Simultaneous determination of cinnamaldehyde, cinnamic acid, and 2-methoxy cinnamic acid in rat whole blood after oral administration of volatile oil of Cinnamoni Ramulus by UHPLC-MS/MS: An application for a pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 1001, Issue , 2015, Pages 107-113

  Ji, Bin ^a   Zhao, Yunli ^a   Zhang, Qili ^a   Wang, Pei ^a   Guan, Jiao ^a,b   Rong, Rong ^a   Yu, Zhiguo ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b JILIN MEDICAL COLLEGE   (China)

Author keywords

2 Methoxy cinnamic acid; Cinnamaldehyde; Cinnamic acid; Cinnamomi Ramulus; Pharmacokinetics; UHPLC MS MS

Indexed keywords

BLOOD; CHROMATOGRAPHY; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NEGATIVE IONS; PHARMACOKINETICS; RATS; VOLATILE ORGANIC COMPOUNDS;

CHROMATOGRAPHIC SEPARATIONS; CINNAMALDEHYDE; CINNAMIC ACIDS; CINNAMOMI RAMULUS; MULTIPLE-REACTION MONITORING MODES; SIMULTANEOUS DETERMINATIONS; U-HPLC-MS; ULTRA-HIGH PERFORMANCE LIQUID CHROMATOGRAPHIES;

ESSENTIAL OILS;

2 METHOXY CINNAMIC ACID; CINNAMALDEHYDE; CINNAMIC ACID; CINNAMOMI RAMULUS OIL; CINNAMON EXTRACT; UNCLASSIFIED DRUG; ACROLEIN; CINNAMIC ACID DERIVATIVE; VEGETABLE OIL;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CINNAMOMI RAMULUS; CINNAMON; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; LIMIT OF QUANTITATION; MALE; NEGATIVE ION ELECTROSPRAY; NONHUMAN; POSITIVE ION ELECTROSPRAY; PRECIPITATION; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CHEMISTRY; CINNAMOMUM ZEYLANICUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF DETECTION; ORAL DRUG ADMINISTRATION; PROCEDURES; VALIDATION STUDY; VOLATILIZATION;

RATTUS;

ACROLEIN; ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CINNAMATES; CINNAMOMUM ZEYLANICUM; LIMIT OF DETECTION; PLANT OILS; RATS; TANDEM MASS SPECTROMETRY; VOLATILIZATION;

EID: 84938869349     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2015.07.049     Document Type: Article

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