Reduced sulfation of MUC5B is linked to xerostomia in patients with Sjögren syndrome

Annals of the Rheumatic Diseases

Volumn 67, Issue 10, 2008, Pages 1480-1487

  Alliende, C ^a   Kwon, Y J ^a   Brito, M ^a   Molina, C ^b   Aguilera, S ^c   Perez P ^a   Leyton, L ^a   Quest, A F G ^a   Mandel, U ^d   Veerman, E ^e   Espinosa, M ^a   Clausen, H ^d   Leyton, C ^a   Romo, R ^f   Gonzalez M J ^a,g  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSIDAD MAYOR   (Chile)

^c UNIVERSIDAD ANDRÉS BELLO   (Chile)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e UNIVERSITY OF AMSTERDAM   (Netherlands)

^f Santa Maria Clinic   (Chile)

^g UNIVERSITY OF CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MUCIN 5B; OLIGOSACCHARIDE; SALIVA PROTEIN;

ACINAR CELL; ADULT; ARTICLE; BASEMENT MEMBRANE; BLOOD GROUP LEWIS SYSTEM; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MICRODENSITOMETRY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALIVARY GLAND; SALIVATION; SJOEGREN SYNDROME; SULFATION; WESTERN BLOTTING; XEROSTOMIA;

ADULT; DENSITOMETRY; FEMALE; GENE EXPRESSION; HUMANS; MIDDLE AGED; MUCINS; OLIGOSACCHARIDES; RNA, MESSENGER; SALIVARY GLANDS; SALIVATION; SJOGREN'S SYNDROME; SULFATES; XEROSTOMIA;

EID: 53149100489     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.2007.078246     Document Type: Article

References (31)

