Sex Differences in Depression: Does Inflammation Play a Role?

Current Psychiatry Reports

Volumn 17, Issue 10, 2015, Pages

  Derry, Heather M ^a,b   Padin, Avelina C ^a,b   Kuo, Jennifer L ^a,b   Hughes, Spenser ^a,b   Kiecolt Glaser, Janice K ^a,b  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Childhood adversity; Depression; Inflammation; Obesity; Relationships; Women

Indexed keywords

C REACTIVE PROTEIN; ESTROGEN; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

AUTOIMMUNE DISEASE; BEHAVIOR CHANGE; CHILD ABUSE; CYTOKINE RESPONSE; DEPRESSION; FAMILY CONFLICT; FATIGUE; HUMAN; ILLNESS BEHAVIOR; INFLAMMATION; INTERPERSONAL STRESS; LONELINESS; MAJOR DEPRESSION; MOOD CHANGE; OBESITY; PHYSICAL INACTIVITY; POSTMENOPAUSE; PREGNANT WOMAN; REVIEW; SEX DIFFERENCE; SLEEP DEPRIVATION; SOCIAL ISOLATION; WEIGHT GAIN; COMPLICATION; FEMALE; IMMUNOLOGY; MALE; PATHOPHYSIOLOGY;

DEPRESSIVE DISORDER; FEMALE; HUMANS; INFLAMMATION; MALE; OBESITY; SEX FACTORS;

EID: 84939139263     PISSN: 15233812     EISSN: 15351645     Source Type: Journal    
DOI: 10.1007/s11920-015-0618-5     Document Type: Review

References (100)

1. Bromet E, Andrade LH, Hwang I, Sampson NA, Alonso J, de Girolamo G, et al. Cross-national epidemiology of DSM-IV major depressive episode. BMC Med. 2011;9(1):90.
2. Kessler RC, McGonagle KA, Swartz M, Blazer DG, Nelson CB. Sex and depression in the National Comorbidity Survey I: lifetime prevalence, chronicity and recurrence. J Affect Disord. 1993;29(2–3):85–96. doi:10.1016/0165-0327(93)90026-G.
3. Cyranowski J, Frank E, Young E, Shear M. Adolescent onset of the gender difference in lifetime rates of major depression: a theoretical model. Arch Gen Psychiatry. 2000;57(1):21–7. doi:10.1001/archpsyc.57.1.21.
4. Hyde JS, Mezulis AH, Abramson LY. The ABCs of depression: integrating affective, biological, and cognitive models to explain the emergence of the gender difference in depression. Psychol Rev. 2008;115(2):291–313. doi:10.1037/0033-295X.115.2.291.
5. Nolen-Hoeksema S, Jackson B. Mediators of the gender difference in rumination. Psychol Women Q. 2001;25(1):37–47. doi:10.1111/1471-6402.00005.
6. Haroon E, Raison CL, Miller AH. Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology. 2012;37(1):137–62. doi:10.1038/npp.2011.205.
7. Slavich GM, Irwin MR. From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. Psychol Bull. 2014;140(3):774–815. This comprehensive review provides an in-depth, mechanistic discussion of how stress, depression, and inflammation impact one another, as well as how other key factors such as early life stress can play important roles in these processes.
8. Howren MB, Lamkin DM, Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med. 2009;71(2):171–86. doi:10.1097/PSY.0b013e3181907c1b.
9. Liu Y, Ho RC-M, Mak A. Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression. J Affect Disord. 2012;139(3):230–9. doi:10.1016/j.jad.2011.08.003.
10. Valkanova V, Ebmeier KP, Allan CL. CRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies. J Affect Disord. 2013;150(3):736–44. doi:10.1016/j.jad.2013.06.004.
11. Fagundes CP, Glaser R, Hwang BS, Malarkey WB, Kiecolt-Glaser JK. Depressive symptoms enhance stress-induced inflammatory responses. Brain Behav Immun. 2013;31:172–6. This study suggests that even lower levels of depressive symptoms can boost inflammatory responses under stress.
12. Pace T, Mletzko T, Alagbe O, Musselman D, Nemeroff C, Miller A, et al. Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress. Am J Psychiatr. 2006;163(9):1630–3.
