Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver

Journal of Lipid Research

Volumn 53, Issue 5, 2012, Pages 990-999

  Hall, Angela M ^a   Kou, Kou ^b   Chen, Zhouji ^a   Pietka, Terri A ^a   Kumar, Mrudula ^a   Korenblat, Kevin M ^a   Lee, Kyuha ^b   Ahn, Kay ^b   Fabbrini, Elisa ^a   Klein, Samuel ^a   Goodwin, Bryan ^b   Finck, Brian N ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PFIZER INC   (United States)

Author keywords

Diacylglycerol; Hepatic steatosis; Nonalcoholic fatty liver disease; Triacylglycerol

Indexed keywords

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; GENE; GENE ACTIVITY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE LOCATION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC CORRELATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER BIOPSY; LIVER CELL; MAJOR CLINICAL STUDY; MALE; MONOACYLGLYCEROL ACYLTRANSFERASE 1 GENE; MONOACYLGLYCEROL ACYLTRANSFERASE 2 GENE; MONOACYLGLYCEROL ACYLTRANSFERASE 3 GENE; NONALCOHOLIC FATTY LIVER; OBESITY; PRIORITY JOURNAL; STOMACH BYPASS; WEIGHT REDUCTION;

ACYLTRANSFERASES; ADULT; AGED; DIACYLGLYCEROL O-ACYLTRANSFERASE; FATTY LIVER; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEP G2 CELLS; HUMANS; INSULIN RESISTANCE; LIVER; MALE; MIDDLE AGED; OBESITY; YOUNG ADULT;

EID: 84860280975     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.P025536     Document Type: Article

References (34)

