Electroblowing and electrospinning of fibrous diclofenac sodium-cyclodextrin complex-based reconstitution injection

Journal of Drug Delivery Science and Technology

Volumn 26, Issue , 2015, Pages 28-34

  Balogh, Attila ^a   Horváthová, Tímea ^a   Fülöp, Zoltán ^b   Loftsson, Thorsteinn ^b   Harasztos, Anna Helga ^a   Marosi, György ^a   Nagy, Zsombor K ^a  

^a BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

^b UNIVERSITY OF ICELAND   (Iceland)

Author keywords

Diclofenac sodium; Enhanced dissolution rate; Freeze drying; Polymer free electroblowing; Polymer free electrospinning; Reconstitution injection

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; DICLOFENAC; DRUG CARRIER; POLYMER;

AIR CONDITIONING; ANALYTIC METHOD; ARTICLE; BOLUS INJECTION; CHEMICAL COMPOSITION; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; ELECTROBLOWING; ELECTROSPINNING; FLOW RATE; FREEZE DRYING; INJECTION; LIQUID; MEASUREMENT ACCURACY; MEMBRANE RECONSTITUTION; SCANNING ELECTRON MICROSCOPY; SOLID; STATIC ELECTRICITY; SURFACE AREA; X RAY DIFFRACTION;

EID: 84939458248     PISSN: 17732247     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jddst.2015.02.003     Document Type: Article

References (40)

