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Volumn 54, Issue 8, 2015, Pages 1518-1527

Salivary mucins induce a Toll-like receptor 4-mediated pro-inflammatory response in human submandibular salivary cells: Are mucins involved in Sjögren's syndrome?

Author keywords

Cytokines; Human salivary cells; Inflammation; Salivary mucins; Sj gren's syndrome; TLR4

Indexed keywords

ADAPTOR PROTEIN; ALPHA INTERFERON; B CELL ACTIVATING FACTOR; BETA INTERFERON; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MUCIN 5B; MUCIN 7; TOLL INTERLEUKIN 1 RECEPTOR DOMAIN CONTAINING ADAPTOR PROTEIN; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84939475273     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/kev026     Document Type: Article
Times cited : (41)

References (50)
  • 1
    • 84926609858 scopus 로고    scopus 로고
    • Validation of EULAR primary Sjögren's syndrome disease activity (ESSDAI) and patient indexes (ESSPRI)
    • Advance Access published 11 March 2014
    • Seror R, Theander E, Brun JG et al. Validation of EULAR primary Sjögren's syndrome disease activity (ESSDAI) and patient indexes (ESSPRI). Ann Rheum Dis 2014, Advance Access published 11 March 2014, doi: 10.1136/annrheumdis-2013-204615.
    • (2014) Ann Rheum Dis
    • Seror, R.1    Theander, E.2    Brun, J.G.3
  • 2
    • 84862490927 scopus 로고    scopus 로고
    • Pathogenesis of Sjögren's syndrome: what we know and what we should learn
    • Tzioufas AG, Kapsogeorgou EK, Moutsopoulos HM. Pathogenesis of Sjögren's syndrome: what we know and what we should learn. J Autoimmun 2012;39:4-8.
    • (2012) J Autoimmun , vol.39 , pp. 4-8
    • Tzioufas, A.G.1    Kapsogeorgou, E.K.2    Moutsopoulos, H.M.3
  • 3
    • 77951711146 scopus 로고    scopus 로고
    • Disruption of tight junction structure in salivary glands from Sjögren's syndrome patients is linked to proinflammatory cytokine exposure
    • Ewert P, Aguilera S, Alliende C et al. Disruption of tight junction structure in salivary glands from Sjögren's syndrome patients is linked to proinflammatory cytokine exposure. Arthritis Rheum 2010;62:1280-9.
    • (2010) Arthritis Rheum , vol.62 , pp. 1280-1289
    • Ewert, P.1    Aguilera, S.2    Alliende, C.3
  • 4
    • 78751613367 scopus 로고    scopus 로고
    • Aberrant localization of ezrin correlates with salivary acini disorganization in Sjögren's Syndrome
    • Perez P, Aguilera S, Olea N et al. Aberrant localization of ezrin correlates with salivary acini disorganization in Sjögren's Syndrome. Rheumatology 2010;49:915-23.
    • (2010) Rheumatology , vol.49 , pp. 915-923
    • Perez, P.1    Aguilera, S.2    Olea, N.3
  • 5
    • 84862502800 scopus 로고    scopus 로고
    • Aberrant localization of fusion receptors involved in regulated exocytosis in salivary glands of Sjögren's syndrome patients is linked to ectopic mucin secretion
    • Barrera MJ, Sanchez M, Aguilera S et al. Aberrant localization of fusion receptors involved in regulated exocytosis in salivary glands of Sjögren's syndrome patients is linked to ectopic mucin secretion. J Autoimmun 2012;39: 83-92.
    • (2012) J Autoimmun , vol.39 , pp. 83-92
    • Barrera, M.J.1    Sanchez, M.2    Aguilera, S.3
  • 6
    • 80053521118 scopus 로고    scopus 로고
    • Changes in Rab3D expression and distribution in the acini of Sjögren's syndrome patients are associated with loss of cell polarity and secretory dysfunction
    • Bahamondes V, Albornoz A, Aguilera S et al. Changes in Rab3D expression and distribution in the acini of Sjögren's syndrome patients are associated with loss of cell polarity and secretory dysfunction. Arthritis Rheum 2011;63: 3126-35.
