메뉴 건너뛰기




Volumn 82, Issue 3, 2015, Pages 184-190

Antidrug Antibodies: B Cell Immunity Against Therapy

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; BETA1A INTERFERON; BLOOD CLOTTING FACTOR 8; CERTOLIZUMAB PEGOL; DRUG ANTIBODY; ETANERCEPT; GOLIMUMAB; INFLIXIMAB; INTERFERON BETA SERINE; NATALIZUMAB; NEUTRALIZING ANTIBODY; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; ANTIBODY; ANTIRHEUMATIC AGENT; BETA INTERFERON; DRUG; MONOCLONAL ANTIBODY; RECOMBINANT FACTOR VIII SQ;

EID: 84939233551     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/sji.12327     Document Type: Review
Times cited : (11)

References (82)
  • 1
    • 84887489815 scopus 로고    scopus 로고
    • The immunogenicity of anti-TNF therapy in immune-mediated inflammatory diseases: a systematic review of the literature with a meta-analysis
    • Garces S, Demengeot J, Benito-Garcia E. The immunogenicity of anti-TNF therapy in immune-mediated inflammatory diseases: a systematic review of the literature with a meta-analysis. Ann Rheum Dis 2013;72:1947-55.
    • (2013) Ann Rheum Dis , vol.72 , pp. 1947-1955
    • Garces, S.1    Demengeot, J.2    Benito-Garcia, E.3
  • 2
    • 84939255213 scopus 로고    scopus 로고
    • Standardizing terms, definitions and concepts for describing and interpreting unwanted immunogenicity of biopharmaceuticals: Recommendations of the innovative medicines initiative ABIRISK consortium
    • [Epub ahead of print]
    • Rup B, Pallardy M, Sikkema D et al. Standardizing terms, definitions and concepts for describing and interpreting unwanted immunogenicity of biopharmaceuticals: Recommendations of the innovative medicines initiative ABIRISK consortium. Clin Exp Immunol 2015; doi:10.1111/cei.12652. [Epub ahead of print].
    • (2015) Clin Exp Immunol
    • Rup, B.1    Pallardy, M.2    Sikkema, D.3
  • 3
    • 84903597970 scopus 로고    scopus 로고
    • Assessment and reporting of the clinical immunogenicity of therapeutic proteins and peptides-harmonized terminology and tactical recommendations
    • Shankar G, Arkin S, Cocea L et al. Assessment and reporting of the clinical immunogenicity of therapeutic proteins and peptides-harmonized terminology and tactical recommendations. AAPS J 2014;16:658-73.
    • (2014) AAPS J , vol.16 , pp. 658-673
    • Shankar, G.1    Arkin, S.2    Cocea, L.3
  • 4
    • 33646262886 scopus 로고    scopus 로고
    • Overview of inhibitors
    • Astermark J. Overview of inhibitors. Semin Hematol 2006;43:S3-7.
    • (2006) Semin Hematol , vol.43 , pp. S3-S7
    • Astermark, J.1
  • 6
    • 84863419863 scopus 로고    scopus 로고
    • F8 gene mutation type and inhibitor development in patients with severe hemophilia A: systematic review and meta-analysis
    • Gouw SC, van den Berg HM, Oldenburg J et al. F8 gene mutation type and inhibitor development in patients with severe hemophilia A: systematic review and meta-analysis. Blood 2012;119:2922-34.
    • (2012) Blood , vol.119 , pp. 2922-2934
    • Gouw, S.C.1    van den Berg, H.M.2    Oldenburg, J.3
  • 7
    • 33645751563 scopus 로고    scopus 로고
    • Polymorphisms in the IL10 but not in the IL1beta and IL4 genes are associated with inhibitor development in patients with hemophilia A
    • Astermark J, Oldenburg J, Pavlova A, Berntorp E, Lefvert AK. Polymorphisms in the IL10 but not in the IL1beta and IL4 genes are associated with inhibitor development in patients with hemophilia A. Blood 2006;107:3167-72.
    • (2006) Blood , vol.107 , pp. 3167-3172
    • Astermark, J.1    Oldenburg, J.2    Pavlova, A.3    Berntorp, E.4    Lefvert, A.K.5
  • 8
    • 77449101167 scopus 로고    scopus 로고
    • Impact of polymorphisms of the major histocompatibility complex class II, interleukin-10, tumor necrosis factor-alpha and cytotoxic T-lymphocyte antigen-4 genes on inhibitor development in severe hemophilia A
    • Pavlova A, Delev D, Lacroix-Desmazes S et al. Impact of polymorphisms of the major histocompatibility complex class II, interleukin-10, tumor necrosis factor-alpha and cytotoxic T-lymphocyte antigen-4 genes on inhibitor development in severe hemophilia A. J Thromb Haemost 2009;7:2006-15.
    • (2009) J Thromb Haemost , vol.7 , pp. 2006-2015
    • Pavlova, A.1    Delev, D.2    Lacroix-Desmazes, S.3
  • 9
    • 77953592167 scopus 로고    scopus 로고
    • Analysis of cytokine genes polymorphism as markers for inhibitor development in haemophilia A
    • Chaves D, Belisario A, Castro G, Santoro M, Rodrigues C. Analysis of cytokine genes polymorphism as markers for inhibitor development in haemophilia A. Int J Immunogenet 2010;37:79-82.
