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Volumn 5, Issue , 2015, Pages

Assessing Cholesterol Storage in Live Cells and C. elegans by Stimulated Raman Scattering Imaging of Phenyl-Diyne Cholesterol

Author keywords

[No Author keywords available]

Indexed keywords

ALKYNE DERIVATIVE; CHOLESTEROL; FAT DROPLET;

EID: 84938951395     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep07930     Document Type: Article
Times cited : (120)

References (62)
  • 1
    • 0022389171 scopus 로고
    • Cholesterol and the cell membrane
    • Yeagle, P. L. Cholesterol and the cell membrane. Biochim. Biophys. Acta 822, 267-287 (1985).
    • (1985) Biochim. Biophys. Acta , vol.822 , pp. 267-287
    • Yeagle, P.L.1
  • 2
    • 74849118341 scopus 로고    scopus 로고
    • Lipid rafts as a membrane-organizing principle
    • Lingwood, D., Simons, K. Lipid rafts as a membrane-organizing principle. Science 327, 46-50 (2010).
    • (2010) Science , vol.327 , pp. 46-50
    • Lingwood, D.1    Simons, K.2
  • 3
    • 14644391519 scopus 로고    scopus 로고
    • OSBP is a cholesterol-regulated scaffolding protein in control of ERK 1/2 activation
    • Wang, P. Y., Weng, J., Anderson, R. G. OSBP is a cholesterol-regulated scaffolding protein in control of ERK 1/2 activation. Science 307, 1472-1476 (2005).
    • (2005) Science , vol.307 , pp. 1472-1476
    • Wang, P.Y.1    Weng, J.2    Anderson, R.G.3
  • 4
    • 84871861963 scopus 로고    scopus 로고
    • Cholesterol modulates cell signaling and protein networking by specifically interacting with PDZ domain-containing scaffold proteins
    • Sheng, R. et al. Cholesterol modulates cell signaling and protein networking by specifically interacting with PDZ domain-containing scaffold proteins. Nat. Commun. 3, 1249 (2012).
    • (2012) Nat. Commun , vol.3 , pp. 1249
    • Sheng, R.1
  • 5
    • 0034672716 scopus 로고    scopus 로고
    • Cholesterol modification of proteins
    • Mann, R. K., Beachy, P. A. Cholesterol modification of proteins. Biochim. Biophys. Acta 1529, 188-202 (2000).
    • (2000) Biochim. Biophys. Acta , vol.1529 , pp. 188-202
    • Mann, R.K.1    Beachy, P.A.2
  • 6
    • 30344473341 scopus 로고    scopus 로고
    • Protein sensors for membrane sterols
    • Goldstein, J. L., DeBose-Boyd, R. A.& Brown, M. S. Protein sensors for membrane sterols. Cell 124, 35-46 (2006).
    • (2006) Cell , vol.124 , pp. 35-46
    • Goldstein, J.L.1    DeBose-Boyd, R.A.2    Brown, M.S.3
  • 7
    • 38549141572 scopus 로고    scopus 로고
    • Cellular cholesterol trafficking and compartmentalization
    • Ikonen, E. Cellular cholesterol trafficking and compartmentalization. Nat. Rev. Mol. Cell Biol. 9, 125-138 (2008).
    • (2008) Nat. Rev. Mol. Cell Biol , vol.9 , pp. 125-138
    • Ikonen, E.1
  • 8
    • 0030943621 scopus 로고    scopus 로고
    • Acyl-coenzyme A: Cholesterol acyltransferase
    • Chang, T. Y., Chang, C. C., Cheng, D. Acyl-coenzyme A: cholesterol acyltransferase. Annu. Rev. Biochem. 66, 613-638 (1997).
    • (1997) Annu. Rev. Biochem , vol.66 , pp. 613-638
    • Chang, T.Y.1    Chang, C.C.2    Cheng, D.3
  • 9
    • 70449769682 scopus 로고    scopus 로고
    • Lipid droplets finally get a little R-E-S-P-E-C-T
    • Farese, R. V., Jr.,Walther, T. C. Lipid droplets finally get a little R-E-S-P-E-C-T. Cell 139, 855-860 (2009).
    • (2009) Cell , vol.139 , pp. 855-860
    • Farese, R.V.1    Walther, T.C.2
  • 10
    • 0036790413 scopus 로고    scopus 로고
    • Consequences of cellular cholesterol accumulation: Basic concepts and physiological implications
    • Tabas, I. Consequences of cellular cholesterol accumulation: basic concepts and physiological implications. J. Clin. Invest. 110, 905-911 (2002).
