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Volumn 277, Issue 1-3, 2010, Pages 59-65

Functional analysis of six human aryl hydrocarbon receptor variants in human breast cancer and mouse hepatoma cell lines

Author keywords

2,3,7,8 Tetrachlorodibenzo p dioxin; Aryl hydrocarbon receptor; Cytochrome P450 1A1; Gene regulation; Single nucleotide polymorphisms

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; CYP1B1 PROTEIN, HUMAN; CYP1B1 PROTEIN, MOUSE; CYTOCHROME P450; UNSPECIFIC MONOOXYGENASE;

EID: 77957879217     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2010.08.015     Document Type: Article
Times cited : (24)

References (37)
  • 3
    • 77957182873 scopus 로고
    • Differential toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL/6J mice congenic at the Ah Locus
    • Birnbaum L.S., McDonald M.M., Blair P.C., Clark A.M., Harris M.W. Differential toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL/6J mice congenic at the Ah Locus. Fundam. Appl. Toxicol. 1990, 15:186-200.
    • (1990) Fundam. Appl. Toxicol. , vol.15 , pp. 186-200
    • Birnbaum, L.S.1    McDonald, M.M.2    Blair, P.C.3    Clark, A.M.4    Harris, M.W.5
  • 5
    • 0036676787 scopus 로고    scopus 로고
    • Resistance of MCF-7 cells to dimethylbenz(a)anthracene-induced apoptosis is due to reduced CYP1A1 expression
    • Ciolino H.P., Dankwah M., Yeh G.C. Resistance of MCF-7 cells to dimethylbenz(a)anthracene-induced apoptosis is due to reduced CYP1A1 expression. Int. J. Oncol. 2002, 21:385-391.
    • (2002) Int. J. Oncol. , vol.21 , pp. 385-391
    • Ciolino, H.P.1    Dankwah, M.2    Yeh, G.C.3
  • 6
    • 33646255248 scopus 로고    scopus 로고
    • Human response to dioxin: aryl hydrocarbon receptor (AhR) molecular structure, function, and dose-response data for enzyme induction indicate an impaired human AhR
    • Connor K.T., Aylward L.L. Human response to dioxin: aryl hydrocarbon receptor (AhR) molecular structure, function, and dose-response data for enzyme induction indicate an impaired human AhR. J. Toxicol. Environ. Health B: Crit. Rev. 2006, 9:147-171.
    • (2006) J. Toxicol. Environ. Health B: Crit. Rev. , vol.9 , pp. 147-171
    • Connor, K.T.1    Aylward, L.L.2
  • 7
  • 9
    • 66849125992 scopus 로고    scopus 로고
    • Ligand selectivity and gene regulation by the human aryl hydrocarbon receptor in transgenic mice
    • Flaveny C.A., Murray I.A., Chiaro C.R., Perdew G.H. Ligand selectivity and gene regulation by the human aryl hydrocarbon receptor in transgenic mice. Mol. Pharmacol. 2009, 75:1412-1420.
    • (2009) Mol. Pharmacol. , vol.75 , pp. 1412-1420
    • Flaveny, C.A.1    Murray, I.A.2    Chiaro, C.R.3    Perdew, G.H.4
  • 11
    • 0037145023 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptors: diversity and evolution
    • Hahn M.E. Aryl hydrocarbon receptors: diversity and evolution. Chem. Biol. Interact. 2002, 141:131-160.
    • (2002) Chem. Biol. Interact. , vol.141 , pp. 131-160
    • Hahn, M.E.1
  • 12
    • 0028987872 scopus 로고
    • The aryl hydrocarbon receptor complex
    • Hankinson O. The aryl hydrocarbon receptor complex. Annu. Rev. Pharmacol. Toxicol. 1995, 35:307-340.
    • (1995) Annu. Rev. Pharmacol. Toxicol. , vol.35 , pp. 307-340
    • Hankinson, O.1
  • 14
    • 0034667405 scopus 로고    scopus 로고
    • Relative contributions of affinity and intrinsic efficacy to aryl hydrocarbon receptor ligand potency
    • Hestermann E.V., Stegeman J.J., Hahn M.E. Relative contributions of affinity and intrinsic efficacy to aryl hydrocarbon receptor ligand potency. Toxicol. Appl. Pharmacol. 2000, 168:160-172.
    • (2000) Toxicol. Appl. Pharmacol. , vol.168 , pp. 160-172
    • Hestermann, E.V.1    Stegeman, J.J.2    Hahn, M.E.3
  • 18
    • 0038053201 scopus 로고    scopus 로고
    • Polymorphism of alpha-estrogen receptor and aryl hydrocarbon receptor genes in dementia patients in Shanghai suburb
