JTP-103237, a novel monoacylglycerol acyltransferase inhibitor, modulates fat absorption and prevents diet-induced obesity

European Journal of Pharmacology

Volumn 758, Issue , 2015, Pages 72-81

  Okuma, Chihiro ^a   Ohta, Takeshi ^a   Tadaki, Hironobu ^a   Hamada, Hiromi ^a   Oda, Tomohiro ^a   Taniuchi, Hideyuki ^a   Yamanaka, Kenji ^a   Ishii, Yukihito ^a   Ohe, Yasuhiro ^a   Yata, Shinji ^a   Nishiu, Jun ^a   Aratsu, Yusuke ^a   Oshida, Shinichi ^a   Kume, Shinichi ^b   Kakutani, Makoto ^a  

^a JAPAN TOBACCO INC   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

JTP 103237; Monoacylglycerol acyltransferase; Obesity; Satiety

Indexed keywords

ACYLGLYCEROL PALMITOYLTRANSFERASE; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; DIACYLGLYCEROL ACYLTRANSFERASE; FATTY ACID; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN; JTP 103237; MONOACYLGLYCEROL; PEPTIDE YY; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; 2-ACYLGLYCEROL O-ACYLTRANSFERASE; 7-(4,6-DI-TERT-BUTYLPYRIMIDIN-2-YL)-3-(4-TRIFLUOROMETHOXYPHENYL)-5,6,7,8-TETRAHYDRO(1,2,4)TRIAZOLO(4,3-A)PYRAZINE; ACYLTRANSFERASE; PIPERAZINE DERIVATIVE; TRIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENERGY EXPENDITURE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME SUBSTRATE; FAT CONTENT; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HORMONE BLOOD LEVEL; IN VIVO STUDY; INSULIN BLOOD LEVEL; LIPID ABSORPTION; LIPID LIVER LEVEL; LIPID METABOLISM; MALE; MOUSE; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SMALL INTESTINE; SPECIES DIFFERENCE; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT REDUCTION; ADVERSE EFFECTS; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; BODY WEIGHT; CHEMICALLY INDUCED; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; DRUG EFFECTS; EATING; GLUCOSE TOLERANCE TEST; HUMAN; INTESTINE ABSORPTION; LIPID DIET; METABOLISM; RAT;

ACYLTRANSFERASES; ANIMALS; BODY WEIGHT; CERCOPITHECUS AETHIOPS; COS CELLS; DIET, HIGH-FAT; EATING; GLUCOSE TOLERANCE TEST; HUMANS; INTESTINAL ABSORPTION; LIPID METABOLISM; MALE; MICE; OBESITY; OXYGEN CONSUMPTION; PEPTIDE YY; PIPERAZINES; RATS; TRIAZOLES;

EID: 84927742056     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.03.072     Document Type: Article

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