Reduced T-cell repertoire restrictions in abatacept-treated rheumatoid arthritis patients

Journal of Translational Medicine

Volumn 13, Issue 1, 2015, Pages

  Imberti, Luisa ^a   Scarsi, Mirko ^a   Zanotti, Cinzia ^a   Chiarini, Marco ^a   Bertoli, Diego ^a   Tincani, Angela ^a   Airò, Paolo ^a  

^a SPEDALI CIVILI   (Italy)

Author keywords

Abatacept; Rheumatoid arthritis; T cell repertoire

Indexed keywords

ABATACEPT; CD28 ANTIGEN; T LYMPHOCYTE RECEPTOR; TELOMERASE REVERSE TRANSCRIPTASE; LEUKOCYTE ANTIGEN; TELOMERASE; TERT PROTEIN, HUMAN;

ADULT; ARTICLE; BIOCHEMICAL ANALYSIS; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CLINICAL ARTICLE; COMPLEMENTARITY DETERMINING REGION 3 SPECTRATYPING; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNOLOGICAL PARAMETERS; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; PHENOTYPE; REAL TIME POLYMERASE CHAIN REACTION; RECENT T EMIGRANT; RHEUMATOID ARTHRITIS; T LYMPHOCYTE; T LYMPHOCYTE RECEPTOR GENE; T LYMPHOCYTE SUBPOPULATION; TCRBV GENE; THYMIC OUTPUT; ARTHRITIS, RHEUMATOID; CASE CONTROL STUDY; DRUG EFFECTS; IMMUNOLOGY; LYMPHOCYTE SUBPOPULATION; METABOLISM; POLYMERASE CHAIN REACTION;

ABATACEPT; ANTIGENS, CD; ARTHRITIS, RHEUMATOID; CASE-CONTROL STUDIES; FEMALE; HUMANS; LYMPHOCYTE SUBSETS; MALE; MIDDLE AGED; PHENOTYPE; POLYMERASE CHAIN REACTION; T-LYMPHOCYTES; TELOMERASE;

EID: 84938894065     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-014-0363-2     Document Type: Article

References (24)