    • (2010) Int J Immunogenet , vol.37 , pp. 79-82
    • Chaves, D.1    Belisario, A.2    Castro, G.3    Santoro, M.4    Rodrigues, C.5
  • 10
    • 79959494195 scopus 로고    scopus 로고
    • A case-control study reveals immunoregulatory gene haplotypes that influence inhibitor risk in severe haemophilia A
    • Lozier JN, Rosenberg PS, Goedert JJ, Menashe I. A case-control study reveals immunoregulatory gene haplotypes that influence inhibitor risk in severe haemophilia A. Haemophilia 2011;17:641-9.
    • (2011) Haemophilia , vol.17 , pp. 641-649
    • Lozier, J.N.1    Rosenberg, P.S.2    Goedert, J.J.3    Menashe, I.4
  • 11
    • 84855314714 scopus 로고    scopus 로고
    • Impact of polymorphisms in genes involved in autoimmune disease on inhibitor development in Chinese patients with haemophilia A
    • Lu Y, Ding Q, Dai J, Wang H, Wang X. Impact of polymorphisms in genes involved in autoimmune disease on inhibitor development in Chinese patients with haemophilia A. Thromb Haemost 2012;107:30-6.
    • (2012) Thromb Haemost , vol.107 , pp. 30-36
    • Lu, Y.1    Ding, Q.2    Dai, J.3    Wang, H.4    Wang, X.5
  • 12
    • 84865536193 scopus 로고    scopus 로고
    • Immune regulatory gene polymorphisms as predisposing risk factors for the development of factor VIII inhibitors in Indian severe haemophilia A patients
    • Pinto P, Ghosh K, Shetty S. Immune regulatory gene polymorphisms as predisposing risk factors for the development of factor VIII inhibitors in Indian severe haemophilia A patients. Haemophilia 2012;18:794-7.
    • (2012) Haemophilia , vol.18 , pp. 794-797
    • Pinto, P.1    Ghosh, K.2    Shetty, S.3
  • 13
    • 84883049801 scopus 로고    scopus 로고
    • Impact of HLA alleles and cytokine polymorphisms on inhibitors development in children with severe haemophilia A
    • Pergantou H, Varela I, Moraloglou O et al. Impact of HLA alleles and cytokine polymorphisms on inhibitors development in children with severe haemophilia A. Haemophilia 2013;19:706-10.
    • (2013) Haemophilia , vol.19 , pp. 706-710
    • Pergantou, H.1    Varela, I.2    Moraloglou, O.3
  • 14
    • 33845239946 scopus 로고    scopus 로고
    • Polymorphisms in the TNFA gene and the risk of inhibitor development in patients with hemophilia A
    • Astermark J, Oldenburg J, Carlson J et al. Polymorphisms in the TNFA gene and the risk of inhibitor development in patients with hemophilia A. Blood 2006;108:3739-45.
    • (2006) Blood , vol.108 , pp. 3739-3745
    • Astermark, J.1    Oldenburg, J.2    Carlson, J.3
  • 15
    • 84926155035 scopus 로고    scopus 로고
    • FVIII inhibitors: pathogenesis and avoidance
    • Astermark J. FVIII inhibitors: pathogenesis and avoidance. Blood 2015;125:2045-51.
    • (2015) Blood , vol.125 , pp. 2045-2051
    • Astermark, J.1
  • 16
    • 77950211350 scopus 로고    scopus 로고
    • New early prophylaxis regimen that avoids immunological danger signals can reduce FVIII inhibitor development
    • Kurnik K, Bidlingmaier C, Engl W, Chehadeh H, Reipert B, Auerswald G. New early prophylaxis regimen that avoids immunological danger signals can reduce FVIII inhibitor development. Haemophilia 2010;16:256-62.
    • (2010) Haemophilia , vol.16 , pp. 256-262
    • Kurnik, K.1    Bidlingmaier, C.2    Engl, W.3    Chehadeh, H.4    Reipert, B.5    Auerswald, G.6
  • 17
    • 33845485057 scopus 로고    scopus 로고
    • Mechanisms of action of immune tolerance induction against factor VIII in patients with congenital haemophilia A and factor VIII inhibitors
    • Reipert BM, van Helden PM, Schwarz HP, Hausl C. Mechanisms of action of immune tolerance induction against factor VIII in patients with congenital haemophilia A and factor VIII inhibitors. Br J Haematol 2007;136:12-25.
    • (2007) Br J Haematol , vol.136 , pp. 12-25
    • Reipert, B.M.1    van Helden, P.M.2    Schwarz, H.P.3    Hausl, C.4
  • 18
    • 0017188375 scopus 로고
    • Antibodies to factor VIII. V. Patterns of immune response to factor VIII in hemophilia A
    • Allain JP, Frommel D. Antibodies to factor VIII. V. Patterns of immune response to factor VIII in hemophilia A. Blood 1976;47:973-82.
    • (1976) Blood , vol.47 , pp. 973-982
    • Allain, J.P.1    Frommel, D.2
  • 19
    • 0017785868 scopus 로고
    • Massive factor-VIII infusion in haemophiliac with factor-VIII inhibitor, high responder
    • Brackmann HH, Gormsen J. Massive factor-VIII infusion in haemophiliac with factor-VIII inhibitor, high responder. Lancet 1977;2:933.
    • (1977) Lancet , vol.2 , pp. 933
    • Brackmann, H.H.1    Gormsen, J.2
  • 20
    • 0032883366 scopus 로고    scopus 로고
    • Induction of immune tolerance in haemophilia A inhibitor patients by the 'Bonn Protocol': predictive parameter for therapy duration and outcome
    • Oldenburg J, Schwaab R, Brackmann HH. Induction of immune tolerance in haemophilia A inhibitor patients by the 'Bonn Protocol': predictive parameter for therapy duration and outcome. Vox Sang 1999;77 (Suppl. 1):49-54.
