Distress of ostracism: Oxytocin receptor gene polymorphism confers sensitivity to social exclusion

Social Cognitive and Affective Neuroscience

Volumn 10, Issue 8, 2014, Pages 1153-1159

  McQuaid, Robyn J ^a   McInnis, Opal A ^a   Matheson, Kimberly ^a   Anisman, Hymie ^a  

^a CARLETON UNIVERSITY   (Canada)

Author keywords

cortisol; Ostracism; Oxytocin; SNP; Social sensitivity

Indexed keywords

HYDROCORTISONE; OXTR PROTEIN, HUMAN; OXYTOCIN RECEPTOR;

AMINO ACID SUBSTITUTION; ANXIETY; ATTITUDE; BLOOD PRESSURE; EMPATHY; FEMALE; GAME; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HETEROZYGOTE; HUMAN; HUMAN RELATION; METABOLISM; MUTATION; PHYSIOLOGY; PSYCHOLOGY; SELF CONCEPT; SINGLE NUCLEOTIDE POLYMORPHISM; SOCIAL DISTANCE; TRUST; YOUNG ADULT;

AMINO ACID SUBSTITUTION; ANXIETY; BLOOD PRESSURE; EMPATHY; FEMALE; GAMES, EXPERIMENTAL; GENOTYPE; HETEROZYGOTE; HUMANS; HYDROCORTISONE; INTERPERSONAL RELATIONS; MUTATION; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, OXYTOCIN; REJECTION (PSYCHOLOGY); SELF CONCEPT; SOCIAL DISTANCE; TRUST; YOUNG ADULT;

EID: 84939552681     PISSN: 17495016     EISSN: 17495024     Source Type: Journal    
DOI: 10.1093/scan/nsu166     Document Type: Article

References (43)