    • Lin G.F., Ma Q.W., Zhang D.S., Zha Y.L., Lou K.J., Shen J.H. Polymorphism of alpha-estrogen receptor and aryl hydrocarbon receptor genes in dementia patients in Shanghai suburb. Acta Pharmacol. Sin. 2003, 24:651-656.
    • (2003) Acta Pharmacol. Sin. , vol.24 , pp. 651-656
    • Lin, G.F.1    Ma, Q.W.2    Zhang, D.S.3    Zha, Y.L.4    Lou, K.J.5    Shen, J.H.6
  • 19
    • 34247240948 scopus 로고    scopus 로고
    • Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival
    • Long J.R., Cai Q., Shu X.O., Cai H., Gao Y.T., Zheng W. Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival. Pharmacogenet. Genomics 2007, 17:331-338.
    • (2007) Pharmacogenet. Genomics , vol.17 , pp. 331-338
    • Long, J.R.1    Cai, Q.2    Shu, X.O.3    Cai, H.4    Gao, Y.T.5    Zheng, W.6
  • 20
    • 67349240845 scopus 로고    scopus 로고
    • Activation function 2 mediates dioxin-induced recruitment of estrogen receptor alpha to CYP1A1 and CYP1B1
    • MacPherson L., Lo R., Ahmed S., Pansoy A., Matthews J. Activation function 2 mediates dioxin-induced recruitment of estrogen receptor alpha to CYP1A1 and CYP1B1. Biochem. Biophys. Res. Commun. 2009, 385:263-268.
    • (2009) Biochem. Biophys. Res. Commun. , vol.385 , pp. 263-268
    • MacPherson, L.1    Lo, R.2    Ahmed, S.3    Pansoy, A.4    Matthews, J.5
  • 21
    • 34548171191 scopus 로고    scopus 로고
    • Co-planar 3,3',4,4',5-pentachlorinated biphenyl and non-co-planar 2,2',4,6,6'-pentachlorinated biphenyl differentially induce recruitment of oestrogen receptor alpha to aryl hydrocarbon receptor target genes
    • Matthews J., Wihlen B., Heldring N., MacPherson L., Helguero L., Treuter E., Haldosen L.A., Gustafsson J.A. Co-planar 3,3',4,4',5-pentachlorinated biphenyl and non-co-planar 2,2',4,6,6'-pentachlorinated biphenyl differentially induce recruitment of oestrogen receptor alpha to aryl hydrocarbon receptor target genes. Biochem. J. 2007, 406:343-353.
    • (2007) Biochem. J. , vol.406 , pp. 343-353
    • Matthews, J.1    Wihlen, B.2    Heldring, N.3    MacPherson, L.4    Helguero, L.5    Treuter, E.6    Haldosen, L.A.7    Gustafsson, J.A.8
  • 22
    • 0030977819 scopus 로고    scopus 로고
    • Human Ah receptor (AHR) gene: localization to 7p15 and suggestive correlation of polymorphism with CYP1A1 inducibility
    • Micka J., Milatovich A., Menon A., Grabowski G.A., Puga A., Nebert D.W. Human Ah receptor (AHR) gene: localization to 7p15 and suggestive correlation of polymorphism with CYP1A1 inducibility. Pharmacogenetics 1997, 7:95-101.
    • (1997) Pharmacogenetics , vol.7 , pp. 95-101
    • Micka, J.1    Milatovich, A.2    Menon, A.3    Grabowski, G.A.4    Puga, A.5    Nebert, D.W.6
  • 23
    • 77951210260 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities
    • Moffat I.D., Boutros P.C., Chen H., Okey A.B., Pohjanvirta R. Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities. BMC Genomics 2010, 11:263.
    • (2010) BMC Genomics , vol.11 , pp. 263
    • Moffat, I.D.1    Boutros, P.C.2    Chen, H.3    Okey, A.B.4    Pohjanvirta, R.5
  • 25
    • 67649612842 scopus 로고    scopus 로고
    • Detection of the TCDD binding-fingerprint within the Ah receptor ligand binding domain by structurally driven mutagenesis and functional analysis
    • Pandini A., Soshilov A.A., Song Y., Zhao J., Bonati L., Denison M.S. Detection of the TCDD binding-fingerprint within the Ah receptor ligand binding domain by structurally driven mutagenesis and functional analysis. Biochemistry 2009, 48:5972-5983.
    • (2009) Biochemistry , vol.48 , pp. 5972-5983
    • Pandini, A.1    Soshilov, A.A.2    Song, Y.3    Zhao, J.4    Bonati, L.5    Denison, M.S.6
  • 26
    • 0031845222 scopus 로고    scopus 로고
    • Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant rat strain
