Peripheral blood mitochondrial DNA as a biomarker of cerebral mitochondrial dysfunction following traumatic brain injury in a porcine model

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Kilbaugh, Todd J ^a   Lvova, Maria ^a   Karlsson, Michael ^b   Zhang, Zhe ^a   Leipzig, Jeremy ^a   Wallace, Douglas C ^a   Margulies, Susan S ^c  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b LUND UNIVERSITY   (Sweden)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS DNA; MITOCHONDRIAL DNA; RNA 16S; BIOLOGICAL MARKER; PRIMER DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOENERGY; BLOOD ANALYSIS; BLOOD LEVEL; BRAIN REGION; CONTROLLED STUDY; DISEASE ACTIVITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FEMALE; GENE DOSAGE; GENE FUNCTION; GENE IDENTIFICATION; HIPPOCAMPUS; IMMUNE SYSTEM; MITOCHONDRIAL RESPIRATION; MOLECULAR PATHOLOGY; NONHUMAN; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; TRAUMATIC BRAIN INJURY; ANIMAL; BIOLOGY; BLOOD; BRAIN INJURY; COMPLICATION; ENERGY METABOLISM; GENETICS; MITOCHONDRIAL DISEASES; NONPARAMETRIC TEST; PHYSIOLOGY; PIG;

SUS;

ANIMALS; BIOMARKERS; BRAIN INJURIES; COMPUTATIONAL BIOLOGY; DNA PRIMERS; DNA, MITOCHONDRIAL; ENERGY METABOLISM; MITOCHONDRIAL DISEASES; REAL-TIME POLYMERASE CHAIN REACTION; STATISTICS, NONPARAMETRIC; SWINE;

EID: 84939152663     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0130927     Document Type: Article

References (36)

