A natural triterpene derivative from Euphorbia kansui inhibits cell proliferation and induces apoptosis against rat intestinal epithelioid cell line in Vitro

International Journal of Molecular Sciences

Volumn 16, Issue 8, 2015, Pages 18956-18975

  Cheng, Fangfang ^a   Yang, Yanjing ^b   Zhang, Li ^a   Cao, Yudan ^a   Yao, Weifeng ^a   Tang, Yuping ^a   Ding, Anwei ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b Zhangjiagang Hospital of Traditional Chinese Medicine   (China)

Author keywords

Cell apoptosis; Cell cycle; Cell damage; Cell proliferation; Death receptor pathway; Kansenone; Mitochondrial pathway

Indexed keywords

KANSENONE; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; PLANT EXTRACT; TRITERPENE;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL DAMAGE; CELL PROLIFERATION; CELL VIABILITY; CONFOCAL LASER MICROSCOPY; CYTOTOXICITY; FLOW CYTOMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTESTINE EPITHELIUM CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MTT ASSAY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION; WESTERN BLOTTING; ANIMAL; BIOLOGICAL MODEL; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; EPITHELIUM CELL; EUPHORBIA; INTESTINE MUCOSA; METABOLISM; RAT;

EUPHORBIA KANSUI; RATTUS;

ANIMALS; APOPTOSIS; BIOMARKERS; CELL CYCLE; CELL LINE; CELL PROLIFERATION; EPITHELIAL CELLS; EUPHORBIA; INTESTINAL MUCOSA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MODELS, BIOLOGICAL; PLANT EXTRACTS; RATS; REACTIVE OXYGEN SPECIES; TRITERPENES;

EID: 84939224160     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms160818956     Document Type: Article

References (46)

