Absence of both Sos-1 and Sos-2 in peripheral CD4+ T cells leads to PI3K pathway activation and defects in migration

European Journal of Immunology

Volumn 45, Issue 8, 2015, Pages 2389-2395

  Guittard, Geoffrey ^a   Kortum, Robert L ^a,b   Balagopalan, Lakshmi ^a   Çuburu, Nicolas ^a   Nguyen, Phan ^a   Sommers, Connie L ^a   Samelson, Lawrence E ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

CD62L; Erk; Grb2; PI3K AKT; Signaling; Sos; T cell

Indexed keywords

GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INTERLEUKIN 2; L SELECTIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SOS 2 PROTEIN; SOS PROTEIN; UNCLASSIFIED DRUG; GRB2 PROTEIN, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR; SOS2 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CELL STIMULATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; KNOCKOUT MOUSE; LYMPHOCYTE MIGRATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; CELL MOTION; GENETICS; IMMUNOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; ENZYME ACTIVATION; GRB2 ADAPTOR PROTEIN; INTERLEUKIN-2; L-SELECTIN; MICE; MICE, KNOCKOUT; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; SON OF SEVENLESS PROTEINS; SOS1 PROTEIN;

EID: 84938984104     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201445226     Document Type: Article

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