., SPEICHER, C.E., PINSKY, D., KOTUR, M., POST, A., BECK, M., and KIECOLT-GLASER, J.K. (1987). Stress-related immune suppression: health implications. Brain Behav. Immun. 1, 7-20.
10. GLASER, R., KIECOLT-GLASER, J.K., SPEICHER, C.E., and HOLLIDAY, J.E. (1985). Stress, loneliness, and changes in herpesvirus latency. J. Behav. Med. 8, 249-253.
11. KUSNECOV, A.W., and RABIN, B.S. (1994). Stressor-induced alterations of immune function, mechanisms and issues. Int. Arch. Allergy Immunol. 105, 107-121.
12. MARSHALL, G.D., AGARWAL, S.K., HENNINGER, E.M., and MORRIS, G.J. (1998). Type-1/type-2 cytokine balance is altered during exam stress in medical students. FASEB J. 12, A485.
13. BONNEAU, R.H., KIECOLT-GLASER, J.K., and GLASER, R. (1990). Stress-induced modulation of the immune response. Ann. NY Acad. Sci. 594, 253-263.
14. MOSMANN, T.R., CHERWINKSI, H., BOND, M.W., GIEDLIN, M.A., and COFFMAN, R.L. (1986). Two types of murine helper T cell clone. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136, 2348-2356.
15. MOSMANN, T.R., and SAD, S. (1996). The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 17, 138-146.
16. MEYERHOFF, J.L., OLESHANSKY, M.A., and MOUGEY, E.H. (1998). Psychological stress increases plasma levels of prolactin, cortisol, and POMC-derived peptides in man. Psychosom. Med. 50, 295-303.
17. RICHTER, S.D., SCHURMEYER, T.H., SCHLEDOWSKI, M., HADICKE, A., TEWES, U., SCHMIDT, R., and WAGNER, T.F. (1996). Time kinetics of the endocrine response to acute psychological stress. J. Clin. Endocrinol. Metabol. 81, 1956-1960.
18. DAYNES, R.A., and ARANEO, B.A. (1989). Contrasting effects of glucocorticoids on the capacity of T cells to produce the growth factors IL-2 and IL-4. Eur. J. Immunol. 19, 2319-2325.
19. + T cells in vitro. J. Immunol. 156, 2406-2412.
20. BYRON, K.A., VARIGOS, G., and WOOTTON, A. (1992). Hydrocortisone inhibition of human IL-4. Immunology 77, 624-626.
21. WU, C.Y., FARGEAS, C., NAKAJIMA, T., and DELESPESSE, G. (1991). Glucocorticoids suppress the production of IL-4 by human lymphocytes. Eur. J. Immunol. 21, 2645-2647.
22. SNIJDEWINT, F.G.M., KAPSENBERG, M.L., WAUBEN-PENRIS, P.J.J., and BOS, J.D. (1995). Corticosteroids class-dependently inhibit in vitro Th-1 and Th-2-type cytokine production. Immunopharmacology 29, 93-101.
23. + lymphocytes. J. Immunol. 158, 5589-5595.
24. ELENKOV, I.J., PAPANICOLAOU, D.A., WOLDER, R.L., and CHROUSOS, G.P. (1996). Modulatory effects of glucocorticoids and catecholamines on human IL-12 and IL-10 production. Proc. Assoc. Am. Phys. 108, 374-381.
25. CROFT, M., CARTER, L., SWAIN, S.L., and DUTTON, R.W. (1994). Generation of polarized antigen-specific CD8 effector populations: reciprocal action of IL-4 and IL-12 in promoting type-2 vs. type-1 cytokine profiles. J. Exp. Med. 180, 1715-1728.
26. AGARWAL, S.K., and MARSHALL, G.D. (1998). In vivo alteration in type-1 and type-2 cytokine balance: a possible mechanism for elevated total IgE in HIV-infected patients. Hum. Immunol. 59, 99-105.
