Simultaneous determination of puerarin, daidzin, daidzein, paeoniflorin, albiflorin, liquiritin and liquiritigenin in rat plasma and its application to a pharmacokinetic study of Ge-Gen Decoction by a liquid chromatography-electrospray ionization-tandem mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 95, Issue , 2014, Pages 76-84

  Yan, Yan ^a   Chai, Cheng Zhi ^a   Wang, Da Wei ^b   Wu, Jie ^b   Xiao, Hong He ^a   Huo, Li Xia ^a   Zhu, Dan Ni ^a   Yu, Bo Yang ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Jiangsu Province Academy of Traditional Chinese Medicine   (China)

Author keywords

Ge Gen Decoction; Isoflavones; LC ESI MS MS; Monoterpene glucosides; Pharmacokinetics

Indexed keywords

ACETONITRILE; ALBIFLORIN; AMMONIUM ACETATE; DAIDZEIN; DAIDZIN; FORMIC ACID; GE GEN DECOCTION; HERBACEOUS AGENT; LIQUIRITIGENIN; LIQUIRITIN; METHANOL; PAEONIFLORIN; PUERARIN; SCHIZANDRIN; UNCLASSIFIED DRUG; WATER; BRIDGED COMPOUND; FLAVANONE DERIVATIVE; GLUCOSIDE; ISOFLAVONE DERIVATIVE; SHUANG-HUANG-LIAN; TERPENE;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CALIBRATION; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; DRUG ISOLATION; DRUG STABILITY; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MAXIMUM PLASMA CONCENTRATION; MEASUREMENT ACCURACY; NONHUMAN; POSITIVE ION ELECTROSPRAY; PRECIPITATION; PRIORITY JOURNAL; RAT; STANDARD; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; VALIDATION STUDY; ANIMAL; BLOOD; PROCEDURES;

ANIMALS; BRIDGED COMPOUNDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; FLAVANONES; GLUCOSIDES; ISOFLAVONES; MONOTERPENES; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84896332447     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.02.013     Document Type: Article

References (38)