13. Quintero OL, Amador-Patarroyo MJ, Montoya-Ortiz G, Rojas-Villarraga A, Anaya J-M. Autoimmune disease and gender: plausible mechanisms for the female predominance of autoimmunity. J Autoimmun. 2012;38(2–3):J109–19. doi:10.1016/j.jaut.2011.10.003.
14. Yang YC, Kozloski M. Sex differences in age trajectories of physiological dysregulation: inflammation, metabolic syndrome, and allostatic load. J Gerontol A: Biol Med Sci. 2011;66A(5):493–500. doi:10.1093/gerona/glr003.
15. Matthews KA, Schott LL, Bromberger JT, Cyranowski JM, Everson-Rose SA, Sowers M. Are there bi-directional associations between depressive symptoms and C-reactive protein in mid-life women? Brain Behav Immun. 2010;24(1):96–101. doi:10.1016/j.bbi.2009.08.005.
16. Khandaker G, Pearson R, Zammit S, Lewis G, Jones P. Association of serum interleukin 6 and C-reactive protein in childhood with depression and psychosis in young adult life: a population-based longitudinal study. JAMA Psychiatry. 2014;71(10):1121–8. doi:10.1001/jamapsychiatry.2014.1332.
17. Capuron L, Miller AH. Immune system to brain signaling: neuropsychopharmacological implications. Pharmacol Ther. 2011;130(2):226–38. doi:10.1016/j.pharmthera.2011.01.014.
18. Schedlowski M, Engler H, Grigoleit J-S. Endotoxin-induced experimental systemic inflammation in humans: a model to disentangle immune-to-brain communication. Brain Behav Immun. 2014;35:1–8. doi:10.1016/j.bbi.2013.09.015.
19. Capuron L, Ravaud A, Miller AH, Dantzer R. Baseline mood and psychosocial characteristics of patients developing depressive symptoms during interleukin-2 and/or interferon-alpha cancer therapy. Brain Behav Immun. 2004;18(3):205–13. doi:10.1016/j.bbi.2003.11.004.
20. Udina M, Moreno-España J, Navinés R, Giménez D, Langohr K, Gratacòs M, et al. Serotonin and interleukin-6: the role of genetic polymorphisms in IFN-induced neuropsychiatric symptoms. Psychoneuroendocrinology. 2013;38(9):1803–13. doi:10.1016/j.psyneuen.2013.03.007.
21. Moieni M, Irwin MR, Jevtic I, Olmstead R, Breen EC, Eisenberger NI. Sex differences in depressive and socioemotional responses to an inflammatory challenge: Implications for sex differences in depression. Neuropsychopharmacology. 2015. doi:10.1038/npp.2015.17. In this key report of a randomized, placebo-controlled, double-blind, laboratory study of endotoxin responses, women appeared more vulnerable to the behavioral effects of inflammation compared to men. In response to endotoxin, women reported more depressive symptoms and social disconnection than men. Among women, those with greater inflammatory responses also had larger increases in social disconnection, one pathway that can help explain sex differences in depression.
22. Kiecolt-Glaser JK, Derry HM, & Fagundes CP (in press) Inflammation: depression fans the flames and feasts on the heat. The American Journal of Psychiatry. This thoughtful review focuses on 'how' and 'for whom' depression and inflammation are linked, and discusses how this information may be used in clinical practice to enhance recovery and prevent recurrence.
23. Duivis HE, de Jonge P, Penninx BW, Na BY, Cohen BE, Whooley MA. Depressive symptoms, health behaviors, and subsequent inflammation in patients with coronary heart disease: prospective findings from the Heart and Soul study. Am J Psychiatr. 2011;168(9):913–20. doi:10.1176/appi.ajp.2011.10081163.
24. Maes M, Ombelet W, Jongh D, Kenis G, Bosmans E. The inflammatory response following delivery is amplified in women who previously suffered from major depression, suggesting that major depression is accompanied by a sensitization of the inflammatory response system. J Affect Disord. 2001;63(1–3):85–92. doi:10.1016/S0165-0327(00)00156-7.