    • (2002) J. Clin. Invest , vol.110 , pp. 905-911
    • Tabas, I.1
  • 11
    • 0344875214 scopus 로고    scopus 로고
    • A riddle wrapped in a mystery: Understanding Niemann-Pick disease, type C
    • Patterson, M. C. A riddle wrapped in a mystery: understanding Niemann-Pick disease, type C. Neurologist 9, 301-310 (2003).
    • (2003) Neurologist , vol.9 , pp. 301-310
    • Patterson, M.C.1
  • 12
    • 84888791736 scopus 로고    scopus 로고
    • 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology
    • Nelson, E. R. et al. 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. Science 342, 1094-1098 (2013).
    • (2013) Science , vol.342 , pp. 1094-1098
    • Nelson, E.R.1
  • 13
    • 84895741045 scopus 로고    scopus 로고
    • Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness
    • Yue, S. et al. Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness. Cell Metab. 19, 393-406 (2014).
    • (2014) Cell Metab , vol.19 , pp. 393-406
    • Yue, S.1
  • 15
    • 36448929114 scopus 로고    scopus 로고
    • Cholesterol reporter molecules
    • Gimpl, G., Gehrig-Burger, K. Cholesterol reporter molecules. Biosci. Rep. 27, 335-358 (2007).
    • (2007) Biosci. Rep , vol.27 , pp. 335-358
    • Gimpl, G.1    Gehrig-Burger, K.2
  • 16
    • 0027096635 scopus 로고
    • Progesterone blocks cholesterol translocation from lysosomes
    • Butler, J. D. et al. Progesterone blocks cholesterol translocation from lysosomes. J. Biol. Chem. 267, 23797-23805 (1992).
    • (1992) J. Biol. Chem , vol.267 , pp. 23797-23805
    • Butler, J.D.1
  • 18
    • 1542513994 scopus 로고    scopus 로고
    • A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain
    • Reid, P. C. et al. A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain. J. Lipid Res. 45, 582-591 (2004).
    • (2004) J. Lipid Res , vol.45 , pp. 582-591
    • Reid, P.C.1
  • 19
    • 0031687965 scopus 로고    scopus 로고
    • Cholesterol distribution in living cells: Fluorescence imaging using dehydroergosterol as a fluorescent cholesterol analog
    • Mukherjee, S., Zha, X., Tabas, I.&Maxfield, F. R. Cholesterol distribution in living cells: fluorescence imaging using dehydroergosterol as a fluorescent cholesterol analog. Biophys. J. 75, 1915-1925 (1998).
    • (1998) Biophys. J , vol.75 , pp. 1915-1925
    • Mukherjee, S.1    Zha, X.2    Tabas, I.3    Maxfield, F.R.4
  • 20
    • 0035167813 scopus 로고    scopus 로고
    • Distribution and transport of cholesterol in Caenorhabditis elegans
    • Matyash, V. et al. Distribution and transport of cholesterol in Caenorhabditis elegans. Mol. Biol. Cell 12, 1725-1736 (2001).
    • (2001) Mol. Biol. Cell , vol.12 , pp. 1725-1736
    • Matyash, V.1
  • 21
    • 53849130991 scopus 로고    scopus 로고
    • BODIPY-cholesterol: A new tool to visualize sterol trafficking in living cells and organisms
    • Holtta-Vuori, M. et al. BODIPY-cholesterol: a new tool to visualize sterol trafficking in living cells and organisms. Traffic 9, 1839-1849 (2008).
    • (2008) Traffic , vol.9 , pp. 1839-1849
    • Holtta-Vuori, M.1
  • 22
    • 84874644958 scopus 로고    scopus 로고
    • Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells
    • Hulce, J. J. et al. Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells. Nat. Methods 10, 259-264 (2013).
    • (2013) Nat. Methods , vol.10 , pp. 259-264
    • Hulce, J.J.1
  • 23
    • 84894765396 scopus 로고    scopus 로고
    • A novel alkyne cholesterol to trace cellular cholesterol metabolism and localization
    • Hofmann, K. et al. A novel alkyne cholesterol to trace cellular cholesterol metabolism and localization. J. Lipid Res. 55, 583-591 (2014).
