The role of non-covalent interactions in anticancer drug loading and kinetic stability of polymeric micelles

Biomaterials

Volumn 33, Issue 10, 2012, Pages 2971-2979

  Yang, Chuan ^a   Ebrahim Attia, Amalina B ^a   Tan, Jeremy P K ^a   Ke, Xiyu ^a   Gao, Shujun ^a   Hedrick, James L ^b   Yang, Yi Yan ^a  

^a INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

^b IBM ALMADEN RESEARCH CENTER   (United States)

Author keywords

Carboxylic acid group; Drug loading; Kinetic stability; Micelles; Non covalent interaction; Urea group

Indexed keywords

CARBOXYLIC ACID GROUPS; DRUG LOADING; KINETIC STABILITY; NON-COVALENT INTERACTION; UREA GROUP;

BLOCK COPOLYMERS; CARBOXYLIC ACIDS; CRITICAL MICELLE CONCENTRATION; DRUG DELIVERY; DRUG INTERACTIONS; DRUG PRODUCTS; ETHYLENE; FUNCTIONAL POLYMERS; GLYCOLS; HYDROGEN; KINETICS; LIVING POLYMERIZATION; LOADING; METABOLISM; MOLECULAR STRUCTURE; POLYCARBONATES; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; RING OPENING POLYMERIZATION; SIZE DISTRIBUTION; STABILITY; STRESS ANALYSIS; TISSUE; UREA;

MICELLES;

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACID; AMINE; ANTINEOPLASTIC AGENT; DOXORUBICIN; HYDROGEN; MACROGOL; POLYCARBONATE; POLYMER; UREA DERIVATIVE;

ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; CELL STRAIN HEK293; CELL STRAIN HEPG2; CHEMICAL INTERACTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG POTENCY; DRUG RELEASE; DRUG STABILITY; FREEZE DRYING; HEART; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; IN VITRO STUDY; INJECTION; LOAD CARRYING CAPACITY; MICELLE; MICELLIZATION; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; POLYMERIZATION; PRIORITY JOURNAL; SERUM; SYNTHESIS;

ACIDS; ANIMALS; ANTINEOPLASTIC AGENTS; CELL DEATH; CELL SURVIVAL; DOXORUBICIN; HEK293 CELLS; HEP G2 CELLS; HUMANS; KINETICS; LIGHT; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICELLES; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; POLYCARBOXYLATE CEMENT; POLYETHYLENE GLYCOLS; POLYMERS; SCATTERING, RADIATION; TISSUE DISTRIBUTION; UREA;

MUS;

EID: 84862812361     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.11.035     Document Type: Article

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