25. Christian LM, Franco A, Iams JD, Sheridan J, Glaser R. Depressive symptoms predict exaggerated inflammatory responses to an in vivo immune challenge among pregnant women. Brain Behav Immun. 2010;24(1):49–53. doi:10.1016/j.bbi.2009.05.055.
26. Husky MM, Mazure CM, Maciejewski PK, Swendsen JD. Past depression and gender interact to influence emotional reactivity to daily life stress. Cogn Ther Res. 2009;33(3):264–71.
27. Hammen C. Generation of stress in the course of unipolar depression. J Abnorm Psychol. 1991;100(4):555.
28. Dantzer R, O’Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci. 2008;9(1):46–56. doi:10.1038/nrn2297.
29. Silverstein B, Edwards T, Gamma A, Ajdacic-Gross V, Rossler W, Angst J. The role played by depression associated with somatic symptomatology in accounting for the gender difference in the prevalence of depression. Soc Psychiatry Psychiatr Epidemiol. 2012;48(2):257–63. doi:10.1007/s00127-012-0540-7.
30. Griffis CA, Breen EC, Compton P, Goldberg A, Witarama T, Kotlerman J, et al. Acute painful stress and inflammatory mediator production. Neuroimmunomodulation. 2013;20(3):127–33. doi:10.1159/000346199.
31. Hilderink PH, Burger H, Deeg DJ, Beekman AT, Oude Voshaar RC. The temporal relation between pain and depression: results from the longitudinal aging study Amsterdam. Psychosom Med. 2012;74(9):945–51. doi:10.1097/PSY.0b013e3182733fdd.
32. Irwin MR, Olmstead R, Carrillo C, Sadeghi N, FitzGerald JD, Ranganath VK, et al. Sleep loss exacerbates fatigue, depression, and pain in rheumatoid arthritis. Sleep. 2012;35(4):537–43. doi:10.5665/sleep.1742.
33. Cho HJ, Seeman TE, Kiefe CI, Lauderdale DS, Irwin MR. Sleep disturbance and longitudinal risk of inflammation: moderating influences of social integration and social isolation in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Brain Behav Immun. 2015;46:319–26. doi:10.1016/j.bbi.2015.02.023.
34. Irwin MR. Why sleep is important for health: a psychoneuroimmunology perspective. Annu Rev Psychol. 2015;66(1):143–72. doi:10.1146/annurev-psych-010213-115205. This thorough paper reviews the current evidence linking sleep disturbances to inflammatory processes, and addresses the sex differences and health implications associated with these findings.
35. Bower JE, Ganz PA, Aziz N, Olmstead R, Irwin MR, Cole SW. Inflammatory responses to psychological stress in fatigued breast cancer survivors: relationship to glucocorticoids. Brain Behav Immun. 2007;21(3):251–8. doi:10.1016/j.bbi.2006.08.001.
36. Irwin MR, Carrillo C, Olmstead R. Sleep loss activates cellular markers of inflammation: sex differences. Brain Behav Immun. 2010;24(1):54–7. doi:10.1016/j.bbi.2009.06.001.
37. Valentine RJ, McAuley E, Vieira VJ, Baynard T, Hu L, Evans EM, et al. Sex differences in the relationship between obesity, C-reactive protein, physical activity, depression, sleep quality and fatigue in older adults. Brain Behav Immun. 2009;23(5):643–8. doi:10.1016/j.bbi.2008.12.003.
38. Kendler KS, Gardner CO. Sex differences in the pathways to major depression: a study of opposite-sex twin pairs. Am J Psychiatr. 2014;171(4):426–35. doi:10.1176/appi.ajp.2013.13101375.
39. Robles TF, Slatcher RB, Trombello JM, McGinn MM. Marital quality and health: a meta-analytic review. Psychol Bull. 2014;140(1):140–87. doi:10.1037/a0031859.
40. Whisman MA, Uebelacker LA. A longitudinal investigation of marital adjustment as a risk factor for metabolic syndrome. Health Psychol. 2012;31(1):80–6. doi:10.1037/a0025671.