    • (2014) J. Lipid Res , vol.55 , pp. 583-591
    • Hofmann, K.1
  • 24
    • 79959224232 scopus 로고    scopus 로고
    • Filipin recognizes both GM1 and cholesterol in GM1 gangliosidosis mouse brain
    • Arthur, J. R., Heinecke, K. A., Seyfried, T. N. Filipin recognizes both GM1 and cholesterol in GM1 gangliosidosis mouse brain. J. Lipid Res. 52, 1345-1351 (2011).
    • (2011) J. Lipid Res , vol.52 , pp. 1345-1351
    • Arthur, J.R.1    Heinecke, K.A.2    Seyfried, T.N.3
  • 25
    • 84887399657 scopus 로고    scopus 로고
    • Membrane orientation and lateral diffusion of BODIPYcholesterol as a function of probe structure
    • Solanko, L. M. et al. Membrane orientation and lateral diffusion of BODIPYcholesterol as a function of probe structure. Biophys. J. 105, 2082-2092 (2013).
    • (2013) Biophys. J , vol.105 , pp. 2082-2092
    • Solanko, L.M.1
  • 26
    • 79955047997 scopus 로고    scopus 로고
    • Imaging of EdU, an alkyne-tagged cell proliferation probe, by Raman microscopy
    • Yamakoshi, H. et al. Imaging of EdU, an alkyne-tagged cell proliferation probe, by Raman microscopy. J. Am. Chem. Soc. 133, 6102-6105 (2011).
    • (2011) J. Am. Chem. Soc , vol.133 , pp. 6102-6105
    • Yamakoshi, H.1
  • 27
    • 84871531946 scopus 로고    scopus 로고
    • Alkyne-tag Raman imaging for visualization of mobile small molecules in live cells
    • Yamakoshi, H. et al. Alkyne-tag Raman imaging for visualization of mobile small molecules in live cells. J. Am. Chem. Soc. 134, 20681-20689 (2012).
    • (2012) J. Am. Chem. Soc , vol.134 , pp. 20681-20689
    • Yamakoshi, H.1
  • 28
    • 79951821202 scopus 로고    scopus 로고
    • Chemical contrast for imaging living systems: Molecular vibrations drive CARS microscopy
    • Pezacki, J. P. et al. Chemical contrast for imaging living systems: molecular vibrations drive CARS microscopy. Nat. Chem. Biol. 7, 137-145 (2011).
    • (2011) Nat. Chem. Biol , vol.7 , pp. 137-145
    • Pezacki, J.P.1
  • 29
    • 84869414363 scopus 로고    scopus 로고
    • Noninvasive imaging of intracellular lipid metabolism in macrophages by Raman microscopy in combination with stable isotopic labeling
    • Matthaus, C. et al. Noninvasive imaging of intracellular lipid metabolism in macrophages by Raman microscopy in combination with stable isotopic labeling. Anal. Chem. 84, 8549-8556 (2012).
    • (2012) Anal. Chem , vol.84 , pp. 8549-8556
    • Matthaus, C.1
  • 31
    • 33645825831 scopus 로고    scopus 로고
    • Living cells as test tubes
    • Xie, X. S., Yu, J., Yang, W. Y. Living cells as test tubes. Science 312, 228-230 (2006).
    • (2006) Science , vol.312 , pp. 228-230
    • Xie, X.S.1    Yu, J.2    Yang, W.Y.3
  • 32
    • 79958184416 scopus 로고    scopus 로고
    • Highly sensitive vibrational imaging by femtosecond pulse stimulated Raman loss
    • Zhang, D., Slipchenko, M. N., Cheng, J. X. Highly sensitive vibrational imaging by femtosecond pulse stimulated Raman loss. J. Phys. Chem. Lett. 2, 1248-1253 (2011).
    • (2011) J. Phys. Chem. Lett , vol.2 , pp. 1248-1253
    • Zhang, D.1    Slipchenko, M.N.2    Cheng, J.X.3
  • 33
    • 84879940801 scopus 로고    scopus 로고
    • Vibrational imaging of newly synthesized proteins in live cells by stimulated Raman scattering microscopy
    • Wei, L. et al. Vibrational imaging of newly synthesized proteins in live cells by stimulated Raman scattering microscopy. Proc. Natl. Acad. Sci. U. S. A. 110, 11226-11231 (2013).
    • (2013) Proc. Natl. Acad. Sci. U. S. A , vol.110 , pp. 11226-11231
    • Wei, L.1
  • 34
    • 80052229059 scopus 로고    scopus 로고
    • Quantitative detection of C-deuterated drugs by CARS microscopy and Raman microspectroscopy
    • Bergner, G. et al. Quantitative detection of C-deuterated drugs by CARS microscopy and Raman microspectroscopy. Analyst 136, 3686-3693 (2011).
