Pharmacological Postconditioning with Lactic Acid and Hydrogen Rich Saline Alleviates Myocardial Reperfusion Injury in Rats

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Zhang, Guoming ^a   Gao, Song ^b   Li, Xiaoyan ^a   Zhang, Lulu ^b   Tan, Hong ^a   Xu, Lin ^a   Chen, Yaoyu ^c   Geng, Yongjian ^b   Lin, Yanliang ^d   Aertker, Benjamin ^b   Sun, Yuanyuan ^a  

^a JINAN MILITARY GENERAL HOSPITAL   (China)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c NANJING MEDICAL UNIVERSITY   (China)

^d SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; HYDROGEN; LACTIC ACID; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; SODIUM CHLORIDE; TNF PROTEIN, HUMAN; TUMOR NECROSIS FACTOR;

ANIMAL; APOPTOSIS; CARDIAC MUSCLE; DISEASE MODEL; DRUG EFFECTS; FEMALE; ISCHEMIC POSTCONDITIONING; MALE; METABOLISM; MITOCHONDRION; MYOCARDIAL REPERFUSION INJURY; PROCEDURES; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; CASPASE 8; DISEASE MODELS, ANIMAL; FEMALE; HYDROGEN; ISCHEMIC POSTCONDITIONING; LACTIC ACID; MALE; MAP KINASE SIGNALING SYSTEM; MITOCHONDRIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84938977818     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep09858     Document Type: Article

References (52)

