Histone deacetylase 6 delays motor neuron degeneration by ameliorating the autophagic flux defect in a transgenic mouse model of amyotrophic lateral sclerosis

Neuroscience Bulletin

Volumn 31, Issue 4, 2015, Pages 459-468

  Chen, Sheng ^a   Zhang, Xiao Jie ^a   Li, Li Xi ^a   Wang, Yin ^b   Zhong, Ru Jia ^b   Le, Weidong ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

amyotrophic lateral sclerosis; autophagy; histone deacetylase 6; motor neuron; motor neuron disease; neurodegenerative disease

Indexed keywords

HISTONE DEACETYLASE 6; COPPER ZINC SUPEROXIDE DISMUTASE; HDAC6 PROTEIN, MOUSE; HISTONE DEACETYLASE; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOLYSOSOME; AUTOPHAGY; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; LIFESPAN; MALE; MOTOR NEURON DISEASE; MOUSE; NERVE CELL DEGENERATION; NONHUMAN; PATHOGENESIS; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; ROTAROD TEST; SIGNAL TRANSDUCTION; ANIMAL; ENZYMOLOGY; GENE VECTOR; GENETICS; KAPLAN MEIER METHOD; METABOLIC FLUX ANALYSIS; METABOLISM; MOTONEURON; SPINAL CORD; TRANSGENIC MOUSE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; AUTOPHAGY; GENETIC VECTORS; HISTONE DEACETYLASES; KAPLAN-MEIER ESTIMATE; MALE; METABOLIC FLUX ANALYSIS; MICE; MICE, TRANSGENIC; MOTOR NEURONS; SPINAL CORD; SUPEROXIDE DISMUTASE;

EID: 84938844663     PISSN: 16737067     EISSN: 19958218     Source Type: Journal    
DOI: 10.1007/s12264-015-1539-3     Document Type: Article

References (38)

