Fmoc-conjugated peg-vitamin e2 micelles for tumor-targeted delivery of paclitaxel: Enhanced drug-carrier interaction and loading capacity

AAPS Journal

Volumn 16, Issue 6, 2014, Pages 1282-1291

  Zhang, Yifei ^a,b   Huang, Yixian ^a,b   Zhao, Wenchen ^a   Lu, Jianqin ^a,b   Zhang, Peng ^a,b   Zhang, Xiaolan ^a,b   Li, Jiang ^a,b   Gao, Xiang ^a,b   Venkataramanan, Raman ^a,b   Li, Song ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

Drug delivery; Drug interactive motif; Micelles; Paclitaxel; Vitamin E derivative

Indexed keywords

ALPHA TOCOPHEROL DERIVATIVE; CARBONYL DERIVATIVE; DRUG CARRIER; FLUORENYLMETHOXYCARBONYL; LYSINE; MACROGOL; PACLITAXEL; UNCLASSIFIED DRUG; VITAMIN E2; ALPHA TOCOPHEROL; ANTINEOPLASTIC AGENT; MACROGOL DERIVATIVE; MICELLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CHEMICAL INTERACTION; CONTROLLED STUDY; CRITICAL MICELLE CONCENTRATION; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG FORMULATION; DRUG LOADING CAPACITY; DRUG SAFETY; DRUG STABILITY; DRUG TISSUE LEVEL; FEMALE; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; MALE; MICELLE; MOUSE; NONHUMAN; PHARMACOLOGICAL PARAMETERS; PHYSICAL CHEMISTRY; RAT; SYNTHESIS; TUMOR CELL LINE; ANALOGS AND DERIVATIVES; ANIMAL; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; MAMMARY NEOPLASMS, EXPERIMENTAL; METABOLISM; MOLECULARLY TARGETED THERAPY; PARTICLE SIZE; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CELL SURVIVAL; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; FEMALE; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MICELLES; MOLECULAR TARGETED THERAPY; NEOPLASM TRANSPLANTATION; PACLITAXEL; PARTICLE SIZE; POLYETHYLENE GLYCOLS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION; VITAMIN E;

EID: 84938771322     PISSN: None     EISSN: 15507416     Source Type: Journal    
DOI: 10.1208/s12248-014-9651-2     Document Type: Article

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