1. Santulli, G. Epidemiology of Cardiovascular Disease in the 21st Century: Updated Numbers and Updated Facts. JCvD. 1, 1-2 (2013
2. Go, A. S. et al. Heart disease and stroke statistics-2014 update: A report from the American Heart Association. Circulation. 129, e28-e292 (2014
3. Lozano, R. et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet. 380, 2095-2128 (2013
4. Mahmood, S. S., Levy, D.,Vasan, R. S.&Wang, T. J. The Framingham Heart Study and the epidemiology of cardiovascular disease: A historical perspective. Lancet. 383, 999-1008 (2014
5. Minamino, T. Cardioprotection from ischemia/reperfusion injury: Basic and translational research. Circ J. 76, 1074-1082 (2012
6. Braunwald, E. & Kloner, R. A. Myocardial reperfusion: A double-edged sword? J Clin Invest. 76, 1713-1719 (1985
7. Zhao, Z. Q. et al. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: Comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol. 285, H579-588 (2003
8. Sanada, S., Komuro, I. & Kitakaze, M. Pathophysiology of myocardial reperfusion injury: Preconditioning, postconditioning, and translational aspects of protective measures. Am J Physiol Heart Circ Physiol. 301, H1723-1741 (2011
9. Liu, X. et al.Attenuation of reperfusion injury by renal ischemic postconditioning: The role of NO. Biochem Biophys Res Commun. 359, 628-634 (2007
10. Zhang, W. H. et al. Post-conditioning protects rat cardiomyocytes via PKCepsilon-mediated calcium-sensing receptors. Biochem Biophys Res Commun. 361, 659-664 (2007
11. Thuny, F. et al. Post-Conditioning Reduces Infarct Size and Edema in Patients With ST-Segment Elevation Myocardial Infarction. J Am Coll Cardiol. 59, 2175-2181 (2012
12. Zhang, G. et al. An improved postconditioning algorithm: Gradually increased reperfusion provides improved cardioprotection in rats. MolMed Rep. 8, 696-702 (2013
13. Meybohm, P. et al. Pharmacological postconditioning with sevoflurane after cardiopulmonary resuscitation reduces myocardial dysfunction. Crit Care. 15, R241 (2011
14. Bouhidel, J. O., Wang, P., Li, Q. & Cai, H. Pharmacological postconditioning treatment of myocardial infarction with netrin-1. Front Biosci (Landmark Ed). 19, 566-570 (2014
15. Duan, X. et al. Acidic buffer or plus cyclosporine A post-conditioning protects isolated rat hearts against ischemia-reperfusion injury. Perfusion. 26, 245-252 (2011
16. Inserte, J. et al. Effect of acidic reperfusion on prolongation of intracellular acidosis and myocardial salvage. Cardiovasc Res. 77, 782-790 (2008
17. Fujita, M. et al. Prolonged transient acidosis during early reperfusion contributes to the cardioprotective effects of postconditioning. Am J Physiol Heart Circ Physiol. 292, H2004-2008 (2007
18. Rodriguez-Sinovas, A. et al. Intracoronary acid infusion as an alternative to ischemic postconditioning in pigs. Basic Res Cardiol. 104,761-771 (2009
19. Gross, G. J. et al. Evidence for role of epoxyeicosatrienoic acids in mediating ischemic preconditioning and postconditioning in dog. Am J Physiol Heart Circ Physiol. 297, H47-52 (2009
20. Katragadda, D. et al. Epoxyeicosatrienoic acids limit damage to mitochondrial function following stress in cardiac cells. J Mol Cell Cardiol. 46, 867-875 (2009
21. Penna, C. et al. Post-ischemic early acidosis in cardiac postconditioning modifies the activity of antioxidant enzymes, reduces nitration, and favors protein S-nitrosylation. Pflugers Arch. 462, 219-233 (2011
22. Ohta, S. Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases. Biochim Biophys Acta. 1820, 586-594 (2012
23. Xu, X. F. & Zhang, J. Saturated hydrogen saline attenuates endotoxin-induced acute liver dysfunction in rats. Physiol Res. 62, 395-403 (2013
24. Liu, Y. et al. Hydrogen saline offers neuroprotection by reducing oxidative stress in a focal cerebral ischemia-reperfusion rat model. Med Gas Res. 1, 15 (2011
25. Sakai, K. et al. Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine. Scand Cardiovasc J. 46, 183-189 (2012
26. Zhang, Y. et al. Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion. Int J Cardiol. 148, 91-95 (2011
27. Sumi, S. et al. Postconditioning effect of granulocyte colony-stimulating factor is mediated through activation of risk pathway and opening of the mitochondrial KATP channels. Am J Physiol Heart Circ Physiol. 299, H1174-1182 (2010
28. Sun, H. Y. et al. Postconditioning attenuates cardiomyocyte apoptosis via inhibition of JNK and p38 mitogen-activated protein kinase signaling pathways. Apoptosis. 11, 1583-1593 (2006
29. Gao, S. et al. Glucose regulated protein 78 prompts scavenger receptor Amediated secretion of tumor necrosis factor-alpha by RAW 264.7 cells. Clin Exp Pharmacol Physiol. 36, 940-944 (2009
30. Luschen, S., Scherer, G., Ussat, S., Ungefroren,H. & Adam-Klages, S. Inhibition of p38 mitogen-activated protein kinase reduces TNF-induced activation of NFkappaB, elicits caspase activity, and enhances cytotoxicity. Exp Cell Res. 293, 196-206 (2004
31. Assefa, Z. et al. p38 mitogen-activated protein kinase regulates a novel, caspaseindependent pathway for the mitochondrial cytochrome c release in ultraviolet B radiation-induced apoptosis. J Biol Chem. 275, 21416-21421 (2000
32. Tissier, R. et al. Pharmacological postconditioning with the phytoestrogen genistein. J Mol Cell Cardiol. 42, 79-87 (2007
33. Tessier-Vetzel, D., Tissier, R.,Waintraub, X.,Ghaleh, B.&Berdeaux, A. Isoflurane inhaled at the onset of reperfusion potentiates the cardioprotective effect of ischemic postconditioning through a NO-dependent mechanism. J Cardiovasc Pharmacol. 47, 487-492 (2006
34. Zhao, Z. Q. & Vinten-Johansen, J. Postconditioning: Reduction of reperfusioninduced injury. Cardiovasc Res. 70, 200-211 (2006
35. Ohsawa, I. et al.Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 13, 688-694 (2007
36. Sun, Q. et al. Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats. Exp Biol Med (Maywood). 234, 1212-1219 (2009
37. Su, N. et al. Hydrogen-rich water reestablishes ROS homeostasis but exerts differential effects on anthocyanin synthesis in two varieties of radish sprouts under UV-A irradiation. J Agric Food Chem. 62, 6454-6462 (2014
38. Qian, L., Shen, J., Chuai, Y. & Cai, J. Hydrogen as a new class of radioprotective agent. Int J Biol Sci. 9, 887-894 (2013
39. Dietl, K. et al. Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes. J Immunol. 184, 1200-1209 (2010
40. Zhang, H. et al. Effect of beta-(3,4-dihydroxyphenyl)lactic acid on oxidative stress stimulated by high glucose levels in human peritoneal mesothelial cells. J Int Med Res. 40, 943-953 (2012
41. Dongo, E., Hornyak, I., Benko, Z. & Kiss, L. The cardioprotective potential of hydrogen sulfide in myocardial ischemia/reperfusion injury (review). Acta Physiol Hung. 98, 369-381 (2011
42. Kinnally, K. W., Peixoto, P. M., Ryu, S. Y. & Dejean, L.M. Is mPTP the gatekeeper for necrosis, apoptosis, or both? Biochim Biophys Acta. 1813, 616-622 (2011
43. Heusch, G., Boengler, K. & Schulz, R. Inhibition of mitochondrial permeability transition pore opening: The Holy Grail of cardioprotection. Basic Res Cardiol. 105, 151-154 (2010
44. Goldstein, J. C. et al. Cytochrome c is released in a single step during apoptosis. Cell Death Differ. 12, 453-462 (2005
45. Drose, S. Differential effects of complex II on mitochondrial ROS production and their relation to cardioprotective pre-and postconditioning. Biochim Biophys Acta. 1827, 578-587 (2013
46. Hausenloy, D. J. Cardioprotection techniques: Preconditioning, postconditioning and remote conditioning (basic science). Curr Pharm Des. 19, 4544-4563 (2013
47. Umanskaya, A. et al. Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging. Proc Natl Acad Sci U S A. 111, 15250-15255 (2014
48. Cardinal, J. S. et al.Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney Int. 77, 101-109 (2010
49. Itoh, T. et al. Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells. Biochem Biophys Res Commun. 389, 651-656 (2009
50. Li, Y., Ge, X. & Liu, X. The cardioprotective effect of postconditioning is mediated by ARC through inhibiting mitochondrial apoptotic pathway. Apoptosis. 14, 164-172 (2009
51. Kerendi, F. et al. Remote postconditioning. Brief renal ischemia and reperfusion applied before coronary artery reperfusion reduces myocardial infarct size via endogenous activation of adenosine receptors. Basic Res Cardiol. 100, 404-412 (2005
52. Lacerda, L., Somers, S., Opie, L. H. & Lecour, S. Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway. Cardiovasc Res. 84, 201-208 (2009).