    • (1999) Vox Sang , vol.77 , pp. 49-54
    • Oldenburg, J.1    Schwaab, R.2    Brackmann, H.H.3
  • 21
    • 84903212553 scopus 로고    scopus 로고
    • ITI choice for the optimal management of inhibitor patients - from a clinical and pharmacoeconomic perspective
    • Oldenburg J, Austin SK, Kessler CM. ITI choice for the optimal management of inhibitor patients - from a clinical and pharmacoeconomic perspective. Haemophilia 2014;20 (Suppl. 6):17-26.
    • (2014) Haemophilia , vol.20 , pp. 17-26
    • Oldenburg, J.1    Austin, S.K.2    Kessler, C.M.3
  • 22
    • 27744530253 scopus 로고    scopus 로고
    • High-dose factor VIII inhibits factor VIII-specific memory B cells in hemophilia A with factor VIII inhibitors
    • Hausl C, Ahmad RU, Sasgary M et al. High-dose factor VIII inhibits factor VIII-specific memory B cells in hemophilia A with factor VIII inhibitors. Blood 2005;106:3415-22.
    • (2005) Blood , vol.106 , pp. 3415-3422
    • Hausl, C.1    Ahmad, R.U.2    Sasgary, M.3
  • 23
    • 77955604541 scopus 로고    scopus 로고
    • Immunomodulation for inhibitors in hemophilia A: the important role of Treg cells
    • Miao CH. Immunomodulation for inhibitors in hemophilia A: the important role of Treg cells. Expert Rev Hematol 2010;3:469-83.
    • (2010) Expert Rev Hematol , vol.3 , pp. 469-483
    • Miao, C.H.1
  • 24
    • 84907270053 scopus 로고    scopus 로고
    • Rituximab for treatment of inhibitors in haemophilia A. A Phase II study
    • Leissinger C, Josephson CD, Granger S et al. Rituximab for treatment of inhibitors in haemophilia A. A Phase II study. Thromb Haemost 2014;112:445-58.
    • (2014) Thromb Haemost , vol.112 , pp. 445-458
    • Leissinger, C.1    Josephson, C.D.2    Granger, S.3
  • 25
    • 66249136346 scopus 로고    scopus 로고
    • Neutralizing antibodies to interferon-beta and other immunological treatments for multiple sclerosis: prevalence and impact on outcomes
    • Deisenhammer F. Neutralizing antibodies to interferon-beta and other immunological treatments for multiple sclerosis: prevalence and impact on outcomes. CNS Drugs 2009;23:379-96.
    • (2009) CNS Drugs , vol.23 , pp. 379-396
    • Deisenhammer, F.1
  • 26
    • 80055068683 scopus 로고    scopus 로고
    • Interferon beta-1b-neutralizing antibodies 5 years after clinically isolated syndrome
    • Hartung HP, Freedman MS, Polman CH et al. Interferon beta-1b-neutralizing antibodies 5 years after clinically isolated syndrome. Neurology 2011;77:835-43.
    • (2011) Neurology , vol.77 , pp. 835-843
    • Hartung, H.P.1    Freedman, M.S.2    Polman, C.H.3
  • 27
    • 33748041958 scopus 로고    scopus 로고
    • Effects of protein aggregates: an immunologic perspective
    • Rosenberg AS. Effects of protein aggregates: an immunologic perspective. AAPS J 2006;8:E501-7.
    • (2006) AAPS J , vol.8 , pp. E501-E507
    • Rosenberg, A.S.1
  • 28
    • 34247092348 scopus 로고    scopus 로고
    • Interferon beta preparations for the treatment of multiple sclerosis patients differ in neutralizing antibody seroprevalence and immunogenicity
    • Sominanda A, Rot U, Suoniemi M, Deisenhammer F, Hillert J, Fogdell-Hahn A. Interferon beta preparations for the treatment of multiple sclerosis patients differ in neutralizing antibody seroprevalence and immunogenicity. Mult Scler 2007;13:208-14.
    • (2007) Mult Scler , vol.13 , pp. 208-214
    • Sominanda, A.1    Rot, U.2    Suoniemi, M.3    Deisenhammer, F.4    Hillert, J.5    Fogdell-Hahn, A.6
  • 29
    • 51349093240 scopus 로고    scopus 로고
    • Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells
    • Klechevsky E, Morita R, Liu M et al. Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells. Immunity 2008;29:497-510.
    • (2008) Immunity , vol.29 , pp. 497-510
    • Klechevsky, E.1    Morita, R.2    Liu, M.3
  • 30
    • 82255162900 scopus 로고    scopus 로고
    • Recent advances in the administration of vaccines for infectious diseases: microneedles as painless delivery devices for mass vaccination
    • Hegde NR, Kaveri SV, Bayry J. Recent advances in the administration of vaccines for infectious diseases: microneedles as painless delivery devices for mass vaccination. Drug Discov Today 2011;16:1061-8.
    • (2011) Drug Discov Today , vol.16 , pp. 1061-1068
    • Hegde, N.R.1    Kaveri, S.V.2    Bayry, J.3
  • 31
    • 58149132609 scopus 로고    scopus 로고
    • Infliximab pharmacokinetics in inflammatory bowel disease patients
    • Ternant D, Aubourg A, Magdelaine-Beuzelin C et al. Infliximab pharmacokinetics in inflammatory bowel disease patients. Ther Drug Monit 2008;30:523-9.
