Bothrops snake venoms and their isolated toxins, an L-amino acid oxidase and a serine protease, modulate human complement system pathways

Journal of Venomous Animals and Toxins Including Tropical Diseases

Volumn 21, Issue 1, 2015, Pages

  Ayres, Lorena Rocha ^a   Récio, Alex dos Reis ^a   Burin, Sandra Mara ^a   Pereira, Juliana Campos ^a   Martins, Andrea Casella ^a   Sampaio, Suely Vilela ^a   de Castro, Fabíola Attié ^a   Pereira Crott, Luciana Simon ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Bothrops jararacussu; Bothrops pirajai; Chemotaxis; Complement system; Kinetic microassay; L amino acid oxidase; Serine protease; Snake venom

Indexed keywords

AMINO ACID OXIDASE; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C5A; SERINE PROTEINASE; SNAKE VENOM;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BOTHROPS; BOTHROPS JARARACUSSU; BOTHROPS PIRAJAI; CELL MIGRATION; CHEMOTAXIS ASSAY; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT CLASSICAL PATHWAY; COMPLEMENT SYSTEM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; HEMOLYSIS; HUMAN; HUMAN CELL; NEUTROPHIL; NEW ZEALAND WHITE (RABBIT); NONHUMAN; SHEEP;

BOTHROPS; BOTHROPS JARARACUSSU; BOTHROPS PIRAJAI; SERPENTES;

EID: 84939163587     PISSN: 16789180     EISSN: 16789199     Source Type: Journal    
DOI: 10.1186/s40409-015-0026-7     Document Type: Article

References (36)

