Tracking autophagy during proliferation and differentiation of trypanosoma brucei

Microbial Cell

Volumn 1, Issue 1, 2014, Pages 9-20

  Proto, William R ^a   Jones, Nathaniel G ^a   Coombs, Graham H ^b   Mottram, Jeremy C ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Autophagy; Cell death; Differentiation; Protozoan; Trypanosome

Indexed keywords

EID: 84939242851     PISSN: None     EISSN: 23112638     Source Type: Journal    
DOI: 10.15698/mic2014.01.120     Document Type: Article

References (37)

1. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V et al. (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8: 445-544.
2. Yang Z, Klionsky DJ (2009) An overview of the molecular mechanism of autophagy. Curr Top Microbiol Immunol 335: 1-32.
3. He C, Klionsky DJ (2009) Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 43: 67-93.
4. Mizushima N, Yamamoto A, Hatano M, Kobayashi Y, Kabeya Y, Suzuki K, Tokuhisa T, Ohsumi Y, Yoshimori T (2001) Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol 152: 657-667.
5. Mizushima N, Noda T, Yoshimori T, Tanaka Y, Ishii T, George MD, Klionsky DJ, Ohsumi M, Ohsumi Y (1998) A protein conjugation system essential for autophagy. Nature 395: 395-398.
6. Ichimura Y, Kirisako T, Takao T, Satomi Y, Shimonishi Y, Ishihara N, Mizushima N, Tanida I, Kominami E, Ohsumi M, Noda T, Ohsumi Y (2000) A ubiquitin-like system mediates protein lipidation. Nature 408: 488-492.
7. Suzuki K, Kubota Y, Sekito T, Ohsumi Y (2007) Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes to Cells 12: 209-218.
8. Mizushima N, Noda T, Ohsumi Y (1999) Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway. EMBO J 18: 3888-3896.
9. Romanov J, Walczak M, Ibiricu I, Schuchner S, Ogris E, Kraft C, Martens S (2012) Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation. EMBO J 31: 4304-4317.
10. Ohsumi Y, Mizushima N (2004) Two ubiquitin-like conjugation systems essential for autophagy. Sem Cell & Dev Biol 15: 231-236.
11. Rigden DJ, Michels PA, Ginger ML (2009) Autophagy in protists: Examples of secondary loss, lineage-specific innovations, and the conundrum of remodeling a single mitochondrion. Autophagy 5: 784-794.
12. Williams RAM, Tetley L, Mottram JC, Coombs GH (2006) Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana. Mol Microbiol 61: 655-674.
13. Herman M, Gillies S, Michels PA, Rigden DJ (2006) Autophagy and related processes in trypanosomatids: insights from genomic and bioinformatic analyses. Autophagy 2: 107-118.
14. Tomlins AM, Ben-Rached F, Williams RAM, Proto WR, Coppens I, Ruch U, Gilberger TW, Coombs GH, Mottram JC, Muller S, Langsley G (2013) Plasmodium falciparum Atg8 implicated in both autophagy and apicoplast formation. Autophagy 9: 1-13.
15. Duszenko M, Ginger ML, Brennand A, Gualdron-lopez M, Colombo MI, Coombs GH, Coppens I, Jayabalasingham B, Langsley G, Lisboa de Castro S, Menna-Barreto R, Mottram JC, Navarro M, Rigden DJ, Romana PS, Stoka V, Turk B, Michels PAM (2011) Autophagy in protists. Autophagy 7: 127-158.
16. Li FJ, Shen Q, Wang C, Sun Y, Yuan AY, He CY (2012) A role of autophagy in Trypanosoma brucei cell death. Cell Microbiol 14: 1242-1256.
17. Ghosh D, Walton JL, Roepe PD, Sinai AP (2012) Autophagy is a cell death mechanism in Toxoplasma gondii. Cell Microbiol 14: 589-607.
18. Proto WR, Coombs GH, Mottram JC (2013) Cell death in parasitic protozoa: regulated or incidental? Nat Rev Microbiol 11: 58-66.
