메뉴 건너뛰기




Volumn 34, Issue 7, 2014, Pages 498-504

Anti-interferon beta antibody titers strongly correlate between two bioassays and in vivo biomarker expression, and indicates that a titer of 150 TRU/mL Is a biologically functional cut-point

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; BIOLOGICAL MARKER; CHEMOKINE RECEPTOR CCR10; MYXOVIRUS RESISTANCE PROTEIN A; NEUTRALIZING ANTIBODY; CXCL10 PROTEIN, HUMAN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; MYXOVIRUS RESISTANCE PROTEIN; TRANSCRIPTOME;

EID: 84903778025     PISSN: 10799907     EISSN: 15577465     Source Type: Journal    
DOI: 10.1089/jir.2013.0097     Document Type: Article
Times cited : (8)

References (31)
  • 1
    • 33947322141 scopus 로고    scopus 로고
    • Development and validation of a real time PCR-based bioassay for quantification of neutralizing antibodies against human interferon-beta
    • DOI 10.1016/j.jim.2006.12.012, PII S0022175907000403
    • Bertolotto A, Sala A, Caldano M, Capobianco M, Malucchi S, Marnetto F, Gilli F. 2007. Development and validation of a real time PCR-based bioassay for quantification of neutralizing antibodies against human interferon-beta. J Immunol Methods 321(1-2):19-31. (Pubitemid 46441209)
    • (2007) Journal of Immunological Methods , vol.321 , Issue.1-2 , pp. 19-31
    • Bertolotto, A.1    Sala, A.2    Caldano, M.3    Capobianco, M.4    Malucchi, S.5    Marnetto, F.6    Gilli, F.7
  • 3
    • 55649101178 scopus 로고    scopus 로고
    • The implications of immunogenicity for protein-based multiple sclerosis therapies
    • Cohen BA, Oger J, Gagnon A, Giovannoni G. 2008. The implications of immunogenicity for protein-based multiple sclerosis therapies. J Neurol Sci 275(1-2):7-17.
    • (2008) J Neurol Sci , vol.275 , Issue.1-2 , pp. 7-17
    • Cohen, B.A.1    Oger, J.2    Gagnon, A.3    Giovannoni, G.4
  • 4
    • 0032893876 scopus 로고    scopus 로고
    • Bioavailability of interferon beta 1b in MS patients with and without neutralizing antibodies
    • Deisenhammer F, Reindl M, Harvey J, Gasse T, Dilitz E, Berger T. 1999. Bioavailability of interferon beta 1b in MS patients with and without neutralizing antibodies. Neurology 52(6):1239-1243. (Pubitemid 29177928)
    • (1999) Neurology , vol.52 , Issue.6 , pp. 1239-1243
    • Deisenhammer, F.1    Reindl, M.2    Harvey, J.3    Gasse, T.4    Dilitz, E.5    Berger, T.6
  • 5
    • 31644440262 scopus 로고    scopus 로고
    • Biological markers of interferon-beta therapy: Comparison among interferon-stimulated genes MxA, TRAIL and XAF-1
    • DOI 10.1191/135248506ms1245oa
    • Gilli F, Marnetto F, Caldano M, Sala A, Malucchi S, Capo-bianco M, Bertolotto A. 2006. Biological markers of interferon-beta therapy: comparison among interferon-stimulated genes MxA, TRAIL and XAF-1. Mult Scler 12(1):47-57. (Pubitemid 43169237)
    • (2006) Multiple Sclerosis , vol.12 , Issue.1 , pp. 47-57
    • Gilli, F.1    Marnetto, F.2    Caldano, M.3    Sala, A.4    Malucchi, S.5    Capobianco, M.6    Bertolotto, A.7
  • 6
    • 0034796419 scopus 로고    scopus 로고
    • The neutralization of interferons by antibody. II. Neutralizing antibody unitage and its relationship to bioassay sensitivity: The tenfold reduction unit
    • DOI 10.1089/107999001753124471
    • Grossberg SE, Kawade Y, Kohase M, Klein JP. 2001a. The neutralization of interferons by antibody. II. Neutralizing antibody unitage and its relationship to bioassay sensitivity: the tenfold reduction unit. J Interferon Cytokine Res 21(9): 743-755. (Pubitemid 32955704)
    • (2001) Journal of Interferon and Cytokine Research , vol.21 , Issue.9 , pp. 743-755
    • Grossberg, S.E.1    Kawade, Y.2    Kohase, M.3    Klein, J.P.4
  • 7
    • 0034798067 scopus 로고    scopus 로고
    • The neutralization of interferons by antibody. I. Quantitative and theoretical analyses of the neutralization reaction in different bioassay systems
    • DOI 10.1089/107999001753124462
    • Grossberg SE, Kawade Y, Kohase M, Yokoyama H, Finter N. 2001b. The neutralization of interferons by antibody. I. Quantitative and theoretical analyses of the neutralization reaction in different bioassay systems. J Interferon Cytokine Res 21(9):729-742. (Pubitemid 32955703)
    • (2001) Journal of Interferon and Cytokine Research , vol.21 , Issue.9 , pp. 729-742