1. Yan, X.J, Zhang, L, Guo, J.M, Cao, Y.D, Shang, E.X, Tang, Y.P, Ding, A.W, Duan, J.A. Processing of kansui roots stir-baked with vinegar reduces kansui-induced hepatocyte cytotoxicity by decreasing the contents of toxic terpenoids and regulating the cell apoptosis pathway. Molecules 2014, 19, 7237-7254.
2. Wang, H.Y, Wang, J.S, Wei, D.D, Wang, X.B, Luo, J, Yang, M.H, Kong, L.Y. Bioactivity-guided isolation of antiproliferative diterpenoids from Euphorbia kansui. Phytother. Res. 2012, 26, 853-859.
3. Zeng, Y, Zhong, J.M, Ye, S.Q, Ni, Z.Y, Miao, X.Q, Mo, Y.K, Li, Z.L. Screening of Epstein-Barr virus early antigen expression inducers from Chinese medicinal herbs and plants. Biomed. Environ. Sci. 1994, 7, 50-55.
4. Zheng, W.F, Cui, Z, Zhu, Q. Cytotoxicity and antiviral activity of the compounds from Euphorbia kansui. Planta Med. 1998, 64, 754-756.
5. Nunomura, S, Kitanaka, S, Ra, C. 3-O-(2,3-dimethylbutanoyl)-13-O-decan-oylingenolfrom Euphorbia kansui suppresses IgE-mediated mast cell activation. Biol. Pharm. Bull. 2006, 29, 286-290.
6. Khiev, P, Kim, J.W, Sung, S.J, Song, H.H, Choung, D.H, Chin, Y.W, Lee, H, Oh, S.R. Ingenane-type Diterpenes with a Modulatory Effect on IFN-γ Production from the Roots of Euphorbia kansui. Arch. Pharm. Res. 2012, 35, 1553-1558.
7. Guo, J, Zhou, L.Y, He, H.P, Leng, Y, Yang, Z, Hao, X.J. Inhibition of 11b-HSD1 by tetracyclic triterpenoids from Euphorbia kansui. Molecules 2012, 17, 1826-11838.
8. Tang, B.W, Ding, J.J, Wu, F.H, Chen, L, Yang, Y.X, Song, F.Y. 1HNMR-based metabonomics study of the urinary biochemical changes in kansui treated rat. J. Ethnopharmacol. 2012, 141, 134-142.
9. Tang, B.W, Ding, J.J, Yang, Y.X, Wu, F.H, Song, F.Y. Systems biochemical responses of rats to kansui and vinegar-processed kansui exposure by integrated metabonomics. J. Ethnopharmacol. 2014, 153, 511-520.
10. Chang, J.S, Lee, S.W, Park, M.H, Kim, M.S, Hudson, B.I, Park, S.J, Lee, W.S. Kansuinine A and Kansuinine B from Euphorbia kansui L. inhibit IL-6-induced Stat3 activation. Planta Med. 2010, 76, 1544-1549.
11. Wang, L.Y, Wang, N.L, Yao, X.S, Miyata, S, Kitanaka, S. Euphane and tirucallane triterpenes from the roots of Euphorbia kansui and their in vitro effects on the cell division of Xenopus. J. Nat. Prod. 2003, 66, 630-633.
12. Guo, J, He, H.P, Fang, X. Kansuinone, a novel euphane-type triterpene from Euphorbia kansui. Tetrahedron Lett. 2010, 51, 6286-6289.
13. Pan, Q, Ip, F.C, Ip, N.Y, Zhu, H.X, Min, Z.D. Activity of macrocyclic jatrophane diterpenes from Euphorbia kansui in a TrkA fibroblast survival assay. J. Nat. Prod. 2004, 67, 1548-1551.
14. Wu, T.S, Lin, Y.M, Haruna, M, Pan, D.J, Shingu, T, Chen, T.P, Hsu, H.Y, Nakano, T, Lee, K.H. Antitumor agent, 119 kansuiphorins A and B, two novel antileukemic diterpene ester from Euphorbia kansui. J. Nat. Prod. 1991, 54, 823-829.
15. Dang, Q.L, Choi, Y.H, Choi, G.J, Jang, K.S, Park, M.S, Park, N.J, Lim, C.H, Kim, H, Ngoc, L.H, Kim, J.C. Pesticidal activity of ingenane diterpenes isolated from Euphorbia kansui against Nilaparvata lugens and Tetranychus urticae. J. Asia Pac. Entomol. 2010, 13, 51-54.
16. Zhang, L, Gao, L, Li, Z.J, Yan, X.J, Yang, Y.J, Tang, Y.P, Cao, Y.D, Ding, A.W. Bio-Guided isolation of the cytotoxic terpenoids from the roots of Euphorbia kansui against human normal cell lines L-O2 and GES-1. Int. J. Mol. Sci. 2012, 13, 11247-11259.
17. Matthews, G.M, Newbold, A, Johnstone, R.W. Intrinsic and extrinsic apoptotic pathway signaling as determinants of histone deacetylase inhibitor antitumor activity. Adv. Cancer Res. 2012, 116, 165-197.
18. Zhai, D, Jin, C, Huang, Z, Satterthwait, A.C, Reed, J.C. Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1. J. Biol. Chem. 2008, 283, 9580-9586.
19. Ashkenazi, A, Dixit, V.M.D. Apoptosis control by death and decoy receptors. Curr. Opin. Cell Biol. 1999, 11, 255-260.
20. Consuelo, G, Faustin, M. Lipid rafts and raft-mediated supramolecular entities in the regulation of CD95 death receptor apoptotic signaling. Apoptosis 2015, 20, 584-606.
21. Cullen, S.P, Martin, S.J. Fas and TRAIL death receptors as initiators of inflammation: Implications for cancer. Semin. Cell Dev. Biol. 2015, 39, 26-34.
22. Reyes, F.J, Centelles, J.J., Lupiáñez, J.A, Cascante M. (2α,3β)-2,3-Dihydroxyolean-12-en-28-oic acid, a new natural triterpene from Olea europea, induces caspase dependent apoptosis selectively in colon adenocarcinoma cells. FEBS Lett. 2006, 580, 6302-6310.
23. Zhang, Y.X, Yang, Z.H, Li, R.J, Geng, H, Dong, C. Investigation of fine chalk dust particles’ chemical compositions and toxicities on alveolar macrophages in vitro. Chemosphere 2015, 120, 500-506.
