Elevated Numbers of Immature/Transitional CD21- B Lymphocytes and Deficiency of Memory CD27+ B Cells Identify Patients with Active Chronic Graft-versus-Host Disease

Biology of Blood and Marrow Transplantation

Volumn 14, Issue 2, 2008, Pages 208-219

  Greinix, Hildegard T ^a   Pohlreich, David ^a   Kouba, Michal ^a   Körmöczi, Ulrike ^b   Lohmann, Imke ^b   Feldmann, Karin ^a   Zielinski, Christoph ^a   Pickl, Winfried F ^b  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

chronic GVHD; immature transitional and memory B lymphocytes

Indexed keywords

ANTINEOPLASTIC AGENT; CALCINEURIN INHIBITOR; CD19 ANTIGEN; CD27 ANTIGEN; COMPLEMENT COMPONENT C3D RECEPTOR; CYCLOSPORIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN D; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; STEROID; TACROLIMUS;

ACUTE GRAFT VERSUS HOST DISEASE; ACUTE LEUKEMIA; ADULT; AGED; ANTIBIOTIC PROPHYLAXIS; ARTICLE; B LYMPHOCYTE; CHRONIC GRAFT VERSUS HOST DISEASE; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DIAGNOSTIC VALUE; DISEASE ACTIVITY; DISEASE MARKER; DISEASE SEVERITY; FEMALE; FLOW CYTOMETRY; HEMATOLOGIC MALIGNANCY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOTHERAPY; INFECTION; LYMPHOCYTE COUNT; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; MEMORY CELL; MYELOABLATIVE CONDITIONING; NATURAL KILLER CELL; PILOT STUDY; REDUCED INTENSITY CONDITIONING; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE;

ADULT; AGED; ANTIGENS, CD27; B-LYMPHOCYTES; CHRONIC DISEASE; FEMALE; FLOW CYTOMETRY; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; PILOT PROJECTS; RECEPTORS, COMPLEMENT 3D;

EID: 38149118876     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2007.10.009     Document Type: Article

References (54)

