Aurantio-obtusin relaxes systemic arteries through endothelial PI3K/AKT/eNOS-dependent signaling pathway in rats

Journal of Pharmacological Sciences

Volumn 128, Issue 3, 2015, Pages 108-115

  Li, Shuzhen ^a   Li, Qian ^a   Lv, Xinyu ^a   Liao, Lin ^a   Yang, Weiwei ^b   Li, Shanshan ^a   Lu, Ping ^a   Zhu, Daling ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b NORTHEAST AGRICULTURAL UNIVERSITY   (China)

Author keywords

Aurantio obtusin; Mesenteric artery; Nitric oxide synthase; PI3K Akt pathway; Vasorelaxation

Indexed keywords

AURANTIO; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; OBTUSIN; PHENYLEPHRINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; SERINE; UNCLASSIFIED DRUG; VASODILATOR AGENT; ANTHRAQUINONE DERIVATIVE; ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT; AURANTIO-OBTUSIN; NITRIC OXIDE SYNTHASE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIHYPERTENSIVE ACTIVITY; ARTERY DIAMETER; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG STRUCTURE; HYPERTENSION; MALE; MESENTERIC ARTERY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; PULMONARY ARTERY; RAT; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; VASODILATATION; ANIMAL; BOVINE; CELL CULTURE; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; VASCULAR ENDOTHELIUM; WISTAR RAT;

ANIMALS; ANTHRAQUINONES; ANTIHYPERTENSIVE AGENTS; CATTLE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HYPOLIPIDEMIC AGENTS; MALE; MESENTERIC ARTERIES; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS, WISTAR; SIGNAL TRANSDUCTION; VASODILATION;

EID: 84938748856     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1016/j.jphs.2015.05.006     Document Type: Article

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