PH-dependent population shift regulates BACE1 activity and inhibition

Journal of the American Chemical Society

Volumn 137, Issue 30, 2015, Pages 9543-9546

  Ellis, Christopher R ^a   Shen, Jana ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MOLECULAR DYNAMICS; NEURODEGENERATIVE DISEASES;

ALZHEIMER'S DISEASE; CONFORMATIONAL SELECTION; CONFORMATIONAL STATE; CONSTANT PH MOLECULAR DYNAMICS; PEPTIDE INHIBITORS; PROTONATION STATE; REGULATORY MECHANISM; THERAPEUTIC TARGETS;

PROTONATION;

BETA SECRETASE 1; ENZYME INHIBITOR; OM 992; UNCLASSIFIED DRUG; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; OLIGOPEPTIDE; OM99-2; SECRETASE;

ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; MOLECULAR DYNAMICS; PH; REGULATORY MECHANISM; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; HUMANS; HYDROGEN-ION CONCENTRATION; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; OLIGOPEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84938841587     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b05891     Document Type: Article

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