TNF-dependent regulation and activation of innate immune cells are essential for host protection against cerebral tuberculosis

Journal of Neuroinflammation

Volumn 12, Issue 1, 2015, Pages

  Francisco, Ngiambudulu M ^a   Hsu, Nai Jen ^a   Keeton, Roanne ^a   Randall, Philippa ^a   Sebesho, Boipelo ^a   Allie, Nasiema ^a,b   Govender, Dhirendra ^a,c   Quesniaux, Valerie ^d,e   Ryffel, Bernhard ^d,e   Kellaway, Lauriston ^a   Jacobs, Muazzam ^a,c  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF THE WESTERN CAPE   (South Africa)

^c NATIONAL HEALTH LABORATORY SERVICE   (South Africa)

^d UNIVERSITÉ D'ORLÉANS   (France)

^e Laboratoire d'Immunologie et Embryologie Moleculaires Orleans   (France)

Author keywords

Infection; Mycobacterium tuberculosis; Neuron; Tumour necrosis factor

Indexed keywords

CHEMOKINE; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR; CYTOKINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC RESISTANCE; ARTICLE; BACILLUS; BACTERIAL LOAD; BRAIN; BRAIN HOMOGENATE; CELL FUNCTION; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM TUBERCULOSIS; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOREGULATION; INNATE IMMUNITY; LUNG; MICROSCOPY; MORTALITY; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NERVE CELL; NERVOUS SYSTEM INFLAMMATION; NEUROPATHOLOGY; NEUTROPHIL; NONHUMAN; OUTCOME ASSESSMENT; PHENOTYPE; SPLEEN; TUBERCULOSIS; ANIMAL; COMPARATIVE STUDY; DEFICIENCY; DENDRITIC CELL; DISEASE MODEL; DISEASE RESISTANCE; GENETICS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; MICROBIOLOGY; MICROGLIA; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; VIRUS REPLICATION;

ANIMALS; BRAIN; CELL PROLIFERATION; CHEMOKINES; CYTOKINES; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; DISEASE RESISTANCE; HOST-PATHOGEN INTERACTIONS; IMMUNITY, INNATE; MACROPHAGES; MICE; MICE, KNOCKOUT; MICROGLIA; MYCOBACTERIUM TUBERCULOSIS; NEURONS; TUBERCULOSIS, CENTRAL NERVOUS SYSTEM; TUMOR NECROSIS FACTOR-ALPHA; VIRUS REPLICATION;

EID: 84938969899     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-015-0345-1     Document Type: Article

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