1. Schmidt D, Goronzy JJ, Weyand CM: CD4 + CD7-CD28-T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity. J Clin Invest 1996, 97:2027-2037.
2. Vallejo AN, Brandes JC, Weyand CM, Goronzy JJ: Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescence. J Immunol 1999, 162:6572-6579.
3. Vallejo AN, Weyand CM, Goronzy JJ: T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection. Trends Mol Med 2004, 10:119-124.
4. Broux B, Markovic-Plese S, Stinissen P, Hellings N: Pathogenic features of CD4 + CD28- T cells in immune disorders. Trends Mol Med 2012, 18:446-453.
5. Pawlik A, Ostanek L, Brzosko I, Brzosko M, Masiuk M, Machalinski B, Gawronska-Szklarz B: The expansion of CD4 + CD28- T cells in patients with rheumatoid arthritis. Arthritis Res Ther 2003, 5:R210-R213.
6. Cutolo M, Nadler SG: Advances in CTLA-4-Ig-mediated modulation of inflammatory cell and immune response activation in rheumatoid arthritis. Autoimmun Rev 2013, 12:758-767.
7. Ndejembi MP, Teijaro JR, Patke DS, Bingaman AW, Chandok MR, Azimzadeh A, Nadler SG, Farber DL: Control of memory CD4 T cell recall by the CD28/B7 costimulatory pathway. J Immunol 2006, 177:7698-7706.
8. Pieper J, Herrath J, Raghavan S, Muhammad K, Vollenhoven RV, Malmström V: CTLA4-Ig (abatacept) therapy modulates T cell effector functions in autoantibody-positive rheumatoid arthritis patients. BMC Immunol 2013, 14:34.
9. Scarsi M, Ziglioli T, Airo' P: Baseline numbers of circulating CD28-negative T cells may predict clinical response to abatacept in patients with rheumatoid arthritis. J Rheumatol 2011, 38:2105-2111.
10. Airò P, Scarsi M: Targeting CD4 + CD28- T cells by blocking CD28 co-stimulation. Trends Mol Med 2013, 19:1-2.
11. Fujii H, Shao L, Colmegna I, Goronzy JJ, Weyand CM: Telomerase insufficiency in rheumatoid arthritis. Proc Natl Acad Sci U S A 2009, 106:4360-4365.
12. Wells G, Becker JC, Teng J, Dougados M, Schiff M, Smolen J, Aletaha D, van Riel PL: Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythrocyte sedimentation rate. Ann Rheum Dis 2009, 68:954-960.
13. Akatsuka Y, Martin EG, Madonik A, Barsoukov AA, Hansen JA: Rapid screening of T-cell receptor (TCR) variable gene usage by multiplex PCR: application for assessment of clonal composition. Tissue Antigens 1999, 53:122-134.
14. Gorochov G, Neumann AU, Kereveur A, Parizot C, Li T, Katlama C, Karmochkine M, Raguin G, Autran B, Debré P: Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy. Nat Med 1998, 4:215-221.
15. Warnke C, Mausberg AK, Stettner M, Dehmel T, Nekrich L, Meyer zu Horste G, Hartung HP, Fogdell-Hahn A, Adams O, Kieseier BC: Natalizumab affects the T-cell receptor repertoire in patients with multiple sclerosis. Neurology 2013, 81:1400-1408.
16. Koetz K, Bryl E, Spickschen K, O'Fallon WM, Goronzy JJ, Weyand CM: T cell homeostasis in patients with rheumatoid arthritis. Proc Natl Acad Sci U S A 2000, 97:9203-9208.
17. Soares MV, Borthwick NJ, Maini MK, Janossy G, Salmon M, Akbar AN: IL-7-dependent extrathymic expansion of CD45RA+ T cells enables preservation of a naive repertoire. J Immunol 1998, 161:5909-5917.
18. Pierer M, Rossol M, Kaltenhäuser S, Arnold S, Häntzschel H, Baerwald C, Wagner U: Clonal expansions in selected TCR BV families of rheumatoid arthritis patients are reduced by treatment with the TNFaα inhibitors etanercept and infliximab. Rheumatol Int 2011, 31:1023-1029.
19. Houston EG Jr, Higdon LE, Fink PJ: Recent thymic emigrants are preferentially incorporated only into the depleted T-cell pool. Proc Natl Acad Sci U S A 2011, 108:5366-5371.
20. Weng NP, Levine BL, June CH, Hodes RJ: Regulated expression of telomerase activity in human T lymphocyte development and activation. J Exp Med 1996, 183:2471-2479.
21. Hodes RJ, Hathcock KS, Weng NP: Telomeres in T and B cells. Nat Rev Immunol 2002, 2:699-706.
22. Mirenda V, Jarmin SJ, David R, Dyson J, Scott D, Gu Y, Lechler RI, Okkenhaug K, Marelli-Berg FM: Physiologic and aberrant regulation of memory T-cell trafficking by the costimulatory molecule CD28. Blood 2007, 109:2968-2977.
23. Fasth AE, Snir O, Johansson AA, Nordmark B, Rahbar A, Af Klint E, Björkström NK, Ulfgren AK, van Vollenhoven RF, Malmström V, Trollmo C: Skewed distribution of proinflammatory CD4 + CD28null T cells in rheumatoid arthritis. Arthritis Res Ther 2007, 9:R87.
24. Scarsi M, Zanotti C, Chiarini M, Imberti L, Piantoni S, Frassi M, Tincani A, Airò P: Reduction of peripheral blood γ-IFN and IL-17 producing T cells after therapy with abatacept for rheumatoid arthritis. Clin Exp Rheumatol 2014, 32:204-210.