    • Grossberg, S.E.1    Kawade, Y.2    Kohase, M.3    Yokoyama, H.4    Finter, N.5
  • 8
    • 33947397632 scopus 로고    scopus 로고
    • Recommendations for the design, optimization, and qualification of cell-based assays used for the detection of neutralizing antibody responses elicited to biological therapeutics
    • DOI 10.1016/j.jim.2006.12.004, PII S0022175906003693
    • Gupta S, Indelicato SR, Jethwa V, Kawabata T, Kelley M, Mire-Sluis AR, Richards SM, Rup B, Shores E, Swanson SJ, Wakshull E. 2007. Recommendations for the design, optimization, and qualification of cell-based assays used for the detection of neutralizing antibody responses elicited to biological therapeutics. J Immunol Methods 321(1-2): 1-18. (Pubitemid 46454303)
    • (2007) Journal of Immunological Methods , vol.321 , Issue.1-2 , pp. 1-18
    • Gupta, S.1    Indelicato, S.R.2    Jethwa, V.3    Kawabata, T.4    Kelley, M.5    Mire-Sluis, A.R.6    Richards, S.M.7    Rup, B.8    Shores, E.9    Swanson, S.J.10    Wakshull, E.11
  • 9
    • 20444470178 scopus 로고    scopus 로고
    • Immune response to immunotherapy: The role of neutralising antibodies to interferon beta in the treatment of multiple sclerosis
    • DOI 10.1016/S1474-4422(05)70117-4, PII S1474442205701174
    • Hemmer B, Stuve O, Kieseier B, Schellekens H, Hartung HP. 2005. Immune response to immunotherapy: the role of neutralising antibodies to interferon beta in the treatment of multiple sclerosis. Lancet Neurol 4(7):403-412. (Pubitemid 40826532)
    • (2005) Lancet Neurology , vol.4 , Issue.7 , pp. 403-412
    • Hemmer, B.1    Stuve, O.2    Kieseier, B.3    Schellekens, H.4    Hartung, H.-P.5
  • 11
    • 68249162126 scopus 로고    scopus 로고
    • Absence of MxA induction by interferon beta in patients with MS reflects complete loss of bioactivity
    • Hesse D, Sellebjerg F, Sorensen PS. 2009. Absence of MxA induction by interferon beta in patients with MS reflects complete loss of bioactivity. Neurology 73(5):372-377.
    • (2009) Neurology , vol.73 , Issue.5 , pp. 372-377
    • Hesse, D.1    Sellebjerg, F.2    Sorensen, P.S.3
  • 12
    • 0027418515 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial
    • The IFNB Multiple Sclerosis Study Group.
    • The IFNB Multiple Sclerosis Study Group. 1993. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 43(4):655-661.
    • (1993) Neurology , vol.43 , Issue.4 , pp. 655-661
  • 15
    • 84871575939 scopus 로고    scopus 로고
    • Prevalence of anti-drug antibodies against interferon beta has decreased since routine analysis of neutralizing antibodies became clinical practice
    • Jungedal R, Lundkvist M, Engdahl E, Ramanujam R, Westerlind H, Sominanda A, Hillert J, Fogdell-Hahn A. 2012. Prevalence of anti-drug antibodies against interferon beta has decreased since routine analysis of neutralizing antibodies became clinical practice. Mult Scler 18(12):1775-1781.
    • (2012) Mult Scler , vol.18 , Issue.12 , pp. 1775-1781
    • Jungedal, R.1    Lundkvist, M.2    Engdahl, E.3    Ramanujam, R.4    Westerlind, H.5    Sominanda, A.6    Hillert, J.7    Fogdell-Hahn, A.8
  • 16
    • 0022555790 scopus 로고
    • Quantitation of neutralization of interferon by antibody
    • Kawade Y. 1986. Quantitation of neutralization of interferon by antibody. Methods Enzymol 119:558-573. (Pubitemid 16025159)
    • (1986) Methods in Enzymology , vol.VOL. 119 , pp. 558-573
    • Kawade, Y.1
  • 18
    • 0035710746 scopus 로고    scopus 로고
    • -ΔΔCT method
    • DOI 10.1006/meth.2001.1262
    • Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25(4):402-408. (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 20
    • 33646189628 scopus 로고    scopus 로고
    • Multiplex analysis of expression of three IFNβ-induced genes in antibody-positive MS patients
    • DOI 10.1212/01.wnl.0000196467.71646.72, PII 0000611420060214000037
    • Pachner AR, Narayan K, Pak E. 2006. Multiplex analysis of expression of three IFNbeta-induced genes in antibody-positive MS patients. Neurology 66(3):444-446. (Pubitemid 43739958)
    • (2006) Neurology , vol.66 , Issue.3 , pp. 444-446
    • Pachner, A.R.1    Narayan, K.2    Pak, E.3
  • 21
    • 84878839989 scopus 로고    scopus 로고
    • The impact of neutralizing antibodies on the risk of disease worsening in interferon beta-treated relapsing multiple sclerosis: A 5 year post-marketing study