    • (2008) Ther Drug Monit , vol.30 , pp. 523-529
    • Ternant, D.1    Aubourg, A.2    Magdelaine-Beuzelin, C.3
  • 32
    • 0034744952 scopus 로고    scopus 로고
    • Interferon-beta (IFN-beta) antibodies in interferon-beta1a- and interferon-beta1b-treated multiple sclerosis patients. Prevalence, kinetics, cross-reactivity, and factors enhancing interferon-beta immunogenicity in vivo
    • Perini P, Facchinetti A, Bulian P et al. Interferon-beta (IFN-beta) antibodies in interferon-beta1a- and interferon-beta1b-treated multiple sclerosis patients. Prevalence, kinetics, cross-reactivity, and factors enhancing interferon-beta immunogenicity in vivo. Eur Cytokine Netw 2001;12:56-61.
    • (2001) Eur Cytokine Netw , vol.12 , pp. 56-61
    • Perini, P.1    Facchinetti, A.2    Bulian, P.3
  • 33
    • 37749040878 scopus 로고    scopus 로고
    • In vivo bioactivity of interferon-beta in multiple sclerosis patients with neutralising antibodies is titre-dependent
    • Sominanda A, Hillert J, Fogdell-Hahn A. In vivo bioactivity of interferon-beta in multiple sclerosis patients with neutralising antibodies is titre-dependent. J Neurol Neurosurg Psychiatry 2008;79:57-62.
    • (2008) J Neurol Neurosurg Psychiatry , vol.79 , pp. 57-62
    • Sominanda, A.1    Hillert, J.2    Fogdell-Hahn, A.3
  • 34
    • 84903778025 scopus 로고    scopus 로고
    • Anti-interferon beta antibody titers strongly correlate between two bioassays and in vivo biomarker expression, and indicates that a titer of 150 TRU/mL is a biologically functional cut-point
    • Hermanrud C, Ryner ML, Engdahl E, Fogdell-Hahn A. Anti-interferon beta antibody titers strongly correlate between two bioassays and in vivo biomarker expression, and indicates that a titer of 150 TRU/mL is a biologically functional cut-point. J Interferon Cytokine Res 2014;34:498-504.
    • (2014) J Interferon Cytokine Res , vol.34 , pp. 498-504
    • Hermanrud, C.1    Ryner, M.L.2    Engdahl, E.3    Fogdell-Hahn, A.4
  • 35
    • 27744509228 scopus 로고    scopus 로고
    • Guidelines on use of anti-IFN-beta antibody measurements in multiple sclerosis: report of an EFNS Task Force on IFN-beta antibodies in multiple sclerosis
    • Sorensen PS, Deisenhammer F, Duda P et al. Guidelines on use of anti-IFN-beta antibody measurements in multiple sclerosis: report of an EFNS Task Force on IFN-beta antibodies in multiple sclerosis. Eur J Neurol 2005;12:817-27.
    • (2005) Eur J Neurol , vol.12 , pp. 817-827
    • Sorensen, P.S.1    Deisenhammer, F.2    Duda, P.3
  • 36
    • 84893824738 scopus 로고    scopus 로고
    • Guidelines on the clinical use for the detection of neutralizing antibodies (NAbs) to IFN beta in multiple sclerosis therapy: report from the Italian Multiple Sclerosis Study group
    • Bertolotto A, Capobianco M, Amato MP et al. Guidelines on the clinical use for the detection of neutralizing antibodies (NAbs) to IFN beta in multiple sclerosis therapy: report from the Italian Multiple Sclerosis Study group. Neurol Sci 2014;35:307-16.
    • (2014) Neurol Sci , vol.35 , pp. 307-316
    • Bertolotto, A.1    Capobianco, M.2    Amato, M.P.3
  • 37
    • 0035849494 scopus 로고    scopus 로고
    • University of British Columbia MSMRIARGTSSG. Randomized controlled trial of interferon-beta-1a in secondary progressive MS: MRI results
    • Li DK, Zhao GJ, Paty DW. University of British Columbia MSMRIARGTSSG. Randomized controlled trial of interferon-beta-1a in secondary progressive MS: MRI results. Neurology 2001;56:1505-13.
    • (2001) Neurology , vol.56 , pp. 1505-1513
    • Li, D.K.1    Zhao, G.J.2    Paty, D.W.3
  • 38
    • 0345601517 scopus 로고    scopus 로고
    • Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group
    • Group PPoRaDbIb-aSiMSS. Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group. Lancet. 1998;352:1498-504.
    • (1998) Lancet , vol.352 , pp. 1498-1504
  • 39
    • 0035954361 scopus 로고    scopus 로고
    • PRISMS-4: Long-term efficacy of interferon-beta-1a in relapsing MS
    • Group PS, the University of British Columbia MSMRIAG. PRISMS-4: Long-term efficacy of interferon-beta-1a in relapsing MS. Neurology 2001;56:1628-36.
    • (2001) Neurology , vol.56 , pp. 1628-1636
  • 40
    • 77953454473 scopus 로고    scopus 로고
    • Recommendations for clinical use of data on neutralising antibodies to interferon-beta therapy in multiple sclerosis
    • Polman CH, Bertolotto A, Deisenhammer F et al. Recommendations for clinical use of data on neutralising antibodies to interferon-beta therapy in multiple sclerosis. Lancet Neurol 2010;9:740-50.