    • (2011) Arthritis Rheum , vol.63 , pp. 3126-3135
    • Bahamondes, V.1    Albornoz, A.2    Aguilera, S.3
  • 7
    • 84877127160 scopus 로고    scopus 로고
    • Sjögren's syndrome and the epithelial target: a comprehensive review
    • Barrera MJ, Bahamondes V, Sepulveda D et al. Sjögren's syndrome and the epithelial target: a comprehensive review. J Autoimmun 2013;42:7-18.
    • (2013) J Autoimmun , vol.42 , pp. 7-18
    • Barrera, M.J.1    Bahamondes, V.2    Sepulveda, D.3
  • 8
    • 0141564937 scopus 로고    scopus 로고
    • Enhanced degradation of proteins of the basal lamina and stroma by matrix metalloproteinases from the salivary glands of Sjögren's syndrome patients: correlation with reduced structural integrity of acini and ducts
    • Goicovich E, Molina C, Perez P et al. Enhanced degradation of proteins of the basal lamina and stroma by matrix metalloproteinases from the salivary glands of Sjögren's syndrome patients: correlation with reduced structural integrity of acini and ducts. Arthritis Rheum 2003;48: 2573-84.
    • (2003) Arthritis Rheum , vol.48 , pp. 2573-2584
    • Goicovich, E.1    Molina, C.2    Perez, P.3
  • 11
    • 84886069094 scopus 로고    scopus 로고
    • Regulated mucin secretion from airway epithelial cells
    • Adler KB, Tuvim MJ, Dickey BF. Regulated mucin secretion from airway epithelial cells. Front Endocrinol 2013;4: 129.
    • (2013) Front Endocrinol , vol.4 , pp. 129
    • Adler, K.B.1    Tuvim, M.J.2    Dickey, B.F.3
  • 12
    • 33846911262 scopus 로고    scopus 로고
    • Mucin granule intraluminal organization
    • Perez-Vilar J. Mucin granule intraluminal organization. Am J Respir Cell Mol Biol 2007;36:183-90.
    • (2007) Am J Respir Cell Mol Biol , vol.36 , pp. 183-190
    • Perez-Vilar, J.1
  • 13
    • 77952668655 scopus 로고    scopus 로고
    • Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cells
    • Bafna S, Kaur S, Batra SK. Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cells. Oncogene 2010;29:2893-904.
    • (2010) Oncogene , vol.29 , pp. 2893-2904
    • Bafna, S.1    Kaur, S.2    Batra, S.K.3
  • 15
    • 0033023581 scopus 로고    scopus 로고
    • Salivary mucin MG1 is comprised almost entirely of different glycosylated forms of the MUC5B gene product
    • Thornton DJ, Khan N, Mehrotra R et al. Salivary mucin MG1 is comprised almost entirely of different glycosylated forms of the MUC5B gene product. Glycobiology 1999;9: 293-302.
    • (1999) Glycobiology , vol.9 , pp. 293-302
    • Thornton, D.J.1    Khan, N.2    Mehrotra, R.3
  • 16
    • 0031055462 scopus 로고    scopus 로고
    • A monoclonal antibody directed against high M(r) salivary mucins recognizes the SO3-3Gal beta 1-3GlcNAc moiety of sulfo-Lewis(a): a histochemical survey of human and rat tissue
    • Veerman EC, Bolscher JG, Appelmelk BJ et al. A monoclonal antibody directed against high M(r) salivary mucins recognizes the SO3-3Gal beta 1-3GlcNAc moiety of sulfo-Lewis(a): a histochemical survey of human and rat tissue. Glycobiology 1997;7:37-43.
    • (1997) Glycobiology , vol.7 , pp. 37-43
    • Veerman, E.C.1    Bolscher, J.G.2    Appelmelk, B.J.3
  • 17
    • 53149100489 scopus 로고    scopus 로고
    • Reduced sulfation of muc5b is linked to xerostomia in patients with Sjögren syndrome
    • Alliende C, Kwon YJ, Brito M et al. Reduced sulfation of muc5b is linked to xerostomia in patients with Sjögren syndrome. Ann Rheum Dis 2008;67:1480-7.