    • Paolicelli D, D'Onghia M, Pellegrini F, Direnzo V, Iaffaldano P, Lavolpe V, Trojano M. 2013. The impact of neutralizing antibodies on the risk of disease worsening in interferon beta-treated relapsing multiple sclerosis: a 5 year post-marketing study. J Neurol 260(6):1562-1568.
    • (2013) J Neurol , vol.260 , Issue.6 , pp. 1562-1568
    • Paolicelli, D.1    D'Onghia, M.2    Pellegrini, F.3    Direnzo, V.4    Iaffaldano, P.5    Lavolpe, V.6    Trojano, M.7
  • 22
    • 1642277003 scopus 로고    scopus 로고
    • The clinical impact of interferon beta antibodies in relapsing-remitting MS
    • DOI 10.1007/s00415-004-0312-8
    • Perini P, Calabrese M, Biasi G, Gallo P. 2004. The clinical impact of interferon beta antibodies in relapsing-remitting MS. J Neurol 251(3):305-309. (Pubitemid 38387148)
    • (2004) Journal of Neurology , vol.251 , Issue.3 , pp. 305-309
    • Perini, P.1    Calabrese, M.2    Biasi, G.3    Gallo, P.4
  • 23
    • 0037435532 scopus 로고    scopus 로고
    • Neutralizing antibodies during treatment of secondary progressive MS with interferon β-1b
    • Polman C, Kappos L, White R, Dahlke F, Beckmann K, Pozzilli C, Thompson A, Petkau J, Miller D, European Study Group in Interferon Beta-1b in Secondary Progressive MS. 2003. Neutralizing antibodies during treatment of secondary progressive MS with interferon beta-1b. Neurology 60(1):37-43. (Pubitemid 36070641)
    • (2003) Neurology , vol.60 , Issue.1 , pp. 37-43
    • Polman, C.1    Kappos, L.2    White, R.3    Dahlke, F.4    Beckmann, K.5    Pozzilli, C.6    Thompson, A.7    Petkau, J.8    Miller, D.9
  • 24
    • 0345601517 scopus 로고    scopus 로고
    • Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis
    • PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group.
    • PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group. 1998. Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. Lancet 352(9139):1498-1504.
    • (1998) Lancet , vol.352 , Issue.9139 , pp. 1498-1504
  • 28
    • 37749040878 scopus 로고    scopus 로고
    • In vivo bioac-tivity of interferon-beta in multiple sclerosis patients with neutralising antibodies is titre-dependent
    • Sominanda A, Hillert J, Fogdell-Hahn A. 2008. In vivo bioac-tivity of interferon-beta in multiple sclerosis patients with neutralising antibodies is titre-dependent. J Neurol Neurosurg Psychiatry 79(1):57-62.
    • (2008) J Neurol Neurosurg Psychiatry , vol.79 , Issue.1 , pp. 57-62
    • Sominanda, A.1    Hillert, J.2    Fogdell-Hahn, A.3
  • 29
    • 34247092348 scopus 로고    scopus 로고
    • Interferon beta preparations for the treatment of multiple sclerosis patients differ in neutralizing antibody seroprevalence and immunogenicity
    • DOI 10.1177/1352458506070762
    • Sominanda A, Rot U, Suoniemi M, Deisenhammer F, Hillert J, Fogdell-Hahn A. 2007. Interferon beta preparations for the treatment of multiple sclerosis patients differ in neutralizing antibody seroprevalence and immunogenicity. Mult Scler 13(2):208-214. (Pubitemid 46592773)
    • (2007) Multiple Sclerosis , vol.13 , Issue.2 , pp. 208-214
    • Sominanda, A.1    Rot, U.2    Suoniemi, M.3    Deisenhammer, F.4    Hillert, J.5    Fogdell-Hahn, A.6
  • 30
    • 84993748625 scopus 로고    scopus 로고
    • Neutralizing antibodies against interferonBeta
    • Sorensen PS. 2008. Neutralizing antibodies against interferonBeta. Ther Adv Neurol Disord 1(2):125-141.
    • (2008) Ther Adv Neurol Disord , vol.1 , Issue.2 , pp. 125-141
    • Sorensen, P.S.1
  • 31
    • 27744509228 scopus 로고    scopus 로고
    • Guidelines on use of anti-IFN-β antibody measurements in multiple sclerosis: Report of an EFNS Task Force on IFN-β antibodies in multiple sclerosis
    • DOI 10.1111/j.1468-1331.2005.01386.x
    • Sorensen PS, Deisenhammer F, Duda P, Hohlfeld R, Myhr KM, Palace J, Polman C, Pozzilli C, Ross C, Sclerosis ETFoA-I-bAiM. 2005. Guidelines on use of anti-IFN-beta antibody measurements in multiple sclerosis: report of an EFNS Task Force on IFN-beta antibodies in multiple sclerosis. Eur J Neurol 12(11):817-827. (Pubitemid 41597593)
    • (2005) European Journal of Neurology , vol.12 , Issue.11 , pp. 817-827
    • Sorensen, P.S.1    Deisenhammer, F.2    Duda, P.3    Hohlfeld, R.4    Myhr, K.-M.5    Palace, J.6    Polman, C.7    Pozzilli, C.8    Ross, C.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.