1. Lee S.J., Vogelsang G., Gilman A., et al. A survey of diagnosis, management, and grading of chronic GVHD. Biol Blood Marrow Transplant 8 (2002) 32-39
2. Filipovich A.H., Weisdorf D., Pavletic S., et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biol Blood Marrow Transplant 11 (2005) 945-956
3. Socie G., Stone J.V., Wingard J.R., et al. Long-term survival and late deaths after allogeneic bone marrow transplantation. Late Effects Working Committee of the International Bone Marrow Transplant Registry. N Engl J Med 341 (1999) 14-21
4. Atkinson K. Reconstruction of the haemopoietic and immune systems after marrow transplantation. Bone Marrow Transplant 5 (1990) 209-226
5. Storek J., Joseph A., Espino G., et al. Immunity of patients surviving 20 to 30 years after allogeneic or syngeneic bone marrow transplantation. Blood 98 (2001) 3505-3512
6. Roberts M.M., To L.B., Gillis D., et al. Immune reconstitution following peripheral blood stem cell transplantation, autologous bone marrow transplantation and allogeneic bone marrow transplantation. Bone Marrow Transplant 12 (1993) 469-475
7. Small T.N., Avigan D., Dupont B., et al. Immune reconstitution following T-cell depleted bone marrow transplantation: effect of age and posttransplant graft rejection prophylaxis. Biol Blood Marrow Transplant 3 (1997) 65-75
8. Barrett J. Improving outcome of allogeneic stem cell transplantation by immunomodulation of the early post-transplant environment. Curr Opin Immunol 18 (2006) 592-598
9. Sullivan K.M., Blume K.G., Forman S.J., and Applbaum F.R. Graft versus host disease. Thomas'Hematopoietic Cell Transplantation (2004), Blackwell Publishers, Malden, MA 635-664
10. Tivol E., Komorowski R., and Drobyski W.R. Emergent autoimmunity in graft-versus-host disease. Blood 105 (2005) 4885-4891
11. Hakim F.T., and Mackall C.L. The immune system: effector and target of graft-versus-host disease. In: Deeg H.J., and Burakoff S.J. (Eds). Graft-vs. -Host Disease (1997), Marcel Dekker, Inc., New York 257-289
12. Cutler C., Miklos D., Kim H.T., et al. Rituximab for steroid-refractory chronic graft-versus host disease. Blood 108 (2006) 756-762
13. Ratanatharathorn V., Ayash L., Reynolds C., et al. Treatment of chronic graft-versus-host disease with anti-CD20 chimeric monoclonal antibody. Biol Blood Marrow Transplant 9 (2003) 505-511
14. Teshima T., Reddy P., Liu C., et al. Impaired thymic negative selection causes autoimmune graft-versus-host disease. Blood 102 (2003) 429-435
15. Kalhs P., Panzer S., Kletter K., et al. Functional asplenia after bone marrow transplantation. A late complication related to extensive chronic graft-versus-host disease. Ann Intern Med 109 (1988) 461-464
16. Kruetzmann S., Rosado M.M., Weber H., et al. Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen. J Exp Med 197 (2003) 939-945
17. Chung J.B., Silverman M., and Monroe J.G. Transitional B cells: step by step towards immune competence. Trends Immunol 24 (2003) 343-349
18. Carsetti R., Rosado M.M., and Wardemann H. Peripheral development of B cells in mouse and man. Immunol Rev 191 (2004) 179-191
19. Mackay F., Silveira P.A., and Brink R. B cells and the BAFF/APRIL axis: fast-forward on autoimmunity and signalling. Curr Opin Immunol 19 (2007) 327-336
20. Zinkernagel R.M., and Hengartner H. Protective 'immunity' by pre-existent neutralizing antibody titers and preactivated T cells but not by so-called 'immunological-memory'. Immunol Rev 211 (2006) 310-319
21. Burrows P.D., and Cooper M.D. B cell development and differentiation. Curr Opin Immunol 9 (1997) 239-244
22. Tedder T.F., Fearon D.T., Gartland G.L., et al. Expression of C3b receptors on human B cells and myelomonocytic cells but not natural killer cells. J Immunol 130 (1983) 1668-1673
23. Sims G.P., Ettinger R., Shirota Y., et al. Identification and characterization of circulating human transitional B cells. Blood 105 (2005) 4390-4398
24. Warnatz K., Wehr C., Drager R., et al. Expansion of CD19(hi)CD21(lo/neg) B cells in common variable immunodeficiency (CVID) patients with autoimmune cytopenia. Immunobiology 206 (2002) 502-513
25. Malaspina A., Moir S., Ho J., et al. Appearance of immature/transitional B cells in HIV-infected individuals with advanced disease: correlation with increased IL-7. Proc Natl Acad Sci U S A 103 (2006) 2262-2267
26. Maurer D., Fischer G.F., Fae I., et al. IgM and IgG but not cytokine secretion is restricted to the CD27+ B lymphocyte subset. J Immunol 148 (1992) 3700-3705
27. Maurer D., Holter W., Majdic O., Fischer G.F., and Knapp W. CD27 expression by a distinct subpopulation of human B lymphocytes. Eur J Immunol 20 (1990) 2679-2684
28. Cancer Therapy Evaluation Program: Common Toxicity Criteria 1999: Bethesda, MD: National Cancer Institute (Accessed July 17, 2006, at http://ctep.cancer.gov/forms/CTCManual_v4_10-4-99.pdf).