    • (2008) Ann Rheum Dis , vol.67 , pp. 1480-1487
    • Alliende, C.1    Kwon, Y.J.2    Brito, M.3
  • 18
    • 84890435435 scopus 로고    scopus 로고
    • Toll-like receptors' pathway disturbances are associated with increased susceptibility to infections in humans
    • Frazao JB, Errante PR, Condino-Neto A. Toll-like receptors' pathway disturbances are associated with increased susceptibility to infections in humans. Arch Immunol Ther Exp 2013;61:427-43.
    • (2013) Arch Immunol Ther Exp , vol.61 , pp. 427-443
    • Frazao, J.B.1    Errante, P.R.2    Condino-Neto, A.3
  • 19
    • 84860919269 scopus 로고    scopus 로고
    • Mucins and toll-like receptors: kith and kin in infection and cancer
    • Tarang S, Kumar S, Batra SK. Mucins and toll-like receptors: kith and kin in infection and cancer. Cancer Lett 2012;321:110-9.
    • (2012) Cancer Lett , vol.321 , pp. 110-119
    • Tarang, S.1    Kumar, S.2    Batra, S.K.3
  • 20
    • 84883785469 scopus 로고    scopus 로고
    • The dendritic cell response to classic, emerging, and homeostatic danger signals. Implications for autoimmunity
    • Gallo PM, Gallucci S. The dendritic cell response to classic, emerging, and homeostatic danger signals. Implications for autoimmunity. Front Immunol 2013;4:138.
    • (2013) Front Immunol , vol.4 , pp. 138
    • Gallo, P.M.1    Gallucci, S.2
  • 21
    • 84867316465 scopus 로고    scopus 로고
    • Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation
    • Brennan TV, Lin L, Huang X et al. Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation. Blood 2012;120: 2899-908.
    • (2012) Blood , vol.120 , pp. 2899-2908
    • Brennan, T.V.1    Lin, L.2    Huang, X.3
  • 22
    • 0037033364 scopus 로고    scopus 로고
    • Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4
    • Termeer C, Benedix F, Sleeman J et al. Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. J Exp Med 2002;195:99-111.
    • (2002) J Exp Med , vol.195 , pp. 99-111
    • Termeer, C.1    Benedix, F.2    Sleeman, J.3
  • 23
    • 0036840405 scopus 로고    scopus 로고
    • The polysaccharide portion plays an indispensable role in Salmonella lipopolysaccharideinduced activation of NF-kappaB through human toll-like receptor 4
    • Muroi M, Tanamoto K. The polysaccharide portion plays an indispensable role in Salmonella lipopolysaccharideinduced activation of NF-kappaB through human toll-like receptor 4. Infect Immun 2002;70:6043-7.
    • (2002) Infect Immun , vol.70 , pp. 6043-6047
    • Muroi, M.1    Tanamoto, K.2
  • 24
    • 43049179999 scopus 로고    scopus 로고
    • LPS/TLR4 signal transduction pathway
    • Lu YC, Yeh WC, Ohashi PS. LPS/TLR4 signal transduction pathway. Cytokine 2008;42:145-51.
    • (2008) Cytokine , vol.42 , pp. 145-151
    • Lu, Y.C.1    Yeh, W.C.2    Ohashi, P.S.3
  • 25
    • 75449093273 scopus 로고    scopus 로고
    • TIR-containing adaptors in Toll-like receptor signalling
    • Jenkins KA, Mansell A. TIR-containing adaptors in Toll-like receptor signalling. Cytokine 2010;49:237-44.
    • (2010) Cytokine , vol.49 , pp. 237-244
    • Jenkins, K.A.1    Mansell, A.2
  • 26
    • 34248680720 scopus 로고    scopus 로고
    • Toll-like receptor in salivary glands from patients with Sjögren's syndrome: functional analysis by human salivary gland cell line
    • Kawakami A, Nakashima K, Tamai M et al. Toll-like receptor in salivary glands from patients with Sjögren's syndrome: functional analysis by human salivary gland cell line. J Rheumatol 2007;34:1019-26.