1. Averbeck, B.B. (2010). Oxytocin and the salience of social cues. Proceedings of the National Academy of Science of the United States of America, 107, 9033-4.
2. Bakermans-Kranenburg, M.J., van Ijzendoorn, M.H. (2008). Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting. Social Cognitive and Affective Neuroscience, 3, 128-34.
3. Bartz, J.A., Zaki, J., Bolger, N., Ochsner, K.N. (2011). Social effect of oxytocin in humans: context and person matter. Trends in Cognitive Science, 15, 301-9.
4. Belsky, J., Jonassaint, C., Pluess, M., Stanton, M., Brummett, B., Williams, R. (2009). Vulnerability genes or plasticity genes? Molecular Psychiatry, 14, 746-54.
5. Bradley, B., Davis, T.A., Wingo, A.P., Mercer, K.B., Ressler, K.J. (2013). Family environment and adult resilience: contributions of positive parenting and the oxytocin receptor gene. European Journal of Psychotraumatology, 4, 21659.
6. Bradley, B., Westen, D., Mercer, K.B., et al. (2011). Association between childhood maltreatment and adult emotional dysregulation in a low-income, urban, African American sample: moderation by oxytocin receptor gene. Development and Psychopathology, 23, 439-52.
7. Cardoso, C., Ellenbogen, M.A., Linnen, A.M. (2014). The effect of intranasal oxytocin on perceiving and understanding emotion on the Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT). Emotion, 14, 43-50.
8. Cardoso, C., Ellenbogen, M.A., Serravalle, L., Linnen, A.M. (2013). Stress-induced negative mood moderates the relation between oxytocin administration and trust: Evidence for the tend-and-befriend response to stress? Psychoneuroendocrinology, 38, 2800-4.
9. Eisenberger, N.I. (2012). The pain of social disconnection: examining the shared neural underpinnings of physical and social pain. Nature Reviews Neuroscience, 13, 421-34.
10. Eisenberger, N.I., Jarcho, J.M., Lieberman, M.D., Naliboff, B.D. (2006). An experimental study of shared sensitivity to physical pain and social rejection. Pain, 126, 132-8.
11. Eisenberger, N.I., Lieberman, M.D., Williams, K.D. (2003). Does rejection hurt? An FMRI study of social exclusion. Science, 302, 290-2.
12. Eisenberger, N.I., Way, B.M., Taylor, S.E., Welch, W.T., Lieberman, M.D. (2007). Understanding genetic risk for aggression: clues from the brain's response to social exclusion. Biological Psychiatry, 61, 1100-8.
13. Feifel, D., Macdonald, K., Cobb, P., Minassian, A. (2012). Adjunctive intranasal oxytocin improves verbal memory in people with schizophrenia. Schizophrenia Research, 139, 207-10.
14. Gimpl, G., Fahrenholz, F. (2001). The oxytocin receptor system: structure, function and regulation. Physiological Reviews, 81, 629-83.
15. Guastella, A.J., Einfeld, S.L., Gray, K.M., et al. (2010). Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders. Biological Psychiatry, 67, 692-4.
16. Huber, D., Veinante, P., Stoop, R. (2005). Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Science, 308, 245-8.
17. Kirsch, P., Esslinger, C., Chen, Q., et al. (2005). Oxytocin modulates neural circuitry for social cognition and fear in humans. The Journal of Neuroscience, 25, 11489-93.
18. Kim, H.S., Sherman, D.K., Sasaki, J.Y., et al. (2010). Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking. Proceedings of the National Academy of Science of the United States of America, 107, 15717-21.
19. Kirschbaum, C., Pirke, K.M., Hellhammer, D.H. (1993). The 'Trier Social Stress Test' - a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology, 28, 76-81.
20. Krueger, F., Parasuraman, R., Iyengar, V., et al. (2012). Oxytocin receptor genetic variation promotes human trust behavior. Frontiers in Human Neuroscience, 6.
21. Linnen, A.-M., Ellenbogen, M.A., Cardoso, C., Joober, R. (2012). Intranasal oxytocin and salivary cortisol concentrations during social rejection in university students. Stress, 15, 393-402.
22. Lin, P.-I., Vance, J.M., Pericak-Vance, M.A., Martin, E.R. (2007). No gene is an island: the flip-flop phenomenon. The American Journal of Human Genetics, 80, 531-8.
23. Love, T.M. (2014). Oxytocin, motivation and the role of dopamine. Pharmacology, Biochemistry, and Behavior, 119C, 49-60.
24. Lucht, M.J., Barnow, S., Sonnenfeld, C., et al. (2009). Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subject. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 33, 860-6.
25. McQuaid, R.J., McInnis, O.A., Abizaid, A., Anisman, H. (2014). Making room for oxytocin in understanding depression. Neuroscience and Biobehavioral Reviews, 45, 305-22.
26. McQuaid, R.J., McInnis, O.A., Stead, J.D., Matheson, K., Anisman, H. (2013). A paradoxical association of an oxytocin receptor gene polymorphism: Early-life adversity and vulnerability to depression. Frontiers in Neuroscience, 7.
27. Mizumoto, Y., Kimura, T., Ivell, R. (1997). A genomic element within the third intron of the human oxytocin receptor gene may be involved in transcriptional suppression. Molecular Cell Endocrinology, 135, 129-38.
28. Norman, G.J., Hawkley, L., Luhmann, M., et al. (2012). Variation in the oxytocin receptor gene influences neurocardiac reactivity to social stress and HPA function: a population based study. Hormones and behavior, 61, 134-9.
29. Petrovic, P., Kalisch, R., Singer, T., Dolan, R.J. (2008). Oxytocin attenuates affective evaluations of conditioned faces and amygdala activity. The Journal of Neuroscience, 28, 6607-15.
30. Pruessner, J.C., Kirschbaum, C., Meinlschmid, G., Hellhammer, D.H. (2003). Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology, 28, 916-31.
31. Rodrigues, S.M., Saslow, L.R., Garcia, N., John, O.P., Keltner, D. (2009). Oxytocin receptor genetic variation related to empathy and stress reactivity in humans. Proceedings of the National Academy of Science of the United States of America, 106, 21437-41.
32. Saphire-Bernstein, S., Way, B.M., Kim, H.S., Sherman, D.K., Taylor, S.E. (2011). Oxytocin receptor gene (OXTR) is related to psychological resources. Proceedings of the National Academy of Science of the United States of America, 108, 15118-22.
33. Scantamburlo, G., Hansenne, M., Fuchs, S., et al. (2007). Plasma oxytocin levels and anxiety in patients with major depression. Psychoneuroendocrinology, 32, 407-10.
34. Seidel, E.M., Silani, G., Metzler, H., et al. (2013). The impact of social exclusion vs. inclusion on subjective and hormonal reactions in females and males. Psychoneuroendocrinology, 38, 2925-32.
35. Smith, K.E., Porges, E.C., Norman, G.J., Connelly, J.J., Decety, J. (2014). Oxytocin receptor gene variation predicts empathetic concern and autonomic arousal while perceiving harm to others. Social Neuroscience, 9, 1-9.
36. Spielberger, C.D. (1983). Manual for the State-Trait Anxiety Inventory (Form Y). Palo Alto, CA: Consulting Psychologists Press.
37. Thompson, S.M., Hammen, C., Starr, L.R., Najman, J.M. (2014). Oxytocin receptor gene polymorphism (rs53576) moderates the intergenerational transmission of depression. Psychoneuroendocrinology, 43, 11-9.
38. Williams, K.D. (1997). Social ostracism. In: Kowalski, R.M., editor.. Aversive Interpersonal Behaviors. New York: Plenum, pp. 133-70.
39. Williams, K.D. (2001). Ostracism: The Power of Silence. New York: Guilford Press.
40. Williams, K.D., Cheung, C.K.T., Choi, W. (2000). CyberOstracism: effects of being ignored over the internet. Journal of Personality and Social Psychology, 79, 748-62.
41. Zadro, L., Williams, K.D., Richardson, R. (2004). How low can you go? Ostracism by a computer is sufficient to lower self-reported levels of belonging, control, self-esteem, and meaningful existence. Journal of Experimental Psychology, 40, 560-7.
42. Zöller, C., Maroof, P., Weik, U., Deinzer, R. (2010). No effect of social exclusion on salivary cortisol secretion in women in a randomized controlled study. Psychoneuroendocrinology, 35, 1294-8.
43. Zwolinski, J. (2012). Psychological and neuroendocrine reactivity to ostracism. Aggressive Behavior, 38, 108-25.