A genomic element within the third intron of the human oxytocin receptor gene may be involved in transcriptional suppression

Molecular and Cellular Endocrinology

Volumn 135, Issue 2, 1997, Pages 129-138

  Mizumoto, Yoshifumi ^a   Kimura, Tadashi ^a   Ivell, Richard ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

Author keywords

DNA methylation; Gene regulation; Human; Myometrium; Oxytocin receptor; Transcription factors

Indexed keywords

NUCLEAR PROTEIN; OXYTOCIN RECEPTOR;

ARTICLE; ASSAY; DNA METHYLATION; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRON; LEUKOCYTE; MALE; MENSTRUAL CYCLE; MYOMETRIUM; NORMAL HUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN DNA BINDING; RECEPTOR GENE; TRANSCRIPTION REGULATION;

BASE SEQUENCE; BLOTTING, NORTHERN; DNA; ENHANCER ELEMENTS (GENETICS); FEMALE; GENES; HUMANS; INTRONS; LEUKOCYTES; MALE; METHYLATION; MOLECULAR SEQUENCE DATA; MYOMETRIUM; NUCLEAR PROTEINS; PREGNANCY; PROTEIN BINDING; RECEPTORS, OXYTOCIN; RNA, MESSENGER; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC;

EID: 0031566065     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(97)00195-0     Document Type: Article

References (28)

1. Bathgate R., Rust W., Balvers M., Hartung S., Morley S., Ivell R. Structure and expression of the bovine oxytocin receptor gene. DNA Cell Biol. 14:1995;1037-1048.
2. Betz A.G., Milstein C., Gonzales-Fernandez A., Pannell R., Larson T., Neuberger M.S. Elements regulating somatic hypermutation of an immunoglobulin K gene: critical role for the intron enhancer/matrix attachment region. Cell. 77:1994;239-248.
3. Bird A. The essentials of DNA methylation. Cell. 70:1992;5-8.
4. Boyes J., Bird A. Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvment of a methyl-CpG binding protein. EMBO J. 11:1992;327-333.
5. Brooks A.R., Nagy B.P., Taylor S., Simonet W.S., Taylor J.M., Levy-Wilson B. Sequences containing the second-intron enhancer are essential for transcription of the human apolipoprotein B gene in the livers of transgenic mice. Mol. Cell. Biol. 14:1994;42243-42256.
6. Dawood M.Y., Ylikorkala O., Trivedi D., Fuchs F. Oxytocin in maternal circulation and amniotic fluid during pregnancy. J. Clin. Endocrinol. Metab. 49:1979;429-434.
7. Deryckere F., Gannon F. A one-hour minipreparation technique for extraction of DNA-binding proteins from animal tissues. Biotechniques. 16:1994;405.
8. Dyer R.B., Herzog N.K. Isolation of intact nuclei for nuclear extract preparation from a fragile B-lymphocyte cell line. Biotechniques. 19:1995;192-195.
9. Eden S., Cedar H. Role of DNA methylation in the regulation of transcription. Curr. Opin. Genet. Dev. 4:1994;255-259.
10. Fuchs A.-R., Fuchs F., Husslein P., Soloff M. Oxytocin receptors in the human uterus during pregnancy and parturition. Am. J. Obstet. Gynecol. 150:1984;734-741.
11. Fuchs A.-R., Romero R., Keefe D., Parra M., Oyarzun E., Behnke E. Oxytocin secretion and human parturition: pulse frequency and duration increase during spontaneous labor in women. Am. J. Obstet. Gynecol. 165:1991;1515-1523.
12. Goomer R.S., Holst B.D., Wood I.C., Jones F.S., Edelman G.M. Regulation in vitro of an L-CAM enhancer by homeobox genes HoxD9 and HNF-1. Proc. Natl. Acad. Sci. USA. 91:1994;7985-7989.
13. Grotewold E., Drummond B.J., Bowen B., Peterson T. The myb-homologous P gene controls phlobaphene pigmentation in maize floral organs by directly activating a flavonoid biosynthetic gene subset. Cell. 76:1994;543-553.
14. Hambor J.E., Mennone J., Coon M.E., Hanke J.H., Kavathas P. Identification and characterization of an Alu-containing, T-cell-specific enhancer located in the last intron of the human CD8α gene. Mol. Cell. Biol. 13:1993;7056-7070.
15. Henkel G., Brown M.A. PU.1 and GATA: components of a mast cell-specific interleukin 4 intronic enhancer. Proc. Natl. Acad. Sci. USA. 91:1994;7737-7741.
16. Inoue T., Kimura T., Azuma C. et al. Structural organization of the human oxytocin receptor gene. J. Biol. Chem. 269:1994;32451-32456.
17. Ivell, R., Russell, J.A., 1995. Oxytocin: Cellular and Molecular Approaches in Medicine and Research. Plenum Press, New York.
18. Kass S.U., Landsberger N., Wolfe A.P. DNA methylation directs a time-dependent repression of transcription initiation. Curr. Biol. 7:1997;157-165.
19. Kimura T., Takemura M., Nomura S. et al. Expression of oxytocin receptor in human pregnant myometrium. Endocrinology. 137:1996;780-785.
20. Levine A., Yeivin A., Ben-Asher E., Aloni Y., Razin A. Histone H1-mediated inhibition of transcription initiation of methylated transcripts in vitro. J. Biol. Chem. 268:1993;21754-21759.
21. Kubota Y., Kimura T., Hashimoto K. et al. Structure and expression of the mouse oxytocin receptor gene. Mol. Cell. Endocrinol. 124:1996;25-32.
22. Mitchell P.J., Tjian R. Transcriptional regulation in mammalian cells by sequence specific DNA binding proteins. Science. 245:1989;371-378.
23. Parry L.J., Bathgate R.A.D., Shaw G., Renfree M.B., Ivell R. Evidence for a local fetal influence on myometrial oxytocin receptors during pregnancy in the tammar wallaby (Macropus eugenli). Biol. Reprod. 56:1997;200-207.
24. Rhodes K., Rippe R.A., Umezawa A., Nehls M., Brenner D.A., Breindl M. DNA methylation represses the murine α1(I) collagen promoter by an indirect mechanism. Mol. Cell. Biol. 14:1994;5950-5960.
25. Rosen F., Russo C., Banville D., Zingg H.H. Structure, characterization and expression of the rat oxytocin receptor gene. Proc. Natl. Acad. Sci. USA. 92:1995;200-204.
26. Sambrook, J., Fritsch, E.F., Maniatis, T., 1989. Molecular Cloning. A Laboratory Manual. Cold Spring Harbor Laboratory Press, New York.
27. Sheldrick E.L., Flick-Smith H.C., Dos Santos Cruz G.J. Oxytocin receptor binding activity in cultured ovine endometrium. J. Reprod. Fert. 98:1993;521-528.
28. Tulchinsky E.M., Georgiev G.P., Lukanidin E.M. Novel AP-1 binding site created by DNA-methylation. Oncogene. 12:1996;1737-1745.