    • (2007) J Rheumatol , vol.34 , pp. 1019-1026
    • Kawakami, A.1    Nakashima, K.2    Tamai, M.3
  • 27
    • 33846799117 scopus 로고    scopus 로고
    • Expression of functional Toll-like receptors by salivary gland epithelial cells: increased mRNA expression in cells derived from patients with primary Sjögren's syndrome
    • Spachidou MP, Bourazopoulou E, Maratheftis CI et al. Expression of functional Toll-like receptors by salivary gland epithelial cells: increased mRNA expression in cells derived from patients with primary Sjögren's syndrome. Clin Exp Immunol 2007;147:497-503.
    • (2007) Clin Exp Immunol , vol.147 , pp. 497-503
    • Spachidou, M.P.1    Bourazopoulou, E.2    Maratheftis, C.I.3
  • 28
    • 0036092482 scopus 로고    scopus 로고
    • Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group
    • Vitali C, Bombardieri S, Jonsson R et al. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002;61:554-8.
    • (2002) Ann Rheum Dis , vol.61 , pp. 554-558
    • Vitali, C.1    Bombardieri, S.2    Jonsson, R.3
  • 29
    • 0021367334 scopus 로고
    • Labial salivary gland biopsy in Sjögren's syndrome. Assessment as a diagnostic criterion in 362 suspected cases
    • Daniels TE. Labial salivary gland biopsy in Sjögren's syndrome. Assessment as a diagnostic criterion in 362 suspected cases. Arthritis Rheum 1984;27:147-56.
    • (1984) Arthritis Rheum , vol.27 , pp. 147-156
    • Daniels, T.E.1
  • 30
    • 0015178094 scopus 로고
    • Histogenic classification of salivary tumors
    • Eversole LR. Histogenic classification of salivary tumors. Arch Pathol 1971;92:433-43.
    • (1971) Arch Pathol , vol.92 , pp. 433-443
    • Eversole, L.R.1
  • 31
    • 0027207233 scopus 로고
    • Cell cycle arrest of proliferating neuronal cells by serum deprivation can result in either apoptosis or differentiation
    • Howard MK, Burke LC, Mailhos C et al. Cell cycle arrest of proliferating neuronal cells by serum deprivation can result in either apoptosis or differentiation. J Neurochem 1993; 60:1783-91.
    • (1993) J Neurochem , vol.60 , pp. 1783-1791
    • Howard, M.K.1    Burke, L.C.2    Mailhos, C.3
  • 32
    • 34548226006 scopus 로고    scopus 로고
    • EGF prevents the neuroendocrine differentiation of LNCaP cells induced by serum deprivation: the modulator role of PI3K/Akt
    • Martin-Orozco RM, Almaraz-Pro C, Rodriguez-Ubreva FJ et al. EGF prevents the neuroendocrine differentiation of LNCaP cells induced by serum deprivation: the modulator role of PI3K/Akt. Neoplasia 2007;9:614-24.
    • (2007) Neoplasia , vol.9 , pp. 614-624
    • Martin-Orozco, R.M.1    Almaraz-Pro, C.2    Rodriguez-Ubreva, F.J.3
  • 33
    • 84872518158 scopus 로고    scopus 로고
    • Derivation and maturation of synthetic and contractile vascular smooth muscle cells from human pluripotent stem cells
    • Wanjare M, Kuo F, Gerecht S. Derivation and maturation of synthetic and contractile vascular smooth muscle cells from human pluripotent stem cells. Cardiovasc Res 2013; 97:321-30.
    • (2013) Cardiovasc Res , vol.97 , pp. 321-330
    • Wanjare, M.1    Kuo, F.2    Gerecht, S.3
  • 34
    • 0032531083 scopus 로고    scopus 로고
    • MUC5B is a major gel-forming, oligomeric mucin from human salivary gland, respiratory tract and endocervix: identification of glycoforms and C-terminal cleavage
    • Wickstrom C, Davies JR, Eriksen GV, Veerman EC, Carlstedt I. MUC5B is a major gel-forming, oligomeric mucin from human salivary gland, respiratory tract and endocervix: identification of glycoforms and C-terminal cleavage. Biochem J 1998;334:685-93.