1. Andersen PM. Amyotrophic lateral sclerosis associated with mutations in the CuZn superoxide dismutase gene. Curr Neurol Neurosci Rep 2006, 6: 37–46.
2. Chen S, Sayana P, Zhang X, Le W. Genetics of amyotrophic lateral sclerosis: an update. Mol Neurodegener 2013, 8: 28.
3. Pasinelli P, Brown RH. Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nat Rev Neurosci 2006, 7: 10–23.
4. Kirby J, Halligan E, Baptista MJ, Allen S, Heath PR, et al. Mutant SOD1 alters the motor neuronal transcriptome: implications for familial ALS. Brain 2005, 128: 1686–1706.
5. Li L, Zhang X, Le W. Altered macroautophagy in the spinal cord of SOD1 mutant mice. Autophagy 2008, 4: 290–293.
6. Banerjee R, Beal MF, Thomas B. Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications. Trends Neurosci 2010, 33: 541–549.
7. Goldberg AL. Protein degradation and protection against misfolded or damaged proteins. Nature 2003, 426: 895–899.
8. Cheung ZH, Ip NY. Autophagy deregulation in neurodegenerative diseases - recent advances and future perspectives. J Neurochem 2011, 118: 317–325.
9. Wong E, Cuervo AM. Autophagy gone awry i n neurodegenerative diseases. Nat Neurosci 2010, 13: 805–811.
10. Sasaki S. Autophagy in spinal cord motor neurons in sporadic amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 2011, 70: 349–359.
11. Zhang X, Li L, Chen S, Yang D, Wang Y, Zhang X, et al. Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Autophagy 2011, 7: 412–425.
12. Zhang X, Chen S, Song L, Tang Y, Shen Y, Jia L, et al. MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis. Autophagy 2014, 10: 588–602.
13. Boyault C, Sadoul K, Pabion M, Khochbin S. HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination. Oncogene 2007, 26: 5468–5476.
14. Kawaguchi Y, Kovacs JJ, Mc Laurin A, Vance JM, Ito A, Yao TP. The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell 2003, 115: 727–738.
15. Lee JY, Koga H, Kawaguchi Y, Tang W, Wong E, Gao YS, et al. HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality control autophagy. EMBO J 2010, 29: 969–980.
16. Boyault C, Zhang Y, Fritah S, Caron C, Gilquin B, et al. HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Gene Dev 2007, 21: 2172–2181.
17. Pandey UB, Nie Z, Batlevi Y, McCray BA, Ritson GP, Nedelsky NB, et al. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 2007, 447: 859–863.
18. Simoes-Pires C, Zwick V, Nurisso A, Schenker E, Carrupt PA, Cuendet M. HDAC6 as a target for neurodegenerative diseases: what make it different from other HDACs? Mol Neurodegener 2013, 29: 7.
19. Tang Y, Li T, Li J, Yang J, Liu H, Zhang XJ, et al. Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson's disease. Cell Death Differ 2014, 21:369–380.
20. Song L, Chen L, Zhang X, Li J, Le W. Resveratrol ameliorates motor neuron degeneration and improves survival in SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Biomed Res Int 2014, 2014: 483501.
21. Zhang X, Chen S, Li L, Wang Q, Le W. Folic acid protects motor neurons against the increased homocysteine inflammation and apoptosis in SOD1G93A transgenic mice. Neuropharmacology 2008, 54: 1112–1119.
22. Manabe Y, Nagano I, Gazi MS, Murakami T, Shiote M, Shoji M, et al. Glial cell line-derived neurotrophic factor protein prevents motor neuron loss of transgenic model mice for amyotrophic lateral sclerosis. Neurol Res 2003, 25: 195–200.
23. Nixon RA, Wegiel J, Kumar A, Yu WH, Peterhoff C, Cataldo A, Cuervo AM. Extensive involvement of autophagy in Alzheimer disease: an immunoelectron microscopy study. J Neuropathol Exp Neurol 2005, 64: 113–122.
24. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo- Arozena A, Adeli K, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012, 8: 445–544.
25. Grozinger CM, Hassig CA, Schreiber SL. Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc Natl Acad Sci U S A 1999, 96: 4868–4873.
26. Verdel A, Khochbin S. Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. J Biol Chem 1999, 274: 2440–2445.
27. Boyault C, Sadoul K, Pabion M, Khochibin S. HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination. Oncogene 2007, 26: 5468–5476
28. Chen S, Zhang X, Song L, Le W. Autophagy dysregulation in amyotrophic lateral sclerosis. Brain Pathol 2012, 22: 110–116.
29. Nassif M, Hetz C. Targeting autophagy in ALS: a complex mission. Autophagy 2011, 7: 450–453.
30. Laird FM, Farah MH, Ackerley S, Hoke A, Maragakis N, Rothstein JD, et al. Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking. J Neurosci 2008, 28: 1997–2005.
31. Webb JL, Ravikumar B, Rubinsztein DC. Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases. Int J Biochem Cell Biol 2004, 36: 2541–2550.
32. Zhang F, Ström AL, Fukada K, Lee S, Hayward LJ, Zhu H. Interaction between familial amyotrophic lateral sclerosis (ALS)-linked SOD1 mutants and the dynein complex. J Biol Chem 2007, 282: 16691–16699.
33. Du G, Jiao R. To prevent neurodegeneration: HDAC6 uses different strategies for different challenge. Autophagy 2011, 4: 139–142.
34. Zilberman Y, Ballestrem C, Carramusa L, Mazitschek R, Khochbin S, Bershadsky A. Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6. J Cell Sci 2009, 122: 3531–3541.
35. Lazo-Gomez R, Ramirez-Jarquin UN, Tovar-Y-Romo LB, Tapia R. Histone deacetylases and their role in motor neuron degeneration. Front Cell Neurosci 2013, 7: 243.
36. Taes I, Timmers M, Hersmus N, Bento- Abreu A, Van Den B, Van Damme P, et al. Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS. Hum Mol Genet 2013, 22: 1783–1790.
37. Marinkovic P, Reuter MS, Brill MS, Godinho L, Kerschensteiner M, Misgeld T. Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A 2012, 109: 4296–4301.
38. Bilsland LG, Sahai E, Kelly G, Golding M, Greensmith L, Schiavo G. Deficits in axonal transport precede ALS symptoms in vivo. Proc Natl Acad Sci U S A 2010, 107: 20523–20528.