Simultaneous determination of paeoniflorin, albiflorin, ferulic acid, tetrahydropalmatine, protopine, typhaneoside, senkyunolide I in Beagle dogs plasma by UPLC-MS/MS and its application to a pharmacokinetic study after Oral Administration of Shaofu Zhuyu Decoction

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 962, Issue , 2014, Pages 75-81

  Huang, Xiaochen ^a,b   Su, Shulan ^a,b   Cui, Wenxia ^a,b   Liu, Pei ^a,b   Duan, Jin ao ^a,b   Guo, Jianming ^a,b   Li, Zhenhao ^a,b   Shang, Erxin ^a,b   Qian, Dawei ^a,b   Huang, Zhijun ^a,b  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b WUHAN UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Beagle dog plasma; Pharmacokinetics; Shaofu Zhuyu decoction; UPLC MS MS

Indexed keywords

BIOCHEMISTRY; PHARMACOKINETICS;

BEAGLE DOG; FOOD AND DRUG ADMINISTRATION; PHARMACOKINETIC STUDIES; PLASMA CONCENTRATION; PROTEIN PRECIPITATION; SHAOFU ZHUYU DECOCTION; SIMULTANEOUS DETERMINATIONS; UPLC-MS/MS;

PLASMAS;

ACETONITRILE; ALBIFLORIN; ANTIMIGRAINE AGENT; ANTIOXIDANT; CHINESE DRUG; CHLORAMPHENICOL; CLARITHROMYCIN; FERULIC ACID; FLAVONOID; FORMIC ACID; METHANOL; PAEONIFLORIN; PLANT MEDICINAL PRODUCT; PROTOPINE; SENKYUNOLIDE I; SHAOFU ZHUYU DECOCTION; TETRAHYDROPALMATINE; TYPHANEOSIDE; UNCLASSIFIED DRUG; BENZOFURAN DERIVATIVE; BENZOPHENANTHRIDINE DERIVATIVE; BERBERINE DERIVATIVE; BRIDGED COMPOUND; COUMARIC ACID; GLUCOSIDE; GLYCOSIDE; HERBACEOUS AGENT; SHAO-FU-ZHU-YU; TERPENE;

ACCURACY; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; BEAGLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; DRUG STABILITY; ENTEROHEPATIC CIRCULATION; FEMALE; FLOW RATE; FOOD AND DRUG ADMINISTRATION; LIMIT OF QUANTITATION; NONHUMAN; PLASMA CLEARANCE; PLASMA CONCENTRATION-TIME CURVE; PRACTICE GUIDELINE; PRECIPITATION; PRIORITY JOURNAL; QUALITY CONTROL; SEPARATION TECHNIQUE; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; BLOOD; DOG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ORAL DRUG ADMINISTRATION; PROCEDURES; VALIDATION STUDY;

ADMINISTRATION, ORAL; ANIMALS; BENZOFURANS; BENZOPHENANTHRIDINES; BERBERINE ALKALOIDS; BRIDGED COMPOUNDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUMARIC ACIDS; DOGS; DRUGS, CHINESE HERBAL; FEMALE; GLUCOSIDES; GLYCOSIDES; MONOTERPENES; TANDEM MASS SPECTROMETRY;

EID: 84901758579     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2014.05.032     Document Type: Article

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