19. Wullschleger S, Loewith R, Hall MN (2006) TOR Signaling in Growth and Metabolism. Cell 124: 471-484.
20. Zheng XF, Fiorentino D, Chen J, Crabtree GR, Schreiber SL (1995) TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin. Cell 82: 121-130.
21. Kamada Y, Funakoshi T, Shintani T, Nagano K, Ohsumi M, Ohsumi Y (2000) Tor-Mediated Induction of Autophagy via an Apg1 Protein Kinase Complex. J Cell Biol 150: 1507-1513.
22. Barquilla A, Crespo JL, Navarro M (2008) Rapamycin inhibits trypanosome cell growth by preventing TOR complex 2 formation. Proc Natl Acad Sci U S A 105: 14579-14584.
23. Koopmann R, Muhammad K, Perbandt M, Betzel C, Duszenko M (2009) Trypanosoma brucei ATG8: Structural insights into autophagic-like mechanisms in protozoa. Autophagy 5: 1085-1091.
24. Wirtz E, Leal S, Ochatt C, Cross GA (1999) A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei. Mol Biochem Parasitol 99: 89-101.
25. Alsford S, Horn D (2008) Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma brucei. Mol Biochem Parasitol 161: 76-79.
26. Myburgh E, Coles JA, Ritchie R, Kennedy PGE, McLatchie AP, Rodgers J, Taylor MC, Barrett MP, Brewer JM, Mottram JC (2013) In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis. PLoS Neg Trop Dis 7: e2384.
27. LaCount DJ, Bruse S, Hill KL, Donelson JE (2000) Double-stranded RNA interference in Trypanosoma brucei using head-to-head promoters. Mol Biochem Parasitol 111: 67-76.
28. Jones N.G, Thomas E.B, Brown E, Dickens NJ, Hammarton TC, Mottram JC (2013) Regulators of Trypanosoma brucei cell cycle progression and differentiation identified using a kinome-wide RNAi screen. PLoS Path, in press.
29. Uzcategui NL, Denninger V, Merkel P, Schoenfeld C, Figarella K, Duszenko M (2007) Dihydroxyacetone induced autophagy in African trypanosomes. Autophagy 3: 626-629.
30. Williams RAM, Smith TK, Cull B, Mottram JC, Coombs GH (2012) ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania. PloS Path 8: e1002695.
31. Ziegelbauer K, Quinten M, Schwarz H, Pearson TW, Overath P (1990) Synchronous differentiation of Trypanosoma brucei from bloodstream to procyclic forms in vitro. Eur J Biochem 192: 373-378.
32. Barquilla A, Saldivia M, Diaz R, Bart JM, Vidal I, Calvo E, Hall MN, Navarro M (2012) Third target of rapamycin complex negatively regulates development of quiescence in Trypanosoma brucei. Proc Natl Acad Sci U S A 109: 14399-14404.
33. Williams RAM, Woods KL, Juliano L, Mottram JC, Coombs GH (2009) Characterisation of unusual families of ATG8-like proteins and ATG12 in the protozoan parasite Leishmania major. Autophagy 5: 159-172.
34. Van den Abbeele J, Claes Y, van Bockstaele D, Le Ray D, Coosemans M (1999) Trypanosoma brucei spp. development in the tsetse fly: characterization of the post-mesocyclic stages in the foregut and proboscis. Parasitol 118: 469-478.
35. Aksoy S, Gibson WC, Lehane MJ (2003) Interactions between tsetse and trypanosomes with implications for the control of trypanosomiasis. Adv Parasitol 53: 1-83.
36. Kelly S, Reed J, Kramer S, Ellis L, Webb H, Sunter J, Salje J, Marinsek N, Gull K, Wickstead B, Carrington M (2007) Functional genomics in Trypanosoma brucei: A collection of vectors for the expression of tagged proteins from endogenous and ectopic gene loci. Mol Biochem Parasitol 154: 103-109.
37. Munday JC, McLuskey K, Brown E, Coombs GH, Mottram JC (2011) Oligopeptidase B-deficient mutants of Leishmania major. Mol Biochem Parasitol 175: 49-57.