    • Pohjanvirta R., Wong J.M., Li W., Harper P.A., Tuomisto J., Okey A.B. Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant rat strain. Mol. Pharmacol. 1998, 54:86-93.
    • (1998) Mol. Pharmacol. , vol.54 , pp. 86-93
    • Pohjanvirta, R.1    Wong, J.M.2    Li, W.3    Harper, P.A.4    Tuomisto, J.5    Okey, A.B.6
  • 27
    • 0027944549 scopus 로고
    • Analysis of the four alleles of the murine aryl hydrocarbon receptor
    • Poland A., Palen D., Glover E. Analysis of the four alleles of the murine aryl hydrocarbon receptor. Mol. Pharmacol. 1994, 46:915-921.
    • (1994) Mol. Pharmacol. , vol.46 , pp. 915-921
    • Poland, A.1    Palen, D.2    Glover, E.3
  • 28
    • 23444441147 scopus 로고    scopus 로고
    • Gene targeting using zinc finger nucleases
    • Porteus M.H., Carroll D. Gene targeting using zinc finger nucleases. Nat. Biotechnol. 2005, 23:967-973.
    • (2005) Nat. Biotechnol. , vol.23 , pp. 967-973
    • Porteus, M.H.1    Carroll, D.2
  • 29
    • 1642463494 scopus 로고    scopus 로고
    • AH receptor antagonist inhibits constitutive CYP1A1 and CYP1B1 expression in rat BP8 cells
    • Roblin S., Okey A.B., Harper P.A. AH receptor antagonist inhibits constitutive CYP1A1 and CYP1B1 expression in rat BP8 cells. Biochem. Biophys. Res. Commun. 2004, 317:142-148.
    • (2004) Biochem. Biophys. Res. Commun. , vol.317 , pp. 142-148
    • Roblin, S.1    Okey, A.B.2    Harper, P.A.3
  • 30
    • 77951432209 scopus 로고    scopus 로고
    • The human AHR: identification of single nucleotide polymorphisms from six ethnic populations
    • Rowlands C.J., Staskal D.F., Gollapudi B., Budinsky R. The human AHR: identification of single nucleotide polymorphisms from six ethnic populations. Pharmacogenet. Genomics 2010, 20:283-290.
    • (2010) Pharmacogenet. Genomics , vol.20 , pp. 283-290
    • Rowlands, C.J.1    Staskal, D.F.2    Gollapudi, B.3    Budinsky, R.4
  • 33
    • 0034054613 scopus 로고    scopus 로고
    • Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms
    • Smart J., Daly A.K. Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms. Pharmacogenetics 2000, 10:11-24.
    • (2000) Pharmacogenetics , vol.10 , pp. 11-24
    • Smart, J.1    Daly, A.K.2
  • 34
    • 0033429278 scopus 로고    scopus 로고
    • Polymorphism at codon 554 of the human Ah receptor: different allelic frequencies in Caucasians and Japanese and no correlation with severity of TCDD induced chloracne in chemical workers
    • Wanner R., Zober A., Abraham K., Kleffe J., Henz B.M., Wittig B. Polymorphism at codon 554 of the human Ah receptor: different allelic frequencies in Caucasians and Japanese and no correlation with severity of TCDD induced chloracne in chemical workers. Pharmacogenetics 1999, 9:777-780.
    • (1999) Pharmacogenetics , vol.9 , pp. 777-780
    • Wanner, R.1    Zober, A.2    Abraham, K.3    Kleffe, J.4    Henz, B.M.5    Wittig, B.6
  • 35
    • 0035834558 scopus 로고    scopus 로고
    • Human aryl hydrocarbon receptor polymorphisms that result in loss of CYP1A1 induction
    • Wong J.M., Okey A.B., Harper P.A. Human aryl hydrocarbon receptor polymorphisms that result in loss of CYP1A1 induction. Biochem. Biophys. Res. Commun. 2001, 288:990-996.
    • (2001) Biochem. Biophys. Res. Commun. , vol.288 , pp. 990-996
    • Wong, J.M.1    Okey, A.B.2    Harper, P.A.3
  • 37
    • 0036158477 scopus 로고    scopus 로고
    • Nonassociation of aryl hydrocarbon receptor genotypes with susceptibility to bladder cancer in Shanghai population
    • Zhang D.S., Lin G.F., Ma Q.W., Shen J.H. Nonassociation of aryl hydrocarbon receptor genotypes with susceptibility to bladder cancer in Shanghai population. Acta Pharmacol. Sin. 2002, 23:188-192.
    • (2002) Acta Pharmacol. Sin. , vol.23 , pp. 188-192
    • Zhang, D.S.1    Lin, G.F.2    Ma, Q.W.3    Shen, J.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.