41. Donoho CJ, Crimmins EM, Seeman TE. Marital quality, gender, and markers of inflammation in the MIDUS cohort. J Marriage Fam. 2013;75(1):127–41. doi:10.1111/j.1741-3737.2012.01023.x. This paper provides a well-written overview of the marital quality and inflammation literature, and explains how this link may differ for men and women. These MIDUS study results suggested spousal support was more strongly linked to inflammation for women than for men, even after accounting for other factors like health behaviors.
42. Whisman MA, Baucom DH. Intimate relationships and psychopathology. Clin Child Fam Psychol Rev. 2011;15(1):4–13. doi:10.1007/s10567-011-0107-2.
43. Kiecolt-Glaser JK, Newton TL. Marriage and health: his and hers. Psychol Bull. 2001;127(4):472–503. doi:10.1037/0033-2909.127.4.472.
44. Kiecolt-Glaser JK, Malarkey W, Chee M, Newton T, Cacioppo J, Mao H, et al. Negative behavior during marital conflict is associated with immunological down-regulation. Psychosom Med. 1993;55(5):395–409.
45. Mayne TJ, O’Leary A, McCrady B, Contrada R, Labouvie E. The differential effects of acute marital distress on emotional, physiological and immune functions in maritally distressed men and women. Psychol Health. 1997;12(2):277–88.
46. Kyrou I, Chrousos GP, Tsigos C. Stress, visceral obesity, and metabolic complications. In: Chrousos GP, Tsigos C, editors. Stress, obesity, and metabolic syndrome, vol. 1083. Oxford: Blackwell Science Publ; 2006. p. 77–110.
47. Shen B-J, Farrell KA, Penedo FJ, Schneiderman N, Orth-Gomer K. Waist circumference moderates the association between marital stress and c-reactive protein in middle-aged healthy women. Ann Behav Med. 2010;40(3):258–64. doi:10.1007/s12160-010-9211-7.
48. Cacioppo JT, Hawkley LC, Thisted RA. Perceived social isolation makes me sad: 5-year cross-lagged analyses of loneliness and depressive symptomatology in the Chicago Health, Aging, and Social Relations Study. Psychol Aging. 2010;25(2):453–63. doi:10.1037/a0017216.
49. Leifheit-Limson EC, Reid KJ, Kasl SV, Lin H, Jones PG, Buchanan DM, et al. The role of social support in health status and depressive symptoms after acute myocardial infarction: evidence for a stronger relationship among women. Circ Cardiovasc Qual Outcomes. 2010;3(2):143–50. doi:10.1161/CIRCOUTCOMES.109.899815.
50. Loerbroks A, Apfelbacher CJ, Bosch JA, Stuermer T. Depressive symptoms, social support, and risk of adult asthma in a population-based cohort study. Psychosom Med. 2010;72(3):309–15. doi:10.1097/PSY.0b013e3181d2f0f1.
51. Yang YC, Schorpp K, Harris KM. Social support, social strain and inflammation: Evidence from a national longitudinal study of U.S. adults. Soc Sci Med. 2014;107:124–35. doi:10.1016/j.socscimed.2014.02.013.
52. Mezuk B, Diez Roux AV, Seeman T. Evaluating the buffering vs. direct effects hypotheses of emotional social support on inflammatory markers: the Multi-Ethnic Study of Atherosclerosis. Brain Behav Immun. 2010;24(8):1294–300. doi:10.1016/j.bbi.2010.06.006.
53. Hughes S, Jaremka LM, Alfano CM, Glaser R, Povoski SP, Lipari AM, et al. Social support predicts inflammation, pain, and depressive symptoms: longitudinal relationships among breast cancer survivors. Psychoneuroendocrinology. 2014;42:38–44. doi:10.1016/j.psyneuen.2013.12.016.
54. Hackett RA, Hamer M, Endrighi R, Brydon L, Steptoe A. Loneliness and stress-related inflammatory and neuroendocrine responses in older men and women. Psychoneuroendocrinology. 2012;37(11):1801–9. doi:10.1016/j.psyneuen.2012.03.016.
55. Jaremka LM, Fagundes CP, Peng J, Bennett JM, Glaser R, Malarkey WB, et al. Loneliness promotes inflammation during acute stress. Psychol Sci. 2013;24(7):1089–97. doi:10.1177/0956797612464059.
