Hexachlorobenzene induces cell proliferation, and aryl hydrocarbon receptor expression (AhR) in rat liver preneoplastic foci, and in the human hepatoma cell line HepG2. AhR is a mediator of ERK1/2 signaling, and cell cycle regulation in HCB-treated HepG2 cells

Toxicology

Volumn 336, Issue , 2015, Pages 36-47

  de Tomaso Portaz, Ana Clara ^a   Caimi, Giselle Romero ^a   Sánchez, Marcela ^a   Chiappini, Florencia ^a   Randi, Andrea S ^a   Kleiman de Pisarev, Diana L ^a   Alvarez, Laura ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Aryl hydrocarbon receptor (AhR); Cell proliferation; HepG2 cells; Hexachlorobenzene; Preneoplastic foci

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; BIOLOGICAL MARKER; CYCLIN D1; CYCLINE; GLUTATHIONE TRANSFERASE; HEXACHLOROBENZENE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CELL FATE; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING; LIVER CARCINOGENESIS; NONHUMAN; PRECANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CELL CYCLE; CELL SURVIVAL; CHEMICALLY INDUCED; DRUG EFFECTS; EXPERIMENTAL LIVER NEOPLASM; GENE EXPRESSION REGULATION; METABOLISM; SIGNAL TRANSDUCTION; WISTAR RAT;

RATTUS; RATTUS NORVEGICUS; RODENTIA;

ANIMALS; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HEXACHLOROBENZENE; HUMANS; LIVER NEOPLASMS, EXPERIMENTAL; MAP KINASE SIGNALING SYSTEM; PRECANCEROUS CONDITIONS; RATS; RATS, WISTAR; RECEPTORS, ARYL HYDROCARBON;

EID: 84939442066     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2015.07.013     Document Type: Article

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