Decrease of glutathione content in the prefrontal cortical mitochondria of rats with acute hepatic encephalopathy: Prevention by histidine

Metabolic Brain Disease

Volumn 28, Issue 1, 2013, Pages 11-14

  Ruszkiewicz, Joanna ^a   Fręśko, Inez ^a   Hilgier, Wojciech ^a   Albrecht, Jan ^a  

^a MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

Author keywords

Acute hepatic encephalopathy; Histidine; Mitochondrial glutathione; Thioacetamide

Indexed keywords

GAMMA GLUTAMYLTRANSFERASE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HISTIDINE; MESSENGER RNA;

ANIMAL CELL; ARTICLE; BRAIN HOMOGENATE; BRAIN MITOCHONDRION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HEPATIC ENCEPHALOPATHY; MALE; MICRODIALYSIS; NITROSATIVE STRESS; NONHUMAN; PREFRONTAL CORTEX; PROTEIN EXPRESSION; RAT;

ANIMALIA; RATTUS;

EID: 84873410890     PISSN: 08857490     EISSN: 15737365     Source Type: Journal    
DOI: 10.1007/s11011-012-9342-6     Document Type: Article

References (17)

1. Albrecht J, Norenberg MD (2006) Glutamine: a Trojan horse in ammonia neurotoxicity. Hepatology 44:788-794
2. Albrecht J, Dolińska M, Hilgier W, Lipkowski AW, Nowacki J (2000) Modulation of glutamine uptake and phosphate - activated glutaminase activity in rat brain mitochondria by amino acids and their synthetic analogues. Neurochem Int 36:341-347
3. Beker MM, Cerniglia GJ, Zaman A (1990) Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples. Anal Biochem 190:360-365
4. Bradford MM (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-256
5. Dringen R (2000) Metabolism and functions of glutathione in brain. Prog Neurobiol 62:649-671
6. Hilgier W, Olson J (1994) Brain ion and amino acid contents during edema development in hepatic encephalopathy. J Neurochem 62:197-204
7. Hilgier W, Wȩgrzynowicz M, Ruszkiewicz J, Oja SS, Saransaari P, Albrecht J (2010) Direct exposure to ammonia and hyperammonemia increase the extracellular accumulation and degradation of astroglia-derived glutathione in the rat prefrontal cortex. Toxicol Sci 117:163-168
8. Lash LH (2006) Mitochondrial glutathione transport: physiological, pathological and toxicological implications. Chem Biol Interact 163:54-67
9. -ΔΔCt method. Methods 25:402-408
10. Mari M, Morales A, Collel A, Garcia-Ruiz C, Fernandez-Checa JC (2009) Mitochondrial glutathione, a key survival antioxidant. Antioxid Redox Signal 11:2685-2700
11. Norenberg MD, Jayakumar AR, Rama Rao KV (2004) Oxidative stress in the pathogenesis of hepatic encephalopathy. Metab Brain Dis 19:313-329
12. Rama Rao KV, Norenberg MD (2012) Brain energy metabolism and mitochondrial dysfunction in acute and chronic hepatic encephalopathy. Metab Brain Dis 60:697-706
13. Rama Rao KV, Reddy PVB, Tong X, Norenberg MD (2010) Brain edema in acute liver failure. Inhibition by L-histidine. Am J Pathol 176:1400-1408
14. Ravindranath V, Reed DJ (1990) Glutathione depletion and formation of glutathione-protein mixed disulfide following exposure of brain mitochondria to oxidative stress. Biochem Biophys Res Commun 169:1075-1079
15. Sims NR, Anderson MF (2008) Isolation of mitochondria from rat brain using Percoll density gradient centrifugation. Nature Protocols 3:1228-1239
16. Wade AM, Tucker HN (1998) Antioxidant characteristics of L-histidine. J Nutr Biochem 9:308-315
17. Zaidan E, Nilsson M, Sims NR (1999) Cyclosporin A-sensitive changes in mitochondrial glutathione are an early response to intrastriatal NMDA or forebrain ischemia in rats. J Neurochem 73:2214-2217