1. Gean AD, Fischbein NJ. Head trauma. Neuroimaging Clin N Am. 2010; 20: 527-556. doi: 10.1016/j.nic.2010.08.001 PMID: 20974375
2. Marcoux J, McArthur DA, Miller C, Glenn TC, Villablanca P, Martin NA, et al. Persistent metabolic crisis as measured by elevated cerebral microdialysis lactate-pyruvate ratio predicts chronic frontal lobe brain atrophy after traumatic brain injury∗. Critical Care Medicine. 2008; 36: 2871-2877. doi: 10.1097/ CCM.0b013e318186a4a0 PMID: 18766106
3. Gilmer LK, Ansari MA, Roberts KN, Scheff SW. Age-related mitochondrial changes after traumatic brain injury. Journal of Neurotrauma. 2010; 27: 939-950. doi: 10.1089/neu.2009.1181 PMID: 20175672
4. Robertson CL, Soane L, Siegel ZT, Fiskum G. The potential role of mitochondria in pediatric traumatic brain injury. Dev Neurosci. Karger Publishers; 2006; 28: 432-446. doi: 10.1159/000094169 PMID: 16943666
5. Lifshitz J, Sullivan PG, Hovda DA, Wieloch T, McIntosh TK. Mitochondrial damage and dysfunction in traumatic brain injury. MITOCHONDRION. 2004; 4: 705-713. doi: 10.1016/j.mito.2004.07.021 PMID: 16120426
6. Das M, Mohapatra S, Mohapatra SS. New perspectives on central and peripheral immune responses to acute traumatic brain injury. J Neuroinflammation. 2012; 9: 236. doi: 10.1186/1742-2094-9-236 PMID: 23061919
7. Morganti-Kossmann MC, Satgunaseelan L, Bye N, Kossmann T. Modulation of immune response by head injury. Injury. 2007; 38: 1392-1400. doi: 10.1016/j.injury.2007.10.005 PMID: 18048036
8. Block ML, Zecca L, Hong J-S. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci. 2007; 8: 57-69. doi: 10.1038/nrn2038 PMID: 17180163
9. Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci. 2007 ed. 2008; 9: 46-56. doi: 10.1038/nrn2297 PMID: 18073775
10. Zhang Q-G, Laird MD, Han D, Nguyen K, Scott E, Dong Y, et al. Critical role of NADPH oxidase in neuronal oxidative damage and microglia activation following traumatic brain injury. Combs C, editor. PLoS ONE. Public Library of Science; 2012; 7: e34504. doi: 10.1371/journal.pone.0034504 PMID: 22485176
11. Di Filippo M, Chiasserini D, Tozzi A, Picconi B, Calabresi P. Mitochondria and the link between neuroinflammation and neurodegeneration. J Alzheimers Dis. 2010; 20 Suppl 2: S369-79. doi: 10.3233/JAD- 2010-100543 PMID: 20463396
12. Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 2010; 464: 104-107. doi: 10.1038/nature08780 PMID: 20203610
13. Malik AN, Czajka A. Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction? MITOCHONDRION. 2013; 13: 481-492. doi: 10.1016/j.mito.2012.10.011 PMID: 23085537
14. Forde CT, Karri SK, Young AMH, Ogilvy CS. Predictive markers in traumatic brain injury: opportunities for a serum biosignature. Br J Neurosurg. 2014; 28: 8-15. doi: 10.3109/02688697.2013.815317 PMID: 23855389
15. Durham SR, Duhaime A- C. Basic science; maturation-dependent response of the immature brain to experimental subdural hematoma. Journal of Neurotrauma. 2007; 24: 5-14. doi: 10.1089/neu.2006.0054 PMID: 17263666
16. Grate LL, Golden JA, Hoopes PJ, Hunter JV, Duhaime A-C. Traumatic brain injury in piglets of different ages: techniques for lesion analysis using histology and magnetic resonance imaging. Journal of Neuroscience Methods. 2003; 123: 201-206. PMID: 12606068
17. Duhaime A-C. Large animal models of traumatic injury to the immature brain. Dev Neurosci. Karger Publishers; 2006; 28: 380-387. doi: 10.1159/000094164 PMID: 16943661
18. Missios S, Harris BT, Dodge CP, Simoni MK, Costine BA, Lee Y-L, et al. Scaled cortical impact in immature swine: effect of age and gender on lesion volume. Journal of Neurotrauma. 2009; 26: 1943-1951. doi: 10.1089/neu.2009-0956 PMID: 19469691
19. Eucker SA, Smith C, Ralston J, Friess SH, Margulies SS. Physiological and histopathological responses following closed rotational head injury depend on direction of head motion. Experimental Neurology. 2011; 227: 79-88. doi: 10.1016/j.expneurol.2010.09.015 PMID: 20875409
20. Adelson PD, Pineda J, Bell MJ, Abend NS, Berger RP, Giza CC, et al. Common data elements for pediatric traumatic brain injury: recommendations from the working group on demographics and clinical assessment. Journal of Neurotrauma. 2012. pp. 639-653. doi: 10.1089/neu.2011.1952
21. Miller AC, Odenkirchen J, Duhaime AC. Common data elements for research on traumatic brain injury: Pediatric considerations. Journal of .... 2012.
22. Karlsson M, Hempel C, Sjövall F, Hansson MJ, Kurtzhals JAL, Elmér E. Brain mitochondrial function in a murine model of cerebral malaria and the therapeutic effects of rhEPO. Int J Biochem Cell Biol. 2012. doi: 10.1016/j.biocel.2012.08.008
23. Gnaiger E. Capacity of oxidative phosphorylation in human skeletal muscle: new perspectives of mitochondrial physiology. Int J Biochem Cell Biol. 2009.
24. Margulies SS, Kilbaugh TJ, Sullivan S, Smith C, Propert K, Byro M, et al. Establishing a Clinically Relevant Large Animal Model Platform for TBI Therapy Development: Using Cyclosporin A as a Case Study. Brain Pathol. 2015; 25: 289-303. doi: 10.1111/bpa.12247 PMID: 25904045
25. Jaber SM, Sullivan S, Margulies SS. Noninvasive metrics for identification of brain injury deficits in piglets. Dev Neuropsychol. 2015; 40: 34-39. doi: 10.1080/87565641.2014.969733 PMID: 25649778
26. Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell. 2010; 140: 805-820. doi: 10.1016/j.cell.2010.01.022 PMID: 20303872
27. Chan JK, Roth J, Oppenheim JJ, Tracey KJ, Vogl T, Feldmann M, et al. Alarmins: awaiting a clinical response. J Clin Invest. American Society for Clinical Investigation; 2012; 122: 2711-2719. doi: 10.1172/JCI62423 PMID: 22850880
28. Zhang Q, Itagaki K, Hauser CJ. Mitochondrial DNA is released by shock and activates neutrophils via p38 map kinase. Shock. 2010; 34: 55-59. doi: 10.1097/SHK.0b013e3181cd8c08 PMID: 19997055
29. Kirkinezos IG, Moraes CT. Reactive oxygen species and mitochondrial diseases. Seminars in Cell & Developmental Biology. 2001; 12: 449-457. doi: 10.1006/scdb.2001.0282
30. Walko TD, Bola RA, Hong JD, Au AK, Bell MJ, Kochanek PM, et al. Cerebrospinal fluid mitochondrial DNA: a novel DAMP in pediatric traumatic brain injury. Shock. 2014; 41: 499-503. doi: 10.1097/SHK.0000000000000160 PMID: 24667615
31. West AP, Shadel GS, Ghosh S. Mitochondria in innate immune responses. Nat Rev Immunol. 2011; 11: 389-402. doi: 10.1038/nri2975 PMID: 21597473
32. Lartigue L, Faustin B. Mitochondria: metabolic regulators of innate immune responses to pathogens and cell stress. Int J Biochem Cell Biol. 2013; 45: 2052-2056. doi: 10.1016/j.biocel.2013.06.014 PMID: 23838171
33. Lu J, Goh SJ, Tng PYL, Deng YY, Ling E-A, Moochhala S. Systemic inflammatory response following acute traumatic brain injury. Front Biosci. 2009; 14: 3795-3813. PMID: 19273311
34. Utagawa A, Truettner JS, Dietrich WD, Bramlett HM. Systemic inflammation exacerbates behavioral and histopathological consequences of isolated traumatic brain injury in rats. Experimental Neurology. 2008; 211: 283-291. doi: 10.1016/j.expneurol.2008.02.001 PMID: 18355811
35. Hunter JV, Wilde EA, Tong KA, Holshouser BA. Emerging imaging tools for use with traumatic brain injury research. Journal of Neurotrauma. Mary Ann Liebert, Inc. 140 Huguenot Street, 3rd Floor New Rochelle, NY 10801 USA; 2012; 29: 654-671. doi: 10.1089/neu.2011.1906 PMID: 21787167
36. Weeks D, Sullivan S, Kilbaugh TJ, Smith C, Margulies SS. Influences of developmental age on the resolution of diffuse traumatic intracranial hemorrhage and axonal injury. Journal of Neurotrauma. 2014; 31: 206-214. doi: 10.1089/neu.2013.3113 PMID: 23984914