1. Zhu X., Proctor M., Bensoussan A., Wu E., Smith C.A. Chinese herbal medicine for primary dysmenorrhoea. Cochrane Database Syst. Rev. 2008, 2:CD005288.
2. Dawood M.Y. Primary dysmenorrhea: advances in pathogenesis and management. Obstet. Gynecol. 2006, 108:428-441.
3. Liu P., Duan J.A., Wang P.J., Qian D.W., Guo J.M., Shang E.X., Su S.L., Tang Y.P., Tang Z.X. Biomarkers of primary dysmenorrhea and herbal formula intervention: an exploratory metabonomics study of blood plasma and urine. Mol. Biosyst. 2013, 9:77-87.
4. Su S.L., Duan J.A., Wang P.J., Liu P., Guo J.M., Shang E.X., Qian D.W., Tang Y.P., Tang Z.X. Metabolomic study of biochemical changes in the plasma and urine of primary dysmenorrhea patients using UPLC-MS coupled with a pattern recognition approach. J. Proteome Res. 2013, 12:852-865.
5. Harel Z. Dysmenorrhea in adolescents and young adults: etiology and management. J. Pediatr. Adolesc. Gynecol. 2006, 19:363-371.
6. Cheng J.F., Lu Z.y.J., Su Y.C., Chiang L.C., Wang R.Y. A traditional Chinese herbal medicine used to treat dysmenorrhoea among Taiwanese women. J. Clin. Nurs. 2008, 17:2588-2595.
7. Rigi S.N., Navidian A., Safabakhsh L., Safarzadeh A., Khazaian S., Shafie S., Salehian T. Comparing the analgesic effect of heat patch containing iron chip and ibuprofen for primary dysmenorrhea: a randomized controlled trial. BMC Women's Health 2012, 10.1186/1472-6874-12-25.
8. Oya A., Oikawa T., Nakai A., Takeshita T., Hanawa T. Clinical efficacy of Kampo medicine (Japanese traditional herbal medicine) in the treatment of primary dysmenorrhea. J. Obst. Gynaecol. Res. 2008, 34:898-908.
9. Johnk C., Tina T.C. Pharmacological Effects and Clinical Research 2008, Art of Medicine Press, Canada. first ed.
10. Chai C.Z., Kou J.P., Zhu D.N., Yu B.Y. Experience in the application of Radix Puerariae decoction in pattern/syndrome differentiation and treatment of primary dysmenorrhea. World J. Integr. Tradit. West. Med. 2012, 3:244-246.
11. C.Z. Chai, B.Y. Yu, D.N. Zhu, J.P. Kou, Chinese medicinal composition for treating dysmenorrhea and preparation method thereof, Patent No.CN101406531, Application No. CN200810235428 (2011).
12. Yue X.Y., Chai C.Z., Kou J.P., Yu B.Y. Effect of Gegen Decoction on primary dysmenorrhea with cold-damp coagulation induced by oxytocin and cold simulating in mice. Chin. J. Exp. Tradit. Med. Formul. 2012, 18:174-177.
13. Yan Y., Chai C.Z., Wang D.W., Yue X.Y., Zhu D.N., Yu B.Y. HPLC-DAD-Q-TOF-MS/MS analysis and HPLC quantitation of chemical constituents in traditional Chinese medicinal formula Ge-Gen Decoction. J. Pharm. Biomed. Anal. 2013, 80:192-202.
14. Hu W.Z., Yang X.J., Zhe C., Zhang Q., Sun L., Cao K.J. Puerarin inhibits iNOS, COX-2 and CRP expression via suppression of NF-κB activation in LPS-induced RAW264.7 macrophage cells. Pharmacol. Rep. 2011, 63:781-789.
15. Park E.K., Shin J., Bae E.A., Lee Y.C., Kim D.H. Intestinal bacteria activate estrogenic effect of main constituents puerarin and daidzin of Pueraria thunbergiana. Biol. Pharm. Bull. 2006, 29:2432-2435.
16. Zheng Y.Q., Wei W., Zhu L., Liu J.X. Effects and mechanisms of Paeoniflorin, a bioactive glucoside from paeony root, on adjuvant arthritis in rats. Inflamm. Res. 2007, 56:182-188.
17. Kobayashi M., Ueda C., Aoki S., Tajima K., Tanaka N., Yamahara J. Anticholinergic action of Paeony root and its active constituents. Yakugaku Zasshi 1990, 110:964-968.
18. Sun Y.X., Tang Y., Wu A.L., Liu T., Dai X.L., Zheng Q.S., Wang Z.B. Neuroprotective effect of liquiritin against focal cerebral ischemia/reperfusion in mice via its antioxidant and antiapoptosis properties. J. Asian Nat. Prod. Res. 2010, 12:1051-1060.
19. Mersereau J.E., Levy N., Staub R.E., Baggett S., Zogric T., Chow S., Ricke W.A., Tagliaferri M., Cohen I., Bjeldanes L.F. Liquiritigenin is a plant-derived highly selective estrogen receptor β agonist. Mol. Cell. Endocrinol. 2008, 283:49-57.
20. Kim Y., Zhao R., Park S., Lee J., Cho I., Yang C., Kim S., Kim S. Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NF-κB-dependent iNOS and proinflammatory cytokines production. Br. J. Pharmacol. 2008, 154:165-173.
21. Yu Z.G., Gao X.X., Yuan H.X., Liu T., Ma M.Y., Chen X.H., Bi K.S. Simultaneous determination of safflor yellow A, puerarin, daidzein, ginsenosides (Rg1, Rb1, Rd), and notoginsenoside R1in rat plasma by liquid chromatography-mass spectrometry. J. Pharm. Biomed. Anal. 2007, 45:327-336.