    • (2010) Lancet Neurol , vol.9 , pp. 740-750
    • Polman, C.H.1    Bertolotto, A.2    Deisenhammer, F.3
  • 41
    • 84871575939 scopus 로고    scopus 로고
    • Prevalence of anti-drug antibodies against interferon beta has decreased since routine analysis of neutralizing antibodies became clinical practice
    • Jungedal R, Lundkvist M, Engdahl E et al. Prevalence of anti-drug antibodies against interferon beta has decreased since routine analysis of neutralizing antibodies became clinical practice. Mult Scler 2012;18:1775-81.
    • (2012) Mult Scler , vol.18 , pp. 1775-1781
    • Jungedal, R.1    Lundkvist, M.2    Engdahl, E.3
  • 42
    • 34547121717 scopus 로고    scopus 로고
    • Immunogenicity and tolerability of an investigational formulation of interferon-beta1a: 24- and 48-week interim analyses of a 2-year, single-arm, historically controlled, phase IIIb study in adults with multiple sclerosis
    • Giovannoni G, Barbarash O, Casset-Semanaz F et al. Immunogenicity and tolerability of an investigational formulation of interferon-beta1a: 24- and 48-week interim analyses of a 2-year, single-arm, historically controlled, phase IIIb study in adults with multiple sclerosis. Clin Ther 2007;29:1128-45.
    • (2007) Clin Ther , vol.29 , pp. 1128-1145
    • Giovannoni, G.1    Barbarash, O.2    Casset-Semanaz, F.3
  • 43
    • 47549097069 scopus 로고    scopus 로고
    • Epoetin-associated pure red cell aplasia: past, present, and future considerations
    • McKoy JM, Stonecash RE, Cournoyer D et al. Epoetin-associated pure red cell aplasia: past, present, and future considerations. Transfusion 2008;48:1754-62.
    • (2008) Transfusion , vol.48 , pp. 1754-1762
    • McKoy, J.M.1    Stonecash, R.E.2    Cournoyer, D.3
  • 44
    • 77957066929 scopus 로고    scopus 로고
    • Inhibition of endogenous interferon beta by neutralizing antibodies against recombinant interferon beta
    • Sominanda A, Lundkvist M, Fogdell-Hahn A et al. Inhibition of endogenous interferon beta by neutralizing antibodies against recombinant interferon beta. Arch Neurol 2010;67:1095-101.
    • (2010) Arch Neurol , vol.67 , pp. 1095-1101
    • Sominanda, A.1    Lundkvist, M.2    Fogdell-Hahn, A.3
  • 45
    • 0030882355 scopus 로고    scopus 로고
    • Humanization of a mouse antibody against human alpha-4 integrin: a potential therapeutic for the treatment of multiple sclerosis
    • Leger OJ, Yednock TA, Tanner L et al. Humanization of a mouse antibody against human alpha-4 integrin: a potential therapeutic for the treatment of multiple sclerosis. Hum Antibodies 1997;8:3-16.
    • (1997) Hum Antibodies , vol.8 , pp. 3-16
    • Leger, O.J.1    Yednock, T.A.2    Tanner, L.3
  • 46
    • 84902458735 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy and JC Virus-related disease in modern neurology practice
    • Carruthers RL, Berger J. Progressive multifocal leukoencephalopathy and JC Virus-related disease in modern neurology practice. Mult Scler Relat Disord 2014;3:419-30.
    • (2014) Mult Scler Relat Disord , vol.3 , pp. 419-430
    • Carruthers, R.L.1    Berger, J.2
  • 47
    • 84860396489 scopus 로고    scopus 로고
    • Occurrence of antibodies against natalizumab in relapsing multiple sclerosis patients treated with natalizumab
    • Sorensen PS, Hyldgaard Jensen PE, Haghikia A et al. Occurrence of antibodies against natalizumab in relapsing multiple sclerosis patients treated with natalizumab. Mult Scler 2011;17:1074-8.
    • (2011) Mult Scler , vol.17 , pp. 1074-1078
    • Sorensen, P.S.1    Hyldgaard Jensen, P.E.2    Haghikia, A.3
  • 48
    • 34848816850 scopus 로고    scopus 로고
    • The incidence and significance of anti-natalizumab antibodies: results from AFFIRM and SENTINEL
    • Calabresi PA, Giovannoni G, Confavreux C et al. The incidence and significance of anti-natalizumab antibodies: results from AFFIRM and SENTINEL. Neurology 2007;69:1391-403.
    • (2007) Neurology , vol.69 , pp. 1391-1403
    • Calabresi, P.A.1    Giovannoni, G.2    Confavreux, C.3
  • 49
    • 84877633406 scopus 로고    scopus 로고
    • Characterization of anti-natalizumab antibodies in multiple sclerosis patients
    • Lundkvist M, Engdahl E, Holmen C et al. Characterization of anti-natalizumab antibodies in multiple sclerosis patients. Mult Scler 2013;19:757-64.
    • (2013) Mult Scler , vol.19 , pp. 757-764
    • Lundkvist, M.1    Engdahl, E.2    Holmen, C.3
  • 50
    • 84876530257 scopus 로고    scopus 로고
    • Clinical relevance of serum natalizumab concentration and anti-natalizumab antibodies in multiple sclerosis
    • Vennegoor A, Rispens T, Strijbis EM et al. Clinical relevance of serum natalizumab concentration and anti-natalizumab antibodies in multiple sclerosis. Mult Scler 2013;19:593-600.