56. Kessler RC, McLaughlin KA, Green JG, Gruber MJ, Sampson NA, Zaslavsky AM, et al. Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys. Br J Psychiatry. 2010;197(5):378–85. doi:10.1192/bjp.bp.110.080499.
57. Keyes KM, Eaton NR, Krueger RF, McLaughlin KA, Wall MM, Grant BF, et al. Childhood maltreatment and the structure of common psychiatric disorders. Br J Psychiatry J Ment Sci. 2012;200(2):107–15. doi:10.1192/bjp.bp.111.093062.
58. Nanni V, Uher R, Danese A. Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: a meta-analysis. Am J Psychiatr. 2012;169(2):141–51. doi:10.1176/appi.ajp.2011.11020335.
59. Miller GE, Cole SW. Clustering of depression and inflammation in adolescents previously exposed to childhood adversity. Biol Psychiatry. 2012;72(1):34–40. doi:10.1016/j.biopsych.2012.02.034.
60. Slopen N, Kubzansky LD, McLaughlin KA, Koenen KC. Childhood adversity and inflammatory processes in youth: a prospective study. Psychoneuroendocrinology. 2013;38(2):188–200. doi:10.1016/j.psyneuen.2012.05.013.
61. Danese A, Moffitt TE, Harrington H, Milne BJ, Polanczyk G, Pariante CM, et al. Adverse childhood experiences and adult risk factors for age-related disease depression, inflammation, and clustering of metabolic risk markers. Arch Pediatr Adolesc Med. 2009;163(12):1135–43.
62. Kiecolt-Glaser JK, Gouin J-P, Weng N, Malarkey WB, Beversdorf DQ, Glaser R. Childhood adversity heightens the impact of later-life caregiving stress on telomere length and inflammation. Psychosom Med. 2011;73(1):16.
63. Carpenter LL, Gawuga CE, Tyrka AR, Lee JK, Anderson GM, Price LH. Association between plasma IL-6 response to acute stress and early-life adversity in healthy adults. Neuropsychopharmacology. 2010;35(13):2617–23. doi:10.1038/npp.2010.159.
64. Gouin J-P, Glaser R, Malarkey WB, Beversdorf D, Kiecolt-Glaser JK. Childhood abuse and inflammatory responses to daily stressors. Ann Behav Med. 2012;44(2):287–92. doi:10.1007/s12160-012-9386-1.
65. Lacey RE, Kumari M, McMunn A. Parental separation in childhood and adult inflammation: the importance of material and psychosocial pathways. Psychoneuroendocrinology. 2013;38(11):2476–84. doi:10.1016/j.psyneuen.2013.05.007.
66. Raposa EB, Bower JE, Hammen CL, Najman JM, Brennan PA. A developmental pathway from early life stress to inflammation: the role of negative health behaviors. Psychol Sci. 2014;25(6):1268–74. doi:10.1177/0956797614530570.
67. Schrepf A, Markon K, Lutgendorf SK. From childhood trauma to elevated C-reactive protein in adulthood: the role of anxiety and emotional eating. Psychosom Med. 2014;76(5):327–36. doi:10.1097/PSY.0000000000000072.
68. Finucane MM, Stevens GA, Cowan MJ, Danaei G, Lin JK, Paciorek CJ, et al. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9 · 1 million participants. Lancet. 2011;377(9765):557–67. doi:10.1016/S0140-6736(10)62037-5.
69. Bauman A, Bull F, Chey T, Craig CL, Ainsworth BE, Sallis JF, et al. The International Prevalence Study on Physical Activity: results from 20 countries. Int J Behav Nutr Phys Act. 2009;6:21. doi:10.1186/1479-5868-6-21.
70. Guthold R, Ono T, Strong KL, Chatterji S, Morabia A. Worldwide variability in physical inactivity a 51-country survey. Am J Prev Med. 2008;34(6):486–94. doi:10.1016/j.amepre.2008.02.013.
71. Wells JCK, Marphatia AA, Cole TJ, McCoy D. Associations of economic and gender inequality with global obesity prevalence: understanding the female excess. Soc Sci Med (1982). 2012;75(3):482–90. doi:10.1016/j.socscimed.2012.03.029.