27. IMADA, M., SIMONS, F.E.R., JAY, F.T., and HAYGLASS, K.T. (1995). Antigen-mediated polyclonal stimulation of human cytokine production elicits qualitatively different patterns of cytokine gene expression. Int. Immunol. 7, 229-237.
28. + Th1 cells pro-inflammatory or anti-inflammatory? The ratio of IL-10 to IFN-γ or IL-2 determines their function. Int. Immunol. 7, 1287-1295.
29. BAULIEU, E.E. (1997). RU486 (mifepristone). A short overview of its mechanisms of action and clinical uses at the end of 1996. Ann. NY Acad. Sci. 828, 47-57.
30. COHEN, S., FRANK, E., DOYLE, W.J., SKONER, D.P., RABIN, B.S., and GWALTNEY, J.M. (1998). Types of Stressors that increase susceptibility to the common cold in healthy adults. Health Psychol. 17, 214-223.
31. ZAKOWSKI, S.G., COHEN, L., HALL, M.H., WOLLMAN, K., and BAUM, M.K. (1994). Differential effects of active and passive laboratory Stressors on immune function in healthy men. Int. J. Behav. Med. 1, 163-184.
32. SCHLEDOWSKI, M., JACOBS, R., STRATMANN, G., RICHTER, S.D., HADICKE, A., TEWES, U., WAGNER, T.F., and SCHMIDT, R. (1993). Changes in natural killer cells during acute psychological stress. J. Clin. Invest. 13, 119-126.
33. YANG-YEN, H.F., CHAMBRAND, J.C., SUN, Y.L., SMEAL, T., SCHMIDT, T.J., DROUIN, J., and KARIN, M. (1990). Tran- scriptional interference between c-jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62, 1205-1210.
34. GARNELLI-PIPERNO, A., NOLAN, P., INABA, K., and STEINMAN, R.N. (1990). The effect of immunosuppressive agents on the induction of nuclear factors that bind sites on the LL-2 promoter. J. Exp. Med. 172, 1869-1875.
35. VACCA, A., FELLI, M.P., FARINA, A.R., MARTINOTTI, S., MARODER, M., SCREPANTI, I., MECO, D., PATRANGELI, E., FRATI, L., and GULINO, A. (1992). Glucocorticoid receptor mediated suppression of IL-2 gene expression through impairment of the cooperativity between NFAT and AP-1 enhancer elements. J. Exp. Med. 175, 637-645.
36. TUOSTO, L., CUNDARI, E., MONTANI, M.S.G., and PICCOLELLA, E. (1994). Analysis of susceptibility of mature human T lymphocytes to dexamethasone-induced apoptosis. Eur. J. Immunol. 24, 1061-1065.
37. FREY, T. (1995). Nucleic acid dyes for detection of apoptosis in live cells. Cytometry 21, 265-274.
38. + T helper type-2 T lymphocytes do not promote recovery from experimental virus infection. J. Exp. Med. 180, 1273-1282.
39. WILDER, R.L. (1995). Neuro-endocrine system interactions and autoimmunity. Annu. Rev. Immunol 13, 307-338.
40. BLALOCK, J.E., BOST, K.L., and SMITH, E.M. (1985). Neuroendocrine peptide hormones and their receptors in the immune system. J. Neuroimmunol. 10, 31-38.
41. KIECOLT-GLASER, J.K., GLASER, R., STRAIN, E.C., STOUT, J.C., TARR, K.L., HOLLIDAY, J.E., and SPEICHER, C.E. (1986). Modulation of cellular immunity in medical students. J. Behav. Med. 9, 5-21.
42. NALIBOFF, B.D., SOLOMON, G.F., GILMORE, S.L., FAHEY, J.L., BENTON, D., and PINE, J. (1995). Rapid changes in cellular immunity following a confrontational role-play Stressor. Brain Behav. Immun. 9, 207-219.