1. Anaya JM, Talal N. Sjögren's syndrome comes of age. Semin Arthritis Rheum 1999;28:355-9.
2. Dawson LJ, Stanbury J, Venn N, Hasdimir B, Rogers SN. Smith PM. Antimuscarniic antibodies in primary Sjögren's syndrome reversibly inhibit the mechanism of fluid secretion by human submandibular salivary acinar cells. Arthritis Rheum 2006;54:1165-73
3. Fox Rl, Kang HI, Ando D, Abrams J, Pisa E. Cytokine mRNA expression in salivary gland biopsies of Sjögren's syndrome. J Immunol 1994;152:5532-9.
4. Konttmen YT, Sorsa T. Hukkanen M, Segerberg M, Kuhlefett-Sundstrom M, Malmstrom M, et al. Topology of innervation of labial salivary glands by protein gene product 9.5 and synaptophysin immunoreactive nerves in patients with Sjögren's syndrome. J Rheumatol 1992;19:30-7.
5. Fox Rl, Tomwall J, Michelson P. Current issues in the diagnosis and treatment of Sjögren's syndrome. Curr Opin Rheumatol 1999;11:364-71.
6. Debtorte C, Steinfeld S. Distribution and roles of aquaporins in salivary glands. Biochim Biophys Acta 2006;1758:1061-70.
7. Dawson U, Fox PC, Smith PM. Sjögren's syndrome - the non-apoptotic model of glandular hypotunction. Rheumatology (Oxford) 2006;45:792-8.
8. Dawson L, Tobin A, Smith P, Gordon T. Antimuscarinic antibodies in Sjögren's syndrome: where are we, and where are we going? Arthritis Rheum 2005;52:2984-95.
9. Molina C, Alliende C, Aguilera S, Kwon YJ, Leyton L. Martinez B, et al. Basal lamina disorganisation of the acini and ducts of labial salivary glands from patients with Sjögren's syndrome: association with mononuclear cell infiltration. Ann Rheum Dis 2006;65:178-83.
10. Goicovich E, Molina C, Perez P, Aguilera S, Fernandez J, Olea N, et al. Enhanced degradation of proteins of the basal lamina and stroma by matrix metalloproteinases from the salivary glands of Sjögren's syndrome patients: correlation with reduced structural integrity of acini and ducts. Arthritis Rheum 2003;48:2573-84.
11. da Costa SR. Wu K, Veigh MM, Pidgeon M, Ding C, Schechter JE, et al. Male NOD mouse external lacrimal glands exhibit profound changes in the exocytotic pathway early in postnatal development. Exp Eye Res 2006;82:33-45.
12. Thornton DJ, Khan N, Mehrotra R, Howard M, Veerman ECI, Packer NH, et al. Salivary mucin MG1 is comprised almost entirely of different glycosylated forms of the MUC5B gene product. Glycobiology 1999;9:293-302.
13. Thomson KA, Prakobphol A, Leffler H, Reddy MS, Levine MJ, Fisher SJ, et al. The salivary mucin MG1 (MUC5B) carries a repertoire of unique oligosaccharides that is large and diverse. Glycobiology 2002;12:1-14.
14. Nieuw Amerongen AV, Bolscher JGM, Veerman ECI. Salivary mucins: protective functions in relation to their diversity. Glycobiology 1995;5:733-40.
15. Saari H, Halinen S, Ganlov K, Sorsa T, Konttinen YT. Salivary mucous grycoprotein MG1 in Sjögren's syndrome. Clin Chim Acta 1997;259:83-96.
16. Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE. et al. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002;61:554-8.
17. Daniels TE, Labial salivary gland biopsy in Sjögren's syndrome. Assessment as a diagnostic criterion in 362 suspected cases. Arthritis Rheum 1984;27:147-56.
18. Perez P, Kwon YJ, Alliende C, Leyton L, Aguilera S, Molina C, et al. Increased acinar damage of salivary glands of patients with Sjögren's syndrome is paralleled by simultaneous imbalance of matrix metalloproteinase 3/tissue inhibitor of metalloproteinases 1 and matrix metalloproteinase 9/tissue inhibitor of metalloproteinases 1 ratios. Arthritis Rheum 2005;52:2751-60.
19. Kwon YJ, Perez P, Aguilera S. Molina C. Leyton L, Alliende C, et al. Involvement of specific laminins and nidogens in the active remodeling of the basal lamina of labial salivary glands from patients with Sjögren's syndrome. Arthritis Rheum 2006;54:3465-75.
20. Choudhury A, Singh RK, Moniaux N. El-Metwalfy TH, Aubert JP. Batra SK. Retinoic acid-dependent transforming growth factor-β 2-mediated induction of MUC4 mucin expression in human pancreatic tumor cells follows retinoic acid receptor-α signaling pathway. J Biol Chem 2000;275:33929-36.
21. Nielsen PA, Mandel U, Therkildsen MH, Clausen H. Differential expression of human high-molecular-weight salivary mucin (MG1) and low-molecular-weight salivary mucin (MG2). J Dent Res 1996;75:1820-6.
22. Rath VL, Verdugo D. Hemmerich S. Sulfotransferase structural biology and inhibitor discovery. Drug Discov Today 2004;9:1003-11.
23. Hempel N, Wang H. LeCluyse EL. McManus ME. Negishi M. The human sulfotransferase SULTIAI gene is regulated in a synergistic manner by Spl and GA binding protein. Mol Pharmacol 2004;66:1690-701.
24. Onto T, Uchida H. Yamazaki H, Keino-Masu K. Matsui A. Masu M. Identification of a novel nonlysosomal sulphatase expressed in the floor plate, choroid plexus and cartilage. Genes Cells 2002;7:173-85.
25. Delcommenne M, Kannagi R, Johnson P. TNF-α increases the carbohydrate sulfation of CD44: induction of 6-sulfo N-acetyl lactosamine on N- and O-linked glycans. Glycobiology 2002;12:613-22.
26. Yang X, Lehotay M, Anastassiades T, Harrison M, Brockhausen I. The effect of TNF-oc on glycosylation pathways in bovine synoviocytes. Biochem Cell Biol 2004;82:559-68.
27. Parnaud G, Hammar E, Rouiller DG, Armanet M, Halban PA, Bosco 0. Blockade of β1 integrin-laminin-5 interaction affects spreading and insulin secretion of rat β-cells attached on extracellular matrix. Diabetes 2006;55:1413-20.
28. Andersson SV, Hamm-Alvarez SF, Gierow JP. Integrin adhesion in regulation of lacrimal gland acinar cell secretion. Exp Eye Res 2006;83:543-53.
29. Laine M, Virtanen I, Salo T, Konttinen YT. Segment-specific but pathologic laminin isoform profiles in human labial salivary glands of patients with Sjögren's syndrome. Arthritis Rheum 2004;50:3968-73.
30. Espinosa M, Noe G, Troncoso C, Ho SB, Villalon M. Acidic pH and increasing [Ca(2+)] reduce the swelling of mucins in primary cultures of human cervical cells. Hum Reprod 2002;17:1964-72.
31. Perez-Vilar J, Mucin granule intraluminal organization. Am J Respir Cell Mol Biol 2007;36:183-90.