Structure Elucidation and Activity of KolossinA, the D -/ L -Pentadecapeptide Product of a Giant Nonribosomal Peptide Synthetase

Angewandte Chemie - International Edition

Volumn 54, Issue 35, 2015, Pages 10352-10355

  Bode, Helge B ^a   Brachmann, Alexander O ^a   Jadhav, Kirtikumar B ^b   Seyfarth, Lydia ^b   Dauth, Christina ^a   Fuchs, Sebastian W ^a   Kaiser, Marcel ^c   Waterfield, Nick R ^d   Sack, Holger ^e   Heinemann, Stefan H ^e   Arndt, Hans Dieter ^b  

^a GOETHE UNIVERSITY   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d UNIVERSITY OF WARWICK   (United Kingdom)

^e JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

biological activity; biosynthesis; natural products; peptides; total synthesis

Indexed keywords

BIOACTIVITY; BIOCHEMISTRY; BIOSYNTHESIS; SYNTHESIS (CHEMICAL);

ANTIBIOTIC ACTIVITY; NATURAL PRODUCTS; NONRIBOSOMAL PEPTIDE SYNTHETASES; PROMOTER EXCHANGES; SLEEPING SICKNESS; STRUCTURE ELUCIDATION; TOTAL SYNTHESIS; TRYPANOSOMA BRUCEI;

PEPTIDES;

ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; NONRIBOSOMAL PEPTIDE SYNTHETASE; PEPTIDE FRAGMENT; PEPTIDE SYNTHASE;

AMINO ACID SEQUENCE; CHEMISTRY; DRUG EFFECTS; MASS SPECTROMETRY; METABOLISM; MICROBIOLOGY; MOLECULAR GENETICS; SEQUENCE HOMOLOGY; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMIASIS, AFRICAN;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PEPTIDE SYNTHASES; SEQUENCE HOMOLOGY, AMINO ACID; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMIASIS, AFRICAN;

EID: 84939565337     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201502835     Document Type: Article

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