72. Zhao G, Ford ES, Li C, Tsai J, Dhingra S, Balluz LS. Waist circumference, abdominal obesity, and depression among overweight and obese U.S. adults: national health and nutrition examination survey 2005–2006. BMC Psychiatry. 2011;11:130. doi:10.1186/1471-244X-11-130.
73. Vogelzangs N, Kritchevsky SB, Beekman AT, Newman AB, Satterfield S, Simonsick EM, et al. Depressive symptoms and change in abdominal obesity among older persons. Arch Gen Psychiatry. 2008;65(12):1386–93. doi:10.1001/archpsyc.65.12.1386.
74. Luppino FS, de Wit LM, Bouvy PF, Stijnen T, Cuijpers P, Penninx BWJH, et al. Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry. 2010;67(3):220–9. doi:10.1001/archgenpsychiatry.2010.2.
75. de Wit L, Luppino F, van Straten A, Penninx B, Zitman F, Cuijpers P. Depression and obesity: a meta-analysis of community-based studies. Psychiatry Res. 2010;178(2):230–5. doi:10.1016/j.psychres.2009.04.015.
76. Kim C-S, Park H-S, Kawada T, Kim J-H, Lim D, Hubbard NE, et al. Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters. Int J Obes. 2006;30(9):1347–55. doi:10.1038/sj.ijo.0803259.
77. Herder C, Peltonen M, Koenig W, Kraft I, Muller-Scholze S, Martin S, et al. Systemic immune mediators and lifestyle changes in the prevention of type 2 diabetes—results from the Finnish diabetes prevention study. Diabetes. 2006;55(8):2340–6. doi:10.2337/db05-1320.
78. Rana JS, Arsenault BJ, Despres J-P, Cote M, Talmud PJ, Ninio E, et al. Inflammatory biomarkers, physical activity, waist circumference, and risk of future coronary heart disease in healthy men and women. Eur Heart J. 2011;32(3):336–44. doi:10.1093/eurheartj/ehp010.
79. Choi J, Joseph L, Pilote L. Obesity and C-reactive protein in various populations: A systematic review and meta-analysis. Obes Rev. 2013;14(3):232–44. doi:10.1111/obr.12003. This meta-analysis provides an excellent test of the obesity-inflammation link across diverse samples. The results suggest that the relationship between obesity and CRP is larger among women than men.
80. Brydon L, Wright CE, O’Donnell K, Zachary I, Wardle J, Steptoe A. Stress-induced cytokine responses and central adiposity in young women. Int J Obes (2005). 2008;32(3):443–50. doi:10.1038/sj.ijo.0803767.
81. McInnis CM, Thoma MV, Gianferante D, Hanlin L, Chen X, Breines JG, et al. Measures of adiposity predict interleukin-6 responses to repeated psychosocial stress. Brain Behav Immun. 2014;42:33–40. doi:10.1016/j.bbi.2014.07.018.
82. Cooney G, Dwan K, Mead G. Exercise for depression. JAMA. 2014;311(23):2432–3.
83. Hamer M, Sabia S, Batty GD, Shipley MJ, Tabak AG, Singh-Manoux A, et al. Physical activity and inflammatory markers over 10 years follow-up in men and women from the Whitehall II Cohort Study. Circulation. 2012;126(8):928–33. doi:10.1161/CIRCULATIONAHA.112.103879.
84. Lavoie M-E, Rabasa-Lhoret R, Doucet E, Mignault D, Messier L, Bastard J-P, et al. Association between physical activity energy expenditure and inflammatory markers in sedentary overweight and obese women. Int J Obes. 2010;34(9):1387–95. doi:10.1038/ijo.2010.55.
85. Henson J, Yates T, Edwardson CL, Khunti K, Talbot D, Gray LJ, et al. Sedentary time and markers of chronic low-grade inflammation in a high risk population. PLoS ONE. 2013;8(10):e78350. doi:10.1371/journal.pone.0078350. This paper highlights the distinct role of sedentary behavior on inflammation. Adults with greater sedentary time, as measured by accelerometer, had higher IL-6 levels than those with less sedentary time, even after accounting for their BMI and levels of moderate to vigorous physical activity.