22. Ren F.Z., Jing Q.F., Shen Y.J., Ma H.M., Cui J.B. Quantitative determination of puerarin in dog plasma by HPLC and study on the relative bioavailability of sustained release tablets. J. Pharm. Biomed. Anal. 2006, 41:549-553.
23. Wen J., Qiao Y., Yang J., Liu X.Y., Song Y., Liu Z.G., Li F.M. UPLC-MS/MS determination of paeoniflorin, naringin, naringenin and glycyrrhetinic acid in rat plasma and its application to a pharmacokinetic study after oral administration of Si Ni San decoction. J. Pharm. Biomed. Anal. 2012, 66:271-277.
24. Yan B., Xing D.M., Ding Y., Tao J.L., Du L.J. HPLC method for the determination and pharmacokinetic studies on puerarin in cerebral ischemia reperfusion rat plasma after intravenous administration of puerariae radix isoflavone. J. Pharm. Biomed. Anal. 2005, 37:297-301.
25. Motoya N., Imata T., Nakano M., Tajima S. Clinical pharmacology study of Kahkon-to, a Kampo Herbal Medicine, in healthy volunteers-evaluation using a thermotracer. Prog. Med. 2000, 20:121-129.
26. Shaw L.H., Lin L.C., Tsai T.H. HPLC-MS/MS analysis of a traditional Chinese medical formulation of Bu-Yang-Huan-Wu-Tang and its pharmacokinetics after oral administration to rats. PLoS One 2012, 7:1-13.
27. Luo C.F., Yuan M., Chen M.S., Liu S.M., Zhu L., Huang B.Y., Liu X.W., Xiong W. Pharmacokinetics, tissue distribution and relative bioavailability of puerarin solid lipid nanoparticles following oral administration. Int. J. Pharm. 2011, 410:138-144.
28. Miao W.J., Wang Q., Bo T., Ye M., Qiao X., Yang W.Z., Xiang C., Guan X.Y., Guo D.A. Rapid characterization of chemical constituents and rats metabolites of the traditional Chinese patent medicine Gegen-Qinlian-Wan by UHPLC/DAD/qTOF-MS. J. Pharm. Biomed. Anal. 2013, 72:99-108.
29. Ku D.H., Yo K.U., Eun-Ah B., Han M.J. Metabolism of puerarin and daidzin by human intestinal bacteria and their relation to in vitro cytotoxicity. Bio. Pharm. Bull. 1998, 6:628-630.
30. Gu L.W., House S.E., Prior R.L., Fang N., Ronis M.J., Clarkson T.B., Wilson M.E., Badger T.M. Metabolic phenotype of isoflavones differ among female rats, pigs, monkeys, and women. J. Nutr. 2006, 136:1215-1221.
31. Lin Y.J., Hou Y.C., Lin C.H., Hsu Y.A., Sheu J.J., Lai C.H., Chen B.H., Lee Chao P.D., Wan L., Tsai F.J. Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells. Biochem. Biophys. Res. Commun. 2009, 378:683-688.
32. Qiao X., Ye M., Xiang C., Wang Q., Liu C.F., Miao W.J., Guo D.A. Analytical strategy to reveal the in vivo process of multi-component herbal medicine: a pharmacokinetic study of licorice using liquid chromatography coupled with triple quadrupole mass spectrometry. J. Chromatogr. A 2012, 1258:84-93.
33. Xiang C., Qiao X., Wang Q., Li R., Miao W.J., Guo D.A., Ye M. From single compounds to herbal extract: a strategy to systematically characterize the metabolites of licorice in rats. Drug Metab. Dispos. 2011, 39:1597-1608.
34. Jayaprakasam B., Doddaga S., Wang R., Holmes D., Goldfarb J., Li X.M. Licorice flavonoids inhibit eotaxin secretion by human fetal lung fibroblasts in vitro. J. Agric. Food Chem. 2009, 57:820-825.
35. Tang N.Y., Liu C.H., Hsieh C.T., Hsieh C.L. The anti-inflammatory effect of paeoniflorin on cerebral infarction induced by ischemia-reperfusion injury in Sprague-Dawley rats. Am. J. Chin. Med. 2010, 38:51-64.
36. Feng C., Liu M., Shi X.W., Yang W., Kong D.Z., Duan K.P., Wang Q. Pharmacokinetic properties of paeoniflorin, albiflorin and oxypaeoniflorin after oral gavage of extracts of Radix Paeoniae Rubra and Radix Paeoniae Alba in rats. J. Ethnopharmacol. 2010, 130:407-413.
37. Tong L., Wan M.X., Zhou D.D., Gao J., Zhu Y.H., Bi K.S. LC-MS/MS determination and pharmacokinetic study of albiflorin and paeoniflorin in rat plasma after oral administration of Radix Paeoniae Alba extract and Tang-Min-Ling-Wan. Biomed. Chromatogr. 2010, 24:1324-1331.
38. Sheng Y., Li L., Wang C., Li Y., Guo D.A. Solid-phase extraction-liquid chromatographic method for the determination and pharmacokinetic studies of albiflorin and paeoniflorin in rat serum after oral administration of Si-Wu decoction. J. Chromatogr. B 2004, 806:127-132.