    • (1998) Biochem J , vol.334 , pp. 685-693
    • Wickstrom, C.1    Davies, J.R.2    Eriksen, G.V.3    Veerman, E.C.4    Carlstedt, I.5
  • 35
    • 33750945342 scopus 로고    scopus 로고
    • Involvement of specific laminins and nidogens in the active remodeling of the basal lamina of labial salivary glands from patients with Sjögren's syndrome
    • Kwon YJ, Perez P, Aguilera S et al. Involvement of specific laminins and nidogens in the active remodeling of the basal lamina of labial salivary glands from patients with Sjögren's syndrome. Arthritis Rheum 2006;54: 3465-75.
    • (2006) Arthritis Rheum , vol.54 , pp. 3465-3475
    • Kwon, Y.J.1    Perez, P.2    Aguilera, S.3
  • 36
    • 0036123711 scopus 로고    scopus 로고
    • The salivary mucin MG1 (MUC5B) carries a repertoire of unique oligosaccharides that is large and diverse
    • Thomsson KA, Prakobphol A, Leffler H et al. The salivary mucin MG1 (MUC5B) carries a repertoire of unique oligosaccharides that is large and diverse. Glycobiology 2002; 12:1-14.
    • (2002) Glycobiology , vol.12 , pp. 1-14
    • Thomsson, K.A.1    Prakobphol, A.2    Leffler, H.3
  • 37
    • 0038056106 scopus 로고    scopus 로고
    • Distinct localization of MUC5B glycoforms in the human salivary glands
    • Veerman EC, van den Keijbus PA, Nazmi K et al. Distinct localization of MUC5B glycoforms in the human salivary glands. Glycobiology 2003;13:363-6.
    • (2003) Glycobiology , vol.13 , pp. 363-366
    • Veerman, E.C.1    van den Keijbus, P.A.2    Nazmi, K.3
  • 38
    • 34247171612 scopus 로고    scopus 로고
    • Functional cell permeable motifs within medically relevant proteins
    • Low W, Mortlock A, Petrovska L et al. Functional cell permeable motifs within medically relevant proteins. J Biotechnol 2007;129:555-64.
    • (2007) J Biotechnol , vol.129 , pp. 555-564
    • Low, W.1    Mortlock, A.2    Petrovska, L.3
  • 39
    • 0035555301 scopus 로고    scopus 로고
    • TIRAP: an adapter molecule in the Toll signaling pathway
    • Horng T, Barton GM, Medzhitov R. TIRAP: an adapter molecule in the Toll signaling pathway. Nat Immunol 2001; 2:835-41.
    • (2001) Nat Immunol , vol.2 , pp. 835-841
    • Horng, T.1    Barton, G.M.2    Medzhitov, R.3
  • 40
    • 65349102966 scopus 로고    scopus 로고
    • Sequence, structure, function, immunity: structural genomics of costimulation
    • Chattopadhyay K, Lazar-Molnar E, Yan Q et al. Sequence, structure, function, immunity: structural genomics of costimulation. Immunol Rev 2009;229:356-86.
    • (2009) Immunol Rev , vol.229 , pp. 356-386
    • Chattopadhyay, K.1    Lazar-Molnar, E.2    Yan, Q.3
  • 41
    • 78751670809 scopus 로고    scopus 로고
    • Hyaluronan as an immune regulator in human diseases
    • Jiang D, Liang J, Noble PW. Hyaluronan as an immune regulator in human diseases. Physiol Rev 2011;91:221-64.
    • (2011) Physiol Rev , vol.91 , pp. 221-264
    • Jiang, D.1    Liang, J.2    Noble, P.W.3
  • 42
    • 84873030415 scopus 로고    scopus 로고
    • The different roles of aggrecan interaction domains
    • Aspberg A. The different roles of aggrecan interaction domains. J Histochem Cytochem 2012;60:987-96.
    • (2012) J Histochem Cytochem , vol.60 , pp. 987-996
    • Aspberg, A.1
  • 43
    • 0038707201 scopus 로고    scopus 로고
    • LPS upregulates mucin and cytokine mRNA expression and stimulates mucin and cytokine secretion in goblet cells
    • Smirnova MG, Guo L, Birchall JP, Pearson JP. LPS upregulates mucin and cytokine mRNA expression and stimulates mucin and cytokine secretion in goblet cells. Cell Immunol 2003;221:42-9.