24. Elledge, S.J. Cell Cycle Checkpoints: Preventing an Identity Crisis. Science 1996, 274, 1664-1672.
25. Mlynarczyk, C, Fåhraeus, R. Endoplasmic reticulum stress sensitizes cells to DNA damage-induced apoptosis through p53-dependent suppression of p21CDKN1A. Nat. Commun. 2014, 5, doi:10.1038/ncomms6067.
26. Huang, F, Ma, B.Y, Wang, Y.G, Xiao, R.J, Kong, Y.P, Zhou, X.M, Xia, D.J. Targeting gene-virus-mediated manganese superoxide dismutase effectively suppresses tumor growth in hepatocellular carcinoma in vitro and in vivo. Cancer Biother. Radiopharm. 2014, 29, 403-411.
27. Jiang, J, Qin, C.X, Shu, X.Q, Chen, R, Song, H.H, Li, Q, Xu, H. 2-Effects of copper on induction of thiol-compounds and antioxidant enzymes by the fruiting body of Oudemansiella radicata. Ecotox. Environ. Saf. 2015, 111, 60-65.
28. Dash, S.K, Ghosh, T, Roy, S, Chattopadhyay, S, Das, D. Zinc sulfide nanoparticles selectively induce cytotoxic and genotoxic effects on leukemic cells: Involvement of reactive oxygen species and tumor necrosis factor α. J. Appl. Toxicol. 2014, 34, 1130-1144.
29. Yin, H, Xu, L, Porter, N.A. Free radical lipid peroxidation: Mechanisms and analysis. Chem. Rev 2011, 111, 5944-5972.
30. Taylor, R.C, Cullen, S.P, Martin, S.J. Apoptosis: Controlled demolition at the cellular level. Nat. Rev. Mol. Cell Biol. 2008, 9, 231-241.
31. García, A, Morales, P, Arranz, N, Delgado, M.E, Rafter, J, Haza, A.I. Antiapoptotic effects of dietary antioxidants towards N-nitrosopiperidine and N-nitrosodibutylamine-induced apoptosis in HL-60 and HepG2 cells. J. Appl. Toxicol. 2009, 29, 403-413.
32. Lee, J.M, Shin, S.Y, Lee, M.S, Koh, D, Lee, Y.H, Lim, Y.A. A new synthetic 2-hydroxy-2,4, 6-trimethoxy-5′,6′-naphthochalcone induces G2/M cell cycle arrest and apoptosis by disrupting the microtubular network of human colon cancer cells. Cancer Lett. 2014, 354, 348-354.
33. Hu, M.M, Xu, L.N, Yin, L.H, Qi, Y, Li, H, Xu, Y.W, Han, X, Peng, J.Y, Wan, X.Y. Cytotoxicity of dioscin in human gastric carcinoma cells through death receptor and mitochondrial pathways. J. Appl. Toxicol. 2011, 33, 712-722.
34. You, R.X, Liu, J.Y, Li, S.J, Wang L, Wang, K.P, Zhang, Y. Alkali-soluble polysaccharide, isolated from lentinus edodes, induces apoptosis and G2/M cell cycle arrest in H22 cells through microtubule depolymerization. Phytother. Res. 2014, 28, 1837-1845.
35. Sun, M.J, Zhang, N, Wang, X.L, Cai, C, Cun, J.J, Li, Y.M, Lv, S.G, Yang, Q.F. Nitidine chloride induces apoptosis, cell cycle arrest, and synergistic cytotoxicity with doxorubicin in breast cancer cells. Tumor Biol. 2014, 35, 10201-10212.
36. Hennet, T, Bertoni, G, Richter, C, Peterhans, E. Expression of BCL-2 protein enhances the survival of mouse fibrosarcoid cells in tumor necrosis factor-mediated cytotoxicity. Cancer Res. 1993, 53, 1456-1460.
37. Czabotar, P.E, Lessene, G, Strasser, A, Adams, J.M. Control of apoptosis by the BCL-2 protein family: Implications for physiology and therapy. Nat. Rev. Mol. Cell Biol. 2014, 15, 49-63.
38. Calandria, C, Irurzun, A, Barco, A, Carrasco, L. Individual expression of poliovirus 2Apro and 3Cpro induces activation of caspase-3 and PARP cleavage in hela cells. Virus Res. 2004, 104, 39-49.
39. Yap, E, Tan, W.L, Ng, I, Ng, Y.K. Combinatorial-approached neuroprotection using pan-caspase inhibitor and poly (ADP-ribose) polymerase (PARP) inhibitor following experimental stroke in rats; is there additional benefit? Brain Res. 2008, 1195, 130-138.
40. Vucic, D, Dixit, V.M.D; Wertz, I.E. Ubiquitylation in apoptosis: A post-translational modification at the edge of life and death. Nat. Rev. Mol. Cell Biol. 2011, 12, 439-452.
41. Lichter, P, Walczak, H, Weitz, S, Behrmann, I, Krammer, P.H. The human APO-1 (APT) antigen maps to 10q23, a region that is syntenic with mouse chromosome 19. Genomics 1992, 14, 179-180.
42. Inazawa, J, Itoh, N, Abe, T, Nagata S. Assignment of the human Fas antigen gene (Fas) to 10q24.1. Genomics 1992, 14, 821-822.
43. Youle, R.J, Strasser, A.T. The BCL-2 protein family: Opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 2008, 9, 47-59.
44. Chattopadhyay, S, Dash, S.K, Tripathy, S; Das, B, Mahapatra, S.K, Pramanik, P, Roy, S. Cobalt oxide nanoparticles induced oxidative stress linked to activation of TNF-α/caspase-8/p38-MAPK signaling in human leukemia cells. J. Appl. Toxicol. 2015, 35, 603-613.
45. Xiong, T, Dong, W.B, Fu, H, Li, Q.P, Deng, C.L, Lei, X.P, Guo, L. Involvement of the nuclear factor-κB pathway in the adhesion of neutrophils to renal tubular cells after injury induced by neonatal postasphyxial serum. Mol. Cell. Biochem. 2014, 388, 85-94.
46. Livak, K.J, Schmittgen, T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCt. Methods 2001, 25, 402-408.