Simultaneous determination of six bioactive constituents of Guizhi Fuling Capsule in rat plasma by UHPLC-MS/MS: Application to a pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 1001, Issue , 2015, Pages 49-57

  Zhao, Longshan ^a,b   Xiong, Zhili ^a   Sui, Yang ^a   Zhu, Heyun ^a   Zhou, Zhiyu ^a   Wang, Zhenzhong ^b   Zhao, Yiwu ^b   Xiao, Wei ^b   Lin, Jianyang ^c   Bi, Kaishun ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b JIANGSU KANION PHARMACEUTICAL CO   (China)

^c CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Guizhi fuling capsule; Pharmacokinetics; Rat plasma; UHPLC MS MS

Indexed keywords

ACETONITRILE; BODY FLUIDS; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; PHARMACOKINETICS; RATS; SPECTROMETRY;

GUIZHI FULING CAPSULE; MASS SPECTROMETRIC DETECTION; MULTIPLE-REACTION MONITORING MODES; RAT PLASMA; RELATIVE STANDARD DEVIATIONS; SIMULTANEOUS DETERMINATIONS; U-HPLC-MS; ULTRA-HIGH PERFORMANCE LIQUID CHROMATOGRAPHIES;

PLASMA STABILITY;

ACETONITRILE; ALBIFLORIN; AMYGDALIN; CINNAMIC ACID; FORMIC ACID; GALLIC ACID; GUIZHI FULING CAPSULE; HERBACEOUS AGENT; PAEONIFLORIN; PEONOL; PHENACETIN; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG; WATER; GUIZHI-FULING;

ACIDIFICATION; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CAPSULE; DRUG DETERMINATION; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; FEMALE; FLOW RATE; LIMIT OF QUANTITATION; MASS SPECTROMETER; MEASUREMENT ACCURACY; MEASUREMENT ERROR; MULTIPLE SCLEROSIS; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; BLOOD; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF DETECTION; PROCEDURES; STANDARD; VALIDATION STUDY; WISTAR RAT;

RATTUS;

ANIMALS; BLOOD; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; FEMALE; LIMIT OF DETECTION; RATS; RATS, WISTAR; REFERENCE STANDARDS; TANDEM MASS SPECTROMETRY;

EID: 84938823401     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2015.07.031     Document Type: Article

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