1. Segura A, Castillo MC, Núñez V, Yarlequé A, Gonçalves LR, Villalta M, et al. Preclinical assessment of the neutralizing capacity of antivenoms produced in six Latin American countries against medically-relevant Bothrops snake venoms. Toxicon. 2010;56(6):980-9.
2. Nascimento JM, Franchi GC, Nowill AE, Collares-Buzato CB, Hyslop S. Cytoeskeletal rearrangement and cell death induced by Bothrops alternatus snake venom in cultured Madin-Darby canine kidney cells. Biochem Cell Biol. 2007;85(5):591-605.
3. Farsky SH, Gonçalves LR, Gutiérrez JM, Correa AP, Rucavado A, Gasque P, et al. Bothrops asper snake venom and its metalloproteinase BaP-1 activate the complement system. Role in leucocyte recruitment. Mediators Inflamm. 2000;9(5):213-21.
4. Teixeira CF, Landucci EC, Antunes E, Chacur M, Cury Y. Inflammatory effects of snake venom myotoxic phospholipases A2. Toxicon. 2003;42(8):947-62.
5. Teixeira C, Cury Y, Moreira V, Picolo G, Chaves F. Inflammation induced by Bothrops asper venom. Toxicon. 2009;54(1):67-76.
6. Correa-Netto C, Teixeira-Araujo R, Aguiar AS, Melgarejo AR, De-Simone SG, Soares MR, et al. Immunome and venome of Bothrops jararacussu: a proteomic approach to study the molecular immunology of snake toxins. Toxicon. 2010;55(7):1222-35.
7. Teixeira CF, Fernandes CM, Zuliani JP, Zamuner SF. Inflammatory effects of snake venom metalloproteinases. Mem Inst Oswaldo Cruz. 2005;100(1):181-4.
8. Carroll MV, Sim RB. Complement in health and disease. Adv Drug Deliv Rev. 2011;63(12):965-75.
9. Wagner E, Frank MM. Therapeutic potential of complement modulation. Nat Rev Drug Discov. 2010;9(1):43-56.
10. Carroll MC. The complement system in regulation of adaptive immunity. Nat Immunol. 2004;5(10):981-6.
11. Turner MW. Mannose-binding lectin: the pluripotent molecule of the innate immune system. Immunol Today. 1996;17(11):532-40.
12. Walport MJ. Complement. First of two parts. N Engl J Med. 2001;344(14):1058-66.
13. Eggertsen G, Fohlman J, Sjöquist J. In vitro studies on complement inactivation by snake venoms. Toxicon. 1980;18(1):87-96.
14. Pidde-Queiroz G, Furtado MF, Filgueiras CF, Pessoa LA, Spadafora-Ferreira M, van den Berg CW, et al. Human complement activation and anaphylatoxins generation induced by snake venom toxins from Bothrops genus. Mol Immunol. 2010;47(16):2537-44.
15. Tanaka GD, Pidde-Queiroz G, Furtado MFD, van den Berg C, Tambourgi DV. Micrurus snake venoms activate human complement system and generate anaphylatoxins. BMC Immunol. 2012;13:4.
16. Serrano SM, Maroun RC. Snake venom serine proteinases: sequence homology vs. substrate specificity, a paradox to be solved. Toxicon. 2005;45(8):1115-32.
17. Menaldo DL, Bernardes CP, Pereira JC, Silveira DS, Mamede CCN, Stanziola L, et al. Effects of two serine proteases from Bothrops pirajai snake venom on the complement system and the inflammatory response. Int Immunopharmacol. 2013;15(4):764-71.
18. Yamamoto C, Tsuru D, Oda-Ueda N, Ohno M, Hattori S, Kim ST. Flavoxobin, a serine protease from Trimeresurus flavoviridis (habu snake) venom, independently cleaves Arg726-Ser727 of human C3 and acts as a novel, heterologous C3 convertase. Immunology. 2002;107(1):111-7.
19. Du XY, Clemetson KJ. Snake venom L-amino acid oxidases. Toxicon. 2002;40(6):659-65.
20. Samel M, Vija H, Ronnholm G, Siigur J, Kalkkinen N, Siigur E. Isolation and characterization of an apoptotic and platelet aggregation inhibiting L-amino acid oxidase from Vipera berus berus (common viper) venom. Biochim Biophys Acta. 2006;1764(4):707-14.
21. Guo C, Liu S, Yao Y, Zhang Q, Sun MZ. Past decade study of snake venom L-amino acid oxidase. Toxicon. 2012;60(3):302-11.
22. Burin SM, Ayres LR, Neves RP, Ambrósio L, de Morais FR, Dias-Baruffi M, et al. L-amino acid oxidase isolated from Bothrops pirajai induces apoptosis in BCR-ABL-positive cells and potentiates imatinib mesylate effect. Basic Clin Pharmacol Toxicol. 2013;113(2):103-12.
23. Costa TR, Burin SM, Menaldo DL, de Castro FA, Sampaio SV. Snake venom L-amino acid oxidases: an overview on their antitumor effects. J Venom Anim Toxins incl Trop Dis. 2014;20:23.
24. Izidoro LF, Ribeiro MC, Souza GR, Sant'Ana CD, Hamaguchi A, Homsi-Brandeburgo MI, et al. Biochemical and functional characterization of an L-amino acid oxidase isolated from Bothrops pirajai snake venom. Bioorg Med Chem. 2006;14(20):7034-43.
25. Bertazzi DT, de Assis-Pandochi AI, Talhaferro VL, Caleiro Seixas Azzolini AE, Pereira-Crott LS, Arantes EC. Activation of the complement system and leukocyte recruitment by Tityus serrulatus scorpion venom. Int Immunopharmacol. 2005;5(6):1077-84.
26. Ayres LR. Modulação de eventos da imunidade humoral e celular por venenos brutos e componentes dos venenos de Bothrops jararacussu e Bothrops pirajai. MSc Thesis. Ribeirão Preto: Faculdade de Ciências Farmacêuticas de Ribeirão Preto - Universidade de São Paulo; 2010.
27. Boyden S. The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. J Exp Med. 1962;115:453-66.
28. Zigmond SH, Hirsch JG. Leukocyte locomotion and chemotaxis. New methods for evaluation, and demonstration of a cell-derived chemotactic factor. J Exp Med. 1973;137(2):387-410.
29. Barros LC, Soares AM, Costa FL, Rodrigues VM, Fuly AL, Giglio JR, et al. Biochemical and biological evaluation of gyroxin isolated from Crotalus durissus terrificus venom. J Venom Anim Toxins incl Trop Dis. 2011;17(1):23-33.
30. Shoibonov BB, Osipov AV, Kryukova EV, Zinchenko AA, Lakhtin VM, Tsetlin VI, et al. Oxiagin from the Naja oxiana cobra venom is the first reprolysin inhibiting the classical pathway of complement. Mol Immunol. 2005;42(10):1141-53.
31. Müller-Eberhard HJ, Fjellström KE. Isolation of the anticomplementary protein from cobra venom and its mode of action on C3. J Immunol. 1971;107(6):1666-72.
32. Gasmi A, Louzir H, Karoui H, el Ayeb M, Dellagi K. Purification from Vipera lebetina (desert adder) venom of a protein that depletes human complement. Nat Toxins. 1994;2(1):44-8.
33. Tambourgi DV, dos Santos MC, Furtado MF, de Freitas MC, da Silva WD, Kipnis TL. Pro-inflammatory activities in elapid snake venoms. Br J Pharmacol. 1994;112(3):723-7.
34. Rodrigues FG, Petretski JH, Kanashiro MM, Lemos L, Silva WD, Kipnis TL. The complement system is involved in acute inflammation but not in the hemorrhage produced by a Bothrops atrox snake venom low molecular mass proteinase. Mol Immunol. 2004;40(16):1149-56.
35. Haas PJ, van Strijp J. Anaphylatoxins: their role in bacterial infection and inflammation. Immunol Res. 2007;37(3):161-75.
36. Luna KPO, da Silva MB, Pereira VRA. Clinical and immunological aspects of envenomation by Bothrops snakes. J Venom Anim Toxins incl Trop Dis. 2011;17(2):130-41.