Small Molecules that Target the Toxic RNA in Myotonic Dystrophy Type 2

ChemMedChem

Volumn 9, Issue 11, 2014, Pages 2455-2462

  Nguyen, Lien ^a   Lee, Ju Yeon ^a   Wong, Chun Ho ^a   Zimmerman, Steven C ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

bisamidinium; DM2 therapeutics; myotonic dystrophy; triaminopyrimidine

Indexed keywords

ACRIDINE DERIVATIVE; MUSCLE PROTEIN; MYOTONIC DYSTROPHY PROTEIN 2; MYOTONIC DYSTROPHY PROTEIN 2 LIGAND; MYOTONIC DYSTROPHY PROTEIN KINASE; N 1, N 3 BIS[2 (2,4,6 TRIAMINOPYRIMIDIN 5 YL)ETHYL]ISOPHTHALIMIDAMIDE HYDROCHLORIDE SALT; N 1, N 3 BIS[3 (2,4,6 TRIAMINOPYRIMIDIN 5 YL)PROPYL]ISOPHTHALIMIDAMIDE HYDROCHLORIDE SALT; N 1, N 3 BIS[4 (2,4,6 TRIAMINOPYRIMIDIN 5 YL)BUTYL]ISOPHTHALIMIDAMIDE HYDROCHLORIDE SALT; N 1, N 4 BIS[2 (2,4,6 TRIAMINOPYRIMIDIN 5 YL)ETHYL]TEREPHTHALIMIDAMIDE HYDROCHLORIDE SALT; N 1, N 4 BIS[3 (2,4,6 TRIAMINOPYRIMIDIN 5 YL)PROPYL]TEREPHTHALIMIDAMIDE HYDROCHLORIDE SALT; N 1, N 4 BIS[4 (2,4,6 TRIAMINOPYRIMIDIN 5 YL)BUTYL]TEREPHTHALIMIDAMIDE HYDROCHLORIDE SALT; PYRIMIDINE DERIVATIVE; RNA; UNCLASSIFIED DRUG; BISAMIDINIUM; IMIDAZOLE DERIVATIVE; INTERCALATING AGENT; LIGAND; MBNL1 PROTEIN, HUMAN; MICROSATELLITE DNA; PYRIMIDINE; RNA BINDING PROTEIN;

ARTICLE; DRUG CYTOTOXICITY; DRUG SYNTHESIS; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GEL MOBILITY SHIFT ASSAY; GENE DISRUPTION; GENE TARGETING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; MUSCULAR DYSTROPHY; MYOTONIC DYSTROPHY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; THIN LAYER CHROMATOGRAPHY; CELL SURVIVAL; CHEMISTRY; CONFOCAL MICROSCOPY; DRUG EFFECTS; GENETICS; HELA CELL LINE; IC50; KINETICS; METABOLISM; PATHOLOGY;

ACRIDINES; CELL SURVIVAL; HELA CELLS; HUMANS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; INTERCALATING AGENTS; KINETICS; LIGANDS; MICROSATELLITE REPEATS; MICROSCOPY, CONFOCAL; MYOTONIC DYSTROPHY; PYRIMIDINES; RNA; RNA-BINDING PROTEINS;

EID: 84939136634     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201402095     Document Type: Article

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