Allosteric modulation of sigma-1 receptors by SKF83959 inhibits microglia-mediated inflammation

Journal of Neurochemistry

Volumn 134, Issue 5, 2015, Pages 904-914

  Wu, Zhuang ^a   Li, Linlang ^a   Zheng, Long Tai ^a   Xu, Zhihong ^b   Guo, Lin ^a   Zhen, Xuechu ^a  

^a SOOCHOW UNIVERSITY   (China)

^b Jiangsu Huayi Technology Co   (China)

Author keywords

allosteric modulation; dehydroepiandrosterone; microglia; neuroinflammation; sigma 1 receptor; SKF83959

Indexed keywords

6 CHLORO 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 3 METHYL 1 (3 METHYLPHENYL) 1H 3 BENZAZEPINE; BD 1063; DOPAMINE 1 RECEPTOR; I KAPPA B ALPHA; I KAPPA B KINASE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; KETOCONAZOLE; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; N [2 (3,4 DICHLOROPHENYL)ETHYL] 2 DIMETHYLAMINO N METHYLETHYLAMINE; OPIATE ANTAGONIST; PRASTERONE; REACTIVE OXYGEN METABOLITE; SIGMA 1 OPIATE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 1-(2-(3,4-DICHLOROPHENYL)ETHYL)-4-METHYLPIPERAZINE; 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; ANTIINFLAMMATORY AGENT; CULTURE MEDIUM; ETHYLENEDIAMINE DERIVATIVE; IL10 PROTEIN, MOUSE; INTERLEUKIN 10; NARCOTIC ANTAGONIST; NITRIC OXIDE; NOS2 PROTEIN, MOUSE; PIPERAZINE DERIVATIVE; PROTEIN BINDING; SIGMA OPIATE RECEPTOR; SIGMA-1 RECEPTOR; SK&F 83959;

ADULT; ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG PROTEIN BINDING; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HT 22 CELL LINE; MALE; MEDIATOR RELEASE; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROBLASTOMA CELL LINE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RAT; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL LINE; DRUG EFFECTS; ENZYME INDUCTION; GENETICS; IMMUNOMODULATION; METABOLISM; NEUROBLASTOMA; PATHOLOGY; PHARMACOLOGY; SECRETION (PROCESS); SPRAGUE DAWLEY RAT;

2,3,4,5-TETRAHYDRO-7,8-DIHYDROXY-1-PHENYL-1H-3-BENZAZEPINE; ALLOSTERIC REGULATION; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CULTURE MEDIA, CONDITIONED; DEHYDROEPIANDROSTERONE; ENZYME INDUCTION; ETHYLENEDIAMINES; INTERLEUKIN-10; KETOCONAZOLE; LIPOPOLYSACCHARIDES; MALE; MICE; MICROGLIA; NARCOTIC ANTAGONISTS; NEUROBLASTOMA; NEUROIMMUNOMODULATION; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PIPERAZINES; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RECEPTORS, SIGMA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84938995787     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.13182     Document Type: Article

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