    • (2013) Mult Scler , vol.19 , pp. 593-600
    • Vennegoor, A.1    Rispens, T.2    Strijbis, E.M.3
  • 51
    • 54049088585 scopus 로고    scopus 로고
    • Activation of natural regulatory T cells by IgG Fc-derived peptide "Tregitopes"
    • De Groot AS, Moise L, McMurry JA et al. Activation of natural regulatory T cells by IgG Fc-derived peptide "Tregitopes". Blood 2008;112:3303-11.
    • (2008) Blood , vol.112 , pp. 3303-3311
    • De Groot, A.S.1    Moise, L.2    McMurry, J.A.3
  • 53
    • 84897568057 scopus 로고    scopus 로고
    • Human leukocyte antigen genes and interferon beta preparations influence risk of developing neutralizing anti-drug antibodies in multiple sclerosis
    • Link J, Lundkvist Ryner M, Fink K et al. Human leukocyte antigen genes and interferon beta preparations influence risk of developing neutralizing anti-drug antibodies in multiple sclerosis. PLoS ONE 2014;9:e90479.
    • (2014) PLoS ONE , vol.9 , pp. e90479
    • Link, J.1    Lundkvist Ryner, M.2    Fink, K.3
  • 54
    • 48349093740 scopus 로고    scopus 로고
    • HLA-DRB1*0401 and HLA-DRB1*0408 are strongly associated with the development of antibodies against interferon-beta therapy in multiple sclerosis
    • Hoffmann S, Cepok S, Grummel V et al. HLA-DRB1*0401 and HLA-DRB1*0408 are strongly associated with the development of antibodies against interferon-beta therapy in multiple sclerosis. Am J Hum Genet 2008;83:219-27.
    • (2008) Am J Hum Genet , vol.83 , pp. 219-227
    • Hoffmann, S.1    Cepok, S.2    Grummel, V.3
  • 55
    • 79953847674 scopus 로고    scopus 로고
    • Influence of the HLA-DRB1 genotype on antibody development to interferon beta in multiple sclerosis
    • Buck D, Cepok S, Hoffmann S et al. Influence of the HLA-DRB1 genotype on antibody development to interferon beta in multiple sclerosis. Arch Neurol 2011;68:480-7.
    • (2011) Arch Neurol , vol.68 , pp. 480-487
    • Buck, D.1    Cepok, S.2    Hoffmann, S.3
  • 56
    • 84901257718 scopus 로고    scopus 로고
    • HLA alleles as biomarkers of high-titre neutralising antibodies to interferon-beta therapy in multiple sclerosis
    • Nunez C, Cenit MC, Alvarez-Lafuente R et al. HLA alleles as biomarkers of high-titre neutralising antibodies to interferon-beta therapy in multiple sclerosis. J Med Genet 2014;51:395-400.
    • (2014) J Med Genet , vol.51 , pp. 395-400
    • Nunez, C.1    Cenit, M.C.2    Alvarez-Lafuente, R.3
  • 57
    • 84896127708 scopus 로고    scopus 로고
    • Smoking and risk of treatment-induced neutralizing antibodies to interferon beta-1a
    • Hedstrom AK, Ryner M, Fink K et al. Smoking and risk of treatment-induced neutralizing antibodies to interferon beta-1a. Mult Scler 2014;20:445-50.
    • (2014) Mult Scler , vol.20 , pp. 445-450
    • Hedstrom, A.K.1    Ryner, M.2    Fink, K.3
  • 59
    • 84865469861 scopus 로고    scopus 로고
    • T cells become licensed in the lung to enter the central nervous system
    • Odoardi F, Sie C, Streyl K et al. T cells become licensed in the lung to enter the central nervous system. Nature 2012;488:675-9.
    • (2012) Nature , vol.488 , pp. 675-679
    • Odoardi, F.1    Sie, C.2    Streyl, K.3
  • 60
    • 79953906254 scopus 로고    scopus 로고
    • Development of antidrug antibodies against adalimumab and association with disease activity and treatment failure during long-term follow-up
    • Bartelds GM, Krieckaert CL, Nurmohamed MT et al. Development of antidrug antibodies against adalimumab and association with disease activity and treatment failure during long-term follow-up. JAMA 2011;305:1460-8.
    • (2011) JAMA , vol.305 , pp. 1460-1468
    • Bartelds, G.M.1    Krieckaert, C.L.2    Nurmohamed, M.T.3
  • 61
    • 84874656491 scopus 로고    scopus 로고
    • Immunogenicity of anti-TNF biologic therapies for rheumatoid arthritis
    • van Schouwenburg PA, Rispens T, Wolbink GJ. Immunogenicity of anti-TNF biologic therapies for rheumatoid arthritis. Nat Rev Rheumatol 2013;9:164-72.
    • (2013) Nat Rev Rheumatol , vol.9 , pp. 164-172
    • van Schouwenburg, P.A.1    Rispens, T.2    Wolbink, G.J.3
  • 62
    • 33644931095 scopus 로고    scopus 로고
    • Development of antiinfliximab antibodies and relationship to clinical response in patients with rheumatoid arthritis
    • Wolbink GJ, Vis M, Lems W et al. Development of antiinfliximab antibodies and relationship to clinical response in patients with rheumatoid arthritis. Arthritis Rheum 2006;54:711-5.
    • (2006) Arthritis Rheum , vol.54 , pp. 711-715
    • Wolbink, G.J.1    Vis, M.2    Lems, W.3
  • 63
    • 0032731690 scopus 로고    scopus 로고
    • Etanercept: therapeutic use in patients with rheumatoid arthritis
    • Garrison L, McDonnell ND. Etanercept: therapeutic use in patients with rheumatoid arthritis. Ann Rheum Dis 1999;58 (Suppl. 1):I65-9.