    • (2011) Analyst , vol.136 , pp. 3686-3693
    • Bergner, G.1
  • 35
    • 84897954092 scopus 로고    scopus 로고
    • Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering
    • Wei, L. et al. Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering. Nat. Methods 4, 410-412 (2014).
    • (2014) Nat. Methods , vol.4 , pp. 410-412
    • Wei, L.1
  • 36
    • 84901757990 scopus 로고    scopus 로고
    • Live-cell stimulated Raman scattering imaging of alkyne-tagged biomolecules
    • Hong, S. et al. Live-cell stimulated Raman scattering imaging of alkyne-tagged biomolecules. Angew. Chem. Int. Ed. Engl. 53, 5827-5831 (2014).
    • (2014) Angew. Chem. Int. Ed. Engl , vol.53 , pp. 5827-5831
    • Hong, S.1
  • 37
    • 84906274051 scopus 로고    scopus 로고
    • Fast vibrational imaging of single cells and tissues by stimulated Raman scattering microscopy
    • Zhang, D.,Wang, P., Slipchenko, M. N., Cheng, J. X. Fast vibrational imaging of single cells and tissues by stimulated Raman scattering microscopy. Acc. Chem. Res. 47, 2282-2290 (2014).
    • (2014) Acc. Chem. Res , vol.47 , pp. 2282-2290
    • Zhang, D.1    Wang, P.2    Slipchenko, M.N.3    Cheng, J.X.4
  • 38
    • 0000668619 scopus 로고    scopus 로고
    • Polyenes vs polyynes: Efficient p-frame for nonlinear optical pathways
    • Lee, J. Y., Suh, S. B., Kim, K. S. Polyenes vs polyynes: Efficient p-frame for nonlinear optical pathways. J. Chem. Phys. 112, 344-348 (2000).
    • (2000) J. Chem. Phys , vol.112 , pp. 344-348
    • Lee, J.Y.1    Suh, S.B.2    Kim, K.S.3
  • 39
    • 3242716095 scopus 로고    scopus 로고
    • Spectral focusing: High spectral resolution spectroscopy with broad-bandwidth laser pulses
    • Hellerer, T., Enejder, A. M. K., Zumbusch, A. Spectral focusing: High spectral resolution spectroscopy with broad-bandwidth laser pulses. Appl. Phys. Lett. 85, 25-27 (2004).
    • (2004) Appl. Phys. Lett , vol.85 , pp. 25-27
    • Hellerer, T.1    Enejder, A.M.K.2    Zumbusch, A.3
  • 40
    • 0024383782 scopus 로고
    • Isolation of Chinese hamster ovary cell lines expressing human acyl-coenzyme A/cholesterol acyltransferase activity
    • Cadigan, K. M., Chang, C. C., Chang, T. Y. Isolation of Chinese hamster ovary cell lines expressing human acyl-coenzyme A/cholesterol acyltransferase activity. J. Cell Biol. 108, 2201-2210 (1989).
    • (1989) J. Cell Biol , vol.108 , pp. 2201-2210
    • Cadigan, K.M.1    Chang, C.C.2    Chang, T.Y.3
  • 41
    • 0030863352 scopus 로고    scopus 로고
    • Niemann-Pick C1 disease gene: Homology to mediators of cholesterol homeostasis
    • Carstea, E. D. et al. Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis. Science 277, 228-231 (1997).
    • (1997) Science , vol.277 , pp. 228-231
    • Carstea, E.D.1
  • 42
    • 0034623958 scopus 로고    scopus 로고
    • Niemann-pick type C1 (NPC1) overexpression alters cellular cholesterol homeostasis
    • Millard, E. E. et al. Niemann-pick type C1 (NPC1) overexpression alters cellular cholesterol homeostasis. J. Biol. Chem. 275, 38445-38451 (2000).
    • (2000) J. Biol. Chem , vol.275 , pp. 38445-38451
    • Millard, E.E.1
  • 43
    • 60549084168 scopus 로고    scopus 로고
    • Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/-mouse
    • Liu, B. et al. Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/-mouse. Proc. Natl. Acad. Sci. U. S. A. 106, 2377-2382 (2009).