86. Troiano RP, Berrigan D, Dodd KW, Mâsse LC, Tilert T, McDowell M. Physical activity in the United States measured by accelerometer. Med Sci Sports Exerc. 2008;40(1):181–8. doi:10.1249/mss.0b013e31815a51b3.
87. Matthews CE, Chen KY, Freedson PS, Buchowski MS, Beech BM, Pate RR, et al. Amount of time spent in sedentary behaviors in the United States, 2003–2004. Am J Epidemiol. 2008;167(7):875–81. doi:10.1093/aje/kwm390.
88. Benros ME, Waltoft BL, Nordentoft M, Ostergaard SD, Eaton WW, Krogh J, et al. Autoimmune diseases and severe infections as risk factors for mood disorders: a nationwide study. JAMA Psychiatry. 2013;70(8):812–20. doi:10.1001/jamapsychiatry.2013.1111.
89. Kiecolt-Glaser JK, Jaremka L, Andridge R, Peng J, Habash D, Fagundes CP, et al. Marital discord, past depression, and metabolic responses to high-fat meals: interpersonal pathways to obesity. Psychoneuroendocrinology. 2015;52:239–50. doi:10.1016/j.psyneuen.2014.11.018.
90. Terrill AL, Garofalo JP, Soliday E, Craft R. Multiple roles and stress burden in women: a conceptual model of heart disease risk. J Appl Biobehav Res. 2012;17(1):4–22. doi:10.1111/j.1751-9861.2011.00071.x.
91. Altemus M, Sarvaiya N, Neill Epperson C. Sex differences in anxiety and depression clinical perspectives. Front Neuroendocrinol. 2014;35(3):320–30. doi:10.1016/j.yfrne.2014.05.004.
92. Gaskins AJ, Wilchesky M, Mumford SL, Whitcomb BW, Browne RW, Wactawski-Wende J, et al. Endogenous reproductive hormones and c-reactive protein across the menstrual cycle: the biocycle study. Am J Epidemiol. 2012;175(5):423–31. doi:10.1093/aje/kwr343.
93. Figueroa-Vega N, Moreno-Frías C, Malacara JM. Alterations in adhesion molecules, pro-inflammatory cytokines and cell-derived microparticles contribute to intima-media thickness and symptoms in postmenopausal women. PLoS ONE. 2015;10(5):e0120990. doi:10.1371/journal.pone.0120990.
94. Kop WJ, & Mommersteeg PMC (2015) Psychoneuroimmunological pathways and sex differences in coronary artery disease: the role of inflammation and estrogen. In K. Orth-Gomér, N. Schneiderman, V. Vaccarino, & H.-C. Deter (Eds.), Psychosocial Stress and Cardiovascular Disease in Women (pp. 129–149). Springer International Publishing. Retrieved from http://link.springer.com/chapter/10.1007/978-3-319-09241-6_9
95. Rubinow DR, Girdler SS. Hormones, heart disease, and health: individualized medicine versus throwing the baby out with the bathwater. Depress Anxiety. 2011;28(4):282–96. doi:10.1002/da.20810.
96. Moreau KL, Hildreth KL. Vascular aging across the menopause transition in healthy women. Adv Vasc Med. 2014;2014:e204390. doi:10.1155/2014/204390.
97. Michaud M, Balardy L, Moulis G, Gaudin C, Peyrot C, Vellas B, et al. Proinflammatory cytokines, aging, and age-related diseases. J Am Med Dir Assoc. 2013;14(12):877–82. doi:10.1016/j.jamda.2013.05.009.
98. Xu J, Kochanek KD, Murphy SL, Arias E. Mortality in the United States, 2012. NCHS Data Brief. 2014;168:1–8.
99. Kaptoge S, Seshasai SRK, Gao P, Freitag DF, Butterworth AS, Borglykke A, Danesh J (2013) Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis. European Heart Journal, eht367. doi:10.1093/eurheartj/eht367
100. Murray CJL, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2197–223. doi:10.1016/S0140-6736(12)61689-4.