Micrurus snake venoms activate human complement system and generate anaphylatoxins

BMC Immunology

Volumn 13, Issue , 2012, Pages

  Tanaka, Gabriela D ^a   Pidde Queiroz, Giselle ^a   Furtado, Maria de Fátima D ^a   van den Berg, Carmen ^b   Tambourgi, Denise V ^a  

^a INSTITUTO BUTANTAN   (Brazil)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,10 PHENANTHROLINE; ANAPHYLATOXIN; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C4A; COMPLEMENT COMPONENT C5A; LECTIN; METALLOPROTEINASE; SNAKE VENOM; COBROTOXIN; COMPLEMENT COMPONENT C1S INHIBITOR; COMPLEMENT COMPONENT C3; MICRURUS VENOM;

ALPHA CHAIN; ARTICLE; BRAZIL; COMPLEMENT SYSTEM; HUMAN; IN VITRO STUDY; MICRURUS ALTIROSTRIS; MICRURUS BIBOBOCA; MICRURUS CORALLINUS; MICRURUS FRONTALIS; MICRURUS LEMNISCATUS; MICRURUS SPIXII; MICRURUS SURINAMENSIS; NONHUMAN; NORMAL HUMAN; SNAKE; ANIMAL; BIOSYNTHESIS; COMPLEMENT ACTIVATION; DRUG EFFECT; ELAPIDAE; ISOLATION AND PURIFICATION; METABOLISM; PROTEIN DEGRADATION;

ANAPHYLATOXINS; ANIMALS; COBRA VENOMS; COMPLEMENT ACTIVATION; COMPLEMENT C1 INHIBITOR PROTEIN; COMPLEMENT C3; ELAPID VENOMS; ELAPIDAE; HUMANS; PROTEOLYSIS;

EID: 84855771661     PISSN: None     EISSN: 14712172     Source Type: Journal    
DOI: 10.1186/1471-2172-13-4     Document Type: Article

References (26)

1. Vital Brazil O, Fontana MD, Pellegrini Filho A. Physiopathologie et therapeutique de l'envenomation experimentale causee par le venin de Micrurus frontalis. Mem Inst Butantan 1976, 40:221-240.
2. Barros ACS, Fernandes DP, Ferreira LCL, Santos MC. Local effects induce by venoms from five species of genus Micrurus sp (coral snakes). Toxicon 1994, 32:445-452. 10.1016/0041-0101(94)90296-8, 8052999.
3. Gutiérrez JM, Lomonte B, Portilla E, Cerdas L, Rojas E. Local effects induced by coral snake venoms: evidence of myonecrosis after experimental inoculation of venoms from five species. Toxicon 1983, 21:777-783. 10.1016/0041-0101(83)90066-1, 6658805.
4. Tan NH, Ponnudurai G. The biologial properties of venoms of some american coral snake (genus Micrurus). Comp Biochem Physiol 1992, 101B:471-474.
5. Aird SD, Jorge da Silva N. Comparative enzymatic composition of Brazilian coral snake (Micrurus) venoms. Comp Biochem Physiol 1991, 99B:287-294.
6. Tanaka GD, Furtado MDFD, Portaro FCV, Sant'Anna OA, Tambourgi DV. Diversity of Micrurus snake species related to their venom toxic effects and the prospective of antivenom neutralization. PLoS Negl Trop Dis 2010, 4:e622. 10.1371/journal.pntd.0000622, 2834742, 20231886.
7. Tambourgi DV, Santos MC, Furtado MF, Freitas MC, Silva WD, Kipnis TL. Pro-inflammatory activities in elapid snake venoms. Br J Pharmacol 1994, 112:723-727. 1910224, 7921595.
8. Köhl J. Self, non-self, and danger: a complementary view. Adv Exp Med Biol 2006, 586:71-94. 10.1007/0-387-34134-X_6, 16893066.
9. Beinrohr L, Dobó J, Závodszky P, Gál P. C1, MBL-MASPs and C1-inhibitor: novel approaches for targeting complement-mediated inflammation. Trends Mol Med 2008, 14:511-521. 10.1016/j.molmed.2008.09.009, 18977695.
10. Unsworth DJ. Complement deficiency and disease. J Clin Pathol 2008, 61:1013-1017. 10.1136/jcp.2008.056317, 18495794.
11. Sjöberg AP, Trouw LA, Blom AM. Complement activation and inhibition: a delicate balance. Trends Immunol 2009, 30:83-90. 10.1016/j.it.2008.11.003, 19144569.
12. Bowen B, Hawk JJ, Sibunka S, Hovick S, Weiler JM. A review of the reported defects in the human C1 esterase inhibitor gene producing hereditary angioedema including four new mutations. Clin Immunol 2001, 98:157-163. 10.1006/clim.2000.4947, 11161971.
13. Miwa T, Song WC. Membrane complement regulatory proteins: insight from animal studies and relevance to human diseases. Int Immunopharmacol 2001, 1:445-459. 10.1016/S1567-5769(00)00043-6, 11367529.
14. Müller-Eberhard HJ, Fjellstrom KE. Isolation of the anti-complementary protein from cobra venom and its mode of action on C3. J Immunol 1971, 6:1666-1672.
15. Götze O, Müller-Eberhard HJ. The C3-activator system: an alternate pathway of complement-activation. J Exp Med 1971, 3:90-108.
16. Vogel CW, Müller-Eberhard HJ. The cobra venom factor-dependent C3 convertase of human complement. A kinetic and thermodynamic analysis of a protease acting on its natural high molecular weight substrate. J Biol Chem 1982, 14:8292-8299.
17. Pidde-Queiroz G, Furtado MDFD, Filgueiras CF, Pessoa LA, Spadafora-Ferreira M, van den Berg CW, Tambourgi DV. Human complement activation and anaphylatoxins generation induced by snake venom toxins from Bothrops genus. Mol Immunol 2010, 47:2537-2544. 10.1016/j.molimm.2010.07.003, 20674029.
18. Zeller EA. Enzymes of snake venoms and their biological significance. Adv Enzymol 1948, 8:459-495.
19. Rocha-e-Silva M, Beraldo WT, Rosenfeld G. Bradykinin, a hypotensive and smooth muscle stimulating factor released from plasma globulin by snake venoms and trypsin. Am J Physiol 1950, 156:261-273.
20. Stocker K, Barlow GH. The coagulant enzyme from Bothrops atrox venom (batroxobin). Methods Enzymol 1976, 45:214-223.
21. Geiger R, Kortmann H. Esterolytic and proteolytic activities of snake venoms and their inhibition by proteinase inhibitors. Toxicon 1977, 15:257-259. 10.1016/0041-0101(77)90052-6, 867442.
22. Stocker K, Fisher H, Meier J. Thrombin-like snake venom proteinases. Toxicon 1982, 20:265-273. 10.1016/0041-0101(82)90225-2, 7043783.
23. O'Keefe MC, Caporale LH, Vogel CW. A novel cleavage product of human complement component C3 with structural and functional properties of cobra venom factor. J Biol Chem 1988, 263:12690-12697.
24. Kress LF, Catanese J, Hirayama T. Analysis of the effects of snake venom proteinases on the activity of human plasma C1 esterase inhibitor, alpha 1-antichymotrypsin and alpha 2-antiplasmin. Biochim Biophys Acta 1983, 15:113-120.
25. Laemmli UK. Clevage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685. 10.1038/227680a0, 5432063.
26. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Biotechnology 1979, 24:145-149.