    • (2009) Proc. Natl. Acad. Sci. U. S. A , vol.106 , pp. 2377-2382
    • Liu, B.1
  • 44
    • 73349138621 scopus 로고    scopus 로고
    • Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells
    • Abi-Mosleh, L. et al. Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells. Proc. Natl. Acad. Sci. U. S. A. 106, 19316-19321 (2009).
    • (2009) Proc. Natl. Acad. Sci. U. S. A , vol.106 , pp. 19316-19321
    • Abi-Mosleh, L.1
  • 45
    • 84858964610 scopus 로고    scopus 로고
    • CUP-1 is a novel protein involved in dietary cholesterol uptake in Caenorhabditis elegans
    • Valdes, V. J. et al. CUP-1 is a novel protein involved in dietary cholesterol uptake in Caenorhabditis elegans. PLoS One 7, e33962 (2012).
    • (2012) PLoS One , vol.7 , pp. e33962
    • Valdes, V.J.1
  • 46
    • 77949524057 scopus 로고    scopus 로고
    • Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis elegans
    • Zhang, S. O. et al. Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U. S. A. 107, 4640-4645 (2010).
    • (2010) Proc. Natl. Acad. Sci. U. S. A , vol.107 , pp. 4640-4645
    • Zhang, S.O.1
  • 47
    • 84874612259 scopus 로고    scopus 로고
    • On terminal alkynes that can react with active-site cysteine nucleophiles in proteases
    • Ekkebus, R. et al. On terminal alkynes that can react with active-site cysteine nucleophiles in proteases. J. Am. Chem. Soc. 135, 2867-2870 (2013).
    • (2013) J. Am. Chem. Soc , vol.135 , pp. 2867-2870
    • Ekkebus, R.1
  • 48
    • 0025115235 scopus 로고
    • Pyrene eximer mapping in cultured fibroblasts by ratio imaging and time-resolved microscopy
    • Dix, J. A.,Verkman, A. S. Pyrene eximer mapping in cultured fibroblasts by ratio imaging and time-resolved microscopy. Biochemistry 29, 1949-1953 (1990).
    • (1990) Biochemistry , vol.29 , pp. 1949-1953
    • Dix, J.A.1    Verkman, A.S.2
  • 49
    • 84876773697 scopus 로고    scopus 로고
    • Hyperspectral imaging with stimulated Raman scattering by chirped femtosecond lasers
    • Fu, D. et al. Hyperspectral imaging with stimulated Raman scattering by chirped femtosecond lasers. J. Phys. Chem. B 117, 4634-4640 (2013).
    • (2013) J. Phys. Chem. B , vol.117 , pp. 4634-4640
    • Fu, D.1
  • 50
    • 0037710127 scopus 로고    scopus 로고
    • Cholesterol homeostasis and function in neurons of the central nervous system
    • Pfrieger, F. W. Cholesterol homeostasis and function in neurons of the central nervous system. Cell. Mol. Life Sci. 60, 1158-1171 (2003).
    • (2003) Cell. Mol. Life Sci , vol.60 , pp. 1158-1171
    • Pfrieger, F.W.1
  • 51
    • 33745223646 scopus 로고    scopus 로고
    • Finding function in novel targets: C elegans as a model organism
    • Kaletta, T., Hengartner, M. O. Finding function in novel targets: C. elegans as a model organism. Nat. Rev. Drug Discov. 5, 387-398 (2006).
    • (2006) Nat. Rev. Drug Discov , vol.5 , pp. 387-398
    • Kaletta, T.1    Hengartner, M.O.2
  • 52
    • 10344229417 scopus 로고    scopus 로고
    • NCR-1 and NCR-2, the C. Elegans homologs of the human Niemann-Pick type C1 disease protein, function upstreamof DAF-9 in the dauer formation pathways
    • Li, J. et al. NCR-1 and NCR-2, the C. elegans homologs of the human Niemann-Pick type C1 disease protein, function upstreamof DAF-9 in the dauer formation pathways. Development 131, 5741-5752 (2004).
    • (2004) Development , vol.131 , pp. 5741-5752
    • Li, J.1
  • 53
    • 0037448528 scopus 로고    scopus 로고
    • Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
    • Ashrafi, K. et al. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature 421, 268-272 (2003).
    • (2003) Nature , vol.421 , pp. 268-272
    • Ashrafi, K.1
  • 54
    • 70350365111 scopus 로고    scopus 로고
    • Elegansmajor Fats Are Stored in Vesicles Distinct from Lysosome-Related Organelles
    • O'Rourke, E. J., Soukas, A. A., Carr, C. E., Ruvkun, G. C. elegansMajor Fats Are Stored in Vesicles Distinct from Lysosome-Related Organelles. Cell Metab. 10, 430-435 (2009).
