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Volumn 104, Issue 9, 2015, Pages 3208-3219

Zanamivir Amidoxime- and N-Hydroxyguanidine-Based Prodrug Approaches to Tackle Poor Oral Bioavailability

Author keywords

bioavailability; drug like properties; guanidine bioisoster; amidine; influenza A; neuraminidase inhibitor; pharmacokinetics; prodrug; synthesis

Indexed keywords

5 ACETYLAMINO 2,6 ANHYDRO 4 [N (N' HYDROXY)ACETIMIDAMIDO] 3,4,5 TRIDEOXY GLYCERO GALACTO NON 2 ENONIC ACID METHYL ESTER; 5 ACETYLAMINO 4 (N ACETIMIDAMIDO) 2,6 ANHYDRO 3,4,5 TRIDEOXY GLYCERO GALACTO NON 2 ENONIC ACID; 5 ACETYLAMINO 7,8,9 TRI O ACETYL 2,6 ANHYDRO 4 [N (N' BENZYLOXYCARBONYL)THIOUREIDO] 3,4,5 TRIDEOXY GLYCERO GALACTO NON 2 ENONIC ACID METHYL ESTER; 5 ACETYLAMINO 7,8,9 TRI O ACETYL 2,6 ANHYDRO 4 [N (N' HYDROXY)ACETIMIDAMIDO] 3,4,5 TRIDEOXY GLYCERO GALACTO NON 2 ENONIC ACID METHYL ESTER; 5 ACETYLAMINO 7,8,9 TRI O ACETYL 2,6 ANHYDRO 4 [N (N' HYDROXY)GUANIDINO] 3,4,5 TRIDEOXY GLYCERO GALACTO NON 2 ENONIC ACID METHYL ESTER; 5 ACETYLAMINO 7,8,9 TRI O ACETYL 2,6 ANHYDRO 4 [N [N' BENZYLOXY CARBONYL N" (TETRAHYDRO 2H PYRAN 1 YL)OXY]GUANIDINO] 3,4,5 TRIDEOXY GLYCERO GALACTO NON 2 ENONIC ACID METHYL ESTER; 5 ACETYLAMINO 7,8,9 TRI O ACETYL 4 (N ACETIMIDAMIDO) 2,6 ANHYDRO 3,4,5 TRIDEOXY GLYCERO GALACTO NON 2 ENONIC ACID METHYL ESTER HYDROBROMIDE; AMIDINE; CARBOXYLIC ACID; GLYCEROL; GUANIDINE DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG; ZANAMIVIR; ACETAMIDINE; ANTIVIRUS AGENT; ENZYME INHIBITOR; HYDROXYGUANIDINE; SIALIDASE;

EID: 84939258930     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24508     Document Type: Article
Times cited : (20)

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