1. Fabbrini, E., F. Magkos, B. S. Mohammed, T. Pietka, N. A. Abumrad, B. W. Patterson, A. Okunade, and S. Klein. 2009. Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc. Natl. Acad. Sci. USA. 106: 15430-15435.
2. Savage, D. B., K. F. Petersen, and G. I. Shulman. 2007. Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol. Rev. 87: 507-520. (Pubitemid 47084679)
3. Schaffer, J. E. 2003. Lipotoxicity: when tissues overeat. Curr. Opin. Lipidol. 14: 281-287. (Pubitemid 36688207)
4. Shi, Y., and D. Cheng. 2009. Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism. Am. J. Physiol. Endocrinol. Metab. 297: E10-E18.
5. Yen, C. L., S. J. Stone, S. Koliwad, C. Harris, and R. V. Farese, Jr. 2008. Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis. J. Lipid Res. 49: 2283-2301.
6. Mostafa, N., B. G. Bhat, and R. A. Coleman. 1993. Increased hepatic monoacylglycerol acyltransferase activity in streptozotocin-induced diabetes: characterization and comparison with activities from adult and neonatal rat liver. Biochim. Biophys. Acta. 1169: 189-195. (Pubitemid 23234596)
7. Bhat, B. G., E. S. Bardes, and R. A. Coleman. 1993. Solubilization and partial purification of neonatally expressed rat hepatic microsomal monoacylglycerol acyltransferase. Arch. Biochem. Biophys. 300: 663-669.
8. Yen, C. L., and R. V. Farese, Jr. 2003. MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine. J. Biol. Chem. 278: 18532-18537.
9. Yen, C. L., S. J. Stone, S. Cases, P. Zhou, and R. V. Farese, Jr. 2002. Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase. Proc. Natl. Acad. Sci. USA. 99: 8512-8517. (Pubitemid 34693593)
10. Cao, J., J. Lockwood, P. Burn, and Y. Shi. 2003. Cloning and functional characterization of a mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2. J. Biol. Chem. 278: 13860-13866. (Pubitemid 36799925)
11. Cheng, D., T. C. Nelson, J. Chen, S. G. Walker, J. Wardwell-Swanson, R. Meegalla, R. Taub, J. T. Billheimer, M. Ramaker, and J. N. Feder. 2003. Identification of acyl coenzyme A:monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorption. J. Biol. Chem. 278: 13611-13614. (Pubitemid 36799893)
12. Yue, Y. G., Y. Q. Chen, Y. Zhang, H. Wang, Y. W. Qian, J. S. Arnold, J. N. Calley, S. D. Li, W. L. Perry 3rd, H. Y. Zhang, et al. 2011. The acyl coenzymeA:monoacylglycerol acyltransferase 3 (MGAT3) gene is a pseudogene in mice but encodes a functional enzyme in rats. Lipids. 46: 513-520.
13. Cao, J., L. Cheng, and Y. Shi. 2007. Catalytic properties of MGAT3, a putative triacylgycerol synthase. J. Lipid Res. 48: 583-591. (Pubitemid 46397461)
14. Cheng, D., J. Iqbal, J. Devenny, C. H. Chu, L. Chen, J. Dong, R. Seethala, W. J. Keim, A. V. Azzara, R. M. Lawrence, et al. 2008. Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption. J. Biol. Chem. 283: 29802-29811.
15. Yen, C. L., M. Monetti, B. J. Burri, and R. V. Farese, Jr. 2005. The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters. J. Lipid Res. 46: 1502-1511. (Pubitemid 43109815)
16. Hoover, H. S., J. L. Blankman, S. Niessen, and B. F. Cravatt. 2008. Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling. Bioorg. Med. Chem. Lett. 18: 5838-5841.
17. Dow, R. L., and M. J. Munchhof. 2010. Substituted bicyclolactam compounds. Patent application number 20090036425.
18. Patterson, B. W., G. Zhao, and S. Klein. 1998. Improved accuracy and precision of gas chromatography/mass spectrometry measurements for metabolic tracers. Metabolism. 47: 706-712. (Pubitemid 28265176)
19. Steele, R. 1959. Influences of glucose loading and of injected insulin on hepatic glucose output. Ann. N. Y. Acad. Sci. 82: 420-430.
20. Matsuda, M., and R. A. DeFronzo. 1999. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care. 22: 1462-1470. (Pubitemid 29418240)
21. Turkish, A. R., A. L. Henneberry, D. Cromley, M. Padamsee, P. Oelkers, H. Bazzi, A. M. Christiano, J. T. Billheimer, and S. L. Sturley. 2005. Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily. J. Biol. Chem. 280: 14755-14764. (Pubitemid 40562823)
22. Cortés, V. A., D. E. Curtis, S. Sukumaran, X. Shao, V. Parameswara, S. Rashid, A. R. Smith, J. Ren, V. Esser, R. E. Hammer, et al. 2009. Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy. Cell Metab. 9: 165-176.
23. Lockwood, J. F., J. Cao, P. Burn, and Y. Shi. 2003. Human intestinal monoacylglycerol acyltransferase: differential features in tissue expression and activity. Am. J. Physiol. Endocrinol. Metab. 285: E927-E937. (Pubitemid 37296313)
24. Satoh, T. 1987. Role of carboxylesterases in xenobiotic metabolism. In Reviews in Biochemical Toxicology. J. R. Benda, B. E. Hodgson, and R. M. Philpot, editors. Elsevier, New York. 155-181.
25. Mentlein, R., H. Rix-Matzen, and E. Heymann. 1988. Subcellular localization of non-specific carboxylesterases, acylcarnitine hydrolase, monoacylglycerol lipase and palmitoyl-CoA hydrolase in rat liver. Biochim. Biophys. Acta. 964: 319-328. (Pubitemid 18084982)
26. Yen, C. L., M. L. Cheong, C. Grueter, P. Zhou, J. Moriwaki, J. S. Wong, B. Hubbard, S. Marmor, and R. V. Farese, Jr. 2009. Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding. Nat. Med. 15: 442-446.
27. Long, J., P. Darroch, K. F. Wan, K. C. Kong, N. Ktistakis, N. J. Pyne, and S. Pyne. 2005. Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools. Biochem. J. 391: 25-32. (Pubitemid 41445472)
28. Reue, K., and D. N. Brindley. 2008. Thematic review series: glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism. J. Lipid Res. 49: 2493-2503.
29. Lee, D. P., A. S. Deonarine, M. Kienetz, Q. Zhu, M. Skrzypczak, M. Chan, and P. C. Choy. 2001. A novel pathway for lipid biosynthesis: the direct acylation of glycerol. J. Lipid Res. 42: 1979-1986. (Pubitemid 34001046)
30. Kang, H. S., K. Okamoto, Y. S. Kim, Y. Takeda, C. D. Bortner, H. Dang, T. Wada, W. Xie, X. P. Yang, G. Liao, et al. 2011. Nuclear orphan receptor TAK1/TR4-deficient mice are protected against obesity-linked inflammation, hepatic steatosis, and insulin resistance. Diabetes. 60: 177-188.
31. Hiramine, Y., H. Emoto, S. Takasuga, and R. Hiramatsu. 2010. Novel acyl-coenzyme A:monoacylglycerol acyltransferase plays an important role in hepatic triacylglycerol secretion. J. Lipid Res. 51: 1424-1431.
32. Klein, S., B. Mittendorfer, J. C. Eagon, B. Patterson, L. Grant, N. Feirt, E. Seki, D. Brenner, K. Korenblat, and J. McCrea. 2006. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Gastroenterology. 130: 1564-1572. (Pubitemid 43668832)
33. Hall, A. M., E. M. Brunt, S. Klein, and B. N. Finck. 2010. Hepatic expression of cell death-inducing DFFA-like effector C in obese subjects is reduced by marked weight loss. Obesity (Silver Spring). 18: 417-419.
34. Croce, M. A., J. C. Eagon, L. L. LaRiviere, K. M. Korenblat, S. Klein, and B. N. Finck. 2007. Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss. Diabetes. 56: 2395-2399. (Pubitemid 47358247)