    • (1999) Ann Rheum Dis , vol.58 , pp. I65-I69
    • Garrison, L.1    McDonnell, N.D.2
  • 64
    • 84928111749 scopus 로고    scopus 로고
    • Significant associations of antidrug antibody levels with serum drug trough levels and therapeutic response of adalimumab and etanercept treatment in rheumatoid arthritis
    • Chen DY, Chen YM, Tsai WC et al. Significant associations of antidrug antibody levels with serum drug trough levels and therapeutic response of adalimumab and etanercept treatment in rheumatoid arthritis. Ann Rheum Dis 2015;74:e16.
    • (2015) Ann Rheum Dis , vol.74 , pp. e16
    • Chen, D.Y.1    Chen, Y.M.2    Tsai, W.C.3
  • 65
    • 84864546448 scopus 로고    scopus 로고
    • Etanercept concentration in patients with rheumatoid arthritis and its potential influence on treatment decisions: a pilot study
    • Daien CI, Daien V, Parussini E, Dupuy AM, Combe B, Morel J. Etanercept concentration in patients with rheumatoid arthritis and its potential influence on treatment decisions: a pilot study. J Rheumatol 2012;39:1533-8.
    • (2012) J Rheumatol , vol.39 , pp. 1533-1538
    • Daien, C.I.1    Daien, V.2    Parussini, E.3    Dupuy, A.M.4    Combe, B.5    Morel, J.6
  • 66
    • 82955189865 scopus 로고    scopus 로고
    • Patients non-responding to etanercept obtain lower etanercept concentrations compared with responding patients
    • Jamnitski A, Krieckaert CL, Nurmohamed MT et al. Patients non-responding to etanercept obtain lower etanercept concentrations compared with responding patients. Ann Rheum Dis 2012;71:88-91.
    • (2012) Ann Rheum Dis , vol.71 , pp. 88-91
    • Jamnitski, A.1    Krieckaert, C.L.2    Nurmohamed, M.T.3
  • 67
    • 80052505451 scopus 로고    scopus 로고
    • Differential effect of drug interference in immunogenicity assays
    • Hart MH, de Vrieze H, Wouters D et al. Differential effect of drug interference in immunogenicity assays. J Immunol Methods 2011;372:196-203.
    • (2011) J Immunol Methods , vol.372 , pp. 196-203
    • Hart, M.H.1    de Vrieze, H.2    Wouters, D.3
  • 68
    • 77958507060 scopus 로고    scopus 로고
    • A novel method for the detection of antibodies to adalimumab in the presence of drug reveals "hidden" immunogenicity in rheumatoid arthritis patients
    • van Schouwenburg PA, Bartelds GM, Hart MH, Aarden L, Wolbink GJ, Wouters D. A novel method for the detection of antibodies to adalimumab in the presence of drug reveals "hidden" immunogenicity in rheumatoid arthritis patients. J Immunol Methods 2010;362:82-8.
    • (2010) J Immunol Methods , vol.362 , pp. 82-88
    • van Schouwenburg, P.A.1    Bartelds, G.M.2    Hart, M.H.3    Aarden, L.4    Wolbink, G.J.5    Wouters, D.6
  • 69
    • 84883822462 scopus 로고    scopus 로고
    • Long-term measurement of anti-adalimumab using pH-shift-anti-idiotype antigen binding test shows predictive value and transient antibody formation
    • van Schouwenburg PA, Krieckaert CL, Rispens T, Aarden L, Wolbink GJ, Wouters D. Long-term measurement of anti-adalimumab using pH-shift-anti-idiotype antigen binding test shows predictive value and transient antibody formation. Ann Rheum Dis 2013;72:1680-6.
    • (2013) Ann Rheum Dis , vol.72 , pp. 1680-1686
    • van Schouwenburg, P.A.1    Krieckaert, C.L.2    Rispens, T.3    Aarden, L.4    Wolbink, G.J.5    Wouters, D.6
  • 70
    • 84899939394 scopus 로고    scopus 로고
    • A preliminary algorithm introducing immunogenicity assessment in the management of patients with RA receiving tumour necrosis factor inhibitor therapies
    • Garces S, Antunes M, Benito-Garcia E, da Silva JC, Aarden L, Demengeot J. A preliminary algorithm introducing immunogenicity assessment in the management of patients with RA receiving tumour necrosis factor inhibitor therapies. Ann Rheum Dis 2014;73:1138-43.
    • (2014) Ann Rheum Dis , vol.73 , pp. 1138-1143
    • Garces, S.1    Antunes, M.2    Benito-Garcia, E.3    da Silva, J.C.4    Aarden, L.5    Demengeot, J.6
  • 71
    • 84918578141 scopus 로고    scopus 로고
    • The antibody response against human and chimeric anti-TNF therapeutic antibodies primarily targets the TNF binding region
    • van Schie KA, Hart MH, de Groot ER et al. The antibody response against human and chimeric anti-TNF therapeutic antibodies primarily targets the TNF binding region. Ann Rheum Dis 2015;74:311-4.
    • (2015) Ann Rheum Dis , vol.74 , pp. 311-314
    • van Schie, K.A.1    Hart, M.H.2    de Groot, E.R.3
  • 72
    • 84902274701 scopus 로고    scopus 로고
    • Towards an individualised target concentration of adalimumab in rheumatoid arthritis
    • Ducourau E, Ternant D, Lequerre T et al. Towards an individualised target concentration of adalimumab in rheumatoid arthritis. Ann Rheum Dis 2014;73:1428-9.
