Alkali-soluble polysaccharide, isolated from Lentinus edodes, induces apoptosis and G2/M cell cycle arrest in H22 cells through microtubule depolymerization

Phytotherapy Research

Volumn 28, Issue 12, 2014, Pages 1837-1845

  You, Ru Xu ^a   Liu, Jin Yu ^a   Li, Shi Jun ^a   Wang, Liu ^a   Wang, Kai Ping ^a   Zhang, Yu ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Anti tumour activity; Apoptosis; Cell cycle; Lentinus edodes; Microtubules network; Polysaccharide

Indexed keywords

POLYSACCHARIDE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL DISRUPTION; CELL STRUCTURE; CONTROLLED STUDY; DEPOLYMERIZATION; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR MEMBRANE; LENTINULA EDODES; MICROTUBULE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NICK END LABELING; NONHUMAN;

LENTINULA EDODES;

EID: 84916221914     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5209     Document Type: Article

References (27)

1. Bhalla K. 2003. Microtubule-targeted anticancer agents and apoptosis. Oncogene 22:9075-9086.
2. Cha J, Jeong M, Kim H, Lee J, Lee K. 2009. MAPK activation is necessary to the apoptotic death of KB cells induced by the essential oil isolated from Artemisia iwayomogi. J Ethnopharmacol 123:308-314.
3. Chakrabarty S, Das A, Bhattacharya A, Chakrabarti G. 2011. Theaflavins depolymerize microtubule network through tubulin binding and cause apoptosis of cervical carcinoma HeLa cells. J Agric Food Chem 59:2040-2048.
4. Chandra J, Samali A, Orrenius S. 2000. Triggering and modulation of apoptosis by oxidative stress. Free Radic Biol Med 29:323-333.
5. Chihara G, Maeda Y, Hamuro J, Sasaki T, Fukuoka F. 1969. Inhibition of mouse sarcoma 180 by polysaccharides from Lentinus edodes (Berk.) sing. Nature 222:687-688.
6. Elmore S. 2007. Apoptosis: a review of programmed cell death. Toxicol Pathol 35:495-516.
7. Hsu M, Lee S, Lin W. 2002. Polysaccharide purified from Ganoderma lucidum inhibits spontaneous and Fas-mediated apoptosis in human neutrophils through activation of the phosphatidylinositol 3 kinase/Akt signaling pathway. J Leukoc Biol 72:207-216.
8. Jordan M, Wilson L. 1998. Microtubules and actin filaments: dynamic targets for cancer chemotherapy. Curr Opin Cell Biol 10:123-130.
9. Jordan M, Wilson L. 2004. Microtubules as a target for anticancer drugs. Nat Rev Cancer 4:253-265.
10. Joza N, Susin SA, Daugas E, et al. 2001. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature 410:549-554.
11. Kannan K, Jain S. 2000. Oxidative stress and apoptosis. Pathophysiology 7:153-163.
12. Kim K, Ham YM, Moon J, et al. 2012. Acanthoic acid induces cell apoptosis through activation of the p38 MAPK pathway in HL-60 human promyelocytic leukaemia. Food Chem 135:2112-2117.
13. Liu X, Hajnóczky G. 2009. Ca2+ -dependent regulation of mitochondrial dynamics by the Miro-Milton complex. Int J Biochem Cell Biol 41:1972-1976.
14. Liu Y, Tang L, Liang Z, You B, Yang S. 2010. Growth inhibitory and apoptosis inducing by effects of total flavonoids from Lysimachia clethroides Duby in human chronicmyeloid leukemia K562 cells. J Ethnopharmacol 131:1-9.
15. Liu H, Xiao Y, Xiong C, Wei A, Ruan J. 2011. Apoptosis induced by a new flavonoid in human hepatoma HepG2 cells involves reactive oxygen species-mediated mitochondrial dysfunction and MAPK activation. Eur J Pharmacol 654:209-216.
16. Liu H, Jiang C, Xiong C, Ruan J. 2012. DEDC, a new flavonoid induces apoptosis via a ROS-dependent mechanism in human neuroblastoma SH-SY5Y cells. Toxicol In Vitro 26:16-23.
17. Lu WZ, Geng GX, Li Q, et al. 2010. Antitumor activity of polysaccharides isolated from Patrinia heterophylla. Pharm Biol 48:1012-1017.
18. Park SE, Park C, Kim SH, et al. 2009. Korean red ginseng extract induces apoptosis and decreases telomerase activity in human leukemia cells. J Ethnopharmacol 121:304-312.
19. Reers M, Smiley ST, Mottola-Hartshorn C, Chen A, Lin M, Chen LB. 1995. Mitochondrial membrane potential monitored by JC-1 dye. Methods Enzymol 260:406-417.
20. Smaili S, Hirata H, Ureshino R, et al. 2009. Calcium and cell death signaling in neurodegeneration and aging. An Acad Bras Cienc 81:467-475.
21. Tan M, Ooi J, Ismail N, Moad A, Muhammad T. 2009. Programmed cell death pathways and current antitumor targets. Pharm Res 26:1547-1560.
22. Tseng CJ, Wang YJ, Liang YC, et al. 2002. Microtubule damaging agents induce apoptosis in HL 60 cells and G2/M cell cycle arrest in HT 29 cells. Toxicology 175:123-142.
23. Wang ZY, Wang DM, Loo TY, et al. 2011. Spatholobus suberectus inhibits cancer cell growth by inducing apoptosis and arresting cell cycle at G2/M checkpoint. J Ethnopharmacol 133:751-758.
24. Yang S, Sales K, Fuller B, Seifalian A, Winslet C. 2009. Apoptosis and colorectal cancer: implications for therapy. Trends Mol Med 15:225-233.
25. You R, Wang K, Liu J, Zhang Y. 2011. A comparison study between different molecular weight polysaccharides derived from Lentinus edodes and their antioxidant activities in vivo. Pharm Biol 49:1298-1305.
26. Zhang M, Chen H, Huang J, et al. 2005. Effect of lycium barbarum polysaccharide on human hepatoma QGY7703 cells: inhibition of proliferation and induction of apoptosis. Life Sci 76:2115-2124.
27. Zhang Y, Li S, Wang X, Zhang L, Cheung P. 2011. Advances in lentinan: isolation, structure, chain conformation and bioactivities. Food Hydrocoll 25:196-206.