Astroglial NMDA receptors inhibit expression of Kir4.1 channels in glutamate-overexposed astrocytes in vitro and in the brain of rats with acute liver failure

Neurochemistry International

Volumn 88, Issue , 2015, Pages 20-25

  Obara Michlewska, Marta ^a   Ruszkiewicz, Joanna ^a   Zielińska, Magdalena ^a   Verkhratsky, Alexei ^a,b   Albrecht, Jan ^a  

^a MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Astrocytic NMDA receptors; Excitotoxicity; Glutamate; Hepatic encephalopathy; Kir4.1; Oxidative nitrosative stress

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 3 [(2 METHYL 4 THIAZOLYL)ETHYNYL]PYRIDINE; DIZOCILPINE; ESTER; GLUTAMIC ACID; GLUTATHIONE; INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR4.1; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NITRIC OXIDE SYNTHASE INHIBITOR; OXIDOREDUCTASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TAURINE; TRICHOSTATIN A; UNCLASSIFIED DRUG; KCNJ10 (CHANNEL);

ACUTE LIVER FAILURE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; IN VITRO STUDY; NITROSATIVE STRESS; NONHUMAN; POTASSIUM TRANSPORT; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA ISOLATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL CULTURE; CELL SURVIVAL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NEWBORN; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BRAIN; CELL SURVIVAL; CELLS, CULTURED; GENE EXPRESSION REGULATION; GLUTAMIC ACID; LIVER FAILURE, ACUTE; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 84939536460     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2014.10.006     Document Type: Article

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