    • (2014) Ann Rheum Dis , vol.73 , pp. 1428-1429
    • Ducourau, E.1    Ternant, D.2    Lequerre, T.3
  • 73
    • 33845660797 scopus 로고    scopus 로고
    • Individualized monitoring of drug bioavailability and immunogenicity in rheumatoid arthritis patients treated with the tumor necrosis factor alpha inhibitor infliximab
    • Bendtzen K, Geborek P, Svenson M, Larsson L, Kapetanovic MC, Saxne T. Individualized monitoring of drug bioavailability and immunogenicity in rheumatoid arthritis patients treated with the tumor necrosis factor alpha inhibitor infliximab. Arthritis Rheum 2006;54:3782-9.
    • (2006) Arthritis Rheum , vol.54 , pp. 3782-3789
    • Bendtzen, K.1    Geborek, P.2    Svenson, M.3    Larsson, L.4    Kapetanovic, M.C.5    Saxne, T.6
  • 74
    • 84902971236 scopus 로고    scopus 로고
    • Relationship between inflammation and infliximab pharmacokinetics in rheumatoid arthritis
    • Ternant D, Ducourau E, Perdriger A et al. Relationship between inflammation and infliximab pharmacokinetics in rheumatoid arthritis. Br J Clin Pharmacol 2014;78:118-28.
    • (2014) Br J Clin Pharmacol , vol.78 , pp. 118-128
    • Ternant, D.1    Ducourau, E.2    Perdriger, A.3
  • 75
    • 0031660364 scopus 로고    scopus 로고
    • Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis
    • Maini RN, Breedveld FC, Kalden JR et al. Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis. Arthritis Rheum 1998;41:1552-63.
    • (1998) Arthritis Rheum , vol.41 , pp. 1552-1563
    • Maini, R.N.1    Breedveld, F.C.2    Kalden, J.R.3
  • 76
    • 84941091583 scopus 로고    scopus 로고
    • Pharmacokinetics and concentration-effect relationship of adalimumab in rheumatoid arthritis
    • Ternant D, Ducourau E, Fuzibet P et al. Pharmacokinetics and concentration-effect relationship of adalimumab in rheumatoid arthritis. Br J Clin Pharmacol 2015;79:286-97.
    • (2015) Br J Clin Pharmacol , vol.79 , pp. 286-297
    • Ternant, D.1    Ducourau, E.2    Fuzibet, P.3
  • 77
    • 3142534409 scopus 로고    scopus 로고
    • Recommendations for the design and optimization of immunoassays used in the detection of host antibodies against biotechnology products
    • Mire-Sluis AR, Barrett YC, Devanarayan V et al. Recommendations for the design and optimization of immunoassays used in the detection of host antibodies against biotechnology products. J Immunol Methods 2004;289:1-16.
    • (2004) J Immunol Methods , vol.289 , pp. 1-16
    • Mire-Sluis, A.R.1    Barrett, Y.C.2    Devanarayan, V.3
  • 78
    • 58249116651 scopus 로고    scopus 로고
    • Recommendations for the validation of immunoassays used for detection of host antibodies against biotechnology products
    • Shankar G, Devanarayan V, Amaravadi L et al. Recommendations for the validation of immunoassays used for detection of host antibodies against biotechnology products. J Pharm Biomed Anal 2008;48:1267-81.
    • (2008) J Pharm Biomed Anal , vol.48 , pp. 1267-1281
    • Shankar, G.1    Devanarayan, V.2    Amaravadi, L.3
  • 79
    • 33947397632 scopus 로고    scopus 로고
    • Recommendations for the design, optimization, and qualification of cell-based assays used for the detection of neutralizing antibody responses elicited to biological therapeutics
    • Gupta S, Indelicato SR, Jethwa V et al. Recommendations for the design, optimization, and qualification of cell-based assays used for the detection of neutralizing antibody responses elicited to biological therapeutics. J Immunol Methods 2007;321:1-18.
    • (2007) J Immunol Methods , vol.321 , pp. 1-18
    • Gupta, S.1    Indelicato, S.R.2    Jethwa, V.3
  • 80
    • 79956136774 scopus 로고    scopus 로고
    • Recommendations for the validation of cell-based assays used for the detection of neutralizing antibody immune responses elicited against biological therapeutics
    • Gupta S, Devanarayan V, Finco D et al. Recommendations for the validation of cell-based assays used for the detection of neutralizing antibody immune responses elicited against biological therapeutics. J Pharm Biomed Anal 2011;55:878-88.
    • (2011) J Pharm Biomed Anal , vol.55 , pp. 878-888
    • Gupta, S.1    Devanarayan, V.2    Finco, D.3
  • 81
    • 41349116947 scopus 로고    scopus 로고
    • Recommendations on risk-based strategies for detection and characterization of antibodies against biotechnology products
    • Koren E, Smith HW, Shores E et al. Recommendations on risk-based strategies for detection and characterization of antibodies against biotechnology products. J Immunol Methods 2008;333:1-9.
    • (2008) J Immunol Methods , vol.333 , pp. 1-9
    • Koren, E.1    Smith, H.W.2    Shores, E.3
  • 82
    • 79952534748 scopus 로고    scopus 로고
    • Taking immunogenicity assessment of therapeutic proteins to the next level
    • Buttel IC, Chamberlain P, Chowers Y et al. Taking immunogenicity assessment of therapeutic proteins to the next level. Biologicals 2011;39:100-9.
    • (2011) Biologicals , vol.39 , pp. 100-109
    • Buttel, I.C.1    Chamberlain, P.2    Chowers, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.