Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils

Journal of Medicinal Chemistry

Volumn 58, Issue 15, 2015, Pages 6002-6017

  Chu, Wenhua ^a   Zhou, Dong ^a   Gaba, Vrinda ^b   Liu, Jialu ^b   Li, Shihong ^a   Peng, Xin ^a   Xu, Jinbin ^a   Dhavale, Dhruva ^b   Bagchi, Devika P ^b   D'Avignon, André ^c   Shakerdge, Naomi B ^d   Bacskai, Brian J ^d   Tu, Zhude ^a   Kotzbauer, Paul T ^b   Mach, Robert H ^a,d,e  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WASHINGTON UNIVERSITY   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (BENZYLIDENE)INDOLIN 2 ONE DERIVATIVE; ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; BENZENE DERIVATIVE; INDOLE DERIVATIVE; LIGAND; NITROGEN; TAU PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FIBER; CHEMISTRY; FLUORESCENCE MICROSCOPY; SYNTHESIS;

ALPHA-SYNUCLEIN; DRUG DESIGN; INDOLES; LIGANDS; MICROSCOPY, FLUORESCENCE;

EID: 84939205714     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00571     Document Type: Article

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