Umbilical cord blood plasma contains soluble NKG2D ligands that mediate loss of natural killer cell function and cytotoxicity

European Journal of Immunology

Volumn 45, Issue 8, 2015, Pages 2324-2334

  Cox, Steven T ^a   Laza Briviesca, Raquel ^a   Pearson, Hayley ^a   Soria, Bernat ^b,c   Gibson, Daniel ^d   Gomez, Susana ^d   Madrigal, J Alejandro ^a,d,e   Saudemont, Aurore ^a,e  

^a ROYAL FREE HOSPITAL   (United Kingdom)

^b CABIMER Andalusian Center for Molecular Biology and Regenerative Medicine CSIC University of Seville UPO   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

^d NOTTINGHAM TRENT UNIVERSITY   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Ligand; NK cell; NKG2D; Pregnancy; Tolerance

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; LIGAND; NATURAL KILLER CELL RECEPTOR NKG2D; NATURAL KILLER CELL RECEPTOR NKG2D LIGAND; SEPHAROSE; UNCLASSIFIED DRUG; IFNG PROTEIN, HUMAN; KLRK1 PROTEIN, HUMAN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY K; SIGNAL PEPTIDE;

ADULT; ARTICLE; CD8+ T LYMPHOCYTE; CHROMIUM RELEASE ASSAY; COCULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXOSOME; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; K562 CELL LINE; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; LYSIS; MALE; NATURAL KILLER CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; T CELL CULTURE; TH1 CELL; TH2 CELL; UMBILICAL CORD BLOOD; BIOSYNTHESIS; BLOOD; CELLULAR IMMUNITY; FETOMATERNAL TRANSFUSION; FETUS BLOOD; GENE EXPRESSION REGULATION; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; PREGNANCY; SECRETION (PROCESS);

ADULT; FEMALE; FETAL BLOOD; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, CELLULAR; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERFERON-GAMMA; K562 CELLS; KILLER CELLS, NATURAL; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 1; MALE; MATERNAL-FETAL EXCHANGE; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY K; PREGNANCY;

EID: 84938896022     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201444990     Document Type: Article

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