1. T. Loftsson, M.E. Brewster, Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization, J. Pharm. Sci. 85 (1996) 1017-1025.
2. J. Szejtli, Past, present and future of cyclodextrin research, Pure Appl. Chem. 76 (2004) 1825-1845.
3. H. Arima, K. Motoyama, T. Irie, Recent findings on safety profiles of cyclodextrins, cyclodextrin conjugates and polypseudorotaxanes, in: E. Bilensoy (Ed.), Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine, John Wiley & Sons Inc., New Jersey, 2011, pp. 91-122.
4. M.E. Davis, M.E. Brewster, Cyclodextrin-based pharmaceutics: past, present and future, Nat. Rev. Drug Discov. 4 (2004) 1023-1035.
5. T. Loftsson, D. Duchêne, Cyclodextrins and their pharmaceutical applications, Int. J. Pharm. 329 (2006) 1-11.
6. G.M. Keseru{combining double acute accent}, G.M. Makara, The influence of lead discovery strategies on the properties of drug candidates, Nat. Rev. Drug Discov. 8 (2009) 203-212.
7. B. Kállai-Szabó, M. Sinka, B. Stiedl, I. Sebe, I. Antal, R. Zelkó, Tracking of the solubility enhancement and drug release stability of melt extrudates containing mebendazole, J. Drug Deliv. Sci. Tec. 24 (2014) 514-518.
8. M.E. Brewster, T. Loftsson, Cyclodextrins as pharmaceutical solubilizers, Adv. Drug. Deliv. Rev. 59 (2007) 645-666.
9. A.T. Florence, D. Attwood, Drug stability, in: A.T. Florence, D. Attwood (Eds.), Physicochemical Principles of Pharmacy, Pharmaceutical Press, London, 2006, pp. 93-138.
10. J.M. DeFoggi, A. Bilstad, I. McPhilliamy, Device for reconstituting medicaments for injection, 2002, US Patent 6,358,236.
11. S.L. Nail, L.A. Gatin, Freeze-drying: principles and practice, in: K.E. Avis, H.A. Lieberman, L. Lechman (Eds.), Pharmaceutical Dosage Forms: Parenteral Medications, vol. 2, Marcel Dekker, New York, 1993, pp. 163-233.
12. T. Österberg, A. Fatouros, M. Mikaelsson, Development of a freeze-dried albumin-free formulation of recombinant factor VIII SQ, Pharm. Res. 14 (1997) 892-898.
13. D.M. Hariyadi, Y. Ma, Y. Wang, T. Bostrom, J. Malouf, M.S. Turner, B. Bhandari, A.G.A. Coombes, The potential for production of freeze-dried oral vaccines using alginate hydrogel microspheres as protein carriers, J. Drug Deliv. Sci. Tec. 24 (2014) 178-184.
14. X.C. Tang, M.J. Pikal, Design of freeze-drying processes for pharmaceuticals: practical advice, Pharm. Res. 21 (2004) 191-200.
15. E.A. Boss, R.M. Filho, E.C. Vasco de Toledo, Freeze drying process: real time model and optimization, Chem. Eng. Process. 43 (2004) 1475-1485.
16. Z.K. Nagy, A. Balogh, G. Drávavölgyi, J. Ferguson, H. Pataki, B. Vajna, G. Marosi, Solvent-free melt electrospinning for preparation of fast dissolving drug delivery system and comparison with solvent-based electrospun and melt extruded systems, J. Pharm. Sci. 102 (2013) 508-517.
17. A. Balogh, G. Drávavölgyi, K. Faragó, A. Farkas, T. Vigh, S.L. Sóti, I. Wagner, J. Madarász, H. Pataki, G. Marosi, Z.K. Nagy, Plasticized drug-loaded melt electrospun polymer mats: characterization, thermal degradation and release kinetics, J. Pharm. Sci. 103 (2014) 1278-1287.
18. Z.K. Nagy, A. Balogh, B. Vajna, A. Farkas, G. Patyi, Á. Kramarics, G. Marosi, Comparison of electrospun and extruded Soluplus®-based solid dosage forms of improved dissolution, J. Pharm. Sci. 101 (2011) 322-332.
19. G. Verreck, I. Chun, J. Peeters, J. Rosenblatt, M.E. Brewster, Preparation and characterization of nanofibers containing amorphous drug dispersions generated by electrostatic spinning, Pharm. Res. 20 (2003) 810-817.
20. Z.K. Nagy, K. Nyúl, I. Wagner, K. Molnár, G. Marosi, Electrospun water soluble polymer mat for ultrafast release of Donepezil HCl, Express Polym. Lett. 4 (2010) 763-772.
21. C. Li, Z.H. Wang, D.G. Yu, Higher quality quercetin sustained release ethyl cellulose nanofibers fabricated using a spinneret with a Teflon nozzle, Colloid Surf. B 114 (2014) 404-409.
22. S. Payab, N. Jafari-Aghdam, M. Barzegar-Jalali, G. Mohammadi, F. Lotfipour, T. Gholikhani, K. Adibkia, Preparation and physicochemical characterization of the azithromycin-Eudragit RS100 nanobeads and nanofibers using electrospinning method, J. Drug Deliv. Sci. Tec. 24 (2014) 585-590.
23. D.G. Yu, Y. Xu, Z. Li, L.P. Du, B.G. Zhao, X. Wang, Coaxial electrospinning with mixed solvents: from flat to round Eudragit L100 nanofibers for better colon-targeted sustained drug release profiles, J. Nanomater. (2014) 1-8.
24. T. Vigh, T. Horváthová, A. Balogh, P.L. Sóti, G. Drávavölgyi, Z.K. Nagy, G. Marosi, Polymer-free and polyvinylpirrolidone-based electrospun solid dosage forms for drug dissolution enhancement, Eur. J. Pharm. Sci. 49 (2013) 595-602.
25. M. Rampichová, L. Martinová, E. Koš͗áková, E. Filová, A. Míčková, M. Buzgo, J. Michálek, M. Přadn͵, A. Nečas, D. Lukáš, E. Amler, A simple drug anchoring microfiber scaffold for chondrocyte seeding and proliferation, J. Mater. Sci. Mater. Med. 23 (2012) 555-563.
26. A. Celebioglu, Z. Aytac, O.C. Umu, A. Dana, T. Tekinaya, T. Uyar, One-step synthesis of size-tunable Ag nanoparticles incorporated in electrospun PVA/cyclodextrin nanofibers, Carbohydrate 99 (2014) 808-816.
27. R. Sridhar, S. Sundarrajan, A. Vanangamudi, G. Singh, T. Matsuura, S. Ramakrishna, Green processing mediated novel polyelectrolyte nanofibers and their antimicrobial evaluation, Macromol. Mater. Eng. 299 (2013) 283-289.
28. S.H. Ranganath, C.H. Wang, Biodegradable microfiber implants delivering paclitaxel for post-surgical chemotherapy against malignant glioma, Biomaterials 29 (2008) 2996-3003.
29. X.M. Wu, C.J. Branford-White, L.M. Zhu, N.P. Chatterton, D.G. Yu, Ester prodrug-loaded electrospun cellulose acetate fiber mats as transdermal drug delivery systems, J. Mater. Sci. Mater. Med. 21 (2010) 2403-2411.
30. D. Jahantigh, M. Saadati, M.F. Ramandi, M. Mousavi, A.M. Zand, Novel intranasal vaccine delivery system by chitosan nanofibrous membrane containing N-terminal region of Ipad antigen as a nasal Shigellosis vaccine, studies in guinea pigs, J. Drug Deliv. Sci. Tec. 24 (2014) 33-39.
31. A. Celebioglu, T. Uyar, Cyclodextrin nanofibers by electrospinning, Chem. Commun. 46 (2010) 6903-6905.
32. A. Celebioglu, T. Uyar, Electrospinning of polymer-free nanofibers from cyclodextrin inclusion complexes, Langmuir 27 (2011) 6218-6226.
33. A. Celebioglu, T. Uyar, Electrospinning of nanofibers from non-polymeric systems: polymer-free nanofibers from cyclodextrin derivatives, Nanoscale 4 (2012) 621-631.
34. A.A. Noyes, W.R. Whitney, The rate of solution of solid substances in their own solutions, J. Am. Chem. Soc. 19 (1897) 930-934.
35. Y.Y. Liu, Q.W. Li, Q.X. Hu, C.J. Jing, Q.G. Wang, A new spurts controllable electrospinning collecting device designed basing on advanced motion control, Appl. Mech. Mater. 44-47 (2011) 1698-1702.
36. I.C. Um, D. Fang, B.S. Hsiao, A. Okamoto, B. Chu, Electro-spinning and electroblowing of hyaluronic acid, Biomacromolecules 5 (2004) 1428-1436.
37. R.M. Leeson, S. Harrison, C.C. Ernst, D.A. Hamilton, F.H. Mermelstein, D.G. Gawarecki, M. Moshman, D.B. Carr, Dyloject, a novel injectable diclofenac formulation, offers greater safety and efficacy than Voltarol for postoperative dental pain, Reg. Anesth. Pain M. 32 (2007) 303-310.
38. T. Loftsson, D. Hreinsdóttir, M. Másson, Evaluation of cyclodextrin solubilization of drugs, Int. J. Pharm. 302 (2006) 18-28.
39. Y. Filatov, A. Budyka, V. Kirichenko, Electrospinning of Micro- and Nanofibers: Fundamentals in Separation and Filtration Processes, Begell House, Danbury, 2007, pp. 1-404.
40. T. Higuchi, K.A. Connors, Phase-solubility techniques, Adv. Anal. Chem. Instrum. 4 (1965) 117-212.