29. Pavletic S.Z., Lee S.J., Socie G., et al. Chronic graft-versus-host disease: implications of the National Institutes of Health consensus development project on criteria for clinical trials. Bone Marrow Transplant (2006) 645-651
30. Rizzo J.D., Wingard J.R., Tichelli A., et al. Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation: joint recommendations of the European Group for Blood and Marrow Transplantation, the Center for International Blood and Marrow Transplant Research, and the American Society of Blood and Marrow Transplantation. Biol Blood Marrow Transplant 12 (2006) 138-151
31. Couriel D., Carpenter P.A., Cutler C., et al. Ancillary therapy and supportive care of chronic graft-versus-host disease: national institutes of health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: V. Ancillary Therapy and Supportive Care Working Group Report. Biol Blood Marrow Transplant 12 (2006) 375-396
32. Keil F., Kalhs P., Chen X., et al. Hematopoietic donor chimerism and graft-versusmyeloma effect in relapse of multiple myeloma after allogeneic bone marrow transplantation. Ann Hematol 78 (1999) 376-379
33. Perreault C., Giasson M., Gyger M., et al. Serum immunoglobulin levels following allogeneic bone marrow transplantation. Blut 51 (1985) 137-142
34. Storek J., Espino G., Dawson M.A., et al. Low B-cell and monocyte counts on day 80 are associated with high infection rates between days 100 and 365 after allogeneic marrow transplantation. Blood 96 (2000) 3290-3293
35. Storek J., Ferrara S., Ku N., et al. B cell reconstitution after human bone marrow transplantation: recapitulation of ontogeny?. Bone Marrow Transplant 12 (1993) 387-398
36. Leitenberg D., Rappeport J.M., and Smith B.R. B cell precursor bone marrow reconstitution after bone marrow transplantation. Am J Clin Pathol 102 (1994) 231-236
37. Storek J., Witherspoon R.P., Webb D., et al. Lack of B cells in marrow transplant recipients with chronic graft-versus-host disease. Am J Hematol 52 (1996) 82-89
38. Sanchez-Garcia J., Serrano J., Gomez P., et al. The impact of acute and chronic graft-versus-host disease on normal and malignant B-lymphoid precursors after allogeneic stem cell transplantation for B-lineage acute lymphoblastic leukemia. Haematologica 91 (2006) 340-347
39. Cuss A.K., Avery D.T., Cannons J.L., et al. Expansion of functionally immature transitional B cells is associated with human-immunodeficient states characterized by impaired humoral immunity. J Immunol 176 (2006) 1506-1516
40. Avanzini M.A., Locatelli F., Dos Santos C., et al. B lymphocyte reconstitution after hematopoietic stem cell transplantation: functional immaturity and slow recovery of memory CD27+ B cells. Exp Hematol 33 (2005) 480-486
41. Warnatz K., Denz A., Drager R., et al. Severe deficiency of switched memory B cells (CD27(+)IgM(-)IgD(-)) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease. Blood 99 (2002) 1544-1551
42. Korthauer U., Graf D., Mages H.W., et al. Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM. Nature 361 (1993) 539-541
43. errari S., Giliani S., Insalaco A., et al. Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM. Proc Natl Acad Sci U S A 98 (2001) 12614-12619
44. Endres R., Alimzhanov M.B., Plitz T., et al. Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells. J Exp Med 189 (1999) 159-168
45. Han S., Hathcock K., Zheng B., et al. Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. J Immunol 155 (1995) 556-567
46. Grimbacher B., Hutloff A., Schlesier M., et al. Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. Nat Immunol 4 (2003) 261-268
47. Malaspina A., Moir S., Chaitt D.G., et al. Idiopathic CD4+ T lymphoctopenia is associated with increases in immature/transitional B cells and serum levels of IL-7. Blood 109 (2007) 2086-2088
48. Rosenberg S.A., Sportes C., Ahmadzadeh M., et al. IL-7 administration to humans leads to expansion of CD8+ and CD4+ but a relative decrease of CD4+ T-regulatory cells. J Immunother 29 3 (2006) 13-319
49. Wardemann H., Yurasov S., Schaefer A., et al. Predominant autoantibody production by early human B cell precursors. Science 301 (2003) 1374-1377
50. Gross J.A., Johnston J., Mudri S., et al. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature 404 (2000) 995-999
51. Zhang M., Ko K.H., Lam Q.L., et al. Expression and function of TNF family member B cell activating factor in the development of autoimmune arthritis. Int Immunol 17 (2005) 1081-1092
52. Yurasov S., Wardemann H., Hammersen J., et al. Defective B cell tolerance checkpoints in systemic lupus erythematosus. J Exp Med 201 (2005) 703-711
53. Samuels J., Ng Y.S., Coupillaud C., et al. Impaired early B cell tolerance in patients with rheumatoid arthritis. J Exp Med 201 (2005) 1659-1667
54. Schultz K.R., Miklos D.B., Fowler D., et al. Toward biomarkers for chronic graft-versus host disease: National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: III. Biomarker Working Group Report. Biol Blood Marrow Transplant 12 (2006) 126-137