    • (2009) Cell Metab , vol.10 , pp. 430-435
    • O'Rourke, E.J.1    Soukas, A.A.2    Carr, C.E.3    Ruvkun, G.C.4
  • 55
    • 84455192422 scopus 로고    scopus 로고
    • Lipid droplets as fat storage organelles in Caenorhabditis elegans: Thematic Review Series: Lipid Droplet Synthesis and Metabolism: From Yeast to Man
    • Mak, H. Y. Lipid droplets as fat storage organelles in Caenorhabditis elegans: Thematic Review Series: Lipid Droplet Synthesis and Metabolism: from Yeast to Man. J. Lipid Res. 53, 28-33 (2012).
    • (2012) J. Lipid Res , vol.53 , pp. 28-33
    • Mak, H.Y.1
  • 56
    • 0037244289 scopus 로고    scopus 로고
    • Sterol effects and sites of sterol accumulation in Caenorhabditis elegans: Developmental requirement for 4alpha-methyl sterols
    • Merris, M. et al. Sterol effects and sites of sterol accumulation in Caenorhabditis elegans: developmental requirement for 4alpha-methyl sterols. J. Lipid Res. 44, 172-181 (2003).
    • (2003) J. Lipid Res , vol.44 , pp. 172-181
    • Merris, M.1
  • 57
    • 77951780747 scopus 로고    scopus 로고
    • Selective visualization of fluorescent sterols in Caenorhabditis elegans by bleach-rate-based image segmentation
    • Wustner, D. et al. Selective visualization of fluorescent sterols in Caenorhabditis elegans by bleach-rate-based image segmentation. Traffic 11, 440-454 (2010).
    • (2010) Traffic , vol.11 , pp. 440-454
    • Wustner, D.1
  • 58
    • 77951926114 scopus 로고    scopus 로고
    • Label-free quantitative analysis of lipid metabolism in living Caenorhabditis elegans[S]
    • Le, T. T. et al. Label-free quantitative analysis of lipid metabolism in living Caenorhabditis elegans[S]. J. Lipid Res. 51, 672-677 (2010).
    • (2010) J. Lipid Res , vol.51 , pp. 672-677
    • Le, T.T.1
  • 59
    • 77958586133 scopus 로고    scopus 로고
    • A comparative study of fat storage quantitation in nematode Caenorhabditis elegans using label and label-free methods
    • Yen, K. et al. A comparative study of fat storage quantitation in nematode Caenorhabditis elegans using label and label-free methods. PLoS One 5, e12810 (2010).
    • (2010) PLoS One , vol.5 , pp. e12810
    • Yen, K.1
  • 60
    • 33746563448 scopus 로고    scopus 로고
    • Advances in methods and algorithms in a modern quantum chemistry program package
    • Shao, Y. et al. Advances in methods and algorithms in a modern quantum chemistry program package. Phys. Chem. Chem. Phys. 8, 3172-3191 (2006).
    • (2006) Phys. Chem. Chem. Phys , vol.8 , pp. 3172-3191
    • Shao, Y.1
  • 61
    • 84885102778 scopus 로고    scopus 로고
    • (eds Clifford E. Dykstra, Gernot Frenking, Kwang S. Kim,&Gustavo E. Scuseria) Elsevier
    • Gordon, M. S., Schmidt, M. W. in Theory and Applications of Computational Chemistry (eds Clifford E. Dykstra, Gernot Frenking, Kwang S. Kim,&Gustavo E. Scuseria) 1167-1189 (Elsevier, 2005).
    • (2005) Theory and Applications of Computational Chemistry , pp. 1167-1189
    • Gordon, M.S.1    Schmidt, M.W.2
  • 62
    • 66749095490 scopus 로고    scopus 로고
    • High-speed vibrational imaging and spectral analysis of lipid bodies by compound Raman microscopy
    • Slipchenko, M. N., Le, T. T., Chen, H., Cheng, J. X. High-speed vibrational imaging and spectral analysis of lipid bodies by compound Raman microscopy. J. Phys. Chem. B 113, 7681-7686 (2009).
    • (2009) J. Phys. Chem. B , vol.113 , pp. 7681-7686
    • Slipchenko, M.N.1    Le, T.T.2    Chen, H.3    Cheng, J.X.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.