    • (2003) Cell Immunol , vol.221 , pp. 42-49
    • Smirnova, M.G.1    Guo, L.2    Birchall, J.P.3    Pearson, J.P.4
  • 44
    • 84861619978 scopus 로고    scopus 로고
    • Macrophages are related to goblet cell hyperplasia and induce MUC5B but not MUC5AC in human bronchus epithelial cells
    • Silva MA, Bercik P. Macrophages are related to goblet cell hyperplasia and induce MUC5B but not MUC5AC in human bronchus epithelial cells. Lab Invest 2012;92:937-48.
    • (2012) Lab Invest , vol.92 , pp. 937-948
    • Silva, M.A.1    Bercik, P.2
  • 45
    • 0035490435 scopus 로고    scopus 로고
    • Transcriptional regulation of the 11p15 mucin genes Towards new biological tools in human therapy, in inflammatory diseases and cancer?
    • Van Seuningen I, Pigny P, Perrais M, Porchet N, Aubert JP. Transcriptional regulation of the 11p15 mucin genes Towards new biological tools in human therapy, in inflammatory diseases and cancer? Front Biosci 2001;6: D1216-34.
    • (2001) Front Biosci , vol.6 , pp. D1216-D1234
    • Van Seuningen, I.1    Pigny, P.2    Perrais, M.3    Porchet, N.4    Aubert, J.P.5
  • 46
    • 0034660633 scopus 로고    scopus 로고
    • Sequence of the 5'-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells
    • Van Seuningen I, Perrais M, Pigny P, Porchet N, Aubert JP. Sequence of the 5'-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells. Biochem J 2000; 348:675-86.
    • (2000) Biochem J , vol.348 , pp. 675-686
    • Van Seuningen, I.1    Perrais, M.2    Pigny, P.3    Porchet, N.4    Aubert, J.P.5
  • 47
    • 84881269653 scopus 로고    scopus 로고
    • PGE(2) induces MUC2 and MUC5AC expression in human intrahepatic biliary epithelial cells via EP4/p38MAPK activation
    • Yang L, Junmin S, Hong Y, Shuodong W. PGE(2) induces MUC2 and MUC5AC expression in human intrahepatic biliary epithelial cells via EP4/p38MAPK activation. Ann Hepatol 2013;12:479-86.
    • (2013) Ann Hepatol , vol.12 , pp. 479-486
    • Yang, L.1    Junmin, S.2    Hong, Y.3    Shuodong, W.4
  • 48
    • 0037592950 scopus 로고    scopus 로고
    • Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop
    • Chen Y, Thai P, Zhao YH et al. Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop. J Biol Chem 2003;278: 17036-43.
    • (2003) J Biol Chem , vol.278 , pp. 17036-17043
    • Chen, Y.1    Thai, P.2    Zhao, Y.H.3
  • 49
    • 84987704182 scopus 로고    scopus 로고
    • Regulation of human MUC7 mucin gene expression by cigarette smoke extract or cigarette smoke and Pseudomonas aeruginosa lipopolysaccharide in human airway epithelial cells and in MUC7 transgenic mice
    • Fan H, Bobek LA. Regulation of human MUC7 mucin gene expression by cigarette smoke extract or cigarette smoke and Pseudomonas aeruginosa lipopolysaccharide in human airway epithelial cells and in MUC7 transgenic mice. Open Respir Med J 2010;4: 63-70.
    • (2010) Open Respir Med J , vol.4 , pp. 63-70
    • Fan, H.1    Bobek, L.A.2
  • 50
    • 33750726143 scopus 로고    scopus 로고
    • Functional analysis of human MUC7 mucin gene 5'-flanking region in lung epithelial cells
    • Li S, Bobek LA. Functional analysis of human MUC7 mucin gene 5'-flanking region in lung epithelial cells. Am J Respir Cell Mol Biol 2006;35:593-601.
    • (2006) Am J Respir Cell Mol Biol , vol.35 , pp. 593-601
    • Li, S.1    Bobek, L.A.2


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