JTP-103237, a monoacylglycerol acyltransferase inhibitor, prevents fatty liver and suppresses both triglyceride synthesis and de novo lipogenesis

Journal of Pharmacological Sciences

Volumn 128, Issue 3, 2015, Pages 150-157

  Okuma, Chihiro ^a   Ohta, Takeshi ^a   Tadaki, Hironobu ^a   Ishigure, Tatsuya ^a   Sakata, Shohei ^a   Taniuchi, Hideyuki ^a   Sano, Ryuhei ^a   Hamada, Hiromi ^a   Kume, Shinichi ^b   Nishiu, Jun ^a   Kakutani, Makoto ^a  

^a JAPAN TOBACCO INC   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

de novo lipogenesis; JTP 103237; Monoacyglycerol acyltransferase; Nonalcoholic fatty liver disease

Indexed keywords

7 (4,6 DI TERT BUTYL PYRIMIDIN 2 YL) 3 (4 TRIFLUOROMETHOXY PHENYL) 5,6,7,8 TETRAHYDRO[1,2,4]TRIAZOLO[4,3 A]PYRAZINE; ACYLGLYCEROL PALMITOYLTRANSFERASE; ACYLTRANSFERASE INHIBITOR; CHOLESTEROL; DIACYLGLYCEROL; FATTY ACID; GLUCOSE; MESSENGER RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; 2-ACYLGLYCEROL O-ACYLTRANSFERASE; 7-(4,6-DI-TERT-BUTYLPYRIMIDIN-2-YL)-3-(4-TRIFLUOROMETHOXYPHENYL)-5,6,7,8-TETRAHYDRO(1,2,4)TRIAZOLO(4,3-A)PYRAZINE; ACYLTRANSFERASE; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; ENZYME INHIBITOR; INVJ PROTEIN, SALMONELLA TYPHIMURIUM; PIPERAZINE DERIVATIVE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE DIET; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFICACY; DRUG MECHANISM; ENZYME INHIBITION; EPIDIDYMIS FAT; FATTY ACID SYNTHESIS; FATTY LIVER; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE UTILIZATION; HISTOPATHOLOGY; INSULIN SENSITIVITY; LIPID LIVER LEVEL; LIPID METABOLISM; LIPID STORAGE; LIPOGENESIS; LOW FAT DIET; MALE; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; GENETICS; INTESTINE ABSORPTION; LIVER; METABOLISM; PHYSIOLOGY;

ACYLTRANSFERASES; ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; DIGLYCERIDES; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FATTY ACIDS; FATTY LIVER; GENE EXPRESSION; INTESTINAL ABSORPTION; LIPOGENESIS; LIVER; MALE; MICE, INBRED C57BL; PIPERAZINES; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIAZOLES; TRIGLYCERIDES;

EID: 84938751450     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1016/j.jphs.2015.06.007     Document Type: Article

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