Humanization of a mouse antibody against human alpha-4 integrin: A potential therapeutic for the treatment of multiple sclerosis

Human Antibodies

Volumn 8, Issue 1, 1997, Pages 3-16

  Léger, Olivier J P ^a   Yednock, Ted A ^b   Tanner, Laura ^b   Horner, Heidi C ^b   Hines, Dawn K ^b   Keen, Simon ^a   Saldanha, José ^a   Jones, S Tarran ^a   Fritz, Lawrence C ^b   Bendig, Mary M ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b Athena Neurosciences Inc   (United States)

Author keywords

Adhesion molecules; Antibodies; CDR grafting; Experimental allergic encephalomyelitis; Humanization; 4 1 integrin

Indexed keywords

ALPHA4 INTEGRIN; ANTIBODY; IMMUNOGLOBULIN HEAVY CHAIN; INTEGRIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIGEN BINDING; ARTICLE; CELL ADHESION; COMPLEMENTARITY DETERMINING REGION; EXTRAVASATION; HUMAN; IMMUNOGLOBULIN GENE; LEUKOCYTE; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL;

EID: 0030882355     PISSN: 10932607     EISSN: None     Source Type: Journal    
DOI: 10.3233/hab-1997-8102     Document Type: Article

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